A physiologically based pharmacokinetic/pharmacodynamic model for carbofuran in sprague-dawley rats using the exposure-related dose estimating model

Toxicological Sciences

Volumn 100, Issue 2, 2007, Pages 345-359

  Zhang, Xiaofei ^a   Tsang, Andy M ^a   Okino, Miles S ^b   Power, Frederick W ^b   Knaak, James B ^c   Harrison, Lynda S ^a   Dary, Curtis C ^b  

^a GENERAL DYNAMICS   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Carbofuran; Exposure Related dose estimating model (ERDEM); Monte Carlo simulation; PBPK PD model; Risk assessment

Indexed keywords

ACETYLCHOLINESTERASE; CARBOFURAN; GLUCURONIC ACID;

ANIMAL EXPERIMENT; ARTICLE; DATA ANALYSIS; DATA ANALYSIS SOFTWARE; DRUG CLEARANCE; DRUG EXPOSURE; ENTEROHEPATIC CIRCULATION; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; HEALTH HAZARD; LIVER METABOLISM; MONTE CARLO METHOD; NONHUMAN; PREDICTION; RAT; RISK ASSESSMENT; SIMULATION; SPRAGUE DAWLEY RAT; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANIMALS; CARBOFURAN; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; INSECTICIDES; LIVER; MODELS, BIOLOGICAL; MONTE CARLO METHOD; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT;

RATTUS;

EID: 36249016829     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm232     Document Type: Article

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