Mechanism-based inactivation of cytochrome P450 2A6 by decursinol angelate isolated from Angelica gigas

Drug Metabolism and Disposition

Volumn 35, Issue 10, 2007, Pages 1759-1765

  Hye, Hyun Yoo ^a   Min, Woo Lee ^a   Young, Choong Kim ^b   Yun, Chul Ho ^c   Kim, Dong Hyun ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Seoul National University   (South Korea)

^c Chonnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANGELICA GIGAS EXTRACT; CATALASE; COUMARIN 7 HYDROXYLASE; CYTOCHROME P450 2A6; DECURSINOL ANGELATE; GLUTATHIONE; NICOTINE C OXIDASE; OXIDOREDUCTASE; PILOCARPINE; PYRANOCOUMARIN DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIALYSIS; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ANGELICA; ANTICARCINOGENIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; BENZOPYRANS; BUTYRIC ACIDS; HUMANS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; PLANT ROOTS; RECOMBINANT PROTEINS;

ANGELICA GIGAS;

EID: 34748913247     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.016584     Document Type: Article

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