Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving

BMC Evolutionary Biology

Volumn 11, Issue 1, 2011, Pages

  Cagliani, Rachele ^a   Riva, Stefania ^a   Pozzoli, Uberto ^a   Fumagalli, Matteo ^a,b   Comi, Giacomo P ^c   Bresolin, Nereo ^a,c   Clerici, Mario ^c,d   Sironi, Manuela ^a  

^a SCIENTIFIC INSTITUTE   (Italy)

^b POLITECNICO DI MILANO   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

autoimmune disease; balancing selection; extended MHC region; opposite risk profile

Indexed keywords

ALLELE; DISEASE; EVOLUTIONARY BIOLOGY; GENETIC VARIATION; HOMINID; HYPOTHESIS TESTING; IMMUNE SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR ANALYSIS; NATURAL SELECTION; POLYMORPHISM; RISK; RISK FACTOR;

ALLELE; ARTICLE; AUTOIMMUNE DISEASE; GENETIC DRIFT; GENETICS; HAPLOTYPE; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; AUTOIMMUNE DISEASES; GENETIC DRIFT; HAPLOTYPES; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79958819516     PISSN: None     EISSN: 14712148     Source Type: Journal    
DOI: 10.1186/1471-2148-11-171     Document Type: Article

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