Combined administration of N-acetylcysteine and monoisoamyl DMSA on tissue oxidative stress during arsenic chelation therapy

Biological Trace Element Research

Volumn 110, Issue 1, 2006, Pages 43-59

  Kannan, Gurusamy M ^a   Flora, Swaran J S ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Antioxidant; Arsenic mobilization; Arsenic poisoning; Essential metals level; Guinea pigs; Monoesters of DMSA; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ACID PHOSPHATASE; ALKALINE PHOSPHATASE; AMINOTRANSFERASE; ARSENIC; CALCIUM; COPPER; DRINKING WATER; GLUTATHIONE; IRON; PORPHOBILINOGEN SYNTHASE; PROTOPORPHYRIN ZINC; SUCCIMER; THIOBARBITURIC ACID; ZINC;

ACID PHOSPHATASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARSENIC POISONING; ARTICLE; CHELATION THERAPY; CHEMICAL ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; EXPOSURE; GUINEA PIG; LIVER INJURY; MALE; MONOTHERAPY; NONHUMAN; OXIDATIVE STRESS;

ACETYLCYSTEINE; ANIMALS; ARSENIC; CHELATION THERAPY; GUINEA PIGS; MALE; OXIDATIVE STRESS; SUCCIMER;

ANIMALIA; CAVIA; CAVIA PORCELLUS;

EID: 33646865247     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: 10.1385/BTER:110:1:43     Document Type: Article

References (56)

1. I. Dreosti, Free radical pathology and the genome, in Trace Elements. Micronutrients over Free Radicals, I. E. Dreosti, ed., Humana, Totowa, NJ, pp. 49-68 (1994).
2. S. Tabacova, D. D. Baird, I. Balabaeva, D. Lolova, and I. Petrove, Placental arsenic and cadmium in relation to lipid peroxides and glutathione levels in maternal-infant pairs from a copper smelter area, Placenta 15, 873-881 (1994).
3. K. Yamanaka, M. Hoshino, M. Okamoto, R. Sawamura, A. Hasegawa, and S. Okada, Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical, Biochem. Biophys. Res. Commun. 168, 58-64 (1990).
4. Y. C. Chen, S. Y. Lin-Shiau, and J. K. Lin, Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis, J. Cell Physiol. 177, 324-329 (1998).
5. K. Yamanaka and S. Okada, Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals, Environ. Health Perspect. 102(Suppl.), 37-40 (1994).
6. E. Graf, J. R. Mahoney, R. G. Bryant, and J. W. Eaton, Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site, J. Biol. Chem. 259, 3620-3624 (1984).
7. S. Ahmad, K. T. Kitchin, and W. R. Cullen, Arsenic species that causes release of iron from ferritin and generation of activated oxygen, Arch. Biochem. Biophys. 382, 195-202 (2000).
8. T. K. Hei, S. X. Liu, and C. Waldren, Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species, Proc. Natl. Acad. Sci. USA 95, 8103-8107 (1998).
9. G. M. Kannan, N. Tripathi, S. N. Dube, M. Gupta, and S. J. S. Flora, Toxic effects of arsenic(III) on some hematopoietic and central nervous system variables in rats and guinea pigs, Clin. Toxicol. 39, 675-682 (2001).
10. A. Meister and M. E. Anderson, Glutathione, Annu. Rev. Biochem. 52, 711-760 (1983).
11. J. E. Biaglow, M. E. Varnes, E. P. Clark, and E. R. Epp, The role of thiols in cellular response to radiation and drugs, Radiat. Res. 95, 437-455 (1983).
12. M. M. Wu, H. Y. Chiou, and T. W. Wang, Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan, Environ. Health Perspect. 109, 1011-1017 (2001).
13. FDA (Food and Drug Administration), Succimer (DMSA) approved for severe lead poisoning, JAMA 265, 1802 (1991).
14. 203Hg retention by intraperitoneal treatment with monoalkyl esters of meso 2,3-dimeracaptosuccinic acid in rats, J. Appl. Toxicol. 13, 321-325 (1983).
15. M. M. Jones, P. K. Singh, and M. A. Basinger, Mobilization of lead in mice by administration of monoalkyl esters of meso 2. 3-dimercaptosuccinic acid, Toxicology 76, 79-87 (1992).
16. S. J. S. Flora, A. Mehta, P. V. L. Rao, et al., Therapeutic potential of monoisoamyl and monomethyl ester of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats, Toxicology 195, 127-146 (2004).
17. M. Pande, A. Mehta, B. P. Pant, and S. J. S. Flora, Combined administration of a chelating agent and an antioxidant in the prevention and treatment of acute lead intoxication in rats, Environ. Toxicol. Pharmacol. 9, 173-184 (2001).
18. 2 retention in rats: 1. Chelation therapy during pregnancy, J. Trace Elements Exp. Med. 10, 173-181 (1997).
19. G. R. Gale, A. B. Smith, M. M. Jones, and P. K. Singh, Meso 2,3-dimercaptosuccinic acid monoalkyl esters: effect on mercury levels in mice, Toxicology 81, 49-56 (1993).
20. P. Grandjean, I. A. Jacobsen, P. J. Jorgensen, S. Lings, and O. Andersen, Treatment of chronic occupational lead poisoning with dimercaptosuccinic acid (DMSA), Ugeskr Laeger. 153, 2897-2899 (1991).
21. J. H. Graziano, Role of 2,3-dimercaptosuccinic acid in the treatment of heavy metal poisoning, Med. Toxicol. 1, 155-162 (1986).
22. S. J. S. Flora, G. M. Kannan, B. P. Pant, and D. K. Jaiswal, Combined administration of oxalic acid, succimer and its analogue for the reversal of gallium arsenide-induced oxidative stress in rats, Arch. Toxicol. 76, 269-276 (2002).
23. S. J. S. Flora, R. Dubey, G. M. Kannan, R. S. Chauhan, B. P. Pant, and D. K. Jaiswal, Meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA effect on gallium arsenide induced pathological liver injury in rats, Toxicol. Lett. 32, 9-17 (2002).
24. A. Mehta, G. M. Kannan S. N. Dube, B. P. Pant, S. C. Pant, and S. J. S. Flora, Hematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA. I. Changes in male rats, J. Appl. Toxicol 22, 359-369 (2002).
25. S. J. S. Flora and A. Mehta, Hematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II. Changes in female rats, J. Appl. Toxicol. 23, 97-102 (2003).
26. S. J. S. Flora, S. N. Dube, U. Arora, G. M. Kannan, M. K. Shukla, and P. R. Malhotra, Therapeutic potential of meso 2,3-dimercaptosuccinic acid or 2,3-dimercaptopropane 1-sulfonate in chronic arsenic intoxication in rats, Biometals 8, 111-116 (1995).
27. N. Tripathi, G. M. Kannan, B. P. Pant, D. K. Jaiswal, P. R. Malhotra, and S. J. S. Flora, Arsenic-induced changes in certain neurotransmitter levels and their recoveries following chelation in rat whole brain, Toxicol. Lett. 92, 201-208 (1997).
28. T. Itoh, Y. F. Zhang, S. Murai, et al., The effects of arsenic trioxide on brain monoamine metabolism and locomotor activity of mice, Toxicol. Lett. 54, 345-353 (1990).
29. D. S. Martin, S. E. Willis, and D. M. Cline, N-Acetylcysteine in the treatment of human arsenic poisoning, J. Am. Board Fam. Pract. 3, 293-296 (1990).
30. H. Gurer, H. Ozgunes, R. Neal, D. R. Spitz, and N. Ercal, Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats, Toxicology 128, 181-189 (1998).
31. P. Moldeus and I. A. Cotgreave, N-Acetylcysteine, Methods Enzymol. 234, 482-492 (1994).
32. O. I. Aruoma, B. Halliwell, B. M. Hoey and J. Butler, The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid, Free Radical Biol. Med. 6, 593-597 (1989).
33. W. Banner, Jr., M. Koch, D. M. Capin, S. B. Hopf, S. Chang, and T. G. Tong, Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds, Toxicol. Appl. Pharmacol. 83, 142-147 (1986).
34. I. Ziment, Acetylcysteine: a drug with an interesting past and a fascinating future, Respiration 50(Suppl. 1), 26-30 (1986).
35. S. J. S. Flora, Arsenic induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats, Clin. Exp. Pharmacol. Physiol. 26, 865-869 (1999).
36. A. Berlin and K. H. Schaller, European standardized method for the determination of delta aminolevulinic acid dehydratase activity in blood, Zeit. Klin. Chem. Klin. Biochem. 12, 389-390 (1974).
37. P. J. Hissin and R. Hilf, A fluorometric method for the determination of oxidized and reduced glutathione in tissue, Anal. Biochem. 74, 214-226 (1973).
38. H. Ohkawa, N. Ohishi, and K. Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal. Biochem. 95, 351-358 (1979).
39. P. B. Halk, B. L. Oser, and W. H. Summerson, Practical Physiology Chemistry, McGraw-Hill, New York (1954).
40. S. Reitman and S. Frankel, A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases, Am. J. Clin. Pathol. 28, 56-63 (1957).
41. D. J. Jollow, J. R. Mitchell, Z. Zamppaglione, and J. R. Gillette, Bromobenzene induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolites, Pharmacology 11, 151 (1974).
42. M. M. Parker, F. L. Humoller, and D. J. Mahler. Determination of copper and zinc in biological materials, Clin. Chem. 13, 40-48 (1967).
43. K. T. Kitchin and S. Ahmad, Oxidative stress as a possible mode of action for arsenic carcinogenesis, Toxicol. Lett. 137, 3-13 (2003).
44. M. F. Hughes, Arsenic toxicity and potential mechanism of action, Toxicol. Lett. 133, 1-16 (2002).
45. T. M. Bray and C. G. Taylor, Tissue glutathione: nutrition and oxidative stress, Can. J. Physiol. Pharmacol. 71, 746-775 (1993).
46. N. Ercal, P. Treeratphan, P. Lutz, T. C. Hammond, and R. H. Matthews, N-Acetylcysteine protects Chinese hamster ovary (CHO) cells from lead-induced oxidative stress, Toxicology 108, 57-64 (1996).
47. S. J. S. Flora, S. Bhadauria, S. C. Pant, and R. K. Dhaked, Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats, Life Sci. 77, 2324-2337 (2005).
48. M. Modi, M., U. Pathak, K. Kalia, and S. J. S. Flora, Arsenic antagonism studies with monoisoamyl DMSA and zinc in male mice, Environ. Toxicol. Pharmacol. 19, 131-138 (2005).
49. S. J. S. Flora and K. Sekhar. Chronic arsenic poisoning: target organ toxicity, diagnosis and treatment, in Pharmacological Perspectives of Some Toxic Chemicals and Their Antidotes, S. J. S. Flora, J. A. Romano, S. I. Baskin, and K. Sekhar, eds., Narosa Publishing House, New Delhi, pp. 271-302 (2004).
50. D. N. Guha Mazumder, Chronic arsenic toxicity: clinical features, epidemiology, and treatment: experience in West Bengal, J. Environ. Sci. Health A: Tox. Hazard Subst. Environ. Eng. 38, 141-163 (2003).
51. K. Lenz, K. Hruby, W. Druml, et al., 2,3-Dimercaptosuccinic acid in human arsenic poisoning, Arch. Toxicol. 47, 241-243 (1981).
52. G. M. Kannan and S. J. S. Flora, Chronic arsenic poisoning in the rat: treatment with combined administration of succimers and an antioxidant, Ecotoxicol. Environ. Safety 58, 37-43 (2004).
53. L. C. Benov, I. C. Benchav, and O. H. Monovich, Thiol antidotes effects on lipid peroxidation in mercury poisoned rats, Chem. Biol. Interact. 76, 321-332 (1990).
54. B. Elsenhans, J. Schaper, G. Hunder, and W. Forth, Arsenic-mediated renal accumulation of copper in rats, guinea pigs and mice - a comparison, Naunyl-Schmiedeberg's Arch. Pharm. 347(Suppl.), R14 (1993).
55. G. Schmolke, B. Elsenhans, C. Ehtechami, and W. Forth, Arsenic-copper interaction in the kidney of the rat: influence of arsenic metabolites, Pharmacol. Toxicol. 78, 154-160 (1992).
56. G. Hunder, J. Schaper, O. Ademuyiwa, and B. Elsenhans, Species differences in arsenic-mediated renal copper accumulation: a comparison between rats, mice and guinea pigs, Hum. Exp. Toxicol. 18, 699-705 (1999).