메뉴 건너뛰기




Volumn 176, Issue 5, 2010, Pages 2447-2455

The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE P22 PHOX; S6 KINASE; SMALL INTERFERING RNA; TUBERIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

EID: 77952079054     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090606     Document Type: Article
Times cited : (38)

References (38)
  • 1
    • 85027722628 scopus 로고    scopus 로고
    • Inhibition of HIF2a is sufficient to suppress pVHL-defective tumor growth
    • Kondo K, Kim WY, Lechpammer M, Kaelin WG Jr: Inhibition of HIF2a is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003, 3:439-444
    • (2003) PLoS Biol , vol.3 , pp. 439-444
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin Jr., W.G.4
  • 2
    • 23844527189 scopus 로고    scopus 로고
    • Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity
    • An J, Rettig MB: Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity. Mol Cell Biol 2005, 17:7546-7556
    • (2005) Mol Cell Biol , vol.17 , pp. 7546-7556
    • An, J.1    Rettig, M.B.2
  • 3
    • 13944252559 scopus 로고    scopus 로고
    • Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma
    • Petrella BL, Lohi J, Brinckerhoff CE: Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005, 24:1043-1052
    • (2005) Oncogene , vol.24 , pp. 1043-1052
    • Petrella, B.L.1    Lohi, J.2    Brinckerhoff, C.E.3
  • 4
    • 33846675525 scopus 로고    scopus 로고
    • Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase
    • Petrella BL, Brinckerhoff CE: Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. Mol Cancer 2006, 5:66
    • (2006) Mol Cancer , vol.5 , pp. 66
    • Petrella, B.L.1    Brinckerhoff, C.E.2
  • 8
    • 4544250814 scopus 로고    scopus 로고
    • Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells
    • DOI 10.1074/jbc.M400078200
    • Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS: Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem 2004, 279:34643-34654 (Pubitemid 39318094)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.33 , pp. 34643-34654
    • Vaquero, E.C.1    Edderkaoui, M.2    Pandol, S.J.3    Gukovsky, I.4    Gukovskaya, A.S.5
  • 10
    • 27144444002 scopus 로고    scopus 로고
    • Nox4 is critical for hypoxia-inducible factor 2-a transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma
    • Maranchie JK, Zhan Y: Nox4 is critical for hypoxia-inducible factor 2-a transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. Cancer Res 2005, 65:9190-9193
    • (2005) Cancer Res , vol.65 , pp. 9190-9193
    • Maranchie, J.K.1    Zhan, Y.2
  • 14
    • 24744468043 scopus 로고    scopus 로고
    • phox are dominant inhibitors of Nox1- And Nox2-dependent reactive oxygen generation
    • DOI 10.1074/jbc.M501882200
    • Kawahara T, Ritsick D, Cheng G, Lambeth JD. Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem 2005, 280:31859-31869 (Pubitemid 41291936)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.36 , pp. 31859-31869
    • Kawahara, T.1    Ritsick, D.2    Cheng, G.3    Lambeth, J.D.4
  • 15
    • 8544270180 scopus 로고    scopus 로고
    • Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase
    • DOI 10.1074/jbc.M406486200
    • Ambasta RK, Kumar P, Griendling KK, Schmidt HH, Busse R, Brandes RP. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem 2004, 279:45935-45941 (Pubitemid 39491586)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.44 , pp. 45935-45941
    • Ambasta, R.K.1    Kumar, P.2    Griendling, K.K.3    Schmidt, H.H.H.W.4    Busse, R.5    Brandes, R.P.6
  • 16
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • DOI 10.1152/physrev.00044.2005
    • Bedard K, Krause KH The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 2007, 87:245-313 (Pubitemid 46209993)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 245-313
    • Bedard, K.1    Krause, K.-H.2
  • 17
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
    • DOI 10.1016/S1097-2765(02)00568-3
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 2002, 10:151-162 (Pubitemid 34876569)
    • (2002) Molecular Cell , vol.10 , Issue.1 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 18
    • 0038362751 scopus 로고    scopus 로고
    • Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
    • Plas DR, Thompson CB: Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem 2003, 14:12361-12366
    • (2003) J Biol Chem , vol.14 , pp. 12361-12366
    • Plas, D.R.1    Thompson, C.B.2
  • 20
    • 26444471810 scopus 로고    scopus 로고
    • The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain
    • Block K, Appikonda S, Lin HR, Bloom J, Pagano M, Yew PR. The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain. Cell Cycle 2005, 4:1421-1427
    • (2005) Cell Cycle , vol.4 , pp. 1421-1427
    • Block, K.1    Appikonda, S.2    Lin, H.R.3    Bloom, J.4    Pagano, M.5    Yew, P.R.6
  • 21
    • 33745260930 scopus 로고    scopus 로고
    • AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling
    • Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN: AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res 2006, 66:5618-5623
    • (2006) Cancer Res , vol.66 , pp. 5618-5623
    • Riemenschneider, M.J.1    Betensky, R.A.2    Pasedag, S.M.3    Louis, D.N.4
  • 22
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 2002, 4:648-657
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 24
    • 0032834055 scopus 로고    scopus 로고
    • EIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
    • Gingras AC, Raught B, Sonenberg N: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 1999, 68:913-963
    • (1999) Annu Rev Biochem , vol.68 , pp. 913-963
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 25
    • 0032849890 scopus 로고    scopus 로고
    • Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase
    • Heesom KJ, Denton RM: Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase. FEBS Lett 1999, 457:489-493
    • (1999) FEBS Lett , vol.457 , pp. 489-493
    • Heesom, K.J.1    Denton, R.M.2
  • 26
    • 9344259718 scopus 로고    scopus 로고
    • Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
    • Kwon J, Lee SR, Yang KS, Ahn Y, Kim YJ, Stadtman ER, Rhee SG: Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci USA 2004, 101:16419-16424
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16419-16424
    • Kwon, J.1    Lee, S.R.2    Yang, K.S.3    Ahn, Y.4    Kim, Y.J.5    Stadtman, E.R.6    Rhee, S.G.7
  • 27
    • 11144279346 scopus 로고    scopus 로고
    • The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway
    • Seo JH, Ahn Y, Lee SR, Yeol Yeo C, Chung Hur K: The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway. Mol Biol Cell 2005, 16:348-357
    • (2005) Mol Biol Cell , vol.16 , pp. 348-357
    • Seo, J.H.1    Ahn, Y.2    Lee, S.R.3    Yeol Yeo, C.4    Chung Hur, K.5
  • 29
    • 68149161087 scopus 로고    scopus 로고
    • PTEN suppression of YY1 induces HIF-2a activity in von Hippel Lindau null renal cell carcinoma
    • Petrella B, Brinckerhoff CE: PTEN suppression of YY1 induces HIF-2a activity in von Hippel Lindau null renal cell carcinoma. Cancer Biol Ther 2009, 8:1-13
    • (2009) Cancer Biol Ther , vol.8 , pp. 1-13
    • Petrella, B.1    Brinckerhoff, C.E.2
  • 30
    • 53549127797 scopus 로고    scopus 로고
    • Differential vascular functions of Nox family NADPH oxidases
    • Brandes RP, Schröder K: Differential vascular functions of Nox family NADPH oxidases. Curr Opin Lipidol 2008, 19:513-518
    • (2008) Curr Opin Lipidol , vol.19 , pp. 513-518
    • Brandes, R.P.1    Schröder, K.2
  • 32
    • 44449125132 scopus 로고    scopus 로고
    • Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy
    • Ushio-Fukai M, Nakamura Y: Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett 2008, 266:37-52
    • (2008) Cancer Lett , vol.266 , pp. 37-52
    • Ushio-Fukai, M.1    Nakamura, Y.2
  • 35
    • 49749100079 scopus 로고    scopus 로고
    • NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts
    • Li S, Tabar SS, Malec V, Eul BG, Klepetko W, Weissmann N, Grimminger F, Seeger W, Rose F, Hanze J: NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts. Antioxid Redox Signal 2008, 10:1687-1698
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1687-1698
    • Li, S.1    Tabar, S.S.2    Malec, V.3    Eul, B.G.4    Klepetko, W.5    Weissmann, N.6    Grimminger, F.7    Seeger, W.8    Rose, F.9    Hanze, J.10
  • 37
    • 0036128675 scopus 로고    scopus 로고
    • Mutational analysis of the von Hippel Lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients
    • Duffy K, Al-Saleem T, Karbowniczek M, Ewalt D, Prowse AH, Henske EP: Mutational analysis of the von Hippel Lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients. Mod Pathol 2002, 3:205-210
    • (2002) Mod Pathol , vol.3 , pp. 205-210
    • Duffy, K.1    Al-Saleem, T.2    Karbowniczek, M.3    Ewalt, D.4    Prowse, A.H.5    Henske, E.P.6
  • 38
    • 0037842275 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factor 2a in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene
    • Liu MY, Poellinger L, Walker CL: Up-regulation of hypoxia-inducible factor 2a in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res 2003, 10:2675-2680
    • (2003) Cancer Res , vol.10 , pp. 2675-2680
    • Liu, M.Y.1    Poellinger, L.2    Walker, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.