Acute phase protein levels and thymus, spleen and plasma protein synthesis rates differ in adult and old rats

Journal of Nutrition

Volumn 133, Issue 1, 2003, Pages 215-219

  Papet, Isabelle ^a   Dardevet, Dominique ^a   Sornet, Claire ^a   Béchereau, Fabienne ^a   Prugnaud, Jacques ^a   Pouyet, Corinne ^a   Obled, Christiane ^a  

^a CEMAGREF   (France)

Author keywords

Aging; Inflammation; Lymphoid tissues; Protein synthesis; Rats

Indexed keywords

ACUTE PHASE PROTEIN; ALBUMIN; ALPHA 2 MACROGLOBULIN; AMINO ACID; FIBRINOGEN; OROSOMUCOID;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNE SYSTEM; IN VIVO STUDY; INFLAMMATION; LYMPHOID ORGAN; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; QUANTITATIVE ASSAY; RAT; SENESCENCE; SPLEEN; SPLENOMEGALY; TECHNIQUE; THYMUS; THYMUS ATROPHY;

ANIMALIA;

EID: 0037224755     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.1.215     Document Type: Article

References (41)

1. Pawelec, G., Barnett, Y., Forsey, R., Frasca, D., Globerson, A., McLeod, J., Caruso, C., Franceschi, C., Fulop, T., Gupta, S., Mariani, E., Mocchegiani, E. & Solana, R. (2002) T cells and aging, January 2002 update. Front BioSci. 7: d1056-1183.
2. Lesourd, B. M. (1997) Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am. J. Clin. Nutr. 66: 478S-484S.
3. Dominguez-Gerpe, L. & Rey-Mendez, M. (1998) Age-related changes in primary and secondary immune organs of the mouse. Immunol. Investig. 27: 153-165.
4. Chakravarti, B. & Abraham, G. N. (1999) Aging and T-cell-mediated immunity. Mech. Ageing Dev. 108: 183-206.
5. Franceschi, C., Bonafe, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E. & De Benedictis, G. (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N.Y. Acad. Sci. 908: 244-254.
6. Bruunsgaard, H., Pedersen, M. & Pedersen, B. K. (2001) Aging and proinflammatory cytokines. Curr. Opin. Hematol. 8: 131-6.
7. Preedy, V. R., Koll, M. & Emery, P. W. (2002) Albumin synthesis measured in vivo. Clin. Sci. (Lond.) 102: 115-117.
8. Krobot, K., Nense, H. W., Cremer, P., Eberle, E. & Keil, U. (1992) Determinants of plasma fibrinogen: relation to body weight, waist-to-hip ratio, smoking, alcohol, age, and sex. Arterioscler. Thromb. 12: 780-788.
9. Ross, R. D., Frengley, J. D., Mion, L. C. & Kushner, I. (1992) Elevated C-reactive protein in older people. J. Am. Geriatr. Soc. 40: 104-105.
10. Yan, S. H. & Franks, J. J. (1968) Albumin metabolism in elderly men and women. J. Lab. Clin. Med. 72: 449-454.
11. Keating, F.R.J., Jones, J. D., Elveback, L. R. & Randall, R. V. (1969) The relation of age and sex to distribution of values in healthy adults of serum calcium, inorganic phosphorus, magnesium, alkaline phosphatase, total proteins, albumin, and blood urea. J. Lab. Clin. Med. 73: 825-834.
12. Vranckx, R., Savu, N., Lambert, G., Vermeil de Conchard, G., Grosse, R., Mourey, M. S. & Corman, B. (1995) Plasma proteins as biomarkers of the aging process. Am. J. Physiol. 268: R536-R548.
13. Morley, J. E., Baumgartner, R. N., Roubenoff, R., Mayer, J. & Nair, K. S. (2001) Sarcopenia. J. Lab. Clin. Med. 137: 231-243.
14. Attaix, D., Mosoni, L., Arnal, M. A., Dardevet, D., Combaret, L., Grizard, J. & Patureau Mirand, P. (2002) Molecular basis of muscle atrophy. In: Neuromuscular Disorders and Ageing (Engel, W. K. & Askanas, V., eds.), Martin Dunitz Publishers, London, UK.
15. Boirie, Y., Gachon, P. & Beaufrère, B. (1997) Splanchnic and whole-body leucine kinetics in young and elderly men. Am. J. Clin. Nutr. 65: 489-495.
16. Macallan, D. C. (2001) Lymphocyte activity and protein synthesis. Clin. Sci. (Lond.) 101: 591-592.
17. Essen, P., McNurlan, M. A., Thorell, A., Tjäder, I., Caso, G., Anderson, S. E., Wernerman, J. & Garlick, P.J. (1996) Determination of protein synthesis in lymphocytes in vivo after surgery. Clin. Sci. (Lond.) 91: 99-106.
18. Caso, G., Garlick, P. J., Gelato, M. C. & McNurlan M.A. (2001) Lymphocyte protein synthesis is increased with the progression of HIV-associated disease to AIDS. Clin. Sci. (Lond.) 101: 583-589.
19. Januszkiewicz, A., Essén, P., McNurlan, M. A., Ringden, O., Garlick, P. J. & Wernerman, J. (2001) A combined stress hormone infusion decreases in vivo protein synthesis in human T lymphocytes in healthy volunteers. Metabolism 50: 1308-1314.
20. Lobley, G. E., Hoskin, S. O, & McNeil, C. J. (2001) Glutamine in animal science and production. J. Nutr. 131: 2525S-2531S.
21. Paper, I., Ruot, B., Breuillé, D., Walrand, S., Farges, M. C., Vasson, M. P. & Obled, C. (2002) Bacterial infection affects protein synthesis in primary lymphoid tissues and circulating lymphocytes in rats. J. Nutr. 132: 2028-2032.
22. Horbach, G. J. M. J. & Van Bezooijen, C. F. A. (1989) Hepatic protein metabolism and aging. In: Liver: Metabolism and Ageing, (Woodhouse, K. W., Yelland, C. & James, O.F.W., eds.), pp. 95-116, Eurage (Rijswijk).
23. Fu, A. & Nair, K. S. (1998) Age effect on fibrinogen and albumin synthesis in humans. Am. J. Physiol. 275: E1023-E1030.
24. Boirie, Y., Gachon, P., Cordat, N., Ritz, P. & Beaufrère, B. (2001) Differential insulin sensitivities of glucose, amino acid, and albumin metabolism in elderly men and women. J. Clin. Endocrinol. Metab. 86: 638-644.
25. Dardevet, D., Sornet, C., Bayle, G., Prugnaud, J., Pouyet, C. & Grizard, J. (2002) Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal. J. Nutr. 132: 95-100.
26. Garlick, P. J., McNurlan, M. A. & Preedy, V. R. (1980) A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of (3H] phenylalanine. Biochem. J. 192: 719-723.
27. Ruot, B., Breuillé, D., Rambourdin, F., Bayle, G., Capitan, P. & Obled, C. (2000) Synthesis rate of plasma albumin is a good indicator of liver albumin synthesis in sepsis. Am. J. Physiol. 279: E244-E251.
28. Breuillé, D., Arnal, M., Rambourdin, F., Bayle, G., Levieux, D. & Obled, C. (1998) Sustained modifications of protein metabolism in various tissues in a rat model of long-lasting sepsis. Clin. Sci. (Lond.) 94: 413-423.
29. Munro, H. N, & Fleck, A. (1969) Analysis of tissues and body fluids for nitrogenous constituents. in: Mammalian, Protein, Metabolism. (Munro, H. N., eds.), pp. 423-525, Academic Press.
30. Ballmer, P. E., McNurlan, M. A., Milne, E., Heys, S. D., Buchan, V., Calder, A. G. & Garlick, P.J. (1990) Measurement of albumin synthesis in humans - a new approach employing stable isotopes. Am. J. Physiol. 259: E797-E803.
31. Haynes, B. F., Markert, M. L., Sempowski, G. D., Patel, D. D. & Hale, L. P. (2000) The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18: 529-560.
32. Lesourd, B. & Mazari, L. (1999) Nutrition and immunity in the elderly. Proc. Nutr. Soc. 58: 685-695.
33. Schoeffner, D. J., Warren, D. A., Muralidara, S., Bruckner, J. V. & Simmons, J. E. (1999) Organ weights and fat volume in rats as a function of strain and age. J. Toxicol. Environ. Health A 56: 449-462.
34. Woda, B. A. & Feldman, J. D. (1979) Density of surface immunoglobulin and capping on rat B lymphocytes, I. Changes with aging. J. Exp. Med. 149: 416-423.
35. Mansoor, O., Cayol, M., Gachon, P., Boirie, Y., Schoeffler, P., Obled, C. & Beaufrére, B. (1997) Albumin and fibrinogen syntheses increase while muscle protein synthesis decreases in head-injured patients. Am. J. Physiol. 273: E898-E902.
36. Ruot, B., Béchereau, F., Bayle, G., Breuilié, D. & Obled, C. (2002) The response of liver albumin synthesis to infection in rats varies with the phase of the inflammatory process. Clin. Sci. (Lond.) 102: 107-114.
37. Cayol, M., Tauveron, I., Rambourdin, F., Prugnaud, J., Gachon, P., Thiéblot, P., Grizard, J. & Obled, C. (1995) Whole-body protein turnover and hepatic protein synthesis are increased by vaccination in man. Clin. Sci. (Lond.) 89: 389-396.
38. Paganelli, R., Quinti, I., Fagiolo, U., Cossarizza, A., Ortolani, C., Guerra, E., Sansoni, P., Pucillo, L. P., Scala, E., Cozzi, E., Bertollo, L., Monti, D. & Franceschi, C. (1992) Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population. Clin. Exp. Immunol. 90: 351-354.
39. Carson, P. J., Nichol, K. L., O'Brien, J., Hilo, P. & Janoff, E. N. (2000) Immune function and vaccine responses in healthy advanced elderly patients. Arch. Intern. Med. 160: 2017-2024.
40. Mosoni, L., Patureau Mirand, P., Houlier, M. L. & Arnal, M. (1993) Age-related in protein synthesis measured in vivo in rat liver and gastrocnemius muscle. Mech. Ageing Dev. 68: 209-220.
41. Zoico, E. & Roubenoff, R. (2002) The role of cytokines in regulating protein metabolism and muscle function. Nutr. Rev. 60: 39-51.