MTBP plays a crucial role in mitotic progression and chromosome segregation

Cell Death and Differentiation

Volumn 18, Issue 7, 2011, Pages 1208-1219

  Agarwal, N ^a   Tochigi, Y ^a   Adhikari, A S ^a   Cui, S ^a   Cui, Y ^a   Iwakuma, T ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

checkpoint; chromosome segregation; MDM2; mitosis; MTBP

Indexed keywords

BINDING PROTEIN; PROTEIN MDM2;

ANEUPLOIDY; ARTICLE; CELL AGING; CELL DEATH; CELL PROLIFERATION; CENTROMERE; CHROMOSOME SEGREGATION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ANEUPLOIDY; APOPTOSIS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL AGING; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMOSOME SEGREGATION; HUMANS; KINETOCHORES; METAPHASE; MITOSIS; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

MURINAE;

EID: 79958822049     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.189     Document Type: Article

References (40)

1. Boyd MT, Vlatkovic N, Haines DS. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J Biol Chem 2000; 275: 31883-31890.
2. Brady M, Vlatkovic N, Boyd MT. Regulation of p53 and MDM2 activity by MTBP. Mol Cell Biol 2005; 25: 545-553. (Pubitemid 40096577)
3. Iwakuma T, Tochigi Y, Van Pelt CS, Caldwell LC, Terzian T, Parant JM et al. Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene 2008; 27: 1813-1820. (Pubitemid 351430821)
4. Odvody J, Vincent T, Arrate MP, Grieb B, Wang S, Garriga J et al. A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis. Oncogene 2010; 29: 3287-3296.
5. Cleveland DW, Mao Y, Sullivan KF. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 2003; 112: 407-421. (Pubitemid 36263076)
6. Suijkerbuijk SJ, Kops GJ. Preventing aneuploidy: the contribution of mitotic checkpoint proteins. Biochim Biophys Acta 2008; 1786: 24-31.
7. Baker DJ, Chen J, van Deursen JM. The mitotic checkpoint in cancer and aging: what have mice taught us? Curr Opin Cell Biol 2005; 17: 583-589. (Pubitemid 41540406)
8. Kops GJ, Weaver BA, Cleveland DW. On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 2005; 5: 773-785. (Pubitemid 41400777)
9. Williams GL, Roberts TM, Gjoerup OV. Bub1: escapades in a cellular world. Cell Cycle 2007; 6: 1699-1704. (Pubitemid 47327921)
10. Niikura Y, Dixit A, Scott R, Perkins G, Kitagawa K. BUB1 mediation of caspaseindependent mitotic death determines cell fate. J Cell Biol 2007; 178: 283-296. (Pubitemid 47076464)
11. Schvartzman JM, Sotillo R, Benezra R. Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nat Rev Cancer 2010; 10: 102-115.
12. Sotillo R, Hernando E, Diaz-Rodriguez E, Teruya-Feldstein J, Cordon-Cardo C, Lowe SW et al. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 2007; 11: 9-23. (Pubitemid 46054519)
13. Sotillo R, Schvartzman JM, Socci ND, Benezra R. Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 2010; 464: 436-440.
14. Niikura Y, Ogi H, Kikuchi K, Kitagawa K. BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD). Cell Death Differ 2010; 17: 1011-1024.
15. Fung MK, Cheung HW, Wong HL, Yuen HF, Ling MT, Chan KW et al. MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour. Biochim Biophys Acta 2007; 1773: 821-832. (Pubitemid 46829442)
16. Qi W, Martinez JD. Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation. Radiat Res 2003; 160: 217-223. (Pubitemid 36897502)
17. Diaz-Rodriguez E, Sotillo R, Schvartzman JM, Benezra R. Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc Natl Acad Sci USA 2008; 105: 16719-16724.
18. Rao CV, Yamada HY, Yao Y, Dai W. Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice. Carcinogenesis 2009; 30: 1469-1474.
19. Perez de Castro I, de Carcer G, Malumbres M. A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy. Carcinogenesis 2007; 28: 899-912. (Pubitemid 47072171)
20. Campbell MS, Chan GK, Yen TJ. Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase. J Cell Sci 2001; 114: 953-963. (Pubitemid 32266266)
21. Chung E, Chen RH. Spindle checkpoint requires Mad1-bound and Mad1-free Mad2. Mol Biol Cell 2002; 13: 1501-1511. (Pubitemid 34522634)
22. Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B et al. Surveillance mechanism linking Bub1 loss to the p53 pathway. Proc Natl Acad Sci USA 2007; 104: 8334-8339. (Pubitemid 47175488)
23. Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W et al. MAD2 haploinsufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 2001; 409: 355-359. (Pubitemid 32151241)
24. Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell 2000; 101: 635-645.
25. Kalitsis P, Fowler KJ, Griffiths B, Earle E, Chow CW, Jamsen K et al. Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice. Genes Chromosomes Cancer 2005; 44: 29-36. (Pubitemid 41060194)
26. Dai W, Wang Q, Liu T, Swamy M, Fang Y, Xie S et al. Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res 2004; 64: 440-445. (Pubitemid 38120879)
27. Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM. Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol 2007; 179: 255-267. (Pubitemid 350004890)
28. Perera D, Tilston V, Hopwood JA, Barchi M, Boot-Handford RP, Taylor SS. Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. Dev Cell 2007; 13: 566-579. (Pubitemid 47500808)
29. Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A et al. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 2004; 36: 744-749. (Pubitemid 38886637)
30. Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, van Deursen JM. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol 2006; 172: 529-540. (Pubitemid 43243874)
31. Schliekelman M, Cowley DO, O'Quinn R, Oliver TG, Lu L, Salmon ED et al. Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. Cancer Res 2009; 69: 45-54.
32. Quimby BB, Arnaoutov A, Dasso M. Ran GTPase regulates Mad2 localization to the nuclear pore complex. Eukaryot Cell 2005; 4: 274-280. (Pubitemid 40257127)
33. Yang M, Li B, Tomchick DR, Machius M, Rizo J, Yu H et al. p31comet blocks Mad2 activation through structural mimicry. Cell 2007; 131: 744-755. (Pubitemid 350087196)
34. Schorl C, Sedivy JM. Analysis of cell cycle phases and progression in cultured mammalian cells. Methods 2007; 41: 143-150. (Pubitemid 44960829)
35. Yun M, Han YH, Yoon SH, Kim HY, Kim BY, Ju YJ et al. p31comet induces cellular senescence through p21 accumulation and Mad2 disruption. Mol Cancer Res 2009; 7: 371-382.
36. Johnson VL, Scott MI, Holt SV, Hussein D, Taylor SS. Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. J Cell Sci 2004; 117: 1577-1589. (Pubitemid 38559832)
37. Luo X, Tang Z, Rizo J, Yu H. The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell 2002; 9: 59-71. (Pubitemid 34127771)
38. Skoufias DA, Andreassen PR, Lacroix FB, Wilson L, Margolis RL. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc Natl Acad Sci USA 2001; 98: 4492-4497. (Pubitemid 32295004)
39. Lee SH, Sterling H, Burlingame A, McCormick F. Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev 2008; 22: 2926-2931.
40. Guenther JF, Cameron JE, Nguyen HT, Wang Y, Sullivan DE, Shan B et al. Modulation of lung inflammation by the Epstein-Barr virus protein Zta. Am J Physiol Lung Cell Mol Physiol 2010; 299: L771-L784.