AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization

Journal of Neuroscience

Volumn 25, Issue 15, 2005, Pages 3752-3762

  Robert, Antoine ^a   Armstrong, Neali ^b   Gouaux, J Eric ^b   Howe, James R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Howard Hughes Medical Institute   (United States)

Author keywords

Affinity; AMPA receptor; Binding cleft; Desensitization; Glutamate; Mutations

Indexed keywords

AMPA RECEPTOR; AMPA RECEPTOR AGONIST; GLUTAMATE RECEPTOR 2; GLUTAMIC ACID; QUISQUALIC ACID;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL LINE; CONCENTRATION RESPONSE; CONFORMATION; CRYSTAL STRUCTURE; HYDROGEN BOND; MOLECULAR STABILITY; MONTE CARLO METHOD; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

BINDING SITES; CELL LINE; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; HUMANS; HYDROGEN BONDING; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MONTE CARLO METHOD; MUTAGENESIS; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUISQUALIC ACID; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 17644377289     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0188-05.2005     Document Type: Article

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