The stability of myocilin olfactomedin domain variants provides new insight into glaucoma as a protein misfolding disorder

Biochemistry

Volumn 50, Issue 26, 2011, Pages 5824-5833

  Burns, J Nicole ^a   Turnage, Katherine C ^a   Walker, Chandler A ^a   Lieberman, Raquel L ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATION PROPENSITY; BIOPHYSICAL FACTORS; CHEMICAL CHAPERONE; EXTRACELLULAR MATRICES; IN-VITRO; MELTING TEMPERATURES; MYOCILIN; OLFACTOMEDIN; OPEN-ANGLE GLAUCOMA; PILOT STUDIES; PROTEIN MISFOLDING; SECONDARY STRUCTURES; SINGLE NUCLEOTIDE POLYMORPHISMS; TRABECULAR MESHWORK CELL; TRIMETHYLAMINE N OXIDES; WILD TYPES;

DICHROISM; OPHTHALMOLOGY; PROTEINS; THERMODYNAMIC STABILITY; TISSUE;

CHEMICAL STABILITY;

MYOCILIN; OLFACTOMEDIN; PROTEIN; TRIMETHYLAMINE OXIDE; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; FLUORESCENCE; GLAUCOMA; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPERATURE; THERMOSTABILITY; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CYTOSKELETAL PROTEINS; EXTRACELLULAR MATRIX PROTEINS; EYE PROTEINS; GLAUCOMA; GLYCOPROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEOSTASIS DEFICIENCIES; RATS;

EID: 79959806015     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200231x     Document Type: Article

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