메뉴 건너뛰기




Volumn 98, Issue 6, 2006, Pages 1946-1958

Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1

Author keywords

Belgrade rat; Blood brain barrier; Brain capillary endothelium; Divalent metal transporter I; Endocytosis; Transferrin receptor

Indexed keywords

FERRIC ION; FERROUS ION; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TRANSFERRIN;

EID: 33748090285     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04023.x     Document Type: Article
Times cited : (78)

References (41)
  • 1
    • 0017110899 scopus 로고
    • 125albumin from blood into the brain and cerebrospinal fluid in the newborn and juvenile rats
    • 125albumin from blood into the brain and cerebrospinal fluid in the newborn and juvenile rats. Acta Physiol. Scand. 96, 399-406.
    • (1976) Acta Physiol. Scand. , vol.96 , pp. 399-406
    • Amtorp, O.1
  • 2
    • 0024159960 scopus 로고
    • Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier
    • Banks W. A., Kastin A. J., Fasold M. B., Barrera C. M. and Augereau G. (1988) Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier. Brain Res. Bull. 21, 881-885.
    • (1988) Brain Res. Bull. , vol.21 , pp. 881-885
    • Banks, W.A.1    Kastin, A.J.2    Fasold, M.B.3    Barrera, C.M.4    Augereau, G.5
  • 3
    • 0015939506 scopus 로고
    • 14C] insulin after intrathecal infusion
    • 14C] insulin after intrathecal infusion. Brain Res. 52, 323-332.
    • (1973) Brain Res. , vol.52 , pp. 323-332
    • Bass, N.H.1    Lundborg, P.2
  • 5
    • 0142185331 scopus 로고    scopus 로고
    • Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system
    • Burdo J. R., Antonetti D. A., Wolpert E. B. and Connor J. R. (2003) Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system. Neuroscience 121, 883-890.
    • (2003) Neuroscience , vol.121 , pp. 883-890
    • Burdo, J.R.1    Antonetti, D.A.2    Wolpert, E.B.3    Connor, J.R.4
  • 7
    • 0032511729 scopus 로고    scopus 로고
    • Cellular distribution of ferritin subunits in postnatal rat brain
    • Cheepsunthorn P., Palmer C. and Connor J. R. (1998) Cellular distribution of ferritin subunits in postnatal rat brain. J. Comp. Neurol. 400, 73-86.
    • (1998) J. Comp. Neurol. , vol.400 , pp. 73-86
    • Cheepsunthorn, P.1    Palmer, C.2    Connor, J.R.3
  • 8
    • 1342347993 scopus 로고    scopus 로고
    • Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake
    • Crossgrove J. S. and Yokel R. A. (2004) Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake. Neurotoxicology. 25, 4514-4560.
    • (2004) Neurotoxicology , vol.25 , pp. 4514-4560
    • Crossgrove, J.S.1    Yokel, R.A.2
  • 9
    • 0026779690 scopus 로고
    • Iron and transferrin uptake by brain and cerebrospinal fluid in the rat
    • Crowe A. and Morgan E. H. (1992) Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res. 592, 8-16.
    • (1992) Brain Res. , vol.592 , pp. 8-16
    • Crowe, A.1    Morgan, E.H.2
  • 10
    • 1042301280 scopus 로고    scopus 로고
    • Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain
    • Deane R., Zheng W. and Zlokovic B. V. (2004) Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J. Neurochem. 88, 813-820.
    • (2004) J. Neurochem. , vol.88 , pp. 813-820
    • Deane, R.1    Zheng, W.2    Zlokovic, B.V.3
  • 11
    • 0025358641 scopus 로고
    • An autoradiographic study of the uptake and distribution of iron by the brain of the young rat
    • Dwork A. J., Lawler G., Zybert P. A., Durkin M., Osman M., Willson N. and Barkai A. I. (1990) An autoradiographic study of the uptake and distribution of iron by the brain of the young rat. Brain Res. 518, 31-39.
    • (1990) Brain Res. , vol.518 , pp. 31-39
    • Dwork, A.J.1    Lawler, G.2    Zybert, P.A.3    Durkin, M.4    Osman, M.5    Willson, N.6    Barkai, A.I.7
  • 12
    • 0026529583 scopus 로고
    • Diminished iron acquisition by cells and tissues of Belgrade laboratory rats
    • Farcich E. and Morgan E. H. (1992) Diminished iron acquisition by cells and tissues of Belgrade laboratory rats. Am. J. Physiol. 262, R220-R224.
    • (1992) Am. J. Physiol. , vol.262
    • Farcich, E.1    Morgan, E.H.2
  • 13
    • 0032477866 scopus 로고    scopus 로고
    • Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
    • Fleming M. D., Romano M. A., Su M. A., Garrick L. M., Garrick M. D. and Andrews N. C. (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. USA 95, 1148-1153.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1148-1153
    • Fleming, M.D.1    Romano, M.A.2    Su, M.A.3    Garrick, L.M.4    Garrick, M.D.5    Andrews, N.C.6
  • 14
    • 0027200226 scopus 로고
    • Iron uptake in the brain of the myelin-deficient rat
    • Gocht A., Keith A. B., Candy J. M. and Morris C. M. (1993) Iron uptake in the brain of the myelin-deficient rat. Neurosci. Lett. 154, 187-190.
    • (1993) Neurosci. Lett. , vol.154 , pp. 187-190
    • Gocht, A.1    Keith, A.B.2    Candy, J.M.3    Morris, C.M.4
  • 15
    • 8344282653 scopus 로고    scopus 로고
    • Targeting antitransferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion
    • Gosk S., Vermehren C., Storm G. and Moos T. (2004) Targeting antitransferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. J. Cereb. Blood Flow Metab. 24, 1193-1204.
    • (2004) J. Cereb. Blood Flow Metab. , vol.24 , pp. 1193-1204
    • Gosk, S.1    Vermehren, C.2    Storm, G.3    Moos, T.4
  • 17
    • 0346881343 scopus 로고    scopus 로고
    • Thrombin preconditioning attenuates brain edema induced by erythrocytes and iron
    • Hua Y., Keep R. F., Hoff J. T. and Xi G. (2003) Thrombin preconditioning attenuates brain edema induced by erythrocytes and iron. J. Cereb. Blood Flow Metab. 23, 1448-1454.
    • (2003) J. Cereb. Blood Flow Metab. , vol.23 , pp. 1448-1454
    • Hua, Y.1    Keep, R.F.2    Hoff, J.T.3    Xi, G.4
  • 18
    • 0036120064 scopus 로고    scopus 로고
    • Brain edema after experimental intracerebral hemorrhage: Role of hemoglobin degradation products
    • Huang F. P., Xi G., Keep R. F., Hua Y., Nemoianu A. and Hoff J. T. (2002) Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J. Neurosurg. 96, 287-293.
    • (2002) J. Neurosurg. , vol.96 , pp. 287-293
    • Huang, F.P.1    Xi, G.2    Keep, R.F.3    Hua, Y.4    Nemoianu, A.5    Hoff, J.T.6
  • 19
    • 33748050557 scopus 로고
    • Permeability and vascularity of the developing brain: Cerebellum vs. cerebral cortex
    • Johanson C. E. (1980) Permeability and vascularity of the developing brain: Cerebellum vs. cerebral cortex. Brain Res. 36, 282-289.
    • (1980) Brain Res. , vol.36 , pp. 282-289
    • Johanson, C.E.1
  • 20
    • 13644278965 scopus 로고    scopus 로고
    • Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain
    • Ke Y., Chang Y. Z., Du X. L., Duan J. R., Zhu L., Wang K., Yang X. D., Ho K. P. and Qian Z. M. (2005) Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain. Neurobiol. Aging 26, 739-778.
    • (2005) Neurobiol. Aging , vol.26 , pp. 739-778
    • Ke, Y.1    Chang, Y.Z.2    Du, X.L.3    Duan, J.R.4    Zhu, L.5    Wang, K.6    Yang, X.D.7    Ho, K.P.8    Qian, Z.M.9
  • 21
    • 0030599398 scopus 로고    scopus 로고
    • Development of blood-brain barrier tight junctions in the rat cortex
    • Kniesel U., Risau W. and Wolburg H. (1996) Development of blood-brain barrier tight junctions in the rat cortex. Dev. Brain Res. 96, 229-240.
    • (1996) Dev. Brain Res. , vol.96 , pp. 229-240
    • Kniesel, U.1    Risau, W.2    Wolburg, H.3
  • 23
    • 0023062680 scopus 로고
    • Transferrin-receptor interaction and iron uptake by reticulocytes of vertebrate animals - A comparative study
    • Lim B. C., McArdle H. J. and Morgan E. H. (1987) Transferrin-receptor interaction and iron uptake by reticulocytes of vertebrate animals - a comparative study. J. Comp. Physiol. 157, 363-371.
    • (1987) J. Comp. Physiol. , vol.157 , pp. 363-371
    • Lim, B.C.1    McArdle, H.J.2    Morgan, E.H.3
  • 24
    • 19344376879 scopus 로고    scopus 로고
    • Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells
    • Lis A., Paradkar P. N., Singleton S., Kuo H. C., Garrick M. D. and Roth J. A. (2005) Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells. Biochem. Pharmacol. 69, 1647-1655.
    • (2005) Biochem. Pharmacol. , vol.69 , pp. 1647-1655
    • Lis, A.1    Paradkar, P.N.2    Singleton, S.3    Kuo, H.C.4    Garrick, M.D.5    Roth, J.A.6
  • 25
    • 0032746341 scopus 로고    scopus 로고
    • Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain
    • Malecki E. A., Cook B. M., Devenyi A. G., Beard J. L. and Connor J. R. (1999) Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain. J. Neurol. Sci. 170, 112-118.
    • (1999) J. Neurol. Sci. , vol.170 , pp. 112-118
    • Malecki, E.A.1    Cook, B.M.2    Devenyi, A.G.3    Beard, J.L.4    Connor, J.R.5
  • 26
    • 0043160592 scopus 로고    scopus 로고
    • Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: Demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat
    • Meguro R., Asano Y., Iwatsuki H. and Shoumura K. (2003) Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat. Histochem. Cell Biol. 120, 73-82.
    • (2003) Histochem. Cell Biol. , vol.120 , pp. 73-82
    • Meguro, R.1    Asano, Y.2    Iwatsuki, H.3    Shoumura, K.4
  • 27
    • 1542463937 scopus 로고    scopus 로고
    • Delivery of transferrin and immunoglobulins to the ventricular system of the rat
    • Moos T. (2003) Delivery of transferrin and immunoglobulins to the ventricular system of the rat. Front. Biosci. 8, 102-109.
    • (2003) Front. Biosci. , vol.8 , pp. 102-109
    • Moos, T.1
  • 28
    • 0032533743 scopus 로고    scopus 로고
    • Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid
    • Moos T. and Morgan E. H. (1998a) Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid. J. Neurosci. Res. 54, 486-494.
    • (1998) J. Neurosci. Res. , vol.54 , pp. 486-494
    • Moos, T.1    Morgan, E.H.2
  • 29
    • 0032549868 scopus 로고    scopus 로고
    • Kinetics and distribution of [59Fe-125I]transferrin injected into the ventricular system of the rat
    • Moos T. and Morgan E. H. (1998b) Kinetics and distribution of [59Fe-125I]transferrin injected into the ventricular system of the rat. Brain Res. 790, 115-128.
    • (1998) Brain Res. , vol.790 , pp. 115-128
    • Moos, T.1    Morgan, E.H.2
  • 30
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferrin receptor function in brain barrier systems
    • Moos T. and Morgan E. H. (2000) Transferrin and transferrin receptor function in brain barrier systems. Cell. Mol. Neurobiol. 20, 77-95.
    • (2000) Cell. Mol. Neurobiol. , vol.20 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 31
    • 0034794883 scopus 로고    scopus 로고
    • Restricted transport of OX26 through the blood-brain barrier in the rat
    • Moos T. and Morgan E. H. (2001) Restricted transport of OX26 through the blood-brain barrier in the rat. J. Neurochem. 79, 119-129.
    • (2001) J. Neurochem. , vol.79 , pp. 119-129
    • Moos, T.1    Morgan, E.H.2
  • 32
    • 0036970417 scopus 로고    scopus 로고
    • A morphological study of the developmentally regulated transport of iron into the brain
    • Moos T. and Morgan E. H. (2002) A morphological study of the developmentally regulated transport of iron into the brain. Dev. Neurosci. 24, 99-105.
    • (2002) Dev. Neurosci. , vol.24 , pp. 99-105
    • Moos, T.1    Morgan, E.H.2
  • 33
    • 0347993815 scopus 로고    scopus 로고
    • The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain
    • Moos T. and Morgan E. H. (2004) The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain. J. Neurochem. 88, 233-245.
    • (2004) J. Neurochem. , vol.88 , pp. 233-245
    • Moos, T.1    Morgan, E.H.2
  • 34
    • 0034184526 scopus 로고    scopus 로고
    • Cellular distribution of ferric iron, ferritin, transferrin and divalent metal transporter (DMT1) in substantia nigra and basal ganglia of normal and β2-microglobulin deficient mouse brain
    • Moos T., Trinder D. and Morgan E. H. (2000) Cellular distribution of ferric iron, ferritin, transferrin and divalent metal transporter (DMT1) in substantia nigra and basal ganglia of normal and β2-microglobulin deficient mouse brain. Cell. Mol. Biol. 46, 549-561.
    • (2000) Cell. Mol. Biol. , vol.46 , pp. 549-561
    • Moos, T.1    Trinder, D.2    Morgan, E.H.3
  • 35
    • 0026689961 scopus 로고
    • Uptake and distribution of iron and transferrin in the adult rat brain
    • Morris C. M., Keith A. B., Edwardson J. A. and Pullen R. G. (1992) Uptake and distribution of iron and transferrin in the adult rat brain. J. Neurochem. 59, 300-306.
    • (1992) J. Neurochem. , vol.59 , pp. 300-306
    • Morris, C.M.1    Keith, A.B.2    Edwardson, J.A.3    Pullen, R.G.4
  • 36
    • 0037097199 scopus 로고    scopus 로고
    • Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain
    • Siddappa A. J., Rao R. B., Wobken J. D., Leibold E. A., Connor J. R. and Georgieff M. K. (2002) Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J. Neurosci. Res. 68, 761-775.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 761-775
    • Siddappa, A.J.1    Rao, R.B.2    Wobken, J.D.3    Leibold, E.A.4    Connor, J.R.5    Georgieff, M.K.6
  • 37
    • 0037405911 scopus 로고    scopus 로고
    • Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain
    • Siddappa A. J., Rao R. B., Wobken J. D., Casperson K., Leibold E. A., Connor J. R. and Georgieff M. K. (2003) Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain. Pediatr. Res. 53, 800-807.
    • (2003) Pediatr. Res. , vol.53 , pp. 800-807
    • Siddappa, A.J.1    Rao, R.B.2    Wobken, J.D.3    Casperson, K.4    Leibold, E.A.5    Connor, J.R.6    Georgieff, M.K.7
  • 38
    • 0025993856 scopus 로고
    • Transferrin and iron uptake by the brain: Effects of altered iron status
    • Taylor E. M., Crowe A. and Morgan E. H. (1991) Transferrin and iron uptake by the brain: effects of altered iron status. J. Neurochem. 57, 1584-1592.
    • (1991) J. Neurochem. , vol.57 , pp. 1584-1592
    • Taylor, E.M.1    Crowe, A.2    Morgan, E.H.3
  • 39
    • 0025295847 scopus 로고
    • Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins
    • Triguero D., Buciak J. and Pardridge W. M. (1990) Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J. Neurochem. 54, 1882-1888.
    • (1990) J. Neurochem. , vol.54 , pp. 1882-1888
    • Triguero, D.1    Buciak, J.2    Pardridge, W.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.