CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation

Nature Medicine

Volumn 16, Issue 9, 2010, Pages 1018-1023

  Marcos, Veronica ^a   Zhou, Zhe ^b   Yildirim, Ali Önder ^c   Bohla, Alexander ^c   Hector, Andreas ^a,d   Vitkov, Ljubomir ^e,f   Wiedenbauer, Eva Maria ^a   Krautgartner, Wolf Dietrich ^f   Stoiber, Walter ^f   Belohradsky, Bernd H ^a   Rieber, Nikolaus ^a   Kormann, Michael ^a,d   Koller, Barbara ^a   Roscher, Adelbert ^a   Roos, Dirk ^g   Griese, Matthias ^a   Eickelberg, Oliver ^c   Döring, Gerd ^d   Mall, Marcus A ^b   Hartl, Dominik ^a,d  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e SAARLAND UNIVERSITY   (Germany)

^f UNIVERSITY OF SALZBURG   (Austria)

^g UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL MOLECULE TRANSPORT AGENT; CATION; CXCL2 CHEMOKINE; CXCL2 PROTEIN, HUMAN; DIPHENYLIODONIUM SALT; ENZYME INHIBITOR; IL8 PROTEIN, HUMAN; INTERLEUKIN 8;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; HOST RESISTANCE; IN VIVO STUDY; LUNG FUNCTION; MOUSE; NEUTROPHIL; NEUTROPHIL EXTRACELLULAR TRAP; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DEATH; CYTOLOGY; DRUG EFFECTS; EXTRACELLULAR SPACE; HUMAN; INFLAMMATION; LEUKOCYTE ACTIVATION; LUNG DISEASE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETRACTED ARTICLE;

ANIMALS; CELL DEATH; CHEMOKINE CXCL2; CYSTIC FIBROSIS; ENZYME INHIBITORS; EXTRACELLULAR SPACE; HUMANS; INFLAMMATION; INTERLEUKIN-8; LUNG DISEASES; MICE; NADPH OXIDASE; NEUTROPHIL ACTIVATION; NEUTROPHILS; ONIUM COMPOUNDS; RECEPTORS, INTERLEUKIN-8B;

EID: 77956426154     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2209     Document Type: Article

References (40)

1. Brinkmann, V. & Zychlinsky, A. Benefcial suicide: why neutrophils die to make NETs. Nat. Rev. Microbiol. 5, 577-582 (2007).
2. Martinelli, S. et al. Induction of genes mediating interferon-dependent extracellular trap formation during neutrophil differentiation. J. Biol. Chem. 279, 44123-44132 (2004).
3. Brinkmann, V. et al. Neutrophil extracellular traps kill bacteria. Science 303, 1532-1535 (2004).
4. Gupta, A.K., Hasler, P., Holzgreve, W., Gebhardt, S. & Hahn, S. Induction of neutrophil extracellular DNA lattices by placental microparticles and IL-8 and their presence in preeclampsia. Hum. Immunol. 66, 1146-1154 (2005).
5. Kessenbrock, K. et al. Netting neutrophils in autoimmune small-vessel vasculitis. Nat. Med. 15, 623-625 (2009).
6. Chmiel, J.F., Berger, M. & Konstan, M.W. The role of infammation in the pathophysiology of CF lung disease. Clin. Rev. Allergy Immunol. 23, 5-27 (2002).
7. McElvaney, N.G. et al. Modulation of airway infammation in cystic fbrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J. Clin. Invest. 90, 1296-1301 (1992).
8. Nathan, C. Neutrophils and immunity: challenges and opportunities. Nat. Rev. Immunol. 6, 173-182 (2006).
9. Fuchs, T.A. et al. Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 176, 231-241 (2007).
10. Yousef, S., Mihalache, C., Kozlowski, E., Schmid, I. & Simon, H.U. Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps. Cell Death Differ. 16, 1438-1444 (2009).
11. Yousef, S. et al. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat. Med. 14, 949-953 (2008).
12. Wang, Y. et al. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J. Cell Biol. 184, 205-213 (2009).
13. Urban, C.F., Reichard, U., Brinkmann, V. & Zychlinsky, A. Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms. Cell. Microbiol. 8, 668-676 (2006).
14. Pease, J.E. & Sabroe, I. The role of interleukin-8 and its receptors in infammatory lung disease: implications for therapy. Am. J. Respir. Med. 1, 19-25 (2002).
15. Olson, T.S. & Ley, K. Chemokines and chemokine receptors in leukocyte traffcking. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283, R7-R28 (2002).
16. Baggiolini, M. Chemokines in pathology and medicine. J. Intern. Med. 250, 91-104 (2001).
17. Richardson, R.M., Pridgen, B.C., Haribabu, B., Ali, H. & Snyderman, R. Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation. J. Biol. Chem. 273, 23830-23836 (1998).
18. Jones, S.A., Wolf, M., Qin, S., Mackay, C.R. & Baggiolini, M. Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2. Proc. Natl. Acad. Sci. USA 93, 6682-6686 (1996).
19. Baggiolini, M., Loetscher, P. & Moser, B. Interleukin-8 and the chemokine family. Int. J. Immunopharmacol. 17, 103-108 (1995).
20. Chakrabarti, S. & Patel, K.D. Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils. J. Leukoc. Biol. 78, 279-288 (2005).
21. Sai, J., Raman, D., Liu, Y., Wikswo, J. & Richmond, A. Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis. J. Biol. Chem. 283, 26538-26547 (2008).
22. Davis, P.B. Cystic fbrosis. Pediatr. Rev. 22, 257-264 (2001).
23. McElvaney, N.G. et al. Modulation of airway infammation in cystic fbrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J. Clin. Invest. 90, 1296-1301 (1992).
24. Hartl, D. et al. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fbrosis lung disease. Nat. Med. 13, 1423-1430 (2007).
25. Frizzell, R.A. & Pilewski, J.M. Finally, mice with CF lung disease. Nat. Med. 10, 452-454 (2004).
26. + absorption produces cystic fbrosis-like lung disease in mice. Nat. Med. 10, 487-493 (2004).
27. Tsai, W.C. et al. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect. Immun. 68, 4289-4296 (2000).
28. Sue, R.D. et al. CXCR2 is critical to hyperoxia-induced lung injury. J. Immunol. 172, 3860-3868 (2004).
29. Mehrad, B. et al. CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis. J. Immunol. 163, 6086-6094 (1999).
30. Herbold, W. et al. Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection. Infect. Immun. 78, 2620-2630 (2010).
31. Ness, T.L., Hogaboam, C.M., Strieter, R.M. & Kunkel, S.L. Immunomodulatory role of CXCR2 during experimental septic peritonitis. J. Immunol. 171, 3775-3784 (2003).
32. Clark, S.R. et al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat. Med. 13, 463-469 (2007).
33. von Köckritz-Blickwede, M. & Nizet, V. Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps. J. Mol. Med. 87, 775-783 (2009).
34. Urban, C. & Zychlinsky, A. Netting bacteria in sepsis. Nat. Med. 13, 403-404 (2007).
35. Chapman, R.W. et al. CXCR2 antagonists for the treatment of pulmonary disease. Pharmacol. Ther. 121, 55-68 (2009).
36. Barnes, P.J. Frontrunners in novel pharmacotherapy of COPD. Curr. Opin. Pharmacol. 8, 300-307 (2008).
37. Zarbock, A., Allegretti, M. & Ley, K. Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice. Br. J. Pharmacol. 155, 357-364 (2008).
38. Viola, A. & Luster, A.D. Chemokines and their receptors: drug targets in immunity and infammation. Annu. Rev. Pharmacol. Toxicol. 48, 171-197 (2008).
39. Belperio, J.A. et al. Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome. J. Clin. Invest. 115, 1150-1162 (2005).
40. Neeli, I., Khan, S.N. & Radic, M. Histone deimination as a response to infammatory stimuli in neutrophils. J. Immunol. 180, 1895-1902 (2008).