Arsenicals: Toxicity, their use as chemical warfare agents, and possible remedial measures

Handbook of Toxicology of Chemical Warfare Agents

Volumn , Issue , 2009, Pages 109-133

  Flora, Swaran J S ^a   Flora, Govinder ^b   Saxena, Geetu ^c  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

^b Spherix Inc   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79959337057     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374484-5.00009-2     Document Type: Chapter

References (216)

1. Ahmad S.A., Sayed M.H.S.U., Barua S., Khan M.H., Faruquee M.H., Jalil A., Haldi S.A., Talukder H.K. Arsenic in drinking water and pregnancy outcomes. Environ. Health Perspect. 2001, 109:629-631.
2. Angle C.R., Kuntzleman D.R. Increased erythrocyte protoporphyrins and blood lead: a pilot study of childhood growth patterns. J. Toxicol. Environ. Health 1989, 26:149-156.
3. Anthonis, P., Baunoe, B., Fallenti, B, Frost, J., Grut, A., Kristens, Lv, Ladefoge, J., Munck, O., Nielsen, B., Pedersen, F., Pedersen, K., Raaschou, F., Thomas, J., Winkler, K. (1968a). Arsine poisoning in metal refining plant -14 simultaneous cases. I. Introduction. Acta Med. Scand. S: 7-8.
4. Anthonis, P., Nielsen, B., Pedersen, K., Raaschou, F. (1968b). Arsine poisoning in metal refining plant -14 simultaneous cases. 3. Clinical picture and treatment in arsine poisoning. Acta Med. Scand. S: 14-15.
5. Aposhian H.V. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu. Rev. Pharmacol. Toxicol. 1997, 37:397-419.
6. Aposhian H.V., Tadlock C.H., Moon T.E. Protection of mice against lethal effects of sodium arsenite -a quantitative comparison of a number of chelating agents. Toxicol. Appl. Pharmacol. 1981, 61:385-392.
7. Aposhian H.V., Bruce D.C., Alter W., Dart R.C., Hurlbut K.M., Aposhian M.M. Urinary mercury after administration of 2,3-dimercaptopropane-1-sulfonic acid: correlation with dental amalgam score. FASEB J. 1992, 6:2472-2476.
8. Aposhian H.V., Zakharyan R.A., Avram M.D., Kopplin M.J., Wollenberg M.L. Oxidation and detoxification of trivalent arsenic species. Toxicol. Appl. Pharmacol. 2003, 193:1-8.
9. Apostoli P., Alessio L., Romeo L., Buchet J.P., Leone R. Metabolism of arsenic after acute occupational arsine intoxication. J. Toxicol. Environ. Health 1997, 52:331-342.
10. Applegate L.A., Luscher P., Tyrrell R.M. Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells. Cancer Res. 1991, 51:974-978.
11. Arroyo C.M., Burman D.L., Kahler D.W., Nelson M.R., Corun C.M., Guzman J.J., Smith M.A., Purcell E.D., Hackley B.E., Soni S.D., Broomfield C.A. TNF-alpha expression patterns as potential molecular biomarker for human skin cells exposed to vesicant chemical warfare agents: sulfur mustard (HD) and Lewisite (L). Cell Biol. Toxicol. 2004, 20:345-359.
12. ATSDR (2000). Toxicological profile for arsenic (update). US Department of Health and Human Services.
13. Bartelt-Hunt S.L., Barlaz M.A., Knappe D.R.U., Kjeldsen P. Fate of chemical warfare agents and toxic industrial chemicals in landfills. Environ. Sci. Tech. 2006, 40:4219-4225.
14. Bartelt-Hunt S.L., Knappe D.R.U., Barlaz M.A. A review of chemical warfare agent simulants for the study of environmental behavior. Crit. Rev. Environ. Sci. Tech. 2008, 38:112-136.
15. Beckett I. The "admiral's secret weapon' -Lord Dundonald and the origins of chemical warfare. TLS The Times Literary Supplement 26 2008.
16. Bellama J.M., Macdiarm Ag Synthesis of hydrides of germanium phosphorus arsenic and antimony by solid-phase reaction of corresponding oxide with lithium aluminum hydride. Inorg. Chem. 1968, 7:2070-2072.
17. Bennett D.W., Dill K. Theoretical study of arsenical antidote adducts. Drug Chem. Toxicol. 1994, 17:69-73.
18. Bhadauria S., Flora S.J.S. Response of arsenic induced oxidative stress, DNA damage and metal imbalance to combined administration of DMSA and monoisoamyl DMSA during chronic arsenic poisoning in rats. Cell Biol. Toxicol. 2007, 23:91-104.
19. Black R.M. An overview of biological markers of exposure to chemical warfare agents. J. Anal. Toxicol. 2008, 32:2-9.
20. Blair P.C., Thompson M.B., Moorman C.R., Moorman M.P., Goering P.L., Fowler B.A. Arsine -alterations in the hematopoietic system of rats and mice. Environ. Health Perspect. 1987, 75:145-146.
21. Blair, P.C., Thompson, M.B., Bechtold, M., Wilson, R.E., Moorman, M.P., Fowler, B.A. (1990a). Evidence for oxidative damage to red blood cells in mice induced by arsine gas. Toxicology63: 25-34.
22. Blair, P.C., Thompson, M.B., Morrissey, R.E., Moorman, M.P., Sloane, R.A., Fowler, B.A. (1990b). Comparative toxicity of arsine gas in B6c3f1 mice, Fischer-344 rats, and Syrian golden hamsters -system organ studies and comparison of clinical indexes of exposure. Fundam. Appl. Toxicol.14: 776-87.
23. Bollinger C.T., Van Z.P., Louw J.A. Multiple organ failure with the adult respiratory distress syndrome in homicidal arsenic poisoning. Respiration 1992, 59:57-61.
24. Boronin A.M., Sakharovskii V.G., Kashparov K.I., Starovoitov I.I., Kashparova E.V., Shvetsov V.N., Morozova K.M., Nechaev I.A., Tugushov V.I., Shpilkov P.A., Kuzmin N.P., Kochergin A.I. A complex approach to utilization of lewisite. Appl. Biochem. Microbiol. 1996, 32:195-201.
25. Braman R.S. Applications of arsine evolution methods to environmental analyses. Environ. Health Perspect. 1977, 19:1-4.
26. Buchet J.P., Apostoli P., Lison D. Arsenobetaine is not a major metabolite of arsine gas in the rat. Arch. Toxicol. 1998, 72:706-710.
27. Carter D.E., Aposhian H.V., GandolfiA.J. The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review. Toxicol. Appl. Pharmacol. 2003, 193:309-334.
28. Chapell W.R., Abernathy C.O., Calderon R.L. Arsenic and health effects. Proceedings of the 4th International Conference on Arsenic Exposure and Health Effects 2001, Elsevier, Amsterdam.
29. Chein H.M., Hsu Y.D., Aggarwal S.G., Chen T.M., Huang C.C. Evaluation of arsenical emission from semiconductor and opto-electronics facilities in Hsinchu, Taiwan. Atmos. Environ. 2006, 40:1901-1907.
30. Clarkson T.W. Inorganic and organometal pesticides. Handbook of Pesticide Toxicology 1991, 545-552. Academic Press, San Diego. W.J. Hayes, E.R. Laws (Eds.).
31. Clay J.E., Dale I., Cross J.D. Arsenic absorption in steel bronze workers. J. Soc. Occup. Med. 1977, 27:102-104.
32. Cohen S.M., Arnold L.L., Eldan M., Lewis A.S., Beck B.D. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit. Rev. Toxicol. 2006, 36:99-133.
33. Coles G.A., Davies H.J., Daley D., Mallick N.P. Acute intravascular haemolysis and renal failure due to arsenic poisoning. Postgrad. Med. J. 1969, 45:170-172.
34. Concha G., Nermell B., Vahter M. Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. Environ. Health Perspect. 1998, 106:355-359.
35. Csanaky I., Gregus Z. Role of glutathione in reduction of arsenate and of g-glutamyltranspeptidase in disposition of arsenite in rats. Toxicology 2005, 207:91-104.
36. Daniels J.M., Liu L., Stewart R.K., Massey T.E. Biotransformation of aflatoxin B1 in rabbit lung and liver microsomes. Carcinogenesis 1990, 11:823-827.
37. Datta S., Saha D.R., Ghosh D., Majumdar T., Bhattacharya S., Mazumder S. Sub-lethal concentration of arsenic interferes with the proliferation of hepatocytes and induces in vivo apoptosis in Clarias batrachus L. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2007, 145:339-349.
38. Delnomdedieu M., Basti M.M., Otvos J.D., Thomas D.J. Reduction of binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study. Chem. Biol. Interact. 1994, 90:139-155.
39. Devesa V., Adair B.M., Liu J., Waalkes M.P., Diwan B.A., Styblo M., Thomas D.J. Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite. Toxicology 2006, 224:147-155.
40. DIA (Defense Intelligence Agency) (1997). Iraqi Chemical Warfare Data, declassified document file 970613-092596.
41. Domingo J.L. Developmental toxicity of metal chelating agents. Reprod. Toxicol 1998, 12(5):499-510.
42. Dunn, M.A., Hackley, B.E.J., Sidell, F.R. (1997). Pretreatment for nerve agent exposure. In Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare (Sidell, F.R., Takafugi, T.E., Franz, D.R., eds), pp. 181-96. Borden Institute, Walter Reed Medical Center, Washington, DC.
43. Engel R.R., Hopenhayn-Rich C., Receveur O., Smith A.H. Vascular effects of chronic arsenic exposure: a review. Epidemiol. Rev. 1994, 16:184-209.
44. Fallenti B., Frost J., Grut A. Arsine poisoning in metal refining plant -14 simultaneous cases. 2. Environmental studies. Acta Med. Scand. 1968, S: 9.
45. Fang Y. Chemical agents development in USSR, trans. from Chinese. VA 1983, Defense Technical Information Center, Alexandria.
46. Flora S.J.S. Arsenic induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3 dimercaptosuccinic acid in rats. Clin. Exp. Pharmacol. Physiol. 1999, 26:865-869.
47. Flora S.J.S., Kumar P. Biochemical and immunological evaluation of metal chelating drugs in rats. Drug Invest. 1993, 5:269-273.
48. Flora S.J.S., Mehta A. Haematological, hepatic and renal alternations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. Changes in female rats. J. Appl. Toxicol. 2003, 23:97-102.
49. Flora S.J.S., Sekhar K. Chronic arsenic poisoning: target organ toxicity, diagnosis and treatment. Pharmacological Perspectives of Some Toxic Chemicals and their Antidotes 2004, 271-302. India, New Delhi, Narosa Publishing House. S.J.S. Flora, J.A. Romano, S.I. Baskin, K. Sekhar (Eds.).
50. Flora S.J.S., Tripathi N. Treatment of arsenic poisoning: an update. Indian J. Pharmacol. 1998, 30:209-217.
51. Flora S.J.S., Kannan G.M., Pant B.P., Jaiswal D.K. Combined administration of oxalic acid, succimer and its analogue in the reversal of gallium arsenide induced oxidative stress in rats. Arch. Toxicology 2002, 76:269-276.
52. Flora S.J.S., Kannan G.M., Pant B.P., Jaiswal D.K. The efficacy of monomethyl ester of dimercaptosuccinic acid in chronic experimental arsenic poisoning in mice. J. Environ. Sci. Health (Part C) 2003, 38:241-253.
53. Flora, S.J.S., Mehta, A., Rao, P.V.L., Kannan, G.M., Bhaskar, A.S.B., Dube, S.N., Pant, B.P. (2004a). Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats. Toxicology195: 127-46.
54. Flora, S.J.S, Pande, M., Kannan, G.M., Mehta, A. (2004b). Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats. Cell. Mol. Biol.50: 543-51.
55. Flora S.J.S., Bhadauria S., Pant S.C., Dhaked R.K. Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats. Life Sci. 2005, 77:2324-2337.
56. Flora, S.J.S., Saxena, G., Gautam, P., Kaur, P., Gill, K.D. (2007a). Lead induced oxidative stress and alterations in biogenic amines in different rat brain regions and their response to combined administration of DMSA and MiADMSA. Chem. Biol. Interact. 170: 209-20.
57. Flora, S.J.S., Flora, G., Saxena, G., Mishra, M. (2007b). Arsenic and lead induced free radical generation and their reversibility following chelation. Cell. Mol. Biol.53: 26-47.
58. Flora, S.J.S., Saxena, G., Mehta, A. (2007c). Reversal of lead-induced neuronal apoptosis by chelation treatment in rats: role of reactive oxygen species and intracellular Ca2{thorn}. J. Pharmacol. Exp. Ther. 322: 108-16.
59. Fowler B.A., Weissber J.B. Arsine poisoning. N. Engl. J. Med. 1974, 291:1171-1174.
60. Franke, S. (1967). Chemistry of chemical warfare agents, trans. from German. In Manual of Military Chemistry, Vol. 1. Defense Technical Information Center, Cameron Station, VA.
61. Fujihara J., Kunito T., Kubota R., Tanaka H., Tanaba S. Arsenic accumulation and distribution in tissues of black footed albatrosses. Mar. Pollut. Bull. 2004, 48:1153-1160.
62. Gao S., Burau R.G. Environmental factors affecting rates of arsine evolution from and mineralization of arsenicals in soil. J. Environ. Qual. 1997, 26:753-763.
63. Garcia-Vargas G.G., Hernandez-Zavala A. Urinary porphyrins and heme biosynthetic enzyme activities measured by HPLC in arsenic toxicity. Biomed. Chromatogr. 1996, 10:278-284.
64. Goebel H.H., Schmidt P.F., Bohl J., Tettenborn B., Kramer G., Guttman L. Polyneuropathy due to acute arsenic intoxication: biopsy studies. J. Neuropathol. Exp. Neurol. 1990, 49:137-149.
65. Goldman M., Dacre J.C. Lewisite -its chemistry, toxicology, and biological effects. Rev. Environ. Contam. Toxicol. 1989, 110:75-115.
66. Golub M.S., Macintosh M.S., Baumrind N. Developmental and reproductive toxicity of inorganic arsenic: animal studies and human concerns. J. Toxicol. Environ. Health 1998, 1:199-241.
67. Gosselin B., Mathieu D., Despreznolf M., Cosson A., Goudemand J., Haguenoer J.M., Wattel F. Acute arsenious hydride intoxication -4 cases. Nouv. Presse Med. 1982, 11:439-442.
68. Guha Mazumder, D.N., Das Gupta, J., Santra, A. (1998). Chronic arsenic toxicity in West Bengal -the worst calamity in the world. J. Indian. Med. Assoc.96: 4-7.
69. Haddad, L.M., Wincester, J.F. (1983). Clinical Management of Poisoning and Drug Overdose. W.B. Saunders Co., Philadelphia.
70. Hafeman D.M., Ahsan H., Louis E.D., Siddique A.B., Slavkovich V., Cheng Z., Van Geen A., Graziano J.H. Association between arsenic exposure and a measure of subclinical sensory neuropathy in Bangladesh. J. Occup. Environ. Med. 2005, 8:778-784.
71. Hall A.H. Chronic arsenic poisoning. Toxicol. Lett. 2002, 128:69-72.
72. Hanaoka S., Nomura K., Kudo S. Identification and quantitative determination of diphenylarsenic compounds in abandoned toxic smoke canisters. J. Chromatogr. A 2005, 1085:213-223.
73. Hatlelid K.M., Carter D.E. Reactive oxygen species do not cause arsine-induced hemoglobin damage. J. Toxicol. Environ. Health 1997, 50:463-474.
74. Hatlelid K.M., Brailsford C., Carter D.E. An in vitro model for arsine toxicity using isolated red blood cells. Fundam Appl. Toxicol. 1995, 25:302-306.
75. Hatlelid K.M., Brailsford C., Carter D.E. Reactions of arsine with hemoglobin. J. Toxicol. Environ. Health 1996, 47:145-157.
76. Hauser W., Weger N. Treatment of arsenic poisoning in mice with sodium dimercaptopropane 1-sulfonate. Proc. Int. Cong. Pharmacol. 1989, Paris (abst.
77. Henriksson J., Johannisson A., Bergqvist P.A., Norrgren L. The toxicity of organo-arsenic-based warfare agents: in vitro and in vivo studies. Arch. Environ. Contam. Toxicol. 1996, 30:213-219.
78. Heyndrickx A. new compounds in biological and chemical warfare: toxicological evaluation, proceedings. State University of Ghent and the National Science Foundation of Belgium 1984, First World CongressGhent, Belgium.
79. Hong H.L., Fowler B.A., Boorman G.A. Hematopoietic effects in mice exposed to arsine gas. Toxicol. Appl. Pharmacol. 1989, 97:173-182.
80. Hoover T.D., Aposhian H.V. BAL increases the arsenic-74 content of rabbit brain. Toxicol. Appl. Pharmacol. 1983, 70:160-162.
81. Hruby K., Donner A. 2,3-Dimercapto-1-propanesulphonate in heavy metal poisoning. Med. Toxicol. Adverse Drug Exp. 1987, 2(5):317-323.
82. HSDB Hazardous Substance Data Bank 1999, US National Library of Medicine, Bethesda, MD.
83. Hu Y., Su L., Snow E.T. Arsenic toxicity an enzyme specific and its effects on ligation are not caused by the direct inhibition of DNA repair enzymes. Mutat. Res. 1998, 408:203-218.
84. Huges M.F., Kenyon E.M., Edwards B.C., Mitchell C.T., Del Razo L.M., Thomas D.J. Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate. Toxicol. Appl. Pharmacol. 2003, 191:202-210.
85. IOM Institute of Medicine. Evaluation of the Department of Defense Persian Gulf Comprehensive Clinical Evaluation Program 1996, National Academy Press, Washington DC.
86. Ishii K., Tamaoka A., Otsuka F., Iwasaki N., Shin K., Matsui A., Endo G., Kumagai Y., Ishii T., Shoji S., Ogata T., Ishizaki M., Doi M., Shimojo N. Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan. Ann. Neurol. 2004, 56:741-745.
87. Ishizaki M., Yanaoka T., Nakamura M., Hakuta T., Ueno S., Komura M., Shibata M., Kitamura T., Honda A., Doy M., Ishii K., Tamaoka A., Shimojo N., Ogata T., Nagasawa E., Hanaoka S. Detection of bis(diphenylarsine)oxide, diphenylarsinic acid and phenylarsonic acid, compounds probably derived from chemical warfare agents, in drinking well water. J. Health Sci. 2005, 51:130-137.
88. James P.S., Woods S.E. Occupational arsine gas exposure. J. Natl Med. Assoc. 2006, 98:1998.
89. Jenkins G.C., Ind J.E., Kazantzi G., Owen R. Arsine poisoning -massive haemolysis with minimal impairment of renal function. BMJ 1965, 78-85. ii.
90. Jones M.M., Singh P.K., Gale G.R., Smith A.B., Atkins L.M. Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso 2,3-dimercaptosuccinic acid. Pharmacol. Toxicol. 1992, 70:336-343.
91. Kalia K., Flora S.J.S. Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. J. Occup. Health 2005, 47:1-21.
92. Kannan G.M., Flora S.J.S. Combined administration of meso 2,3-dimercaptosuccinic acid (DMSA) or monoisoamyl DMSA with an antioxidant for the treatment of chronic experimental arsenic poisoning in rats. Ecotoxicol. Environ. Saf. 2004, 58:37-43.
93. Kannan G.M., Flora S.J.S. Combined administration of N-acetylcysteine (NAC) and monoisoamyl DMSA on tissue oxidative stress during arsenic chelation therapy. Biol. Trace Elem. Res. 2006, 110:43-60.
94. Kannan G.M., Tripathi N., Dube S.N., Gupta M., Flora S.J.S. Toxic effects of arsenic (III) on some hematopoietic and central nervous system variables in rats and guinea pigs. Clin. Toxicol. 2001, 39:675-682.
95. Kato K., Mizoi M., An Y., Nakano M., Wanibuchi H., Endo G., Endo Y., Hoshino M., Okada S., Yamanaka K. Oral administration of diphenylarsinic acid, a degradation product of chemical warfare agents, induces oxidative and nitrosative stress in cerebellar Purkinje cells. Life Sci. 2007, 81:1518-1525.
96. Katos A.M., Conti M.L., Moran T.S., Gordon R.K., Doctor B.P., Sciuto A.M., Nambiar M.P. Abdominal bloating and irritable bowel syndrome like symptoms following microinstillation inhalation exposure to chemical warfare nerve agent VX in guinea pigs. Toxicol. Ind. Health 2007, 23:231-240.
97. Kimmecki W.T., Carter D.E. Arsine toxicity: chemical and mechanistic implications. J. Toxicol. Environ. Health 1995, 46(4):399-409.
98. King J.R., Riviere J.E., Monteiroriviere N.A. Characterization of lewisite toxicity in isolated perfused skin. Toxicol. Appl. Pharmacol. 1992, 116:189-201.
99. King J.R., Peters B.P., Monteiroriviere N.A. Laminin in the cutaneous basement-membrane as a potential target in lewisite vesication. Toxicol. Appl. Pharmacol. 1994, 126:164-173.
100. Kinoshita A., Wanibuchi H., Wei M., Yunokl T., Fukushima S. Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder. Toxicol. Appl. Pharmacol. 2007, 221:295-305.
101. Kitchin K.T. Recent advances in arsenic carcinogenesis: mode of action, animal model system and methylated arsenic metabolites. Toxicol. Appl. Pharmacol. 2001, 172:249-261.
102. Kleinfeld M.J. Arsine poisoning. J. Occup. Environ. Med. 1980, 22:820-821.
103. Kojima C., Qu W., Waalkes M.P., Himeno S., Sakurai T. Chronic exposure to methylated arsenicals stimulates arsenic excretion pathways and induces arsenic tolerance in rat liver cells. Toxicol. Sci. 2006, 91:70-81.
104. Koons R.D., Peters C.A. Axial distribution of arsenic in individual human hairs by solid sampling graphite furnace AAS. J. Anal. Toxicol. 1994, 18:36.
105. Kosnett, M. (1990). Arsenic toxicity. In Case Studies in Environmental Medicine, No. 5 (Kreiss, K. ed.). Agency for Toxic Substances and Disease Registry, Atlanta.
106. Kreppel H., Reichl F.X., Klein A., Szincz L., Singh P.K., Jones M.M. Antidotal efficacy of newly synthesized dimercaptosuccinic acid (DMSA) monoesters in experimental poisoning in mice. Fundam Appl. Toxicol. 1995, 26:239-245.
107. Kunz M. Chemical warfare -from tears to frenzy. Chemicke Listy 1994, 88:789-793.
108. Landrigan P.J., Costello R.J., Stringer W.T. Occupational exposure to arsine -an epidemiologic reappraisal. Scand. J. Work Environ. Health 1983, 9:56.
109. Le X.C., Lu X., Ma M., Cullen W.R., Aposhian H.V., Zheng B. Speciation of key arsenic metabolic intermediates in human urine. Anal. Chem. 2000, 72:5172-5177.
110. Lee T.C., Ho I.C. Modulation of cellular antioxidant defense activities by sodium arsenite inhuman fibroblasts. Arch. Toxicol. 1994, 69:498-504.
111. Lee T.C., Tanaka N., Lamb P.W., Gilmer T.M., Barrett J.C. Induction of gene amplification by arsenic. Science 1988, 241:79-81.
112. Lenza C. Arsine gas exposure and toxicity -a case report. J. Gen. Intern. Med. 2006, 21:222.
113. Levinsky W.J., Smalley R.V., Hillyer P.N., Shindler R.L. Arsine hemolysis. Arch. Environ. Health 1970, 20:436-440.
114. Levvy G.A. study of arsine poisoning. Q.J. Exp. Physiol. 1947, 34:47-67. A.
115. Hawley's Condensed Chemical Dictionary 1993, 98. Van Nostrand Reinhold Co., New York. 12th edition. R.J. Lewis, Sr (Eds.).
116. Lewis D.R., Southwick J.W., Ouellet-Hellstrom R., Rench J., Calderon R.L. Drinking water arsenic in Utah. A cohort study. Environ. Health Perspect. 1999, 107(5):359-365.
117. Li J.X., Waters S.B., Drobna Z., Devesa V., Styblo M., Thomas D.J. Arsenic ({thorn}3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype. Toxicol. Appl. Pharmacol. 2005, 204:164-169.
118. Lin S., Cullen W.R., Thomas D.J. Methyl arsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase. Chem. Res. Toxicol. 1999, 12:924-930.
119. Lin T.H., Huang Y.L., Wang M.Y. Arsenic species in drinking water, hair, fingernails, and urine of patients with Blackfoot disease. J. Toxicol. Environ. Health A 1998, 53:85-93.
120. Liu J., Kaduska M., Liu Y., Qu W., Mason R.P., Walker M.P. Acute arsenic induced free radical production and oxidative stress related gene expression in mice. Toxicologists 2000, 54:280-281.
121. Lu M., Wang H., Li X.F., Lu X., Cullen W.R., Arnold L.L., Cohen S.M., Le X.C. Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood. Chem. Res. Toxicol. 2004, 17:1733-1742.
122. Mandal B.K., Ogra Y., Suzuki K.T. Identification of dimethylarsenous and monomethylarsenous acids in human urine of arsenic affected areas in West Bengal, India. Chem. Res. Toxicol. 2001, 14:371-378.
123. Mann S., Droz P.O., Vahter M. A physiologically based pharmacokinetic model for arsenic exposure. I. Development in hamsters and rabbits. Toxicol. Appl. Pharmacol. 1996, 137:8-22.
124. Marrs T.C., Maynard R.L., Sidell F.R. Chemical Warfare Agents: Toxicology and Treatment 1996, John Wiley & Sons, New York.
125. Martinez G., Cebrian M., Chamorro G., Jauge P. Urinary uroporphyrin as an indicator of arsenic exposure in rats. Proc. West. Pharmacol. Soc. 1983, 26:171-174.
126. Mazumder D.N.G., Haque R., Ghosh N., De B.K., Santra A., Chakraborty D., Smith A.H. Arsenic levels in drinking water and the prevalence of skin lesions in West Bengal. India. Int. J. Epidemiol. 1998, 27:871-877.
127. Mazumder D.N., Haque R., Ghosh N. Arsenic in drinking water and the prevalence of respiratory effects in West Bengal. India. Int. J. Epidemiol. 2000, 29:1047-1052.
128. McManus J., Huebner K. Vesicants. Crit. Care Clin. 2005, 21:707-717.
129. Mehta A., Flora S.J.S. Possible role of metal redistribution, hepatotoxicity and oxidative stress in chelating agents induced hepatic and renal metallothionein in rats. Food. Chem. Toxicol. 2001, 39:1029-1038.
130. Mehta A., Kannan G.M., Dube S.N., Pant B.P., Pant S.C., Flora S.J.S. Hematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA I. Changes in male rats. J. Appl. Toxicol. 2002, 22:359-369.
131. Mehta A., Pant S.C., Flora S.J.S. Monoisoamyl dimercaptosuccinic acid induced changes in pregnant female rats during late gestation and lactation. Reprod. Toxicol. 2006, 21:94-103.
132. Menkes J.H. Man, metals. Mineral and Metal Neurotoxicology 1997, 5-13. Informa HealthCare, New York, minerals. M. Yasui, M.J. Strong, K. Ota, M.A. Verity (Eds.).
133. Mishra D., Mehta A., Flora S.J.S. Reversal of hepatic apoptosis with combined administration of DMSA and its analogues in guinea pigs: role of glutathione and linked enzymes. Chem. Res. Toxicol. 2008, 21:400-408.
134. Moore M.M., Harrington Brock K., Doerr C.L. Relative genotoxic potency of arsenic and its methylated metabolites. Mutat. Res. Rev. Mutat. Res. 1997, 386:279-290.
135. Mora V., Pairon J.C., Garnier R., Laureillard J., Lionnet F., Hoguet L., Schaeffer A., Efthymiou M.L., Brochard P. Acute arsine poisoning in a ferrous metal foundry. A report of two cases. Arch. Malad. Profess. 1992, 53:167-173.
136. Morse K.M., Setterlind A.N. Arsine poisoning in the smelting and refining industry. Arch. Ind. Hyg. Occup. Med. 1950, 2:148-169.
137. Morton W.E., Caron G.A. an uncommon manifestation of workplace arsenic poisoning?. Am. J. Ind. Med. 1989, 15:1-5. Encephalopathy.
138. Muehrcke R.C., Pirani C.L. Arsine-induced anuria -a correlative clinicopathological study with electron microscopic observations. Ann. Intern. Med. 1968, 68:853-858.
139. Naranmandura H., Suzuki K.T. Formation of dimethylthioarsenicals in red blood cells. Toxicol. Appl. Pharmacol. 2008, 227:390-399.
140. NAS National Academy of Sciences, National Research Council, Committee on Toxicology, Subcommittee on Toxicity. Values for Selected Nerve and Vesicant Agents 1997, National Academy Press, Washington, DC.
141. NATO (1973). North Atlantic Treaty Organization. Handbook on the Medical Aspects of NBC Defensive Operations, Part III. Departments of the Army, the Navy, and the Air Force.
142. Nesnow S., Roop B.C., Lambert G., Kadiiska M., Mason R.P., Cullen W.R., Mass M.J. DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem. Res. Toxicol. 2002, 15:1627-1634.
143. Noort D., Benschop H.P., Black R.M. Biomonitoring of exposure to chemical warfare agents: a review. Toxicol. Appl. Pharmacol. 2002, 184:116-126.
144. Ochi T., Suzuki T., Isono H., Kaise T. In vitro cytotoxic and genotoxic effects of diphenylarsinic acid, a degradation product of chemical warfare agents. Toxicol. Appl. Pharmacol. 2004, 200:64-72.
145. Parish G.G., Glass R., Kimbrough R. Acute arsine poisoning in 2 workers cleaning a clogged drain. Arch. Environ. Health 1979, 34:224-227.
146. Pechura C.M., Rall D.P. Veterans at Risk: The Health Effects of Mustard Gas and Lewisite 1993, National Academy Press, Washington, DC.
147. Pernis B., Magistretti M. A study of the mechanism of acute hemolytic anemia from arsine. Med. Lav. 1960, 51:37-41.
148. Peterson D.P., Bhattacharyya M.H. Hematological responses to arsine exposure -quantitation of exposure response in mice. Fundam. Appl. Toxicol. 1985, 5:499-505.
149. 50 in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem. Res. Toxicol. 2001, 14:651-656.
150. Pinto S.S., Varner M.O., Nelson K.W., Labbe A.L., White L.D. Arsenic trioxide absorption and excretion in industry. J. Occup. Environ. Med. 1976, 18:677-680.
151. Pitten F.A., Muller G., Konig P., Schmidt D., Thurow K., Kramer A. Risk assessment of a former military base contaminated with organo-arsenic-based warfare agents: uptake of arsenic by terrestrial plants. Sci. Total Environ. 1999, 226:237-245.
152. Pullen-James S., Woods S.E. Occupational arsine gas exposure. J. Nat. Med. Assoc. 2006, 98:1998-2001.
153. Radabaugh T.R., Aposhian H.V. Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. Chem. Res. Toxicol. 2000, 13:26-30.
154. Radabaugh T.R., Sampayo-Reyes A., Zakharyan R.A., Aposhian H.V. Arsenate reductase II. Purine nucleotide phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. Chem. Res. Toxicol. 2002, 15:692-698.
155. Rahman M., Tondel M., Ahmad S.A., Axelson O. Diabetes mellitus associated with arsenic exposure in Bangladesh. Am. J. Epidemiol. 1998, 148:198-203.
156. Rahman M., Tondel M., Ahmad S.A., Chowdhary I.A., Faruquee M.H., Axelson O. Hypertension and arsenic exposure in Bangladesh. Hypertension 1999, 33:74-78.
157. 3.. Arch. Toxicol. 1991, 65:235-238.
158. Rezuke W.N., Anderson C., Pastuszak W.T., Conway S.R., Firshein S.I. Arsenic intoxication presenting as a myelodysplastic syndrome: a case report Am. J. Hematol. 1991, 36:291-293.
159. Risk M., Fuortes L. Chronic arsenicalism suspected from arsine exposure -a case report and literature review. Vet. Hum. Toxicol. 1991, 33:590-595.
160. Rodriguez V.M., Jimenez M.E., Giordano M. The effects of arsenic on the nervous system. Toxicol. Lett. 2003, 145:1-18.
161. Rogge H., Fassbinder W., Martin H. Arsine (Ash3) poisoning -hemolysis and renal failure. Dtsch. Med. Wochenschr. 1983, 108:1720-1725.
162. Romeo L., Apostoli P., Kovacic M., Martini S., Brugnone F. Acute arsine intoxication as a consequence of metal burnishing operations. Am. J. Ind. Med. 1997, 32:211-216.
163. Rossman T.G. Mechanism of arsenic carcinogenesis: an integral approach. Mutat. Res. 2003, 533:37-65.
164. Saha K.C., Dikshit A.K., Bandopadhayay M., Saha K.C. A review of arsenic poisoning and its effects on human health. Crit. Rev. Environ. Sci. 1999, 29:281-313.
165. Santra A., Das Gupta J., De B.K., Roy B., Guha Mazumder D.N. Hepatic manifestations in chronic arsenic toxicity. Indian J. Gastroenterol. 1999, 18:152-155.
166. Santra A., Maiti A., Das S., Lahiri S., Chakraborty S.K., Guha Mazumder D.N. Hepatic damage caused by chronic arsenic toxicity in experimental animals. Clin. Toxicol. 2000, 38:395-405.
167. Sarkar M., Chaudhuri G.R., Chattopadhyay A., Biswas N.M. Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian J. Androl. 2003, 5:27-31.
168. Sasser L.B., Cushing J.A., Mellick P.W., Kalkwarf D.R., Dacre J.C. Sub chronic toxicity evaluation of lewisite in rats. J. Toxicol. Environ. Health 1996, 47:321-334.
169. Sasser L.B., Cushing J.A., Lindenmeier C.W., Mellick P.W., Dacre J.C. Two-generation reproduction study of lewisite in rats. J. Appl. Toxicol. 1999, 19:229-235.
170. Saxena G., Flora S.J.S. Lead induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J. Biochem. Mol. Toxicol. 2004, 18:221-233.
171. Saxena G., Pathak U., Flora S.J.S. Beneficial role of monoesters of meso 2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats. Toxicology 2005, 214:39-56.
172. Scott N., Hatelid K.M., MacKenzie N.E., Carter D.E. Reactions of arsenic(III) and arsenic(V) species with glutathione. Chem. Res. Toxicol. 1993, 6:102-106.
173. Sheehy J.W., Jones J.H. Assessment of arsenic exposures and controls in gallium-arsenide production. Am. Ind. Hyg. Assoc. J. 1993, 54:61-69.
174. Sidell F.R., Takafuji E.T., Franz D.R. Textbook of Military Medicine, Part I: Warfare, Weaponry, and the Casualty. Borden Institute 1997, Walter Reed Medical Center, Washington, DC.
175. Simeonova P.P., Luster M.I. Arsenic and atherosclerosis. Toxicol. Appl. Pharmacol. 2004, 198:444-449.
176. Snider T.H., Wientjes M.G., Joiner R.L., Fisher G.L. Arsenic distribution in rabbits after lewisite administration and treatment with British Anti-Lewisite (BAL). Fundam. Appl. Toxicol. 1990, 14:262-272.
177. Somani S.M. Chemical Warfare Agents 1992, Academic Press, New York.
178. Song Y.G., Wang D.X., Li H.L., Hao F.T. Severe acute arsine poisoning treated by plasma exchange and hemodialysis. Clin. Toxicol. 2006, 44:725.
179. Stanek J. Chemical warfare -from Greek fire to yellow rain. Chemicke Listy 1991, 85:827-839.
180. Stephenson C. Stink vessels (chemical warfare). History Today 2006, 56:2-3.
181. Styblo M., Thomas D.J. Binding of arsenicals to proteins in an in vitro methylation system. Toxicol. Appl. Pharmacol. 1997, 147:1-8.
182. Styblo M., Serves S.V., Cullen W.R., Thomas D.J. Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols. Chem. Res. Toxicol. 1997, 10:27-33.
183. Sugden J. The admiral's secret weapon: Lord Dundonald and the origins of chemical warfare. Mariners Mirror 2008, 94:106-109.
184. 2 in HaCaT cells. Wei Sheng Yan Jiu 2005, 34:46-48.
185. Szinicz L. History of chemical and biological warfare agents. Toxicology 2005, 214:167-181.
186. Szinicz L., Wiedemann P., Haring H., Weger N. Effects of repeated treatment with sodium 2,3-dimercaptopropane-1-sulfonate in beagle dogs. Arzneimittelforschung. 1983, 33:818-821.
187. Tabacova S., Baird D.D., Balabaeva I., Lolova D., Petrove I. Placental arsenic and cadmium in relation to lipid peroxides and glutathione levels in maternal-infant pairs from a copper smelter area. Placenta 1994, 15:873-881.
188. Tanaka A. Toxicity of indium arsenide, gallium arsenide and aluminum gallium arsenide. Toxicol. Appl. Pharmacol. 2004, 198:405-411.
189. Telolahy P., Morel G., Cluet J.L., Yang H.M., Thieffry N., deCeaurriz J. An attempt to explain interindividual variability in 24-h urinary excretion of inorganic arsenic metabolites by C57 BL/6J mice. Toxicology 1995, 103:105-112.
190. Thomas R., Young R. Arsine. Inhal. Toxicol. 2001, 13:43-77.
191. TPHD (Taiwan Provincial Health Department) (1993). Blackfoot Disease Control and Prevention in Taiwan Republic of China.
192. Tripathi N., Kannan G.M., Pant B.P., Jaiswal D.K., Malhotra P.R., Flora S.J.S. Arsenic induced changes in certain neurotransmitters levels and their recoveries following chelation in rat whole brain. Toxicol. Lett. 1997, 92:201-208.
193. Tsai S.M., Wang T.N., Ko Y.C. Mortality for certain diseases in areas with high levels of arsenic in drinking water. Arch. Environ. Health 1999, 54:186-193.
194. Tseng C.H. An overview on peripheral vascular disease in Blackfoot disease-hyperendemic villages in Taiwan. Angiology 2002, 53:529-537.
195. Tseng C.H. The potential biological mechanisms of arsenic-induced diabetes mellitus. Toxicol. Appl. Pharmacol. 2004, 197:67-83.
196. Tsuda T., Babazono A., Yamamoto E., Kurumatani N., Mino Y., Ogawa T., Kishi Y., Aoyama H. Ingested arsenic and internal cancer, a historical cohort study followed for 33 years. Am. J. Epidemiol. 1995, 141:198-209.
197. UN Use of chemical weapons by Iraqi regime report of the specialists appointed by the secretary-general to investigate allegations by the Islamic Republic of Iran concerning the use of chemical weapons 1984, United Nations, New York, NY.
198. USDHHS Final recommendation for protecting the health and safety against potential adverse effects of long-term exposure to low doses of agents GA, GB, VX, and mustard agent (H, HD, HT) and lewisite (L). U.S. Department of Health and Human Services. Federal Register 1988, Vol. 53:8504.
199. Vahter M. Mechanism of arsenic biotransformation. Toxicology 2002, 181-2:211-217.
200. Vega L., Styblo M., Patterson R., Cullen W., Wang C., Germolec D. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicol. Appl. Pharmacol. 2001, 172:225-232.
201. Venugopal B., Luckey T.D. Toxicity of Group V Metals and Metalloids 1978, Plenum Press, New York, NY.
202. Vilensky J.A., Redman K. British anti-Lewisite (dimercaprol): an amazing history. Ann. Emerg. Med. 2003, 41:378-383.
203. Wachtel C. Chemical Warfare. Chemical Publishing Co. 1941, Brooklyn, NY.
204. Wald P.H., Becker C.E. Toxic gases used in the microelectronics industry. Occup. Med. State of the Art Reviews 1986, 1:105-117.
205. Waters S.B., Devesa V., Fricke M.W., Creed J.T., Styblo M., Thomas D.J. Glutathione modulates recombinant rat arsenic ({thorn}3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine. Chem. Res. Toxicol. 2004, 17:1621-1629.
206. Watson A.P., Griffin G.D. Toxicity of vesicant agents scheduled for destruction by the Chemical Stockpile Disposal Program. Environ. Health Perspect. 1992, 98:259-280.
207. Wei M., Arnold L., Cano M., Cohen S.M. Effects of co-administration of antioxidants and arsenicals on the rat urinary bladder epithelium. Toxicol. Sci. 2005, 83(2):237-245.
208. Wexler P. The US National Library of Medicine's Toxicology and Environmental Health Information Program. Toxicology 2004, 198:161-168.
209. Winski S.L., Barber D.S., Rael L.T., Carter D.E. Of toxic events in arsine-induced hemolysis in vitro. Implications for the mechanism of toxicity in human erythrocytes. Fundam. Appl. Toxicol. 1997, 38:123-128.
210. Wong S.S., Tan K.C., Goh C.L. Cutaneous manifestations of chronic arsenicism: review of seventeen cases. J. Am. Acad. Med. 1998, 38:179-185.
211. Woods J.S., Fowler B.A. Altered regulation of mammalian hepatic heme biosynthesis and urinary porphyrin excretion during prolonged exposure to sodium arsenate. Toxicol. Appl. Pharmacol 1978, 43(2):361-371.
212. Woods J.S., Southern M.R. Studies on the etiology of trace metal-induced porphyria: effects of porphyrinogenic metals on coproporphyrinogen oxidase in rat liver and kidney. Toxicol. Appl. Pharmacol. 1989, 97:183-190.
213. 3 in rabbits: evidence of reversible chronic toxicity and tissue accumulation of arsenicals after parenteral administration. Toxicol. Appl. Pharmacol. 2003, 189:214-220.
214. Xu C., Holscher M.A., Jones M.M., Singh P.K. Effect of monoisoamyl meso-2,3-dimercaptosuccinate on the pathology of acute cadmium intoxication. J. Toxicol. Environ. Health 1995, 45:261-277.
215. Yamauchi H., Takahashi K., Mashiko M., Yamamura Y. Biological monitoring of arsenic exposure of gallium arsenide-and inorganic arsenic-exposed workers by determination of inorganic arsenic and its metabolites in urine and hair. Am. Ind. Hyg. Assoc. J. 1989, 50:606-612.
216. Young R., Thomas R., Garrett R., Krewski D., Bakshi K. Acute exposure guideline levels (AEGLs) for arsine. Toxicol. Sci. 2003, 72:160.