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Volumn 93, Issue 2, 2011, Pages 173-181

One step forward: The use of transgenic zebrafish tumor model in drug screens

Author keywords

Drug screening; Liver cancer; Transgenic fish; Zebrafish

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANTINEOPLASTIC AGENT; CYCLOPAMINE; DOXYCYCLINE; INDIRUBIN; MIFEPRISTONE; SU 4312; UNCLASSIFIED DRUG;

EID: 79958847884     PISSN: 1542975X     EISSN: 15429768     Source Type: Journal    
DOI: 10.1002/bdrc.20208     Document Type: Review
Times cited : (16)

References (70)
  • 2
    • 78650921882 scopus 로고    scopus 로고
    • Screening: the age of fishes
    • Baker M. 2011. Screening: the age of fishes. Nat Methods 8: 47-51.
    • (2011) Nat Methods , vol.8 , pp. 47-51
    • Baker, M.1
  • 3
    • 34249813382 scopus 로고    scopus 로고
    • Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants
    • Berghmans S, Hunt J, Roach A, Goldsmith P. 2007. Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants. Epilepsy Res 75: 18-28.
    • (2007) Epilepsy Res , vol.75 , pp. 18-28
    • Berghmans, S.1    Hunt, J.2    Roach, A.3    Goldsmith, P.4
  • 4
    • 77449155155 scopus 로고    scopus 로고
    • Swimming into the future of drug discovery: in vivo chemical screens in zebrafish
    • Bowman TV, Zon LI. 2010. Swimming into the future of drug discovery: in vivo chemical screens in zebrafish. ACS Chem Biol 5: 159-161.
    • (2010) ACS Chem Biol , vol.5 , pp. 159-161
    • Bowman, T.V.1    Zon, L.I.2
  • 5
    • 0036527350 scopus 로고    scopus 로고
    • Dissection of angiogenic signaling in zebrafish using a chemical genetic approach
    • Chan J, Bayliss PE, Wood JM, Roberts TM. 2002. Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell 1: 257-267.
    • (2002) Cancer Cell , vol.1 , pp. 257-267
    • Chan, J.1    Bayliss, P.E.2    Wood, J.M.3    Roberts, T.M.4
  • 6
    • 75149125686 scopus 로고    scopus 로고
    • Recent advances and method development for drug target identification
    • Chan JN, Nislow C, Emili A. 2010. Recent advances and method development for drug target identification. Trends Pharmacol Sci 31: 82-88.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 82-88
    • Chan, J.N.1    Nislow, C.2    Emili, A.3
  • 7
    • 76049117207 scopus 로고    scopus 로고
    • Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen Hedgehog-inhibiting compounds
    • Chen YH, Wang YH, Yu TH, et al. 2009. Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen Hedgehog-inhibiting compounds. Transgenic Res 18: 855-864.
    • (2009) Transgenic Res , vol.18 , pp. 855-864
    • Chen, Y.H.1    Wang, Y.H.2    Yu, T.H.3
  • 8
    • 44449176477 scopus 로고    scopus 로고
    • Using the zebrafish lateral line to screen for ototoxicity
    • Chiu LL, Cunningham LL, Raible DW, et al. 2008. Using the zebrafish lateral line to screen for ototoxicity. JAssoc Res Otolaryngol 9: 178-190.
    • (2008) JAssoc Res Otolaryngol , vol.9 , pp. 178-190
    • Chiu, L.L.1    Cunningham, L.L.2    Raible, D.W.3
  • 9
    • 33947310623 scopus 로고    scopus 로고
    • Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds
    • Choi TY, Kim JH, Ko DH, et al. 2007. Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds. Pigment Cell Res 20: 120-127.
    • (2007) Pigment Cell Res , vol.20 , pp. 120-127
    • Choi, T.Y.1    Kim, J.H.2    Ko, D.H.3
  • 10
    • 77951677864 scopus 로고    scopus 로고
    • The zebrafish model for liver carcinogenesis
    • In: Wang X,Grisham J,Thorgeirsson S, editors. 1st ed. New York: Springer.
    • Gong ZY, Koh CHV, Nguyen AT, et al. 2010. The zebrafish model for liver carcinogenesis. In: Wang X, Grisham J, Thorgeirsson S, editors. Molecular genetics of liver neoplasia.1st ed. New York: Springer. pp. 197-217.
    • (2010) Molecular genetics of liver neoplasia , pp. 197-217
    • Gong, Z.Y.1    Koh, C.H.V.2    Nguyen, A.T.3
  • 11
    • 0021754941 scopus 로고
    • Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris (beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders
    • Goodman LS, Wintrobe MM, Dameshek W, et al. 1984. Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris (beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. JAMA 251: 2255-2261.
    • (1984) JAMA , vol.251 , pp. 2255-2261
    • Goodman, L.S.1    Wintrobe, M.M.2    Dameshek, W.3
  • 12
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89: 5547-5551.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 13
    • 45549103009 scopus 로고    scopus 로고
    • Gal4/UAS transgenic tools and their application to zebrafish
    • Halpern ME, Rhee J, Goll MG, et al. 2008. Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish 5: 97-110.
    • (2008) Zebrafish , vol.5 , pp. 97-110
    • Halpern, M.E.1    Rhee, J.2    Goll, M.G.3
  • 14
    • 78650406074 scopus 로고    scopus 로고
    • Generation of a non-leaky heat shock-inducible Cre line for conditional Cre/lox strategies in zebrafish
    • Hans S, Freudenreich D, Geffarth M, et al. 2011. Generation of a non-leaky heat shock-inducible Cre line for conditional Cre/lox strategies in zebrafish. Dev Dyn 240: 108-115.
    • (2011) Dev Dyn , vol.240 , pp. 108-115
    • Hans, S.1    Freudenreich, D.2    Geffarth, M.3
  • 15
    • 3242875731 scopus 로고    scopus 로고
    • her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling
    • Hans S, Scheer N, Riedl I, et al. 2004. her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling. Development 131: 2957-2969.
    • (2004) Development , vol.131 , pp. 2957-2969
    • Hans, S.1    Scheer, N.2    Riedl, I.3
  • 16
    • 0021952603 scopus 로고
    • Development of aquarium fish models for environmental carcinogenesis: tumor induction in seven species
    • Hawkins WE, Overstreet RM, Fournie JW, Walker WW. 1985. Development of aquarium fish models for environmental carcinogenesis: tumor induction in seven species. J Appl Toxicol 5: 261-264.
    • (1985) J Appl Toxicol , vol.5 , pp. 261-264
    • Hawkins, W.E.1    Overstreet, R.M.2    Fournie, J.W.3    Walker, W.W.4
  • 17
    • 0037434880 scopus 로고    scopus 로고
    • In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio)
    • Her GM, Chiang CC, Chen WY, Wu JL. 2003. In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio). FEBS Lett 538: 125-133.
    • (2003) FEBS Lett , vol.538 , pp. 125-133
    • Her, G.M.1    Chiang, C.C.2    Chen, W.Y.3    Wu, J.L.4
  • 18
    • 0012972680 scopus 로고
    • The effects of 2-acetylaminofluorene on the embryonic development of the zebrafish. II. Histochemical studies
    • Hisaoka KK. 1958. The effects of 2-acetylaminofluorene on the embryonic development of the zebrafish. II. Histochemical studies. Cancer Res 18: 664-667.
    • (1958) Cancer Res , vol.18 , pp. 664-667
    • Hisaoka, K.K.1
  • 19
    • 0030859249 scopus 로고    scopus 로고
    • A hemophilia model in zebrafish: analysis of hemostasis
    • Jagadeeswaran P, Liu YC. 1997. A hemophilia model in zebrafish: analysis of hemostasis. Blood Cells Mol Dis 23: 52-57.
    • (1997) Blood Cells Mol Dis , vol.23 , pp. 52-57
    • Jagadeeswaran, P.1    Liu, Y.C.2
  • 20
    • 33846490910 scopus 로고    scopus 로고
    • Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl
    • Jeong JY, Einhorn Z, Mathur P, et al. 2007. Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development 134: 127-136.
    • (2007) Development , vol.134 , pp. 127-136
    • Jeong, J.Y.1    Einhorn, Z.2    Mathur, P.3
  • 21
    • 0035872916 scopus 로고    scopus 로고
    • Tracing transgene expression in living zebrafish embryos
    • Koster RW, Fraser SE. 2001. Tracing transgene expression in living zebrafish embryos. Dev Biol 233: 329-346.
    • (2001) Dev Biol , vol.233 , pp. 329-346
    • Koster, R.W.1    Fraser, S.E.2
  • 22
    • 30544433311 scopus 로고    scopus 로고
    • Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
    • Lam SH, Wu YL, Vega VB, et al. 2006. Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat Biotechnol 24: 73-75.
    • (2006) Nat Biotechnol , vol.24 , pp. 73-75
    • Lam, S.H.1    Wu, Y.L.2    Vega, V.B.3
  • 23
    • 17844403755 scopus 로고    scopus 로고
    • Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia
    • Langenau DM, Feng H, Berghmans S, et al. 2005. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci USA 102: 6068-6073.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6068-6073
    • Langenau, D.M.1    Feng, H.2    Berghmans, S.3
  • 24
    • 17044423445 scopus 로고    scopus 로고
    • Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish
    • Langenau DM, Jette C, Berghmans S, et al. 2005. Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Blood 105: 3278-3285.
    • (2005) Blood , vol.105 , pp. 3278-3285
    • Langenau, D.M.1    Jette, C.2    Berghmans, S.3
  • 25
    • 34249905448 scopus 로고    scopus 로고
    • Effects of RAS on the genesis of embryonal rhabdomyosarcoma
    • Langenau DM, Keefe MD, Storer NY, et al. 2007. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev 21: 1382-1395.
    • (2007) Genes Dev , vol.21 , pp. 1382-1395
    • Langenau, D.M.1    Keefe, M.D.2    Storer, N.Y.3
  • 26
    • 0347785481 scopus 로고    scopus 로고
    • Myc-induced T cell leukemia in transgenic zebrafish
    • Langenau DM, Traver D, Ferrando AA, et al. 2003. Myc-induced T cell leukemia in transgenic zebrafish. Science 299: 887-890.
    • (2003) Science , vol.299 , pp. 887-890
    • Langenau, D.M.1    Traver, D.2    Ferrando, A.A.3
  • 27
    • 77953928484 scopus 로고    scopus 로고
    • Toxicity and cytopathogenic properties toward human melanoma cells of activated cancer therapeutics in zebra fish
    • Lewis TJ. 2010. Toxicity and cytopathogenic properties toward human melanoma cells of activated cancer therapeutics in zebra fish. Integr Cancer Ther 9: 84-92.
    • (2010) Integr Cancer Ther , vol.9 , pp. 84-92
    • Lewis, T.J.1
  • 28
    • 38149067307 scopus 로고    scopus 로고
    • Prostaglandin E2: making more of your marrow
    • Lord AM, North TE, Zon LI. 2007. Prostaglandin E2: making more of your marrow. Cell Cycle 6: 3054-3057.
    • (2007) Cell Cycle , vol.6 , pp. 3054-3057
    • Lord, A.M.1    North, T.E.2    Zon, L.I.3
  • 30
    • 33751032262 scopus 로고    scopus 로고
    • A chemical genetic screen for cell cycle inhibitors in zebrafish embryos
    • Murphey RD, Stern HM, Straub CT, Zon LI. 2006. A chemical genetic screen for cell cycle inhibitors in zebrafish embryos. Chem Biol Drug Des 68: 213-219.
    • (2006) Chem Biol Drug Des , vol.68 , pp. 213-219
    • Murphey, R.D.1    Stern, H.M.2    Straub, C.T.3    Zon, L.I.4
  • 31
    • 39149110311 scopus 로고    scopus 로고
    • The zebrafish/tumor xenograft angiogenesis assay
    • Nicoli S, Presta M. 2007. The zebrafish/tumor xenograft angiogenesis assay. Nat Protoc 2: 2918-2923.
    • (2007) Nat Protoc , vol.2 , pp. 2918-2923
    • Nicoli, S.1    Presta, M.2
  • 32
    • 34250883337 scopus 로고    scopus 로고
    • Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
    • North TE, Goessling W, Walkley CR, et al. 2007. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature 447: 1007-1011.
    • (2007) Nature , vol.447 , pp. 1007-1011
    • North, T.E.1    Goessling, W.2    Walkley, C.R.3
  • 33
    • 67349234898 scopus 로고    scopus 로고
    • Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle
    • Ou HC, Cunningham LL, Francis SP, et al. 2009. Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle. J Assoc Res Otolaryngol 10: 191-203.
    • (2009) J Assoc Res Otolaryngol , vol.10 , pp. 191-203
    • Ou, H.C.1    Cunningham, L.L.2    Francis, S.P.3
  • 34
    • 77950923677 scopus 로고    scopus 로고
    • Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss
    • Ou HC, Santos F, Raible DW, et al. 2010. Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss. Drug Discov Today 15: 265-271.
    • (2010) Drug Discov Today , vol.15 , pp. 265-271
    • Ou, H.C.1    Santos, F.2    Raible, D.W.3
  • 35
    • 40149095948 scopus 로고    scopus 로고
    • Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death
    • Owens KN, Santos F, Roberts B, et al. 2008. Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death. PLoS Genet 4: e1000020.
    • (2008) PLoS Genet , vol.4
    • Owens, K.N.1    Santos, F.2    Roberts, B.3
  • 36
    • 44649114063 scopus 로고    scopus 로고
    • Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas
    • Park SW, Davison JM, Rhee J, et al. 2008. Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology 134: 2080-2090.
    • (2008) Gastroenterology , vol.134 , pp. 2080-2090
    • Park, S.W.1    Davison, J.M.2    Rhee, J.3
  • 37
    • 13444258032 scopus 로고    scopus 로고
    • BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
    • Patton EE, Widlund HR, Kutok JL, et al. 2005. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 15: 249-254.
    • (2005) Curr Biol , vol.15 , pp. 249-254
    • Patton, E.E.1    Widlund, H.R.2    Kutok, J.L.3
  • 38
    • 0034700166 scopus 로고    scopus 로고
    • Small molecule developmental screens reveal the logic and timing of vertebrate development
    • Peterson RT, Link BA, Dowling JE, Schreiber SL. 2000. Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc Natl Acad Sci USA 97: 12965-12969.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12965-12969
    • Peterson, R.T.1    Link, B.A.2    Dowling, J.E.3    Schreiber, S.L.4
  • 39
    • 0023789310 scopus 로고
    • A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
    • Picard D, Salser SJ, Yamamoto KR. 1988. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell 54: 1073-1080.
    • (1988) Cell , vol.54 , pp. 1073-1080
    • Picard, D.1    Salser, S.J.2    Yamamoto, K.R.3
  • 40
    • 79953907200 scopus 로고    scopus 로고
    • Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy
    • Pruvot B, Jacquel A, Droin N, et al. 2011. Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy. Haematologica 96: 612-616.
    • (2011) Haematologica , vol.96 , pp. 612-616
    • Pruvot, B.1    Jacquel, A.2    Droin, N.3
  • 42
    • 74549126594 scopus 로고    scopus 로고
    • Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
    • Rihel J, Prober DA, Arvanites A, et al. 2010. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 327: 348-351.
    • (2010) Science , vol.327 , pp. 348-351
    • Rihel, J.1    Prober, D.A.2    Arvanites, A.3
  • 43
    • 0023697252 scopus 로고
    • GAL4-VP16 is an unusually potent transcriptional activator
    • Sadowski I, Ma J, Triezenberg S, Ptashne M. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature 335: 563-564.
    • (1988) Nature , vol.335 , pp. 563-564
    • Sadowski, I.1    Ma, J.2    Triezenberg, S.3    Ptashne, M.4
  • 44
    • 78650748163 scopus 로고    scopus 로고
    • Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
    • Santoriello C, Gennaro E, Anelli V, et al. 2010. Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PLoS One 5: e15170.
    • (2010) PLoS One , vol.5
    • Santoriello, C.1    Gennaro, E.2    Anelli, V.3
  • 45
    • 0025650598 scopus 로고
    • Homology of melanoma-inducing loci in the genus Xiphophorus
    • Schartl M. 1990. Homology of melanoma-inducing loci in the genus Xiphophorus. Genetics 126: 1083-1091.
    • (1990) Genetics , vol.126 , pp. 1083-1091
    • Schartl, M.1
  • 46
    • 0033054017 scopus 로고    scopus 로고
    • Use of the Gal4-UAS technique for targeted gene expression in the zebrafish
    • Scheer N, Campos-Ortega JA. 1999. Use of the Gal4-UAS technique for targeted gene expression in the zebrafish. Mech Dev 80: 153-158.
    • (1999) Mech Dev , vol.80 , pp. 153-158
    • Scheer, N.1    Campos-Ortega, J.A.2
  • 47
    • 0035028574 scopus 로고    scopus 로고
    • An instructive function for Notch in promoting gliogenesis in the zebrafish retina
    • Scheer N, Groth A, Hans S, Campos-Ortega JA. 2001. An instructive function for Notch in promoting gliogenesis in the zebrafish retina. Development 128: 1099-1107.
    • (2001) Development , vol.128 , pp. 1099-1107
    • Scheer, N.1    Groth, A.2    Hans, S.3    Campos-Ortega, J.A.4
  • 48
    • 0000905788 scopus 로고    scopus 로고
    • Zebrafish angiogenesis: a new model for drug screening
    • Serbedzija GN, Flynn E, Willett CE. 1999. Zebrafish angiogenesis: a new model for drug screening. Angiogenesis 3: 353-359.
    • (1999) Angiogenesis , vol.3 , pp. 353-359
    • Serbedzija, G.N.1    Flynn, E.2    Willett, C.E.3
  • 49
    • 77249141191 scopus 로고    scopus 로고
    • Recent development in high-throughput bioanalytical support for in vitro ADMET profiling
    • Shou WZ, Zhang J. 2010. Recent development in high-throughput bioanalytical support for in vitro ADMET profiling. Expert Opin Drug Metab Toxicol 6: 321-336.
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , pp. 321-336
    • Shou, W.Z.1    Zhang, J.2
  • 50
    • 0037257973 scopus 로고    scopus 로고
    • The state of the art of the zebrafish model for toxicology and toxicologic pathology research-advantages and current limitations
    • Spitsbergen JM, Kent ML. 2003. The state of the art of the zebrafish model for toxicology and toxicologic pathology research-advantages and current limitations. Toxicol Pathol 31: 62-87.
    • (2003) Toxicol Pathol , vol.31 , pp. 62-87
    • Spitsbergen, J.M.1    Kent, M.L.2
  • 51
    • 0033785662 scopus 로고    scopus 로고
    • Neoplasia in zebrafish (Danio rerio) treated with 7,12-dimethylbenz[a]anthracene by two exposure routes at different developmental stages
    • Spitsbergen JM, Tsai HW, Reddy A, et al. 2000a. Neoplasia in zebrafish (Danio rerio) treated with 7, 12-dimethylbenz[a]anthracene by two exposure routes at different developmental stages. Toxicol Pathol 28: 705-715.
    • (2000) Toxicol Pathol , vol.28 , pp. 705-715
    • Spitsbergen, J.M.1    Tsai, H.W.2    Reddy, A.3
  • 52
    • 0033789044 scopus 로고    scopus 로고
    • Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N′-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages
    • Spitsbergen JM, Tsai HW, Reddy A, et al. 2000b. Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N′-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages. Toxicol Pathol 28: 716-725.
    • (2000) Toxicol Pathol , vol.28 , pp. 716-725
    • Spitsbergen, J.M.1    Tsai, H.W.2    Reddy, A.3
  • 53
    • 0033789044 scopus 로고    scopus 로고
    • Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N′-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages
    • Spitsbergen JM, Tsai HW, Reddy A, et al. 2000c. Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N′-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages. Toxicol Pathol 28: 716-725.
    • (2000) Toxicol Pathol , vol.28 , pp. 716-725
    • Spitsbergen, J.M.1    Tsai, H.W.2    Reddy, A.3
  • 54
    • 77957229274 scopus 로고    scopus 로고
    • In vivo alternative assessment of the chemicals that interfere with anterior pituitary POMC expression and interrenal steroidogenesis in POMC: EGFP transgenic zebrafish
    • Sun L, Xu W, He J, Yin Z. 2010. In vivo alternative assessment of the chemicals that interfere with anterior pituitary POMC expression and interrenal steroidogenesis in POMC: EGFP transgenic zebrafish. Toxicol Appl Pharmacol 248: 217-225.
    • (2010) Toxicol Appl Pharmacol , vol.248 , pp. 217-225
    • Sun, L.1    Xu, W.2    He, J.3    Yin, Z.4
  • 55
    • 26444544427 scopus 로고    scopus 로고
    • The use of zebrafish for assessing ototoxic and otoprotective agents
    • Ton C, Parng C. 2005. The use of zebrafish for assessing ototoxic and otoprotective agents. Hear Res 208: 79-88.
    • (2005) Hear Res , vol.208 , pp. 79-88
    • Ton, C.1    Parng, C.2
  • 56
    • 37049028158 scopus 로고    scopus 로고
    • Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish
    • Tran TC, Sneed B, Haider J, et al. 2007. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res 67: 11386-11392.
    • (2007) Cancer Res , vol.67 , pp. 11386-11392
    • Tran, T.C.1    Sneed, B.2    Haider, J.3
  • 57
    • 74049125233 scopus 로고    scopus 로고
    • Comparative transcriptome analyses revealed conserved biological and transcription factor target modules between the zebrafish and human tumors
    • Ung CY, Lam SH, Gong Z. 2009. Comparative transcriptome analyses revealed conserved biological and transcription factor target modules between the zebrafish and human tumors. Zebrafish 6: 425-431.
    • (2009) Zebrafish , vol.6 , pp. 425-431
    • Ung, C.Y.1    Lam, S.H.2    Gong, Z.3
  • 58
    • 0034608802 scopus 로고    scopus 로고
    • Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity
    • Urlinger S, Baron U, Thellmann M, et al. 2000. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci USA 97: 7963-7968.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7963-7968
    • Urlinger, S.1    Baron, U.2    Thellmann, M.3
  • 59
    • 0025196554 scopus 로고
    • Fish embryos as teratogenicity screens: a comparison of embryotoxicity between fish and birds
    • Van Leeuwen CJ, Grootelaar EM, Niebeek G. 1990. Fish embryos as teratogenicity screens: a comparison of embryotoxicity between fish and birds. Ecotoxicol Environ Saf 20: 42-52.
    • (1990) Ecotoxicol Environ Saf , vol.20 , pp. 42-52
    • Van Leeuwen, C.J.1    Grootelaar, E.M.2    Niebeek, G.3
  • 60
    • 0035224708 scopus 로고    scopus 로고
    • Xiphophorus interspecies hybrids as genetic models of induced neoplasia
    • Walter RB, Kazianis S. 2001. Xiphophorus interspecies hybrids as genetic models of induced neoplasia. ILAR J 42: 299-321.
    • (2001) ILAR J , vol.42 , pp. 299-321
    • Walter, R.B.1    Kazianis, S.2
  • 61
    • 77955513656 scopus 로고    scopus 로고
    • Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer
    • Wang C, Tao W, Wang Y, et al. 2010. Rosuvastatin, identified from a zebrafish chemical genetic screen for antiangiogenic compounds, suppresses the growth of prostate cancer. Eur Urol 58: 418-426.
    • (2010) Eur Urol , vol.58 , pp. 418-426
    • Wang, C.1    Tao, W.2    Wang, Y.3
  • 62
    • 63449120674 scopus 로고    scopus 로고
    • Development of a whole-organism model to screen new compounds for sun protection
    • Wang YH, Wen CC, Yang ZS, et al. 2009. Development of a whole-organism model to screen new compounds for sun protection. Mar Biotechnol (NY) 11: 419-429.
    • (2009) Mar Biotechnol (NY) , vol.11 , pp. 419-429
    • Wang, Y.H.1    Wen, C.C.2    Yang, Z.S.3
  • 63
    • 69949181177 scopus 로고    scopus 로고
    • The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery
    • Weigelt J. 2009. The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery. EMBO Rep 10: 941-945.
    • (2009) EMBO Rep , vol.10 , pp. 941-945
    • Weigelt, J.1
  • 64
    • 84887212571 scopus 로고    scopus 로고
    • Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays
    • Xiang J, Yang H, Che C, et al. 2009. Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assays. PLoS One 4: e4361.
    • (2009) PLoS One , vol.4
    • Xiang, J.1    Yang, H.2    Che, C.3
  • 65
    • 5644221402 scopus 로고    scopus 로고
    • Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish
    • Yang HW, Kutok JL, Lee NH, et al. 2004. Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish. Cancer Res 64: 7256-7262.
    • (2004) Cancer Res , vol.64 , pp. 7256-7262
    • Yang, H.W.1    Kutok, J.L.2    Lee, N.H.3
  • 66
    • 37249010753 scopus 로고    scopus 로고
    • Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    • Yu PB, Hong CC, Sachidanandan C, et al. 2008. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4: 33-41.
    • (2008) Nat Chem Biol , vol.4 , pp. 33-41
    • Yu, P.B.1    Hong, C.C.2    Sachidanandan, C.3
  • 67
    • 67449138856 scopus 로고    scopus 로고
    • Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma
    • Zhang J, Sattler M, Tonon G, et al. 2009. Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma. Cancer Res 69: 5082-5090.
    • (2009) Cancer Res , vol.69 , pp. 5082-5090
    • Zhang, J.1    Sattler, M.2    Tonon, G.3
  • 68
    • 79956188899 scopus 로고    scopus 로고
    • Chemical screening with zebrafish embryos
    • Zhong H, Lin S. 2011. Chemical screening with zebrafish embryos. Methods Mol Biol 716: 193-205.
    • (2011) Methods Mol Biol , vol.716 , pp. 193-205
    • Zhong, H.1    Lin, S.2
  • 69
    • 77954600984 scopus 로고    scopus 로고
    • Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish
    • Zhong H, Xin S, Zhao Y, et al. 2010. Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using zebrafish. Mol Biosyst 6: 1463-1468.
    • (2010) Mol Biosyst , vol.6 , pp. 1463-1468
    • Zhong, H.1    Xin, S.2    Zhao, Y.3
  • 70
    • 70349974745 scopus 로고    scopus 로고
    • Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling
    • Zhong H, Zou H, Semenov MV, et al. 2009. Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Mol Biosyst 5: 1356-1360.
    • (2009) Mol Biosyst , vol.5 , pp. 1356-1360
    • Zhong, H.1    Zou, H.2    Semenov, M.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.