Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Fertility and Sterility

Volumn 95, Issue 8, 2011, Pages

  Ewens, Kathryn G ^a   Jones, Michelle R ^b   Ankener, Wendy ^a   Stewart, Douglas R ^c   Urbanek, Margrit ^d   Dunaif, Andrea ^d   Legro, Richard S ^e   Chua, Angela ^b   Azziz, Ricardo ^b   Spielman, Richard S ^a   Goodarzi, Mark O ^b   Strauss III, Jerome F ^f  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e PENN STATE COLLEGE OF MEDICINE   (United States)

^f VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Polycystic ovary syndrome (PCOS); SNP; transmission disequilibrium test (TDT)

Indexed keywords

CYCLIN DEPENDENT KINASE AL1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; PROTEIN HHEX; PROTEIN IRS1; PROTEIN SLC30A8; PROTEIN WFS1; SOMATOMEDIN B BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CELL FUNCTION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FAMILY; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; INSULIN BLOOD LEVEL; INSULIN METABOLISM; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY POLYCYSTIC DISEASE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 79959741221     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.02.050     Document Type: Article

References (29)

1. R.S. Legro, A.R. Kunselman, W.C. Dodson, and A. Dunaif Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women J Clin Endocrinol Metab 84 1999 165 169 (Pubitemid 29036695)
2. D.A. Ehrmann Genetic contributions to glucose intolerance in polycystic ovary syndrome Reprod Biomed Online 9 2004 28 34 (Pubitemid 38961708)
3. B. Pelusi, A. Gambineri, and R. Pasquali Type 2 diabetes and the polycystic ovary syndrome Minerva Ginecol 56 2004 41 51 (Pubitemid 38313780)
4. A. Dunaif, and D.T. Finegood Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome J Clin Endocrinol Metab 81 1996 942 947 (Pubitemid 26083951)
5. S. Colilla, N.J. Cox, and D.A. Ehrmann Heritability of insulin secretion and insulin action in women with polycystic ovary syndrome and their first degree relatives J Clin Endocrinol Metab 86 2001 2027 2031 (Pubitemid 32472915)
6. A.M. Venkatesan, A. Dunaif, and A. Corbould Insulin resistance in polycystic ovary syndrome: progress and paradoxes Recent Prog Horm Res 56 2001 295 308
7. R. Saxena, B.F. Voight, V. Lyssenko, N.P. Burtt, P.I.W. de Bakker, and H. Chen Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 2007 1331 1336 (Pubitemid 46871653)
8. L.J. Scott, K.L. Mohlke, L.L. Bonnycastle, C.J. Willer, Y. Li, and W.L. Duren A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 2007 1341 1345 (Pubitemid 46871655)
9. R. Sladek, G. Rocheleau, J. Rung, C. Dina, L. Shen, and D. Serre A genome-wide association study identifies novel risk loci for type 2 diabetes Nature 445 2007 881 885
10. V. Steinthorsdottir, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, T. Jonsdottir, and G.B. Walters A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Nat Genet 39 2007 770 775 (Pubitemid 46848592)
11. E. Zeggini, L.J. Scott, R. Saxena, B.F. Voight, J.L. Marchini, and T. Hu Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet 40 2008 638 645 (Pubitemid 351601209)
12. The Wellcome Trust Case Control C Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 2007 661 678
13. D. Altshuler, J.N. Hirschhorn, M. Klannemark, C.M. Lindgren, M.-C. Vohl, and J. Nemesh The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat Genet 26 2000 76 80
14. S.F. Grant, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, A. Manolescu, and J. Sainz Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 2006 320 323
15. J.A.L. Minton, A.T. Hattersley, K. Owen, M.I. McCarthy, M. Walker, and F. Latif Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations Diabetes 51 2002 1287 1290 (Pubitemid 34438381)
16. M.S. Sandhu, M.N. Weedon, K.A. Fawcett, J. Wasson, S.L. Debenham, and A. Daly Common variants in WFS1 confer risk of type 2 diabetes Nat Genet 39 2007 951 953 (Pubitemid 47185173)
17. J. Rung, S. Cauchi, A. Albrechtsen, L. Shen, G. Rocheleau, and C. Cavalcanti-Proenca Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia Nat Genet 41 2009 1110 1115
18. R.S. Legro, D. Driscoll, J.F. Strauss 3rd, J. Fox, and A. Dunaif Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome Proc Natl Acad Sci USA 95 1998 14956 14960 (Pubitemid 29003738)
19. M. Urbanek, A. Woodroffe, K.G. Ewens, E. Diamanti-Kandarakis, R.S. Legro, and J.F. Strauss 3rd Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2 J Clin Endocrinol Metab 90 2005 6623 6629 (Pubitemid 41759325)
20. J. Zawadzki, and A. Dunaif Diagnostic criteria for polycystic ovary syndrome: towards a rational approach A. Dunaif, J.R. Givens, F.P. Haseltine, G.R. Merriam, Polycystic ovary syndrome 1992 Blackwell Scientific Boston 377 384
21. R. Azziz, K.S. Woods, R. Reyna, T.J. Key, E.S. Knochenhauer, and B.O. Yildiz The prevalence and features of the polycystic ovary syndrome in an unselected population J Clin Endocrinol Metab 89 2004 2745 2749 (Pubitemid 38766360)
22. K.L. Gunderson, K.M. Kuhn, F.J. Steemers, P. Ng, S.S. Murray, and R. Shen Whole-genome genotyping of haplotype tag single nucleotide polymorphisms Pharmacogenomics 7 2006 641 648 (Pubitemid 43891420)
23. K.L. Gunderson, F.J. Steemers, H. Ren, P. Ng, L. Zhou, and C. Tsan Whole-genome genotyping Methods Enzymol 410 2006 359 376 (Pubitemid 44287014)
24. G.R. Abecasis, L.R. Cardon, and W.O. Cookson A general test of association for quantitative traits in nuclear families Am J Hum Genet 66 2000 279 292 (Pubitemid 30481489)
25. R.S. Spielman, R.E. McGinnis, and W.J. Ewens Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am J Hum Genet 52 1993 506 516 (Pubitemid 23311321)
26. S. Purcell, S.S. Cherny, and P.C. Sham Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits Bioinformatics 19 2003 149 150 (Pubitemid 36150192)
27. T.M. Barber, A.J. Bennett, A.L. Gloyn, C.J. Groves, U. Sovio, and A. Ruokonen Relationship between E23K (an established type II diabetes- susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels Eur J Hum Genet 15 2007 679 684 (Pubitemid 46825058)
28. T.M. Barber, A.J. Bennett, C.J. Groves, U. Sovio, A. Ruokonen, and H.P. Martikainen Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS Diabetologia 50 2007 2318 2322 (Pubitemid 47512408)
29. A. Biyasheva, R.S. Legro, A. Dunaif, and M. Urbanek Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2 J Clin Endocrinol Metab 94 2009 2617 2625