Platelets kill intraerythrocytic malarial parasites and mediate survival to infection

Science

Volumn 323, Issue 5915, 2009, Pages 797-800

  McMorran, Brendan J ^a   Marshall, Vikki M ^b,d   De Graaf, Carolyn ^b,c   Drysdale, Karen E ^a   Shabbar, Meriam ^a   Smyth, Gordon K ^b   Corbin, Jason E ^b   Alexander, Warren S ^b   Foote, Simon J ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; THROMBOCYTE SLOWING FACTOR;

BLOOD; CYTOLOGY; INHIBITION; MALARIA; PARASITE; PATHOGEN; SURVIVAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL KILLING; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INFECTION PREVENTION; MALE; MOUSE; NONHUMAN; PARASITE SURVIVAL; PATHOGENESIS; PLASMODIUM CHABAUDI INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; THROMBOCYTE; THROMBOCYTE FUNCTION;

ADENOSINE DIPHOSPHATE; ANIMALS; ASPIRIN; BLOOD PLATELETS; ERYTHROCYTES; FEMALE; HUMANS; IN SITU NICK-END LABELING; MALARIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PLATELET COUNT; RECEPTORS, PURINERGIC P2; RECEPTORS, THROMBOPOIETIN;

MUS; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM;

EID: 59849088412     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1166296     Document Type: Article

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26. We thank M. Cozens for flow cytometry support; D. Senyschen, G. Panoschi, and F. Rodda for technical support; the Australian Red Cross Blood Service for providing purified red blood cells; S. Jackson for advice; R. Anders for providing the P. falciparum parasites; and C. Flowers for manuscript preparation. Funding support was from the National Health and Medical Research Council of Australia (Program Grants 490037 and 461219), Australian Cancer Research Foundation, and Howard Hughes Medical Institute. Statistical Analysis. P values were calculated by means of two-tailed t tests, except where specifically mentioned. Ethics approval for animal experiments was received from the Royal Melbourne Hospital, Melbourne, Australia (2002.053), and University of Tasmania (A0008702). Ethics approval for the platelet donations was received from Human Research Ethics Committee (Tasmania) Network (H0009004).