Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS

Diabetologia

Volumn 50, Issue 11, 2007, Pages 2318-2322

  Barber, T M ^a   Bennett, A J ^a   Groves, C J ^a   Sovio, U ^c   Ruokonen, A ^d   Martikainen, H ^d   Pouta, A ^d,e   Hartikainen, A L ^d   Elliott, P ^c   Wass, J A H ^a   Jarvelin M R ^c,d   Zeggini, E ^b   Franks, S ^c   McCarthy, M I ^a,b  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d OULU UNIVERSITY HOSPITAL   (Finland)

^e NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Polycystic ovary syndrome; TCF7L2 variants; Type 2 diabetes mellitus

Indexed keywords

ANDROGEN; TRANSCRIPTION FACTOR 7;

ADULT; ANDROGEN BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SYMPTOMATOLOGY;

COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TCF TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 34848903683     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0804-z     Document Type: Article

References (10)

1. Franks S (1995) Polycystic ovary syndrome. N Engl J Med 333:853-861
2. Grant SF, Thorleifsson G, Reynisdottir I et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
3. Zeggini E, McCarthy MI (2007) TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia 50:1-4
4. Groves CJ, Zeggini E, Minton J et al (2006) Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 55:2640-2644
5. Freathy RM, Weedon MN, Bennett A et al (2007) Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet 80:1150-1161
6. Holte J, Bergh T, Berne C, Berglund L, Lithell H (1994) Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance. J Clin Endocrinol Metab 78:1052-1058
7. Helgason A, Palsson S, Thorleifsson G et al (2007) Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39:218-225
8. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19:41-47
9. Powell BL, Haddad L, Bennett A et al (2005) Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits. J Clin Endocrinol Metab 90:2988-2993
10. Taponen S, Martikainen H, Jarvelin MR et al (2004) Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study. J Clin Endocrinol Metab 89:2114-2118