Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate

Toxicology and Applied Pharmacology

Volumn 191, Issue 3, 2003, Pages 202-210

  Hughes, Michael F ^a   Kenyon, Elaina M ^a   Edwards, Brenda C ^a   Mitchell, Carol T ^a   Del Razo, Luz Maria ^b   Thomas, David J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Accumulation; Arsenate; Arsenic; Disposition; Metabolism; Repeated exposure

Indexed keywords

ARSENIC ACID; CACODYLIC ACID; METHANEARSONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARSENIC POISONING; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BIOACCUMULATION; BIOAVAILABILITY; BLADDER; BLOOD LEVEL; CARCINOGENESIS; CONTROLLED STUDY; EUTHANASIA; FECES ANALYSIS; FEMALE; KIDNEY; LIVER; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PLASMA HALF LIFE; RADIOACTIVITY; RADIOIMMUNOASSAY; SKIN; STEADY STATE; TARGET ORGAN; TISSUE DISTRIBUTION; WHOLE BODY AUTORADIOGRAPHY;

EID: 0042232822     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00249-7     Document Type: Article

References (50)

1. Aposhian H.V., Gurzau E.S., Le X.C., Gurzau A., Healy S.M., Lu X., Ma M., Yip L., Zakharyan R.A., Maiorino R.M., Dart R.C., Tircus M.G., Gonzales-Ramirez D., Morgan D.L., Avram D., Aposhian M.M. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. Chem. Res. Toxicol. 13:2000;693-697.
2. Bencko V., Rossner P., Havrankova H., Puzanova A., Tucek M. Effects of the combined action of selenium and arsenic on mice versus suspension culture of mice fibroblasts. Fouts J.R., Gut I. Industrial and Environmental Xenobiotics In Vitro, Versus In Vivo Biotransformation and Toxicity . 1978;312-316 Excerpta Medica, Amsterdam.
3. Carmignani M., Boscolo P., Iannaccone A. Effects of chronic exposure to arsenate on the cardiovascular function of rats. Br. J. Ind. Med. 40:1983;280-284.
4. Cebrian M.E., Albores A., Aguilar M., Blakely E. Chronic arsenic poisoning in the north of Mexico. Hum. Toxicol. 2:1983;121-133.
5. Chiou H.Y., Hsueh Y.M., Liaw K.F., Horng S.F., Chiang M.H., Pu Y.S., Lin J.S.N., Huang C.H., Chen C.H. Incidence of internal cancers and ingested inorganic arsenic a seven-year follow-up study in Taiwan . Cancer Res. 55:1995;1296-1300.
6. Cohen S.M., Arnold L.L., Uzvolgyi E., Cano M., St. John M., Yamamoto S., Lu X., Le X.C. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Chem. Res. Toxicol. 15:2002;1150-1157.
7. Del Razo L.M., Styblo M., Cullen W.R., Thomas D.J. Determination of trivalent methylated arsenicals in biological matrices. Toxicol. Appl. Pharmacol. 174:2001;283-293.
8. Dixon H.B.F. The biochemical action of arsonic acids especially as phosphate analogues. Adv. Inorg. Chem. 44:1997;191-227.
9. Ginsburg J.M. Renal mechanism for excretion and transformation of arsenic in the dog. Am. J. Physiol. 208:1965;832-840.
10. Ginsburg J.M., Lotspeich W.D. Interrelations of arsenate and phosphate transport in the dog kidney. Am. J. Physiol. 205:1963;707-714.
11. Healy S.M., Casarez E.A., Ayala-Fierro F., Aposhian H.V. Enzymatic methylation of arsenic compounds. V. Arsenite methyltransferase activity in tissues of mice. Toxicol. Appl. Pharmacol. 148:1998;65-70.
12. Healy S.M., Zakharyan R.A., Aposhian H.V. Enzymatic methylation of arsenic compounds. IV. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig. Mutat. Res. 386:1997;229-239.
13. Hopenhayn-Rich C., Biggs M.L., Fuchs A., Bergoglio R., Tello E.E., Nicoli H., Smith A. Bladder cancer mortality associated with arsenic in drinking water in Argentina. Epidemiology. 7:1996;117-124.
14. Hughes M.F., Del Razo L.M., Kenyon E.M. Dose-dependent effects on tissue distribution of dimethylarsinic acid in the mouse after intravenous administration. Toxicology. 143:2000;155-166.
15. Hughes M.F., Kenyon E.M. Dose dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse afater intravenous administration. J. Toxicol. Environ. Health. 53:1998;95-112.
16. Hughes M.F., Kenyon E.M., Edwards B.C., Mitchell C.T., Thomas D.J. Strain-dependent disposition of inorganic arsenic in the mouse. Toxicology. 137:1999;95-108.
17. Hughes M.F., Menache M., Thompson D.J. Dose-dependent disposition of sodium arsenate in mice following acute oral exposure. Fundam. Appl. Toxicol. 22:1994;80-89.
18. Hughes M.F., Thompson D.J. Subchronic disposition and toxicological effects of arsenate administered in drinking water to mice. J. Toxicol. Environ. Health. 49:1996;177-196.
19. Labaune J.P. Handbook of Pharmacokinetics. 1989;Wiley, New York.
20. Lerman S., Clarkson T.W. The metabolism of arsenite and arsenate by the rat. Fundam. Appl. Toxicol. 3:1983;309-314.
21. Li W., Wanibuchi H., Salim E.I., Yamamoto S., Yoshida K., Endo G., Fukushima S. Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound. Cancer Lett. 135:1998;29-36.
22. Lin S., Cullen W.R., Thomas D.J. Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase. Chem. Res. Toxicol. 12:1999;924-930.
23. Lin S., Shi Q., Nix F.B., Styblo M., Beck M.A., Herbin-Davis K.M., Hall L.L., Simeonsson J.B., Thomas D.J. A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol. J. Biol. Chem. 277:2002;10795-10803.
24. Mandal B.K., Ogra Y., Suzuki K.T. Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India. Chem. Res. Toxicol. 14:2001;371-378.
25. Marafante E., Vahter M., Norin H., Envall J., Sandstrom M., Christakopoulos A., Ryhage R. Biotransformation of dimethylarsinic acid in mouse, hamster and man. J. Appl. Toxicol. 7:1987;111-117.
26. Mass M.J., Tennant A., Roop B.C., Cullen W.R., Styblo M., Thomas D.J., Kligerman A.D. Methylated trivalent arsenic species are genotoxic. Chem. Res. Toxicol. 14:2001;355-361.
27. Neiger R.D., Osweiler G.D. Arsenic concentrations in tissues and body fluids of dogs on chronic low-level dietary sodium arsenite. J. Vet. Diagn. Invest. 4:1992;334-337.
28. Guide for the Care and Use of Laboratory Animals. Institute of Laboratory Animal Resources, Commission on Life Sciences. 1996;National Academy Press, Washington, DC.
29. Odanaka Y., Matano O., Goto S. Biomethylation of inorganic arsenic by the rat and some laboratory animals. Bull. Environ. Contam. Toxicol. 24:1980;452-459.
30. Petrick J.S., Ayala-Fierro F., Cullen W.R., Carter D.E., Aposhian H.V. Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes. Toxicol. Appl. Pharmacol. 13:2000;203-207.
31. 50 in hamsters and in vitro inhibition of pyruvate dehydrogenase . Chem. Res. Toxicol. 14:2001;651-656.
32. Salim E.I., Wanibuchi H., Morimura K., Wei M., Mitsuhashi M., Yoshida K., Endo G., Fukushima S. Carcinogenicity of dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice. Carcinogenesis. 24:2003;335-342.
33. Simeonova P.P., Wang S., Toriuma W., Kommineni V., Matheson J., Unimye N., Kayama F., Harki D., Ding M., Vallyathan V., Luster M.I. Arsenic mediates cell proliferation and gene expression in the bladder epithelium association with activating protein-1 transactivation . Cancer Res. 60:2000;3445-3453.
34. Smith A.H., Hopenhayn-Rich C., Bates M.N., Goeden H.M., Hertz-Picciotto I., Duggan H.M., Wood R., Kosnett M.J., Smith M.T. Cancer risks from arsenic in drinking water. Environ. Health Perspect. 97:1992;259-267.
35. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., Wang C., Cullen W.R., Thomas D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in human cells. Arch. Toxicol. 74:2000;289-299.
36. Styblo M., Hughes M.F., Thomas D.J. Liberation and analysis of protein-bound arsenicals. J. Chromatogr. B. 677:1996;161-166.
37. Tseng W.P., Chu H.M., How S.W., Fong J.M., Lin C.S., Yeh S. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J. Natl. Cancer Inst. 40:1968;453-463.
38. Tsukamoto H., Parker H.R., Peoples S.A. Metabolism and renal handling of sodium arsenate in dogs. Am. J. Vet. Res. 44:1983;2331-2335.
39. Vahter M. Biotransformation of trivalent and pentavalent inorganic arsenic in mice and rats. Environ. Res. 25:1981;286-293.
40. Vahter M. Species differences in the metabolism of arsenic compounds. Appl. Organomet. Chem. 8:1994;175-182.
41. Vahter M., Couch R., Nermell B., Nilsson R. Lack of methylation of inorganic arsenic in the chimpanzee. Toxicol. Appl. Pharmacol. 133:1995;262-268.
42. Vahter M., Envall J. In vivo reduction of arsenate in mice and rabbits. Environ. Res. 32:1983;14-24.
43. Vahter M., Marafante E. Reduction and binding of arsenate in marmoset monkeys. Arch. Toxicol. 57:1985;119-124.
44. 74As-dimethylarsinic acid in mice and rats. Arch. Environ. Contam. Toxicol. 13:1984;259-264.
45. 74As-labeled trivalent and pentavalent inorganic arsenic in mice. Environ. Res. 21:1980;446-457.
46. Wanibuchi H., Yamamoto S., Chen H., Yoshida K., Endo G., Hori T., Fukushima S. Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats. Carcinogenesis. 17:1996;2435-2439.
47. Wei M., Wanibuchi H., Morimura K., Iwaj S., Yoshida K., Endo G., Nakae D., Fukushima S. Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis. 23:2002;1387-1397.
48. Yamanaka, K., Ohtsubo, K., Hasegawa, A., Hayashi, H., Ohji, H., Kanisawa, M., Okada, S., 1996. Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice. Carcinogenesis 17, 767-770.
49. Yamauchi H., Yamamura Y. Metabolism and excretion of orally administrated arsenic trioxide in the hamster. Toxicology. 34:1985;113-121.
50. Yoshida K., Inoue Y., Kuroda K., Chen H., Wanibuchi H., Fukushima S., Endo G. Urinary excretion of arsenic metabolites after long-term oral administration of various arsenic compounds to rats. J. Toxicol. Environ. Health. 54:1998;179-192.