MICA polymorphism: biology and importance in immunity and disease

Trends in Molecular Medicine

Volumn 16, Issue 3, 2010, Pages 97-106

  Choy, Mun Kit ^a   Phipps, Maude E ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ARTICLE; CHROMOSOME 6; GENE; GENETIC POLYMORPHISM; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HUMAN; HUMORAL IMMUNITY; IMMUNITY; IMMUNOGENETICS; MALIGNANT NEOPLASTIC DISEASE; MICA GENE; NATURAL KILLER CELL; NONHUMAN; VIRUS INFECTION;

ALLELES; CYTOTOXICITY, IMMUNOLOGIC; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; PHYLOGENY; POLYMORPHISM, GENETIC;

EID: 77949322380     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2010.01.002     Document Type: Article

References (112)

1. Horton R., et al. Gene map of the extended human MHC. Nat. Rev. Genet. 5 (2004) 889-899
2. Brocke P., et al. HLA-DM, HLA-DO and tapasin: functional similarities and differences. Current Opinion in Immunology 14 (2002) 22-29
3. Arnaiz-Villena A. 14th International HLA and Immunogenetics Workshop: report on non-classical class I genes. Tissue Antigens 69 (2007) 130-131
4. Bahram S., et al. A second lineage of mammalian major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 6259-6263
5. Leelayuwat C., et al. A new polymorphic and multicopy MHC gene family related to nonmammalian class I. Immunogenetics 40 (1994) 339-351
6. Stephens H.A.F. MICA and MICB genes: can the enigma of their polymorphism be resolved?. Trends in Immunology 22 (2001) 378-385
7. Klein J., and O'hUigin C. The conundrum of nonclassical major histocompatibility complex genes. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 6251-6252
8. The MHC sequencing consortium (1999) Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium. Nature 401, 921-923
9. Horton R., et al. Gene map of the extended human MHC. Nat. Rev. Genet. 5 (2004) 889-899
10. Bahram S. MIC genes: from genetics to biology. Adv. Immunol. 76 (2000) 1-60
11. Shiina T., et al. Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 13282-13287
12. Bahram S., et al. A second lineage of mammalian major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. U. S. A 91 (1994) 6259-6263
13. Groh V., et al. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 12445-12450
14. Groh V., et al. Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science 279 (1998) 1737-1740
15. Li P., et al. Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand. Immunity 10 (1999) 577-584
16. Li P., et al. Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat. Immunol. 2 (2001) 443-451
17. Schrambach S., et al. In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer. PLoS ONE 2 (2007) e518
18. Groh V., et al. Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2 (2001) 255-260
19. Schreiner B., et al. Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands. Faseb. J. 20 (2006) 118-120
20. Gasser S., et al. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436 (2005) 1186-1190
21. Tang K.F., et al. Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB. J. Cell Biol. 182 (2008) 233-239
22. Hankey K.G., et al. MIC expression in renal and pancreatic allografts. Transplantation 73 (2002) 304-306
23. Mizutani K., et al. Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure. Am. J. Transplant. 5 (2005) 2265-2272
24. Zou Y., et al. MICA is a target for complement-dependent cytotoxicity with mouse monoclonal antibodies and human alloantibodies. Hum. Immunol. 63 (2002) 30-39
25. Zwirner N.W., et al. MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes. Immunogenetics 47 (1998) 139-148
26. Seliger B., et al. HLA-G and MIC expression in tumors and their role in anti-tumor immunity. Trends Immunol. 24 (2003) 82-87
27. Andresen L., et al. Molecular regulation of MHC class I chain-related protein A expression after HDAC-inhibitor treatment of Jurkat T cells. J. Immunol. 179 (2007) 8235-8242
28. Jinushi M., et al. Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid. Int. J. Cancer 104 (2003) 354-361
29. Kumanovics A., et al. Genomic organization of the mammalian MHC. Annu. Rev. Immunol. 21 (2003) 629-657
30. Groh V., et al. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 6879-6884
31. Bauer S., et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285 (1999) 727-729
32. Wu J., et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285 (1999) 730-732
33. Vivier E., et al. Functions of natural killer cells. Nat. Immunol. 9 (2008) 503-510
34. Thomas M., et al. Natural killer cell evasion by an E3 ubiquitin ligase from Kaposi's sarcoma-associated herpesvirus. Biochem. Soc. Trans. 36 (2008) 459-463
35. Stern-Ginossar N., et al. Host immune system gene targeting by a viral miRNA. Science 317 (2007) 376-381
36. Stern-Ginossar N., et al. Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D. Nat. Immunol. 9 (2008) 1065-1073
37. Groh V., et al. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419 (2002) 734-738
38. Kaiser B.K., et al. Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands. Nature 447 (2007) 482-486
39. Waldhauer I., et al. Tumor-associated MICA is shed by ADAM proteases. Cancer Res. 68 (2008) 6368-6376
40. Groh V., et al. Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity. Nat. Immunol. 7 (2006) 755-762
41. Doubrovina E.S., et al. Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma. J. Immunol. 171 (2003) 6891-6899
42. Kriegeskorte A.K., et al. NKG2D-independent suppression of T cell proliferation by H60 and MICA. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 11805-11810
43. Mason P.M., and Parham P. HLA class I region sequences, 1998. Tissue Antigens 51 (1998) 417-466
44. Strong R.K. Class (I) will come to order--not. Nat. Struct. Biol. 7 (2000) 173-176
45. Penn D.J., et al. MHC heterozygosity confers a selective advantage against multiple-strain infections. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 11260-11264
46. Shiina T., et al. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. Genetics 173 (2006) 1555-1570
47. Choy M.-K., and Phipps M. Possible polyphyletic origin of major histocompatibility complex class i chain-related gene A (MICA) alleles. Journal of Molecular Evolution 57 (2003) 38-43
48. Duquesnoy R.J., et al. Structurally based epitope analysis of major histocompatibility complex class I-related chain A (MICA) antibody specificity patterns. Hum. Immunol. 69 (2008) 826-832
49. Zou Y., et al. Polymorphisms of MICA recognized by human alloantibodies. Immunogenetics 61 (2009) 91-100
50. Mizuki N., et al. Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behcet disease. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 1298-1303
51. Doxiadis G.G., et al. MIC gene polymorphism and haplotype diversity in rhesus macaques. Tissue Antigens 69 (2007) 212-219
52. Cattley S.K., et al. Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4. Eur. J. Immunogenet. 26 (1999) 233-238
53. Seo J.W., et al. Major histocompatibility complex-linked MIC genes in rhesus macaques and other primates. Immunogenetics 50 (1999) 358-362
54. Nei M., and Rooney A.P. Concerted and birth-and-death evolution of multigene families*. Annu. Rev. Genet. 39 (2005) 121-152
55. Aida K., et al. High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107N) in the Angaite Amerindian community in Paraguay. Immunogenetics 54 (2002) 439-441
56. Komatsu-Wakui M., et al. MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype. Immunogenetics 49 (1999) 620-628
57. Oliveira L.A., et al. High frequencies of alleles MICA*020 and MICA*027 in Amerindians and evidence of positive selection on exon 3. Genes Immun. 9 (2008) 697-705
58. Goto K., et al. MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane-encoded triplet repeat polymorphism. Tissue Antigens 49 (1997) 503-507
59. Caillat-Zucman S. How NKG2D ligands trigger autoimmunity?. Hum Immunol. 67 (2006) 204-207
60. Mizuki N., et al. Association of major histocompatibility complex class i chain-related gene A and HLA-B alleles with Behcet's disease in Turkey. Jpn. J. Ophthalmol. 51 (2007) 431-436
61. Nishiyama M., et al. Microsatellite polymorphisms of the MICA gene among Japanese patients with Behcet's disease. Can. J. Ophthalmol. 41 (2006) 210-215
62. Salvarani C., et al. Association of MICA alleles and HLA-B51 in Italian patients with Behcet's disease. J. Rheumatol. 28 (2001) 1867-1870
63. Wallace G.R., et al. MIC-A allele profiles and HLA class I associations in Behcet's disease. Immunogenetics 49 (1999) 613-617
64. Martinez-Borra J., et al. HLA-B27 alone rather than B27-related class I haplotypes contributes to ankylosing spondylitis susceptibility. Hum Immunol. 61 (2000) 131-139
65. Gonzalez S., et al. The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. Arthritis Rheum. 42 (1999) 1010-1016
66. Choi H.B., et al. MICA 5.1 allele is a susceptibility marker for psoriasis in the Korean population. Tissue Antigens 56 (2000) 548-550
67. Groh V., et al. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 9452-9457
68. Amroun H., et al. Early-onset ankylosing spondylitis is associated with a functional MICA polymorphism. Hum. Immunol. 66 (2005) 1057-1061
69. Kirsten H., et al. Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study. Arthritis Res. Ther. 11 (2009) R60
70. Ghaderi M., et al. MICA gene polymorphism and the risk to develop cervical intraepithelial neoplasia. Hum. Immunol. 60 (1999) 970-973
71. Chen J.R., et al. MHC class I chain-related gene A (MICA) polymorphism and the different histological types of cervical cancer. Neoplasma 52 (2005) 369-373
72. Ghaderi M., et al. Tumor necrosis factor A and MHC class I chain related gene A (MIC-A) polymorphisms in Swedish patients with cervical cancer. Hum. Immunol. 62 (2001) 1153-1158
73. Jumnainsong A., et al. Association of polymorphic extracellular domains of MICA with cervical cancer in northeastern Thai population. Tissue Antigens 69 (2007) 326-333
74. Tian W., et al. Gender-specific associations between MICA-STR and nasopharyngeal carcinoma in a southern Chinese Han population. Immunogenetics 58 (2006) 113-121
75. Douik H., et al. Association of MICA-129 polymorphism with nasopharyngeal cancer risk in a Tunisian population. Hum. Immunol. 70 (2009) 45-48
76. Steinle A., et al. Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. Immunogenetics 53 (2001) 279-287
77. Tamaki S., et al. An association between the MICA-A5.1 allele and an increased susceptibility to oral squamous cell carcinoma in Japanese patients. J. Oral. Pathol. Med. 36 (2007) 351-356
78. Tamaki S., et al. Relationship between soluble MICA and the MICA A5.1 homozygous genotype in patients with oral squamous cell carcinoma. Clin. Immunol. 130 (2009) 331-337
79. Lavado-Valenzuela R., et al. MHC class I chain-related gene A transmembrane polymorphism in Spanish women with breast cancer. Tissue Antigens 74 (2009) 46-49
80. Chalupny N.J., et al. Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142. Biochem. Biophys. Res. Commun. 346 (2006) 175-181
81. Zou Y., et al. Effect of human cytomegalovirus on expression of MHC class I-related chains A. J. Immunol. 174 (2005) 3098-3104
82. Wills M.R., et al. Human cytomegalovirus encodes an MHC class I-like molecule (UL142) that functions to inhibit NK cell lysis. J. Immunol. 175 (2005) 7457-7465
83. Moenkemeyer M., et al. Higher risk of cytomegalovirus reactivation in human immunodeficiency virus-1-infected patients homozygous for MICA5.1. Hum. Immunol. 70 (2009) 175-178
84. Karacki P.S., et al. MICA and recovery from hepatitis C virus and hepatitis B virus infections. Genes Immun. 5 (2004) 261-266
85. Jinushi M., et al. Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection. J. Immunol. 171 (2003) 5423-5429
86. Jinushi M., et al. Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection. J. Immunol. 170 (2003) 1249-1256
87. Shojima J., et al. Identification of MICA as a susceptibility gene for pulmonary Mycobacterium avium complex infection. J. Infect. Dis. 199 (2009) 1707-1715
88. Sumitran-Holgersson S. Relevance of MICA and other non-HLA antibodies in clinical transplantation. Curr. Opin. Immunol. 20 (2008) 607-613
89. Suarez-Alvarez B., et al. Potential role of NKG2D and its ligands in organ transplantation: new target for immunointervention. Am. J. Transplant. 9 (2009) 251-257
90. Zou Y., and Stastny P. The role of major histocompatibility complex class I chain-related gene A antibodies in organ transplantation. Curr. Opin. Organ. Transplant. 14 (2009) 414-418
91. Suarez-Alvarez B., et al. The relationship of anti-MICA antibodies and MICA expression with heart allograft rejection. Am. J. Transplant. 7 (2007) 1842-1848
92. Zou Y., et al. Detection of anti-MICA antibodies in patients awaiting kidney transplantation, during the post-transplant course, and in eluates from rejected kidney allografts by Luminex flow cytometry. Hum. Immunol. 67 (2006) 230-237
93. Mizutani K., et al. Frequency of MIC antibody in rejected renal transplant patients without HLA antibody. Hum. Immunol. 67 (2006) 223-229
94. Mizutani K., et al. Detection of HLA and MICA antibodies before kidney graft failure. Clin. Transpl. (2006) 255-264
95. Mizutani K., et al. Association of kidney transplant failure and antibodies against MICA. Hum. Immunol. 67 (2006) 683-691
96. Panigrahi A., et al. Post transplant development of MICA and anti-HLA antibodies is associated with acute rejection episodes and renal allograft loss. Hum. Immunol. 68 (2007) 362-367
97. Zou Y., et al. Antibodies against MICA antigens and kidney-transplant rejection. N. Engl. J. Med. 357 (2007) 1293-1300
98. Terasaki P.I., et al. Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival. Am. J. Transplant. 7 (2007) 408-415
99. Zwirner N.W., et al. Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients. Hum. Immunol. 61 (2000) 917-924
100. Sasazuki T., et al. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N. Engl. J. Med. 339 (1998) 1177-1185
101. Petersdorf E.W., et al. Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient. Blood 92 (1998) 3515-3520
102. Morishima Y., et al. The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors. Blood 99 (2002) 4200-4206
103. Tay G.K., et al. Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation. Bone Marrow Transplant. 15 (1995) 381-385
104. Tay G.K., et al. The identification of MHC identical siblings without HLA typing. Exp. Hematol. 23 (1995) 1655-1660
105. Kitcharoen K., et al. MICA, MICB, and MHC beta block matching in bone marrow transplantation: relevance to transplantation outcome. Hum. Immunol. 67 (2006) 238-246
106. Gaudieri S., et al. Sequence analysis of the MHC class I region reveals the basis of the genomic matching technique. Hum. Immunol. 62 (2001) 279-285
107. Parmar S., et al. Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease. Blood 114 (2009) 2884-2887
108. Moretta A., et al. Activating and inhibitory killer immunoglobulin-like receptors (KIR) in haploidentical haemopoietic stem cell transplantation to cure high-risk leukaemias. Clin. Exp. Immunol. 157 (2009) 325-331
109. de Groot N.G., et al. Reduced MIC gene repertoire variation in West African chimpanzees as compared to humans. Mol. Biol. Evol. 22 (2005) 1375-1385
110. Jinushi M., et al. Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 9190-9195
111. Boukouaci W., et al. MICA-129 genotype, soluble MICA, and anti-MICA antibodies as biomarkers of chronic graft-versus-host disease. Blood 114 (2009) 5216-5224
112. Suarez-Alvarez B., et al. The predictive value of soluble major histocompatibility complex class I chain-related molecule A (MICA) levels on heart allograft rejection. Transplantation 82 (2006) 354-361