Drug screening for hearing loss: Using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss

Drug Discovery Today

Volumn 15, Issue 7-8, 2010, Pages 265-271

  Ou, Henry C ^a,b,c   Santos, Felipe ^a,b   Raible, David W ^a   Simon, Julian A ^d   Rubel, Edwin W ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c SEATTLE CHILDREN S HOSPITAL   (United States)

^d USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; AMINOGLYCOSIDE; AMSACRINE; ANTIOXIDANT; CARVEDILOL; CASPASE INHIBITOR; CEPHARANTHINE; CHLORAMPHENICOL; CHLORTETRACYCLINE; CISPLATIN; DROFENINE; EBSELEN; ESTRADIOL VALERATE; ETACRYNIC ACID; FLUNARIZINE; GENTAMICIN; MEFLOQUINE; METHIONINE; NEOMYCIN; NEW DRUG; PENTAMIDINE ISETHIONATE; PENTETRAZOLE; PHENOXYBENZAMINE; PROPANTHELINE BROMIDE; SPERMIDINE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TACRINE; TOBRAMYCIN; UNINDEXED DRUG;

CELL DEATH; CELL PROTECTION; CLINICAL TRIAL; DRUG SCREENING; HAIR CELL; HEARING LOSS; HIGH THROUGHPUT SCREENING; HUMAN; IMAGING; IN VIVO STUDY; NONHUMAN; OTOTOXICITY; PERCEPTION DEAFNESS; PRESBYACUSIS; REVIEW; ZEBRA FISH;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HAIR CELLS, AUDITORY; HEARING LOSS; HUMANS; LATERAL LINE SYSTEM; PHARMACEUTICAL PREPARATIONS; PROTECTIVE AGENTS; ZEBRAFISH;

EID: 77950923677     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2010.01.001     Document Type: Review

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