Heterogenous distribution of ferroportin-containing neurons in mouse brain

BioMetals

Volumn 24, Issue 2, 2011, Pages 357-375

  Boserup, Michael W ^a   Lichota, Jacek ^a   Haile, David ^b   Moos, Torben ^a  

^a AALBORG UNIVERSITY   (Denmark)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Blood brain barrier; Iron; Neurodegeneration; Oxidative stress; qPCR; Transferrin

Indexed keywords

FERROPORTIN; CATION TRANSPORT PROTEIN; METAL TRANSPORTING PROTEIN 1;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN MAPPING; BRAIN STEM; CELL CULTURE; CELL LABELING; CEREBELLUM; CHOROID PLEXUS; CONTROLLED STUDY; CRANIAL NERVE; ENDOTHELIUM CELL; GLOBUS PALLIDUS; HABENULA; HIPPOCAMPUS; HYPOTHALAMUS; IMMUNOREACTIVITY; MALE; MOUSE; NERVE CELL; NONHUMAN; PONS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN POLYMORPHISM; THALAMUS; TISSUE DISTRIBUTION; TISSUE SECTION; ANIMAL; BRAIN; CYTOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; CATION TRANSPORT PROTEINS; CEREBRAL CORTEX; IMMUNOHISTOCHEMISTRY; MALE; MICE; NEURONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79959528020     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-010-9405-2     Document Type: Article

References (43)

1. Abboud S, Haile DJ (2000) A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275:19906-19912 (Pubitemid 30441595)
2. Adamek GD, Shipley MT, Sanders MS (1984) The indusium griseum in the mouse: architecture, Timm's histochemistry and some afferent connections. Brain Res Bull 12:657-668 (Pubitemid 14065431)
3. Altamura S, Muckenthaler MU (2009) Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis. J Alzheimers Dis 16:879-895
4. Balin BJ, Broadwell RD, Salcman M, el-Kalliny M (1986) Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 251:260-280 (Pubitemid 16027854)
5. Benkovic SA, Connor JR (1993) Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain. J Comp Neurol 338:97-113 (Pubitemid 23337259)
6. Burdo JR, Menzies SL, Simpson IA, Garrick LM, Garrick MD, Dolan KG, Haile DJ, Beard JL, Connor JR (2001) Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res 66:1198-1207 (Pubitemid 33135606)
7. Chua AC, Graham RM, Trinder D, Olynyk JK (2007) The regulation of cellular iron metabolism. Crit Rev Clin Lab Sci 44:413-459 (Pubitemid 47619398)
8. Clardy SL, Wang X, Boyer PJ, Earley CJ, Allen RP, Connor JR (2006) Is ferroportin-hepcidin signaling altered in restless legs syndrome? J Neurol Sci 247:173-179 (Pubitemid 44339542)
9. Crichton R (2009) Iron metabolism: from molecular mechanisms to clinical consequences. Wiley, Chichester
10. De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J (2007) Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J 26:2823-2831 (Pubitemid 46975784)
11. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI (2000) Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter. Nature 403:776-781 (Pubitemid 30111839)
12. Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC (2005) The iron exporter ferroportin/ Slc40a1 is essential for iron homeostasis. Cell Metab 1: 191-200 (Pubitemid 43960600)
13. Farcich EA, Morgan EH (1992) Diminished iron acquisition by cells and tissues of Belgrade laboratory rats. Am J Physiol 262:R220-R224
14. Focht SJ, Snyder BS, Beard JL, Van Gelder W, Williams LR, Connor JR (1997) Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains. Neuroscience 79:255-261 (Pubitemid 27245016)
15. Franklin KBJ, Paxinos G (2008) The mouse brain in stereotaxic coordinates, 3rd edn. Elsevier, Amsterdam
16. Gosk S, Moos T, Gottstein C, Bendas G (2008) VCAM-1 directed immunoliposomes selectively target tumor vasculature in vivo. Biochim Biophys Acta 1778:854-863
17. Hamilton KA, Heinbockel T, Ennis M, Szabó G, Erdélyi F, Hayar A (2005) Properties of external plexiform layer interneurons in mouse olfactory bulb slices. Neuroscience 133:819-829 (Pubitemid 40798333)
18. Hansen TM, Nielsen H, Bernth N, Moos T (1999) Expression of ferritin protein and subunit mRNAs in normal and iron deficient rat brain. Brain Res Mol Brain Res 65: 18-197
19. Huang E, Ong WY, Go ML, Connor JR (2006) Upregulation of iron regulatory proteins and divalent metal transporter-1 isoforms in the rat hippocampus after kainate induced neuronal injury. Exp Brain Res 170:376-386
20. Jeong SY, David S (2003) Glycosylphosphatidylinositolanchored ceruloplasmin is required for iron efflux from cells in the central nervous system. J Biol Chem 278:27144-27148 (Pubitemid 36876870)
21. Jeong SY, Rathore KI, Schulz K, Ponka P, Arosio P, David S (2009) Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis. J Neurosci 29:610-619
22. Klomp LW, Farhangrazi ZS, Dugan LL, Gitlin JD (1996) Ceruloplasmin gene expression in the murine central nervous system. J Clin Invest 98:207-215 (Pubitemid 26243838)
23. Koeppen AH, Michael SC, Knutson MD, Haile DJ, Qian J, Levi S, Santambrogio P, Garrick MD, Lamarche JB (2007) The dentate nucleus in Friedreich's ataxia: the role of ironresponsive proteins. Acta Neuropathol 114:163-173 (Pubitemid 47103527)
24. Lis A, Barone TA, Paradkar PN, Plunkett RJ, Roth JA (2004) Expression and localization of different forms of DMT1 in normal and tumor astroglial cells. Brain Res Mol Brain Res 122:62-70 (Pubitemid 38264547)
25. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ (2000) A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5:299-309 (Pubitemid 30628088)
26. Moos T (1996) Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol 25:675-692 (Pubitemid 26398347)
27. Moos T, Morgan EH (1998) Kinetics and distribution of [59Fe-125I]transferrin injected into the ventricular system of the rat. Brain Res 790:115-128 (Pubitemid 28234495)
28. Moos T, Rosengren Nielsen T (2006) Ferroportin in the postnatal rat brain: implications for axonal transport and neuronal export of iron. Semin Pediatr Neurol 13:149-157 (Pubitemid 44709652)
29. Moos T, Oates PS, Morgan EH (1998) Expression of the neuronal transferrin receptor is age dependent and susceptible to iron deficiency. J Comp Neurol 398:420-430 (Pubitemid 28360043)
30. Moos T, Skjoerringe T, Gosk S, Morgan EH (2006) Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1. J Neurochem 98:1946-1958 (Pubitemid 44298257)
31. Moos T, Rosengren Nielsen T, Skjørringe T, Morgan EH (2007) Iron trafficking inside the brain. J Neurochem 103:1730-1740 (Pubitemid 350126643)
32. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-2093 (Pubitemid 40007660)
33. Patel BN, David S (1997) Anovel glycosylphosphatidylinositolanchored form of ceruloplasmin is expressed by mammalian astrocytes. J Biol Chem 272:20185-20190 (Pubitemid 27340128)
34. Rouault TA, Cooperman S (2006) Brain iron metabolism. Semin Pediatr Neurol 13:142-148 (Pubitemid 44709651)
35. Rouault TA, Zhang DL, Jeong SY (2009) Brain iron homeostasis, the choroid plexus, and localization of iron transport proteins. Metab Brain Dis 24:673-684
36. Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR (2008) Tim-2 is the receptor for H-ferritin on oligodendrocytes. J Neurochem 107:1495-1505
37. Todorich B, Pasquini JM, Garcia CI, Paez PM, Connor JR (2009) Oligodendrocytes and myelination: the role of iron. Glia 57:467-478
38. Wang SM, Fu LJ, Duan XL, Crooks DR, Yu P, Qian ZM, Di XJ, Li J, Rouault TA, Chang YZ (2009) Role of hepcidin in murine brain iron metabolism. Cell Mol Life Sci 67:123-133
39. West AE, Neve RL, Buckley KM (1997) Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. J Neurosci 17:6038-6047 (Pubitemid 27329879)
40. Wu LJ, Leenders AG, Cooperman S, Meyron-Holtz E, Smith S, Land W, Tsai RY, Berger UV, Sheng ZH, Rouault TA (2004) Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res 1001:108-117 (Pubitemid 38221533)
41. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR (2004) Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5:863-873 (Pubitemid 39482155)
42. Zhu X, Su B, Wang X, Smith MA, Perry G (2007) Causes of oxidative stress in Alzheimer disease. Cell Mol Life Sci 64:2202-2210 (Pubitemid 47347959)
43. Zohn IE, De Domenico I, Pollock A, Ward DM, Goodman JF, Liang X, Sanchez AJ, Niswander L, Kaplan J (2007) The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood 109:4174-4180 (Pubitemid 46743381)