Detection of tumor glutamate metabolism in vivo using 13C magnetic resonance spectroscopy and hyperpolarized [1-13C]glutamate

Magnetic Resonance in Medicine

Volumn 66, Issue 1, 2011, Pages 18-23

  Gallagher, Ferdia A ^a   Kettunen, Mikko I ^a   Day, Sam E ^a   Hu, De En ^a   Karlsson, Magnus ^b   Gisselsson, Anna ^b   Lerche, Mathilde H ^b   Brindle, Kevin M ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Imagnia AB   (Sweden)

^c CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

Author keywords

alanine transaminase; glutamate; pyruvate; ketoglutarate

Indexed keywords

AMINO ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLISM; RATE CONSTANTS; TUMORS;

ALANINE TRANSAMINASE; APPARENT RATE CONSTANT; DYNAMIC NUCLEAR POLARIZATION; GLUTAMATE; HUMAN HEPATOMA CELLS; KETOGLUTARATE; ORDERS OF MAGNITUDE; PYRUVATES;

MAGNETIC RESONANCE;

2 OXOGLUTARIC ACID; ALANINE AMINOTRANSFERASE; CARBON 13; GADOLINIUM CHELATE; GLUTAMIC ACID; PYRUVATE SODIUM; TROMETAMOL;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; DYNAMIC NUCLEAR POLARIZATION; ENZYME MECHANISM; HEPATOMA CELL; HUMAN; HUMAN TISSUE; HYPERPOLARIZATION; IN VIVO STUDY; LYMPHOMA CELL; MOUSE; NONHUMAN; POLARIZATION; TUMOR DIAGNOSIS;

EID: 79959534706     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22851     Document Type: Article

References (20)

1. Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K,. Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR. Proc Natl Acad Sci USA 2003; 100: 10158-10163. (Pubitemid 37071849)
2. 13C magnetic resonance imaging and spectroscopy. Nat Med 2007; 13: 1382-1387. (Pubitemid 350073590)
3. 2]fumarate is a marker of cell necrosis and treatment response in tumors. Proc Natl Acad Sci USA 2009; 106: 19801-19806.
4. 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci USA 2007; 104: 19773-19777.
5. 31P MRS study. Cardiovasc Res 2010; 86: 82-91.
6. 13C-pyruvate. Mol Imaging Biol 2009; 11: 399-407.
7. 13C-labelled bicarbonate. Nature 2008; 453: 940-943. (Pubitemid 351832568)
8. 13C-labeled glutamine. Magn Reson Med 2008; 60: 253-257.
9. Jensen PR, Peitersen T, Karlsson M, In 't Zandt R, Gisselsson A, Hansson G, Meier S, Lerche MH,. Tissue-specific short chain fatty acid metabolism and slow metabolic recovery after ischemia from hyperpolarized NMR in vivo. J Biol Chem 2009; 284: 36077-36082.
10. 13C ketoisocaproate. Int J Cancer 2010; 127: 729-736.
11. Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S,. The current state of serum biomarkers of hepatotoxicity. Toxicology 2008; 245: 194-205.
12. Jensen PR, Karlsson M, Meier S, Duus JO, Lerche MH,. Hyperpolarized amino acids for in vivo assays of transaminase activity. Chemistry 2009; 15: 10010-10012.
13. Dang CV, Kim JW, Gao P, Yustein J,. The interplay between MYC and HIF in cancer. Nat Rev Cancer 2008; 8: 51-56.
14. Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM,. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009; 462: 739-744.
15. Theberge J, Al-Semaan Y, Williamson PC, Menon RS, Neufeld RW, Rajakumar N, Schaefer B, Densmore M, Drost DJ,. Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS. Am J Psychiatry 2003; 160: 2231-2233. (Pubitemid 39619619)
16. Ametamey SM, Treyer V, Streffer J, Wyss MT, Schmidt M, Blagoev M, Hintermann S, Auberson Y, Gasparini F, Fischer UC, Buck A,. Human PET studies of metabotropic glutamate receptor subtype 5 with 11C-ABP688. J Nucl Med 2007; 48: 247-252. (Pubitemid 47555351)
17. Zhao M, Beauregard DA, Loizou L, Davletov B, Brindle KM,. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat Med 2001; 7: 1241-1244. (Pubitemid 33063780)
18. 13C magnetic resonance imaging. Prog NMR Spect 2009; 55: 285-295.
19. Shen J, Xu S,. Theoretical analysis of carbon-13 magnetization transfer for in vivo exchange between alpha-ketoglutarate and glutamate. NMR Biomed 2006; 19: 248-254.
20. Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y,. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 2009; 324: 261-265.