Interaction of ibogaine with human α3β4-nicotinic acetylcholine receptors in different conformational states

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 9, 2010, Pages 1525-1535

  Arias, Hugo R ^a   Rosenberg, Avraham ^b   Targowska Duda, Katarzyna M ^c   Feuerbach, Dominik ^d   Yuan, Xiao Juan ^e   Jozwiak, Krzysztof ^c   Moaddel, Ruin ^b   Wainer, Irving W ^b  

^a MIDWESTERN UNIVERSITY   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^d NOVARTIS PHARMA AG   (Switzerland)

^e WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Conformational states; Ibogaine; Nicotinic acetylcholine receptors; Noncompetitive antagonists; Phencyclidine

Indexed keywords

ALPHA3BETA4 NICOTINIC ACETYLCHOLINE RECEPTOR; EPIBATIDINE; IBOGAINE; ION CHANNEL; NICOTINIC RECEPTOR; PHENCYCLIDINE; PHENYLALANINE; SERINE; UNCLASSIFIED DRUG; VALINE; CALCIUM; FUSED HETEROCYCLIC RINGS; NICOTINIC RECEPTOR ALPHA3BETA4; PROTEIN BINDING; PYRIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CELL STRAIN HEK293; CELLULAR MEMBRANE AFFINITY CHROMATOGRAPHY; CHEMICAL REACTION; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; CONFORMATIONAL TRANSITION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KINETICS; MOLECULAR DOCKING; RADIOASSAY; RECEPTOR DOWN REGULATION; THERMODYNAMICS; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PROTEIN SECONDARY STRUCTURE; TRANSPORT AT THE CELLULAR LEVEL;

BICYCLO COMPOUNDS, HETEROCYCLIC; BIOLOGICAL TRANSPORT; CALCIUM; CELL LINE; HUMANS; IBOGAINE; KINETICS; PHENCYCLIDINE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PYRIDINES; RECEPTORS, NICOTINIC; THERMODYNAMICS;

EID: 77955096530     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.05.011     Document Type: Article

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