Novel therapeutic agents for bone resorption. Part 1. Synthesis and protonation thermodynamics of poly(amido-amine)s containing bis-phosphonate residues

Biomacromolecules

Volumn 7, Issue 12, 2006, Pages 3417-3427

  Casolaro, Mario ^a   Casolaro, Ilaria ^a   Spreafico, Adriano ^b   Capperucci, Caterina ^b   Frediani, Bruno ^b   Marcolongo, Roberto ^b   Margiotta, Nicola ^c   Ostuni, Rosa ^c   Mendichi, Raniero ^d   Samperi, Filippo ^e   Ishii, Takehiko ^f   Ito, Yoshihiro ^f,g  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY HOSPITAL OF SIENA   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d CNR   (Italy)

^e UNIVERSITY OF CATANIA   (Italy)

^f INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^g KANAGAWA ACADEMY OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE RESORPTION; MATRIX ASSISTED LASER DESORPTION IONIZATION; POLYAMIDO-AMINES; POLYDISPERSITY INDEX;

BONE; IONIZATION; MOLECULAR WEIGHT; OLIGOMERS; SIZE EXCLUSION CHROMATOGRAPHY; SYNTHESIS (CHEMICAL); THERMODYNAMICS;

BIOMEDICAL ENGINEERING;

1,4 BISACRYLOLPIPERAZINE; ALKALINE PHOSPHATASE; BISPHOSPHONIC ACID DERIVATIVE; NERIDRONIC ACID; PAMIDRONIC ACID; POLYAMIDOAMINE; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ARTICLE; BONE REMODELING; CELL ACTIVITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; OLIGOMERIZATION; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

BONE RESORPTION; CELL SURVIVAL; DIPHOSPHONATES; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PIPERAZINES; POTENTIOMETRY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THERMODYNAMICS; VISCOSITY;

ANIMALIA;

EID: 33846279808     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm0607630     Document Type: Article

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