Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study

Nutrition and Metabolism

Volumn 8, Issue , 2011, Pages

  Chin, Siok Fong ^a   Ibahim, Johari ^a   Makpol, Suzana ^a   Abdul Hamid, Noor Aini ^a   Abdul Latiff, Azian ^a   Zakaria, Zaiton ^a   Mazlan, Musalmah ^a   Mohd Yusof, Yasmin Anum ^a   Abdul Karim, Aminuddin ^a   Wan Ngah, Wan Zurinah ^a  

^a DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ASCORBIC ACID; CARBONYL DERIVATIVE; CATALASE; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; SUPEROXIDE DISMUTASE; TOCOTRIENOL RICH FRACTION; TRI E; UNCLASSIFIED DRUG;

ADULT; AGE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENZYME ACTIVITY; EVENING DOSAGE; FEMALE; HUMAN; MALE; NORMAL HUMAN; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 79959417365     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-8-42     Document Type: Article

References (61)

1. Telomerase therapeutics for cancer: challenges and new directions. JW Shay WE Wright, Nat Rev Drug Discov 2006 5 7 577 584 10.1038/nrd2081 16773071 (Pubitemid 43971192)
2. -Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. WN Yap PN Chang HY Han DTW Lee MT Ling YC Wong YL Yap, British Journal of Cancer 2008 99 11 1832 1841 10.1038/sj.bjc. 6604763 19002171
3. Vitamin E modulation of cardiovascular disease. M Meydani, Ann NY Acad Sci 2004 1031 271 279 10.1196/annals.1331.027 15753153 (Pubitemid 40361762)
4. Vitamin E supplementation suppresses macrophage accumulation and endothelial cell expression of adhesion molecules in the aorta of hypercholesterolemic rabbits. T Koga P Kwan L Zubik C Ameho D Smith M Meydani, Atherosclerosis 2004 176 2 265 272 10.1016/j.atherosclerosis.2004.05.034 15380448 (Pubitemid 39369515)
5. Role of oxidative stress on beta-amyloid neurotoxicity elicited during impairment of energy metabolism in the hippocampus: protection by antioxidants. T Montiel R Quiroz-Baez L Massieu C Arias, Exp Neurol 2006 200 496 508 10.1016/j.expneurol.2006.02.126 16626708 (Pubitemid 44107928)
6. Vitamin E and neurodegenerative disorders associated with oxidative stress. DA Butterfield A Castegna J Drake G Scapagnini V Calabrese, Nutr Neurosci 2002 5 229 239 10.1080/10284150290028954 12168685 (Pubitemid 34823459)
7. Antiangiogenic activity of tocotrienol. H Inokuchi H Hirokane T Tsuzuki K Nakagawa M Igarashi T Miyazawa, Biosci Biotechnol Biochem 2003 67 7 1623 1627 10.1271/bbb.67.1623 12913317
8. Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis. Y Mizushina K Nakagawa A Shibata Y Awata I Kuriyama N Shimazaki O Koiwai Y Uchiyama K Sakaguchi T Miyazawa H Yoshida, Biochem Biophys Res Commun 2006 339 3 949 955 10.1016/j.bbrc.2005.11.085 16325764 (Pubitemid 41772903)
9. Tocotrienols inhibit growth of ZR-75-1 breast cancer cells. K Nesaretnam S Dorasamy PD Darbre, Int J Food Sci Nutr 2000 Suppl 51 95 S103
10. Effects of administration of alpha-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activity. HT Khor TT Ng, Int J Food Sci Nutr 2000 Suppl 51 3 S11
11. Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee). AA Qureshi N Qureshi JJ Wright Z Shen G Kramer A Gapor YH Chong G DeWitt A Ong DM Peterson, Am J Clin Nutr 1991 53 Suppl 4 1021S 1026S 2012010 (Pubitemid 21898866)
12. Response of hypercholesterolemic subjects to administration of tocotrienols. AA Qureshi BA Bradlow L Brace J Manganello DM Peterson BC Pearce JJ Wright A Gapor CE Elson, Lipids 1995 30 12 1171 1177 10.1007/BF02536620 8614309
13. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. AA Qureshi SA Sami WA Salser FA Khan, Atherosclerosis 2002 161 1 199 207 10.1016/S0021-9150(01) 00619-0 11882333 (Pubitemid 34214837)
14. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. CK Sen S Khanna S Roy L Packer, J Biol Chem 2000 275 17 13049 13055 10.1074/jbc.275.17.13049 10777609 (Pubitemid 30241466)
15. Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. S Khanna S Roy NL Parinandi M Maurer CK Sen, J Neurochem 2006 98 5 1474 1486 10.1111/j.1471-4159.2006.04000.x 16923160 (Pubitemid 44200439)
16. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. B Halliwell, Drugs Aging 2001 18 685 716 10.2165/00002512-200118090-00004 11599635 (Pubitemid 32948277)
17. Aging is no longer an unsolved problem in biology. R Holliday, Ann NY Acad Sci 2006 1067 1 9 10.1196/annals.1354.002 16848030 (Pubitemid 43806303)
18. Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. SJ Duthie A Ma MA Ross AR Collins, Cancer Res 1996 56 6 1291 1295 8640816 (Pubitemid 26080971)
19. Inhibition of oxidative DNA damage, 8-OHdG and carbonyl contents in smokers treated with antioxidants (vitamin E, vitamin C, beta-carotene and red ginseng). BM Lee SK Lee HS Kim, Cancer Lett 1998 132 1/2 219 227 10397477 (Pubitemid 28535208)
20. The effect of increased intakes of polyunsaturated fatty acids and vitamin E on DNA damage in human lymphocytes. AM Jenkinson AR Collins SJ Duthie KW Wahle GG Duthie, FASEB J 1999 13 15 2138 2142 10593860
21. Short-term, moderate dosage vitamin E supplementation may have no effect on platelet aggregation, coagulation profile and bleeding time in healthy individuals. NH Dereska EC McLemore DJ Tessier DS Bash CM Brophy, J Surg Res 2006 132 121 129 10.1016/j.jss.2005.09.031 16337968
22. Vitamin E supplementation and cardiovascular events in high-risk patients. The HOPE Study Investigators, N Engl J Med 2000 342 154 160 10639540
23. Effect of vitamin E and beta carotene on the incidence of angina pectoris: A randomized, double-blind, controlled trial. JM Rapola J Virtamo JK Haukka OP Heinonen D Albanes PR Taylor JK Huttunen, JAMA 1996 275 693 698 10.1001/jama.275.9.693 8594266 (Pubitemid 26073277)
24. More optimal forms of vitamin E. Letters to the editor. K Krishnan W Stone S Campbell, J Am Diet Assoc 2005 105 2 204 205 10.1016/j.jada.2004.12.021 15668675 (Pubitemid 40164683)
25. Does aging affect the response of vitamin E status to vitamin E depletion and supplementation? BM Winklhofer-Roob JM Roob M Maritschnegg G Sprinz D Hiller E Marktfelder M Preinsberger S Wuga I Sundl B Tiran N Cardinault J Ribalta E Rock Vitage Study Group, Ann NY Acad Sci 2004 1031 381 384 10.1196/annals.1331.050 15753175 (Pubitemid 40361784)
26. Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study. M Andriollo-Sanchez I Hininger-Favier N Meunier E Venneria JM O'Connor G Maiani C Coudray AM Roussel, Eur J Clin Nutr 2005 59 Suppl 2 58 S62 16254584
27. Reduction of DNA damage in older healthy adults by Tri E ® Tocotrienol supplementation. SF Chin AH Noor Aini AL Azian Z Zaiton M Musalmah AMY Yasmin AK Aminuddin I Johari H Zalina WN Wan Zurinah, Nutrition 2008 24 1 10 10.1016/j.nut.2007.08.006 17884341
28. Oxidative stress in athletes during extreme endurance exercise. A Mastaloudis SW Leonard MJ Traber, Free Radic Biol Med 2001 31 7 911 922 10.1016/S0891-5849(01)00667-0 11585710 (Pubitemid 32925089)
29. Studies of LDL oxidation following -, -, or -tocotrienyl acetate supplementation of hypercholesterolemic humans. D O'Byrne S Grundy L Packer S Devaraj K Baldenius PP Hoppe K Kraemer I Jialal MG Traber, Free Radic Biol Med 2000 29 9 834 845 10.1016/S0891-5849(00)00371-3 11063909
30. Analysis of ascorbate by liquid chromatography with amperometric detection. LA Pachla PT Kissinger, Methods Enzymol 1979 62 15 24 440098
31. Carbonyl assays for determination of oxidatively modified proteins. RL Levine JA Williams EP Stadtman E Shacter, Methods Enzymol 1994 233 346 357 8015469
32. An enzyme immunoassay for advanced glycosylation end-products in serum. WM Wan Nazaimoon BAK Khalid, Malaysian J Pathol 1998 20 2 83 89
33. Measurement of free and bound malondialdehyde in plasma by high-performance liquid chromatography as the 2, 4-dinitrophenylhydrazine derivative. J Pilz I Meineke CH Gleiter, J Chrom B 2000 742 315 325 10.1016/S0378-4347(00)00174-2 (Pubitemid 30331049)
34. Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. WF Beyer Jr I Fridovich, Anal Biochem 1987 161 2 559 566 10.1016/0003-2697(87)90489-1 3034103 (Pubitemid 17046011)
35. Catalase in vitro. H Aebi, Methods Enzymol 1984 105 121 126 6727660
36. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. DE Paglia WN Valentine, J Clin Med 1967 70 158 169
37. Acute phase protein levels and thymus, spleen and plasma protein synthesis rates differ in adult and old rats. I Papet D Dardevet C Sornet F Béchereau J Prugnaud C Pouyet C Obled, J Nutr 2003 133 215 219 12514293 (Pubitemid 36070603)
38. Flies and their golden apples: The effect of dietary restriction on Drosophila aging and age-dependent gene expression. SD Pletcher S Libert D Skorupa, Ageing Res Rev 2005 4 451 480 10.1016/j.arr.2005.06.007 16263339 (Pubitemid 43293163)
39. Antioxidant status and oxidant stress may be associated with vitamin E intakes in very low birth weight infants during the first month of life. JK Friel JA Widness T Jiang SL Belkhode CJ Rebouche EE Ziegler, Nutr Res 2002 22 55 64 10.1016/S0271-5317(01)00371-2 (Pubitemid 34150956)
40. Cholesterol measures to identify and treat individuals at risk for coronary heart disease. S Natarajan H Glick M Criqui D Horowitz SR Lipsitz B Kinosian, Am J Prev Med 2003 25 50 57 10.1016/S0749-3797(03)00092-8 12818310 (Pubitemid 36724692)
41. Multivariate assessment of lipid parameters as predictors of coronary heart disease among postmenopausal women: Potential implications for clinical guidelines. I Shai EB Rimm SE Hankinson G Curhan JAE Manson N Rifai MJ Stampfer J Ma, Circulation 2004 110 2824 2830 10.1161/01.CIR.0000146339.57154.9B 15492318 (Pubitemid 39473604)
42. Rationale for new American Diabetes Association Guidelines: are national cholesterol education program goals adequate for the patient with Diabetes Mellitus? S Haffner, Am J Cardiol 2005 96 4A 33E 36E 16098841 (Pubitemid 41140367)
43. Effect of -tocopherol supplementation on blood pressure and lipidic profile in streptozotocin-induced diabetes mellitus in spontaneously hypertensive rats. VAV da Costa LM Vianna, Clin Chim Acta 2005 351 101 104 10.1016/j.cccn.2004.08.007 15563877 (Pubitemid 39563562)
44. Effect of vitamin E on cholesterol plasma lipoprotein distribution and metabolism in rabbit. P Komaratat N Chupukcharoen P Wilairat, Int J Vitam Nutr Res 1985 55 167 171 4019071 (Pubitemid 15061283)
45. The effect of tocopherol on high-density lipoprotein cholesterol. A clinical observation. WJ Hermann Jr K Ward J Faucett, Am J Clin Pathol 1979 72 848 852 228547 (Pubitemid 10158905)
46. Effects of -tocopherol on superoxide production and plasma intercellular adhesion molecule-1 and antibodies to oxidized LDL in chronic smokers. LJH van Tits F de Waart HLM Hak-Lemmers P van Heijst J de Graaf PNM Demacker AFH Stalenhoef, Free Radic Biol Med 2001 30 10 1122 1129 10.1016/S0891-5849(01) 00519-6 11369502 (Pubitemid 32441837)
47. Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. II. Effects of in vivo supplementation with -tocopherol. C Perugini M Bagnati C Cau R Bordone P Paffoni R Re E Zoppis E Albano G Bellomo, Pharmacol Res 2000 41 1 67 74 10600271 (Pubitemid 30008938)
48. Molecular aspects of -tocotrienol antioxidant action and cell signalling. L Packer SU Weber G Rimbach, J Nutr 2001 369S 373S (Pubitemid 32115383)
49. 25) of rice bran in hypercholesterolemic humans. AA Qureshi SA Sami WA Salser FA Khan, Atherosclerosis 2002 161 199 207 10.1016/S0021-9150(01)00619-0 11882333 (Pubitemid 34214837)
50. Regulation of gene and protein expression by Vitamin E. A Azzi R Gysin P Kempna R Ricciarelli L Villacorta T Visarius JM Zingg, Free Radic Res 2002 36 1 30 35
51. Increases in high-density lipoprotein cholesterol with endurance exercise training are blunted in obese compared with lean men. BJ Nicklas LI Katzel J Busby-Whitehead AP Goldberg, Metabolism 1997 46 5 556 561 10.1016/S0026-0495(97) 90194-3 9160824 (Pubitemid 27214881)
52. Physical exercise reverses diet-induced increases in LDL-cholesterol and apo B levels in healthy ovo-lactovegetarian subjects. M Delgado M González-Gross MD Cano A Gutiérrez MJ Castillo, Nutr Res 2000 20 12 1707 1714 10.1016/S0271-5317(00)00276-1 (Pubitemid 32038660)
53. Tocotrienols in health and disease: the other half of the natural vitamin E family. CK Sen S Khanna S Roy, Mol Aspects Med 2007 28 692 728 10.1016/j.mam.2007.03.001 17507086 (Pubitemid 47625534)
54. Bioavailability and potency of natural-source and all-racemic alpha-tocopherol in the human: a dispute. PP Hoppe G Krennrich, Eur J Nutr 2000 39 183 193 10.1007/s003940070010 11131364
55. Human plasma and tissue alphatocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. GW Burton MG Traber RV Acuff DN Walters H Kayden L Hughes KU Ingold, Am J Clin Nutr 1998 67 669 684 9537614 (Pubitemid 28153169)
56. Vitamin E bioavailability in humans. JK Lodge, J Plant Physiol 2005 162 790 796 10.1016/j.jplph.2005.04.012 16008106 (Pubitemid 40772094)
57. Vitamin C as an antioxidant: Evaluation of its role in disease prevention. SJ Padayatty A Katz Y Wang P Eck O Kwon JH Lee S Chen C Corpe A Dutta SK Dutta M Levine, J Am Coll Nutr 2003 22 1 18 35 12569111 (Pubitemid 36164454)
58. Requirement for promotion or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation. J Neuzil SR Thomas R Stocker, Free Radic Biol Med 1997 22 57 71 10.1016/S0891-5849(96) 00224-9 8958130 (Pubitemid 26399311)
59. Protein oxidation. ER Stadtman RL Levine, Ann NY Acad Sci 2000 899 191 208 10863540 (Pubitemid 30352787)
60. Oxidative protein damage with carbohydrates and lipids in uremia: 'Carbonyl stress'. R Inagi T Miyata, Blood Purif 1999 17 95 98 10.1159/000014380 10449866 (Pubitemid 29403566)
61. Tocotrienol: the natural vitamin E to defend the nervous system? CK 61 Sen S Khanna S Roy, Ann NY Acad Sci 2004 1031 127 142 10.1196/annals.1331.013 15753140 (Pubitemid 40361749)