-
1
-
-
85027722628
-
Inhibition of HIF2a is sufficient to suppress pVHL-defective tumor growth
-
Kondo K, Kim WY, Lechpammer M, Kaelin WG Jr: Inhibition of HIF2a is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003, 3:439-444
-
(2003)
PLoS Biol
, vol.3
, pp. 439-444
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin Jr., W.G.4
-
2
-
-
23844527189
-
Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity
-
An J, Rettig MB: Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity. Mol Cell Biol 2005, 17:7546-7556
-
(2005)
Mol Cell Biol
, vol.17
, pp. 7546-7556
-
-
An, J.1
Rettig, M.B.2
-
3
-
-
13944252559
-
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma
-
Petrella BL, Lohi J, Brinckerhoff CE: Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005, 24:1043-1052
-
(2005)
Oncogene
, vol.24
, pp. 1043-1052
-
-
Petrella, B.L.1
Lohi, J.2
Brinckerhoff, C.E.3
-
4
-
-
33846675525
-
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase
-
Petrella BL, Brinckerhoff CE: Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. Mol Cancer 2006, 5:66
-
(2006)
Mol Cancer
, vol.5
, pp. 66
-
-
Petrella, B.L.1
Brinckerhoff, C.E.2
-
5
-
-
0033517275
-
Cell transformation by the superoxidegenerating oxidase Mox1
-
Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, Chung AB, Griendling KK, Lambeth JD: Cell transformation by the superoxidegenerating oxidase Mox1. Nature 1999, 401:79-82
-
(1999)
Nature
, vol.401
, pp. 79-82
-
-
Suh, Y.A.1
Arnold, R.S.2
Lassegue, B.3
Shi, J.4
Xu, X.5
Sorescu, D.6
Chung, A.B.7
Griendling, K.K.8
Lambeth, J.D.9
-
6
-
-
0037154250
-
Reactive oxygen generated by Nox1 triggers the angiogenic switch
-
Arbiser JL, Petros J, Klafter R, Govindajaran B, McLaughlin ER, Brown LF, Cohen C, Moses M, Kilroy S, Arnold RS, Lambeth JD: Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc Natl Acad Sci USA 2002, 99:715-720
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 715-720
-
-
Arbiser, J.L.1
Petros, J.2
Klafter, R.3
Govindajaran, B.4
McLaughlin, E.R.5
Brown, L.F.6
Cohen, C.7
Moses, M.8
Kilroy, S.9
Arnold, R.S.10
Lambeth, J.D.11
-
7
-
-
0035008369
-
Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells
-
Brar SS, Kennedy TP, Whorton AR, Sturrock AB, Huecksteadt TP, Ghio AJ, Hoidal JR: Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-kappaB in malignant melanoma cells. Am J Physiol Cell Physiol 2001, 280:C659-C676
-
(2001)
Am J Physiol Cell Physiol
, vol.280
-
-
Brar, S.S.1
Kennedy, T.P.2
Whorton, A.R.3
Sturrock, A.B.4
Huecksteadt, T.P.5
Ghio, A.J.6
Hoidal, J.R.7
-
8
-
-
4544250814
-
Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells
-
DOI 10.1074/jbc.M400078200
-
Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS: Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem 2004, 279:34643-34654 (Pubitemid 39318094)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.33
, pp. 34643-34654
-
-
Vaquero, E.C.1
Edderkaoui, M.2
Pandol, S.J.3
Gukovsky, I.4
Gukovskaya, A.S.5
-
9
-
-
0042242883
-
NOX5 NAD(P)H oxidase regulates growth and apoptosis in du 145 prostate cancer cells
-
Brar SS, Corbin Z, Kennedy TP, Hemendinger R, Thornton L, Bommarius B, Arnold RS, Whorton AR, Sturrock AB, Huecksteadt TP, Quinn MT, Krenitsky K, Ardie KG, Lambeth JD Hoidal JR: NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol 2003, 285:C353-C369
-
(2003)
Am J Physiol Cell Physiol
, vol.285
-
-
Brar, S.S.1
Corbin, Z.2
Kennedy, T.P.3
Hemendinger, R.4
Thornton, L.5
Bommarius, B.6
Arnold, R.S.7
Whorton, A.R.8
Sturrock, A.B.9
Huecksteadt, T.P.10
Quinn, M.T.11
Krenitsky, K.12
Ardie, K.G.13
Lambeth, J.D.14
Hoidal, J.R.15
-
10
-
-
27144444002
-
Nox4 is critical for hypoxia-inducible factor 2-a transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma
-
Maranchie JK, Zhan Y: Nox4 is critical for hypoxia-inducible factor 2-a transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. Cancer Res 2005, 65:9190-9193
-
(2005)
Cancer Res
, vol.65
, pp. 9190-9193
-
-
Maranchie, J.K.1
Zhan, Y.2
-
11
-
-
34247250752
-
NAD(P)H oxidases regulate HIF-2alpha protein expression
-
DOI 10.1074/jbc.M611569200
-
Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE: NAD(P)H oxidases regulate HIF-2a protein expression. J Biol Chem 2007, 282:8019-8026 (Pubitemid 47093603)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.11
, pp. 8019-8026
-
-
Block, K.1
Gorin, Y.2
Hoover, P.3
Williams, P.4
Chelmicki, T.5
Clark, R.A.6
Yoneda, T.7
Abboud, H.E.8
-
12
-
-
67651204610
-
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxiainducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species
-
Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L: Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxiainducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol 2009, 29:4080-4090
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4080-4090
-
-
Sudarshan, S.1
Sourbier, C.2
Kong, H.S.3
Block, K.4
Valera Romero, V.A.5
Yang, Y.6
Galindo, C.7
Mollapour, M.8
Scroggins, B.9
Goode, N.10
Lee, M.J.11
Gourlay, C.W.12
Trepel, J.13
Linehan, W.M.14
Neckers, L.15
-
13
-
-
33750083602
-
Deletion mutagenesis of p22phox subunit of flavocytochrome b558: Identification of regions critical for gp91phox maturation and NADPH oxidase activity
-
Zhu Y, Marchal CC, Casbon AJ, Stull N, von Löhneysen K, Knaus UG, Jesaitis AJ, McCormick S, Nauseef WM, Dinauer MC. Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity. J Biol Chem 2006, 281:30336-30346
-
(2006)
J Biol Chem
, vol.281
, pp. 30336-30346
-
-
Zhu, Y.1
Marchal, C.C.2
Casbon, A.J.3
Stull, N.4
Von Löhneysen, K.5
Knaus, U.G.6
Jesaitis, A.J.7
McCormick, S.8
Nauseef, W.M.9
Dinauer, M.C.10
-
14
-
-
24744468043
-
phox are dominant inhibitors of Nox1- And Nox2-dependent reactive oxygen generation
-
DOI 10.1074/jbc.M501882200
-
Kawahara T, Ritsick D, Cheng G, Lambeth JD. Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem 2005, 280:31859-31869 (Pubitemid 41291936)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.36
, pp. 31859-31869
-
-
Kawahara, T.1
Ritsick, D.2
Cheng, G.3
Lambeth, J.D.4
-
15
-
-
8544270180
-
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase
-
DOI 10.1074/jbc.M406486200
-
Ambasta RK, Kumar P, Griendling KK, Schmidt HH, Busse R, Brandes RP. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem 2004, 279:45935-45941 (Pubitemid 39491586)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.44
, pp. 45935-45941
-
-
Ambasta, R.K.1
Kumar, P.2
Griendling, K.K.3
Schmidt, H.H.H.W.4
Busse, R.5
Brandes, R.P.6
-
16
-
-
33846794822
-
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
-
DOI 10.1152/physrev.00044.2005
-
Bedard K, Krause KH The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007, 87:245-313 (Pubitemid 46209993)
-
(2007)
Physiological Reviews
, vol.87
, Issue.1
, pp. 245-313
-
-
Bedard, K.1
Krause, K.-H.2
-
17
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
-
DOI 10.1016/S1097-2765(02)00568-3
-
Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 2002, 10:151-162 (Pubitemid 34876569)
-
(2002)
Molecular Cell
, vol.10
, Issue.1
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
18
-
-
0038362751
-
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
-
Plas DR, Thompson CB: Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem 2003, 14:12361-12366
-
(2003)
J Biol Chem
, vol.14
, pp. 12361-12366
-
-
Plas, D.R.1
Thompson, C.B.2
-
19
-
-
37549032568
-
Raptor-rictor axis in TGF-beta-induced protein synthesis
-
Das F, Ghosh-Choudhury N, Mahimainathan L, Venkatesan B, Feliers D, Riley DJ, Kasinath BS, Choudhury GG: Raptor-rictor axis in TGF-beta-induced protein synthesis. Cell Signal 2008, 20:409-423
-
(2008)
Cell Signal
, vol.20
, pp. 409-423
-
-
Das, F.1
Ghosh-Choudhury, N.2
Mahimainathan, L.3
Venkatesan, B.4
Feliers, D.5
Riley, D.J.6
Kasinath, B.S.7
Choudhury, G.G.8
-
20
-
-
26444471810
-
The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain
-
Block K, Appikonda S, Lin HR, Bloom J, Pagano M, Yew PR. The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain. Cell Cycle 2005, 4:1421-1427
-
(2005)
Cell Cycle
, vol.4
, pp. 1421-1427
-
-
Block, K.1
Appikonda, S.2
Lin, H.R.3
Bloom, J.4
Pagano, M.5
Yew, P.R.6
-
21
-
-
33745260930
-
AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling
-
Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN: AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res 2006, 66:5618-5623
-
(2006)
Cancer Res
, vol.66
, pp. 5618-5623
-
-
Riemenschneider, M.J.1
Betensky, R.A.2
Pasedag, S.M.3
Louis, D.N.4
-
22
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 2002, 4:648-657
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
24
-
-
0032834055
-
EIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
-
Gingras AC, Raught B, Sonenberg N: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 1999, 68:913-963
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 913-963
-
-
Gingras, A.C.1
Raught, B.2
Sonenberg, N.3
-
25
-
-
0032849890
-
Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase
-
Heesom KJ, Denton RM: Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase. FEBS Lett 1999, 457:489-493
-
(1999)
FEBS Lett
, vol.457
, pp. 489-493
-
-
Heesom, K.J.1
Denton, R.M.2
-
26
-
-
9344259718
-
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
-
Kwon J, Lee SR, Yang KS, Ahn Y, Kim YJ, Stadtman ER, Rhee SG: Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci USA 2004, 101:16419-16424
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 16419-16424
-
-
Kwon, J.1
Lee, S.R.2
Yang, K.S.3
Ahn, Y.4
Kim, Y.J.5
Stadtman, E.R.6
Rhee, S.G.7
-
27
-
-
11144279346
-
The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway
-
Seo JH, Ahn Y, Lee SR, Yeol Yeo C, Chung Hur K: The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway. Mol Biol Cell 2005, 16:348-357
-
(2005)
Mol Biol Cell
, vol.16
, pp. 348-357
-
-
Seo, J.H.1
Ahn, Y.2
Lee, S.R.3
Yeol Yeo, C.4
Chung Hur, K.5
-
28
-
-
33744902875
-
The phosphoinosititde 3-kinase/Akt pathway: A new target in human renal cell carcinoma therapy
-
Sourbier C, Lindner V, Lang H, Agouni A, Schordan E, Danilin S, Rothhut S, Jacqmin D, Helwig JJ, Massfelder T: The phosphoinosititde 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy. Cancer Res 2006, 66:5130-5142
-
(2006)
Cancer Res
, vol.66
, pp. 5130-5142
-
-
Sourbier, C.1
Lindner, V.2
Lang, H.3
Agouni, A.4
Schordan, E.5
Danilin, S.6
Rothhut, S.7
Jacqmin, D.8
Helwig, J.J.9
Massfelder, T.10
-
29
-
-
68149161087
-
PTEN suppression of YY1 induces HIF-2a activity in von Hippel Lindau null renal cell carcinoma
-
Petrella B, Brinckerhoff CE: PTEN suppression of YY1 induces HIF-2a activity in von Hippel Lindau null renal cell carcinoma. Cancer Biol Ther 2009, 8:1-13
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1-13
-
-
Petrella, B.1
Brinckerhoff, C.E.2
-
30
-
-
53549127797
-
Differential vascular functions of Nox family NADPH oxidases
-
Brandes RP, Schröder K: Differential vascular functions of Nox family NADPH oxidases. Curr Opin Lipidol 2008, 19:513-518
-
(2008)
Curr Opin Lipidol
, vol.19
, pp. 513-518
-
-
Brandes, R.P.1
Schröder, K.2
-
32
-
-
44449125132
-
Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy
-
Ushio-Fukai M, Nakamura Y: Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett 2008, 266:37-52
-
(2008)
Cancer Lett
, vol.266
, pp. 37-52
-
-
Ushio-Fukai, M.1
Nakamura, Y.2
-
33
-
-
11144356447
-
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxiainducible factor 1 via increase in reactive oxygen species
-
Goyal P, Weissmann N, Grimminger F, Hegel C, Bader L, Rose F, Fink L, Ghofrani HA, Schermuly RT, Schmidt HH, Seeger W, Hanze J: Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxiainducible factor 1 via increase in reactive oxygen species. Free Radic Biol Med 2004, 36:1279-1288
-
(2004)
Free Radic Biol Med
, vol.36
, pp. 1279-1288
-
-
Goyal, P.1
Weissmann, N.2
Grimminger, F.3
Hegel, C.4
Bader, L.5
Rose, F.6
Fink, L.7
Ghofrani, H.A.8
Schermuly, R.T.9
Schmidt, H.H.10
Seeger, W.11
Hanze, J.12
-
34
-
-
34548330008
-
Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature
-
Mittal M, Roth M, König P, Hofmann S, Dony E, Goyal P, Selbitz AC, Schermuly RT, Ghofrani HA, Kwapiszewska G, Kummer W, Klepetko W, Hoda MA, Fink L, Hanze J, Seeger W, Grimminger F, Schmidt HH, Weissmann N: Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res 2007, 101:258-267
-
(2007)
Circ Res
, vol.101
, pp. 258-267
-
-
Mittal, M.1
Roth, M.2
König, P.3
Hofmann, S.4
Dony, E.5
Goyal, P.6
Selbitz, A.C.7
Schermuly, R.T.8
Ghofrani, H.A.9
Kwapiszewska, G.10
Kummer, W.11
Klepetko, W.12
Hoda, M.A.13
Fink, L.14
Hanze, J.15
Seeger, W.16
Grimminger, F.17
Schmidt, H.H.18
Weissmann, N.19
-
35
-
-
49749100079
-
NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts
-
Li S, Tabar SS, Malec V, Eul BG, Klepetko W, Weissmann N, Grimminger F, Seeger W, Rose F, Hanze J: NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. Antioxid Redox Signal 2008, 10:1687-1698
-
(2008)
Antioxid Redox Signal
, vol.10
, pp. 1687-1698
-
-
Li, S.1
Tabar, S.S.2
Malec, V.3
Eul, B.G.4
Klepetko, W.5
Weissmann, N.6
Grimminger, F.7
Seeger, W.8
Rose, F.9
Hanze, J.10
-
36
-
-
0035914269
-
Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas
-
Parry L, Maynard JH, Patel A, Clifford SC, Morrissey C, Maher ER, Cheadle JP, Sampson JR: Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas. Br J Cancer 2001, 8:1226-1230
-
(2001)
Br J Cancer
, vol.8
, pp. 1226-1230
-
-
Parry, L.1
Maynard, J.H.2
Patel, A.3
Clifford, S.C.4
Morrissey, C.5
Maher, E.R.6
Cheadle, J.P.7
Sampson, J.R.8
-
37
-
-
0036128675
-
Mutational analysis of the von Hippel Lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients
-
Duffy K, Al-Saleem T, Karbowniczek M, Ewalt D, Prowse AH, Henske EP: Mutational analysis of the von Hippel Lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients. Mod Pathol 2002, 3:205-210
-
(2002)
Mod Pathol
, vol.3
, pp. 205-210
-
-
Duffy, K.1
Al-Saleem, T.2
Karbowniczek, M.3
Ewalt, D.4
Prowse, A.H.5
Henske, E.P.6
-
38
-
-
0037842275
-
Up-regulation of hypoxia-inducible factor 2a in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene
-
Liu MY, Poellinger L, Walker CL: Up-regulation of hypoxia-inducible factor 2a in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res 2003, 10:2675-2680
-
(2003)
Cancer Res
, vol.10
, pp. 2675-2680
-
-
Liu, M.Y.1
Poellinger, L.2
Walker, C.L.3
|