Histocompatibility testing after fifty years of transplantation

Journal of Immunological Methods

Volumn 369, Issue 1-2, 2011, Pages 1-21

  Eng, Hooi Sian ^a   Leffell, Mary S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hematopoietic cell transplantation; Histocompatibility; HLA antibodies; HLA antigens; Immunogenetics; Solid organ transplantation

Indexed keywords

ANTIBODY; HISTOCOMPATIBILITY ANTIGEN; HLA ANTIBODY; HLA ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; MONOCLONAL ANTIBODY;

AGGLUTINATION TEST; ALLELE; ANTIBODY SCREENING; BIOTECHNOLOGY; BLOOD GROUP TYPING; CELL ASSAY; CELL BASED CROSSMATCH TEST; COMPLEMENT DEPENDENT CYTOTOXICITY; CYTOTOXICITY; DNA DETERMINATION; DNA MODIFICATION; DNA POLYMORPHISM; DNA SEQUENCE; FLOW CYTOMETRY; GENETIC POLYMORPHISM; GENOTYPE; GRAFT SURVIVAL; HEMAGGLUTINATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY TEST; HLA SYSTEM; HLA TYPING; HUMAN; IMMUNOASSAY; LYMPHOCYTE; MIXED LYMPHOCYTE CULTURE; MOLECULAR TYPING; NOMENCLATURE; NON HLA ANTIBODY; NONHUMAN; OLIGONUCLEOTIDE PROBE; ORGAN TRANSPLANTATION; OUTCOME ASSESSMENT; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PRIMED LYMPHOCYTE TYPING; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; SENSITIVITY AND SPECIFICITY; SEQUENCE SPECIFIC OLIGONUCLEOTIDE PROBE; SEQUENCE SPECIFIC PRIMER; SEQUENCING BASED TYPING; SOLID; SOLID PHASE CROSSMATCH; SOLID PHASE IMMUNOASSAY; VIRTUAL CROSSMATCH;

ANTIBODIES; EPITOPES; HISTOCOMPATIBILITY TESTING; HUMANS; SEQUENCE ANALYSIS, DNA; TRANSPLANTATION IMMUNOLOGY;

EID: 79958774832     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2011.04.005     Document Type: Review

References (215)

1. Adams S.D., Barracchini K.C., Chen D., Robbins F., Wang L., Larsen P., Luhm R., Stroncek D.F. Ambiguous allele combinations in HLA Class I and Class II sequence-based typing: when precise nucleotide sequencing leads to imprecise allele identification. J. Transl. Med. 2004, 2:30.
2. Allen F.H., Amos D.B., Batchelor J.R., Bodmer W.F., Ceppellini R., Dausset J., Kissmeyer-Nielson F., Morris P.J., Payne R., van Rood J.J., Terasaki P.I., Trnka Z., Walford R.L. Nomenclature for factors of the HL-A system. Bull. World Health Org. 1968, 39:483.
3. Alvarez-Marquez A., Aguilera I., Blanco R.M., Pascual D., Encarnacion-Carrizosa M., Alvarez-Lopez M.R., Wichmann I., Nunez-Roldan A. Positive association of anticytoskeletal endothelial cell antibodies and cardiac allograft rejection. Hum. Immunol. 2008, 69:143.
4. Amos D.B. Histocompatibility Testing: Report of a Conference and Workshop 1965, National Academy of Sciences-National Research Council, Washington DC.
5. Angelini G., de Preval C., Gorski J., Mach B. High-resolution analysis of the human HLA-DR polymorphism by hybridization with sequence-specific oligonucleotide probes. Proc. Natl. Acad. Sci. U.S.A. 1986, 83:4489.
6. Appel J.Z., Hartwig M.G., Cantu E., Palmer S.M., Reinsmoen N.L., Davis R.D. Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies. Transplantation 2006, 81:1049.
7. Arguello J.R., Little A.M., Bohan E., Goldman J.M., Marsh S.G., Madrigal J.A. High resolution HLA class I typing by reference strand mediated conformation analysis (RSCA). Tissue Antigens 1998, 52:57.
8. Arnold M.L., Dechant M., Doxiadis I.I., Spriewald B.M. Prevalence and specificity of immunoglobulin G and immunoglobulin A non-complement-binding anti-HLA alloantibodies in retransplant candidates. Tissue Antigens 2008, 72:60.
9. Baas E.J., Bontrop R.E., Otting N., Giphart M.J. Molecular analysis of HLA-DP specificities HLA-DPw1, -DPw2 and -DPw4: DP beta chain heterogeneity correlates with PLT subtyping. Tissue Antigens 1988, 31:5.
10. Bach F.H., Amos D.B. Hu-1: major histocompatibility locus in man. Science 1967, 156:1506.
11. Badders J.L., Houp J.A., Sholander J.T., Leffell M.S., Zachary A.A. Considerations in interpretating solid phase antibody data. Hum. Immunol. 2010, 71(1):S18.
12. Balan V., Ruppert K., Demetris A.J., Ledneva T., Duquesnoy R.J., Detre K.M., Wei Y.L., Rakela J., Schafer D.F., Roberts J.P., Everhart J.E., Wiesner R.H. Long-term outcome of human leukocyte antigen mismatching in liver transplantation: results of the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database. Hepatology 2008, 48:878.
13. Bartel G., Wahrmann M., Exner M., Regele H., Huttary N., Schillinger M., Körmöczi G.F., Hörl W.H., Böhmig G.A. In vitro detection of C4d-fixing HLA alloantibodies: associations with capillary C4d deposition in kidney allografts. Am. J. Transplant. 2008, 8:41.
14. Bearden C.M., Agarwal A., Book B.K., Sidner R.A., Gebel H.M., Bray R.A., Pescovitz M.D. Pronase treatment facilitates alloantibody flow cytometric and cytotoxic crossmatching in the presence of rituximab. Hum. Immunol. 2004, 65:803.
15. Bentley G., Higuchi R., Hoglund B., Goodridge D., Sayer D., Trachtenberg E.A., Erlich H.A. High-resolution, high-throughput HLA genotyping by next-generation sequencing. Tissue Antigens 2009, 74:393.
16. Bharat A., Saini D., Steward N., Hachem R., Trulock E.P., Patterson G.A., Meyers B.F., Mohanakumar T. Antibodies to self-antigens predispose to primary lung allograft dysfunction and chronic rejection. Ann. Thorac. Surg. 2010, 90:1094.
17. Bielmann D., Honger G., Lutz D., Mihatsch M.J., Steiger J., Schaub S. Pretransplant risk assessment in renal allograft recipients using virtual crossmatching. Am. J. Transplant. 2007, 7:626.
18. Billen E., Voorter C., Christiaans M., van den Berg-Loonen E. Luminex donor-specific crossmatches. Tissue Antigens 2008, 71:507.
19. Bingaman A., Murphey C., Palma-Vargas J., Wright F. A virtual crossmatch protocol significantly increases access of highly sensitized patients to deceased donor kidney transplantation. Transplantation 2008, 86:1864.
20. Bodmer W.F., Albert E., Bodmer J.G., Dausset J., Kissmeyer-Nielsen F., Mayr W., Payne R., van Rood J.J., Trnka Z., Walford R.L. Nomenclature for factors of the HLA system, 1984. Histocompatibility Testing, 1984 1985, 4. Springer-Verlag, Berlin. E.D. Albert, M.P. Baur, W.R. Mayr (Eds.).
21. Bodmer J.G., Marsh S.G., Parham P., Erlich H.A., Albert E., Bodmer W.F., Dupont B., Mach B., Mayr W.R., Sasazuki T., Schreuder G.M.T.H., Svejgaard A., Terasaki P.I. Nomenclature for factors of the HLA system, 1989. Tissue Antigens 1990, 35:1.
22. Boyum A. Separation of lymphocytes, lymphocyte subgroups and monocytes: a review. Lymphology 1977, 10:71.
23. Bray R.A., Nolen J., Larsen C., Pearson T., Newell K., Kokko K., Guasch A., Tso P., Mendel J., Gebel H. Transplanting the highly sensitzed patient: The Emory algorithm. Am. J. Transplant. 2006, 6:2307.
24. Breimer M.E., Rydberg L., Jackson A.M., Lucas D.P., Zachary A.A., Melancon J.K., Von Visger J., Pelletier R., Saidman S.L., Williams W.W., Holgersson J., Tyden G., Klintmalm G.K., Coultrup S., Sumitran-Holgersson S., Grufman P. Multicenter evaluation of a novel endothelial cell crossmatch test in kidney transplantation. Transplantation 2009, 87:549.
25. Brodsky F.M., Parham P., Barnstable C.J., Crumpton M.J., Bodmer W.F. Monoclonal antibodies for analysis of the HLA system. Immunol. Rev. 1979, 47:3.
26. Brugiere O., Thabut G., Suberbielle C., Reynaud-Gaubert M., Thomas P., Pison C., Saint Raymond C., Mornex J.F., Bertocchi M., Dromer C., Velly J.F., Stern M., Philippe B., Dauriat G., Biondi G., Castier Y., Fournier M. Relative impact of human leukocyte antigen mismatching and graft ischemic time after lung transplantation. J. Heart Lung Transplant. 2008, 27:628.
27. Bruning J.W., van Leeuwan A., van Rood J.J. Leukocyte antigens. Histocompatibility Testing 1965 1965, 275. J.J. Rood (Ed.).
28. Bryan C., Shield C., Warady B., Aeder M., Helling T., Luger A., Martinez J., Nelson P., Pierce G., Ross G., Muruve N., Thien E. Influence of an historically positive crossmatch on cadaveric renal transplantation. Transplant. Proc. 1999, 31:225.
29. Bryan C., Martinez J., Muruve N., Nelson P., Pierce G., Ross G., Shield C., Warady B., Aeder M., Harrell K., Helling T., Luger A. IgM antibodies identified by a DTT-ameliorated positive crossmatch do not influence renal graft outcome but the strength of the IgM lymphocytotoxicity is associated with DR phenotype. Clin. Transplant. 2001, 15:28.
30. Bryan C.F., MacDonald S.B., Luger A.M., SHield C.F., Winklhofer F.T., Micheal B.A., Aeder B.A., Murillo D. Successful renal transplantation despite low levels of donor-specific HLA class I antibody without IvIg or plasmapheresis. Clin. Transplant. 2006, 20:563.
31. Bugawan T.L., Begovich A.B., Erlich H.A. Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes. Immunogenetics 1990, 32:231.
32. Cano P., Klitz W., Mack S.J., Maiers M., Marsh S.G., Noreen H., Reed E.F., Senitzer D., Setterholm M., Smith A., Fernandez-Vina M. Common and well-documented HLA alleles: report of the Ad-Hoc committee of the American Society for Histocompatiblity and Immunogenetics. Hum. Immunol. 2007, 68:392.
33. Cardella C.J., Falk J.A., Nicholson M.J., Harding M., Cook G.T. Successful renal transplantation in patients with T-cell reactivity to donor. Lancet 1982, 2:1240.
34. Cecka J.M. Calculated PRA (CPRA): the new measure of sensitization for transplant candidates. Am. J. Transplant. 2010, 10:26.
35. Cecka J.M., Kucheryavaya A.Y., Reinsmoen N.L., Leffell M.S. Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive corssmatches. Am. J. Transplant 2010, Nov 29 [Epub ahead of print]. 10.1111/j.1600-6143.2010.03340.x.
36. Cesbron-Gautier A., Achard S.P., Cury S., Follea G., Bignon J.D. Luminex techonology for HLA typing by PCR-SSO and identification of HLA antibody specificities. Ann. Biol. Clin. (Paris) 2004, 62:93.
37. Chapman J.R., Taylor C.J., Ting A., Morris P.J. Immunoglobulin class and specificity of antibodies causing positive T cell crossmatch: relationship to renal transplant outcome. Transplantation 1986, 42:608.
38. Cooley S., Weisdorf D.J., Guethlein L.A., Klein J.P., Wang T., Le C.T., Marsh S.G., Geraghty D., Spellman S., Haagenson M.D., Ladner M., Trachtenberg E., Parham P., Miller J.S. Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood 2010, 116:2411.
39. Dausset J. Iso-leuco-antibodies. Acta Haematol. 1958, 20:156.
40. Dausset J. The leukoagglutinins. Transfusion 1962, 2:209.
41. Dausset J., Rapaport F.T., Legrand L., Colombani J., Barge A., Feingold N. Studies on transplantation antigens (HL-A) by means of skin grafts from 90 children onto their fathers. Nouv. Rev. Fr. Hematol. 1969, 9:215.
42. Dragun D., Hegner B. Non-HLA antibodies post-transplantation: clinical relevance and treatment in solid organ transplantation. Contrib. Nephrol. 2009, 162:129.
43. Dragun D., Philippe A., Catar R., Hegner B. Autoimmune mediated G-protein receptor activation in cardiovascular and renal pathologies. Thromb. Haemost. 2009, 101:643.
44. Duquesnoy R.J., Marrari M. MB system. Histocompatibility Testing, 1980 1980, 552. UCLA Tissue Typing Laboratory, Los Angeles, CA. P.I. Terasaki (Ed.).
45. Duquesnoy R.J., Marrari M., Annen K. Identification of an HLA-DR-associated system of B-cell alloantigens. Transplant. Proc. 1979, 11:1757.
46. Eisen S.A., Wedner H.J., Parker C.W. Isolation of pure human peripheral blood T-lymphocytes using nylon wool columns. Immunol. Commun. 1972, 1:571.
47. El-Awar N., Lee J.H., Tarsitani C., Terasaki P.I. HLA class I epitopes: recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens. Hum. Immunol. 2007, 68:170.
48. El-Awar N., Terasaki P.I., Nguyen A., Sasaki N., Morales-Buenrosto L.E., Saji H., Maruya E., Poli F. Epitopes of human leukocyte antigen class I antibodies found in sera of normal healthy males and cord blood. Hum. Immunol. 2009, 70:844.
49. Erlich H.A., Opelz G., Hansen J. HLA DNA typing and transplantation. Immunity 2001, 14:347.
50. Felix N.J., Allen P.M. Specificity of T-cell alloreactivity. Nat. Rev. Immunol. 2007, 7:942.
51. Flomenberg N., Baxter-Lowe L.A., Confer D., Fernandez-Vina M., Filipovich A., Horowitz M., Hurley C., Kollman C., Anasetti C., Noreen H., Begovich A., Hildebrand W., Petersdorf E., Schmeckpeper B., Setterholm M., Trachtenberg E., Williams T., Yunis E., Weisdorf D. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 2004, 104:1923.
52. Froland S.S. Binding of sheep erythrocytes to human lymphocytes. A probable marker of T lymphocytes. Scand. J. Immunol. 1972, 1:269.
53. Fuller A.A., Rodey G.E., Parham P., Fuller T.C. Epitope map of the HLA-B7 CREG using affinity-purified human alloantibody probes. Hum. Immunol. 1990, 28:306.
54. Garovoy M.R., Reinschmidt M.A., Bigos M. Flow cytometry analysis. A high technology crossmatch technique facilitating transplantation. Transplant. Proc. 1983, 15:1939.
55. Gloor J.M., Moore S.B., Schneider B.A., Degoey S.R., Stegall M.D. The effect of antithymocyte globulin on anti-human leukocyte antigen antibody detection assays. Transplantation 2007, 84:258.
56. Gorer P. The detection of antigenic differences in mouse erythrocytes by the employment of immune sera. Br. J. Exp. Biol. 1936, 17. 42-46.
57. Gorer P. The genetic and antigenic basis of tumour transplantation. J. Pathol. Bacteriol. 1937, 44:691.
58. Gorer P., Lyman S., Snell G. Studies on the fenetics and antigenic basis of tumor transplantation. Linkage between a histocompatibility gene and "fused" in mice. Proc. R. Soc. Lond. B Biol. Sci. 1948, 135:499.
59. Guerin G., Pomier G., Fleuru H., Laverne S., Le Petit J., Berthoux F. Renal transplantation with positive allocrossmatch (B/T Historic/Current) but current T negative. Transplant. Proc. 1991, 23:417.
60. Hambach L., Vermeij M., Buser A., Aghai Z., van der Kwast T., Goulmy E. Targeting a single mismatched minor histocompatibility antigen with tumor-restricted expression eradicates human solid tumors. Blood 2008, 112:1844.
61. Hetrick S.J., Badders J.L., Schillinger K.P., Zachary A.A., Leffell M.S. The pronase predicament. Hum. Immunol. 2009, 70:S24.
62. Hetrick S.J., Schillinger K.P., Zachary A.A., Jackson A.M. Impact of pronase on flow cytometric crossmatch outcome. Hum. Immunol. 2011, 72:330.
63. Holdsworth R., Hurley C.K., Marsh S.G., Lau M., Noreen H.J., Kempenich J.H., Setterholm M., Maiers M. The HLA dictionary 2008: a summary of HLA-A, -B, -C, -DRB1/3/4/5, and -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens. Tissue Antigens 2009, 73:95.
64. Hopkins K.A. The basic lymphocyte microcytotoxicity tests: standard and AHG enhancement. The ASHI Laboratory Manual, Fourth edition 2000, I.C.1.1. American Society for Histocompatbility and Immunogenetics, Lenexa, Kansas. A.B. Hahn, G.A. Land, R.M. Strothman (Eds.).
65. Hoshino S., Kimura A., Fukuda Y., Dohi K., Sasazuki T. Polymerase chain reaction-single-strand conformation polymorphism analysis of polymorphism in DPA1 and DPB1 genes: a simple, economical, and rapid method for histocompatibility testing. Hum. Immunol. 1992, 33:98.
66. Hsu K.C., Keever-Taylor C.A., Wilton A., Pinto C., Heller G., Arkun K., O'Reilly R.J., Horowitz M.M., Dupont B. Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes. Blood 2005, 105:4878.
67. Hume D., Merrill J., Miller B., Thorn G. Experiences with renal homotransplantation in the human: report of nine cases. J. Clin. Invest. 1955, 34:327.
68. Hurley C., Cao K., Tang T., Steiner N., Lazaro A.M., Howard C.A., Ng J. Molecular methods: HLA alleles. Manual of Molecular and Clinical Laboratory Immunology 2006, 1198. ASM Press, Washington, D.C. 7th ed. B. Detrick, R.G. Hamilton, J.D. Folds (Eds.).
69. Hurley C.K., Wagner J.E., Setterholm M.I., Confer D.L. Advances in HLA: practical implications for selecting adult donors and cord blood units. Biol. Blood Marrow Transplant. 2006, 12:28.
70. Idica A.K., Kaneku H.K., Sasaki N., Rebellato L.M., Teresaki P.I. Denatured and intact HLA-specific antibody in kidney transplantation. Am. J. Transplant. 2009, 9(Suppl. 2):470.
71. IMGT/HLA Database Release 3.3.0 Accessed 01/20/2011. http://www.ebi.ac.uk/imgt/hla/.
72. Issa N., Cosio F.G., Gloor J.M., Sethi S., Dean P.G., Moore S.B., DeGoey S., Stegall M.D. Transplant glomerulopathy: risk and prognosis related to anti-human leukocyte antigen class II antibody levels. Transplantation 2008, 86:681.
73. Itoh Y., Mizuki N., Shimada T., Azuma F., Itakura M., Kashiwase K., Kikkawa E., Kulski J.K., Satake M., Inoko H. High throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics 2005, 57:717.
74. Jackson A.M., Zachary A.A. The problem of transplanting the sensitized patient: whose problem is it?. Front. Biosci. 2008, 13:1396.
75. Jurcevic S., Ainsworth M.E., Pomerance A., Smith J.D., Robinson D.R., Dunn M.J., Yacoub M.H., Rose M.L. Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation. Transplantation 2001, 71:886.
76. Kaczmarek I., Deutsch M.A., Rohrer M.E., Beiras-Fernandez A., Groetzner J., Daebritz S., Schmoeckel M., Spannagl M., Meiser B., Reichart B. HLA-DR matching improves survival after heart transplantation: is it time to change allocation policies?. J. Heart Lung Transplant. 2006, 25:1057.
77. Kasamon Y.L., Luznik L., Leffell M.S., Kowalski J., Tsai H.L., Bolanos-Meade J., Morris L.E., Crilley P.A., O'Donnell P.V., Rossiter N., Huff C.A., Brodsky R.A., Matsui W.H., Swinnen L.J., Borrello I., Powell J.D., Ambinder R.F., Jones R.J., Fuchs E.J. Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol. Blood Marrow Transplant. 2010, 16:482.
78. Kauke T., Kaczmarek I., Dick A., Schmoeckel M., Deutsch M.A., Beiras-Fernandez A., Reichart B., Spannagl M. Anti-MICA antibodies are related to adverse outcome in heart transplant recipients. J. Heart Lung Transplant. 2009, 28:305.
79. Kissmeyer-Nielsen F., Olsen S., Petersen V.P., Fjeldborg O. Hyperacute rejection of kidney allografts, associated with pre-existing humoral antibodies against donor cells. Lancet 1966, 2:662.
80. Klein J.S.D.C. The H-2 model for the major histocompatibility systems. Transplant. Rev. 1971, 6:3.
81. Klein J., Sato A. The HLA system: first of two parts. N. Engl. J. Med. 2000, 343:702.
82. Koka P., Chia D., Terasaki P.I., Chan H., Chia J., Ozawa M., Lim E. The role of IgA anti-HLA class I antibodies in kidney transplant survival. Transplantation 1993, 56:207.
83. Kosmoliaptsis V., O'Rourke C., Bradley J.A., Taylor C.J. Improved luminex-based human leukocyte antigen-specific antibody screening using dithiothreitol-treated sera. Hum. Immunol. 2010, 71:45.
84. Lahesmaa R., Skurnik M., Vaara M., Leirisalo-Repo M., Nissila M., Granfors K., Tovanene P. Molecular mimickry between HLA B27 and Yersinis, Salmonells, Shigella and Klebsiella with the same region of HLA alpha 1-helix. Clin. Exp. Immunol. 1991, 86:399.
85. Lee J.H., Lias M., Deng C.T., Etessami S., Loon J., Chen M., Banh L., Conger N., Connors D., Manzo A. A one-step monoclonal antibody typing procedure that simplifies HLA class I and class II typing. Tissue Antigens 1994, 44:34.
86. Lee S.J., Klein J., Haagenson M., Baxter-Lowe L.A., Confer D.L., Eapen M., Fernandez-Vina M., Flomenberg N., Horowitz M., Hurley C.K., Noreen H., Oudshoorn M., Petersdorf E., Setterholm M., Spellman S., Weisdorf D., Williams T.M., Anasetti C. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 2007, 110:4576.
87. Lee P.C., Zhu L., Terasaki P.I., Everly M.J. HLA-sepcific antibodies developed in the first year posttransplant are predictive of chronic rejection and renal graft loss. Transplantation 2009, 88:568.
88. Leffell M.S., Zachary A.A. Antiallograft antibodies: relevance, detection, and monitoring. Curr. Opin. Organ Transplant. 2010, 15:2.
89. Leffell M.S., Zachary A.A. Anti-allograft antibodies: some are harmful, some can be overcome, and some may be beneficial. Discov. Med. 2010, 9:478.
90. Leffell M.S., Cherikh W.S., Land G., Zachary A.A. Improved definition of human leukocyte antigen frequencies among minorities and applicability to estimates of transplant compatibility. Transplantation 2007, 83:964.
91. Leffell M.S., Cao K., Coppage M., Hansen J.A., Hart J.M., Pereira N., Pereira S., Reinsmoen N.L., Senitzer D., Smith A., Torres M., Vega R., Fuchs E. Incidence of humoral sensitization in HLA partially mismatched hematopoietic stem cell transplantation. Tissue Antigens 2009, 74:494.
92. LeFor W.M. Isolation of lymphocytes from lymph nodes and spleen. American Society for Histocompatibility and Immunogenetics Laboratory Manual 2000, I.A.4.1. American Society for Histocompatibility and Immunogenetics, Lenexa, Kans. Fourth ed. A. Hahn, G.A. Land, R.M. Strothman (Eds.).
93. Lemy A., Andrien M., Wissing K.M., Ryhahi K., Vandersarren A., Racape J., Heylen C., Ghisdal L., Broeders E., Vereerstraeten P., Toungouz M., Abramowicz D. Major histocompatibility complex class 1 chain related antigen a antibodies: sensitizing events and impact on renal grant outcomes. Transplantation 2010, 90:168.
94. Li F., Atz M.E., Reed E.F. Human leukocyte antigen antibodies in chronic transplant vasculopathy-mechanisms and pathways. Curr. Opin. Immunol. 2009, 21:557.
95. Lim E.C., Chia D., Gjertson D.W., Koka P., Terasaki P.I. In vitro studies to explain high renal allograft survival in IgA nephropathy patients. Transplantation 1993, 55:996.
96. Lind C., Ferriola D., Mackiewicz K., Heron S., Rogers M., Slavich L., Walker R., Hsiao T., McLaughlin L., D'Arcy M., Gai X., Goodridge D., Sayer D., Monos D. Next-generation sequencing: the solution for high-resolution, unambiguous human leukocyte antigen typing. Hum. Immunol. 2010, 71:1033.
97. Little C., Tyzzer E. Further experimental studies on the inheritance of susceptibility to a transplantable tumor, Carcinoma (J. W. A.) of the Japanese waltzing mouse. J. Med. Res. 1916, 33:393.
98. Lobo P.I., Isaacs R.B., Spencer C.E., Pruett T.L., Sanfey H.A., Sawyer R.G., McCullough C. Improved specificity and sensitivity when using pronase-digested lymphocytes to perform flow-cytometric crossmatch prior to renal transplantation. Transpl. Int. 2002, 15:563.
99. Locke J.E., Zachary A.A., Warren D.S., Segev D.L., Houp J.A., Montgomery R.A., Leffell M.S. Proinflammatory events are associated with significant increases in breadth and strength of HLA-specific antibody. Am. J. Transplant. 2009, 9:2136.
100. Lowe E.J., Turner V., Handgretinger R., Horwitz E.M., Benaim E., Hale G.A., Woodard P., Leung W. T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation. Br. J. Haematol. 2003, 123:323.
101. Lowry R., Goguen J., Carpenter C.B., Strom T.B., Garovoy M.R. Improved B cell typing for HLA-DR using nylon wool column enriched B lymphocyte preparations. Tissue Antigens 1979, 14:325.
102. Lyons A.B., Parish C.R. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 1994, 171:131.
103. Macdonald W.A., Chen Z., Gras S., Archbold J.K., Tynan F.E., Clements C.S., Bharadwaj M., Kjer-Nielsen L., Saunders P.M., Wilce M.C., Crawford F., Stadinsky B., Jackson D., Brooks A.G., Purcell A.W., Kappler J.W., Burrows S.R., Rossjohn J., McCluskey J. Tcell allorecognition via molecular mimicry. Immunity 2009, 31:897.
104. Malaise J., Berney T., Morel P., Toso C., Demuylder-Mischler S., Majno P., Buhler L., Mentha G., van Ophem D., Squifflet J.P., EUROSPK Study Group Effect of HLA matching in simultaneous pancreas-kidney transplantation. Transplant. Proc. 2005, 37:2846.
105. Mann D.L., Abelson L., Harris S., Amos D.B. Second genetic locus in the HLA region for human B-cell alloantigens. Nature 1976, 259:145.
106. Marcadet A., O'Cornell P., Cohen D. Standardized southern blot technique. Immunobiology of HLA: Histocompatibility Testing 1987 1989, 553. Springer-Verlag, NY. B. Dupont (Ed.).
107. Marin L., Minguela A., Torio A., Moya-Quiles M.R., Muro M., Montes-Ares O., Parrado A., Alvarez-Lopez D.M., Garcia-Alonso A.M. Flow cytometric quantification of apoptosis and proliferation in mixed lymphocyte culture. Cytometry A 2003, 51:107.
108. Marsh S.G., Albert E.D., Bodmer W.F., Bontrop R.E., Dupont B., Erlich H.A., Fernandez-Vina M., Geraghty D.E., Holdsworth R., Hurley C.K., Lau M., Lee K.W., Mach B., Maiers M., Mayr W.R., Muller C.R., Parham P., Petersdorf E.W., Sasazuki T., Strominger J.L., Svejgaard A., Terasaki P.I., Tiercy J.M., Trowsdale J. An update to HLA nomenclature, 2010. Bone Marrow Transplant. 2010, 45:846.
109. Matas A.J., Nehlsen-Cannarella S., Tellis V.A., Kuemmel P., Soberman R., Veith F.J. Successful kidney transplantation with current-sera-negative/hitoric-sera-positive T-cell crossmatch. Transplantation 1984, 37:111.
110. Mauiyyedi S., Pelle P.D., Saidman S., Collins A.B., Pascual M., Tolkoff-Rubin N.E., Williams W.W., Cosimi A.A., Schneeberger E.E., Colvin R.B. Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J. Am. Soc. Nephrol. 2001, 12:574.
111. McCalmon R., Tardif G., Sheehan M., Fitting K., Kortz W., Kam I. IgM antibodies in renal transplantation. Clin. Transplant. 1997, 11:558.
112. McGinnis M.D., Conrad M.P., Bouwens A.G.M., Tilanus M.G.J., Kronick M.N. Automated, solid-phase sequencing of DRB region genes using T7 sequencing chemistry and dye-labeled primers. Tissue Antigens 1995, 46:173.
113. McKenna R., Takemoto S., Terasaki P. Anti-antibodies after solid organ transplantation. Transplantation 2000, 69:319.
114. McQueen K.L., Dorighi K.M., Guethlein L.A., Wong R., Sanjanwala B., Parham P. Donor-recipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell transplantation. Hum. Immunol. 2007, 68:309.
115. Meier-Kriesche H.U., Scornik J.C., Susskind B., Rehman S., Schold J.D. A lifetime versus a graft life approach redefines the importance of HLA matching in kidney transplant patients. Transplantation 2009, 88:23.
116. Merrill J.P., Murray J.E., Harrison J.H., Guild W.R. Successful homotransplantation of the human kidney between identical twins. J. Am. Med. Assoc. 1956, 160:277.
117. Mizutani K., Terasaki P., Rosen A., Esquenazi V., Miller J., Shih R.N., Pei R., Ozawa M., Lee J. Serial ten-year follow-up of HLA and MICA antibody production prior to kidney graft failure. Am. J. Transplant. 2005, 5:2265.
118. Montgomery R.A. Renal transplantation across HLA and ABO antibody barriers: integrating paired donation into desensitization protocols. Am. J. Transplant. 2010, 10:449.
119. Morales-Buenrostro L.E., Terasaki P.I., Marino-Vazquez L.A., Lee J.-H., El-Awar N., Alberu J. "Natural" human leukocyte antigen antibodies found in nonalloimmunized healthy males. Transplantation 2008, 86:1111.
120. Morling N., Jakobsen B.K., Platz P., Ryder L.P., Svegaard A., Thomsen M. A "new" primed lymphocyte typing (PLT) defined DP-antigen associated with a private HLA-DR antigen. Tissue Antigens 1980, 15:471.
121. Mulder A., Kardol M.J., Niterink J.G.S., Parvliet J.H., Marrari M., Tanke J., Bruning J.W., Duquesnoy R.J. Successful strategy for the large scale development of HLA-human monoclonal antibodies. Proceedings of the Twelfth International Histocompatibility Workshop and Conference 1996, vol II:354. EDK, Paris, France. D. Charron (Ed.).
122. Mullis K.B., Faloona F.A. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol. 1987, 155:335.
123. Nagy M., Entz P., Otremba P., Schoenemann C., Murphy N., Dapprich J. Haplotype-specific extraction: a universal method to resolve ambiguous genotypes and detect new alleles-demonstrated on HLA-B. Tissue Antigens 2007, 69:176.
124. Nath D.S., Ilias Basha H., Tiriveedhi V., Alur C., Phelan D., Ewald G.A., Moazami N., Mohanakumar T. Characterization of immune responses to cardiac self-antigens myosin and vimentin in human cardiac allograft recipients with antibody-mediated rejection and cardiac allograft vasculopathy. J. Heart Lung Transplant. 2010, 71:1191.
125. Navarro V., Herrine S., Katopes C., Colombe B., Spain C.V. The effect of HLA class I (A and B) and class II (DR) compatibility on liver transplantation outcomes: an analysis of the OPTN database. Liver Transpl. 2006, 12:652.
126. Nevinny-Stickel C., Hinzpeter M., Andreas A., Albert E.D. Non-radioactive oligotyping for HLA-DR1-DRw10 using polymerase chain reaction, digoxigenin-labelled oligonucleotides and chemiluminescence detection. Eur. J. Immunogenet. 1991, 18:323.
127. Olerup O., Zetterquist H. HLA-DRB1*01 subtyping by allele-specific PCR amplification: a sensitive, specific and rapid technique. Tissue Antigens 1991, 37:197.
128. Opelz G., Dohler B. Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades. Transplantation 2007, 84:137.
129. Park M.S., Terasaki P.I., Nakata S., Aoki D. Supertypic DR groups:MT1,MT2,MT3. Eighth International Workshop Newsletter 1979, 16:20.
130. Parkkonen P., Hyoty H., Ilonen J., Reijonen H., Yia-Herttuala S., Leinikki P. Antibody reactivity to an Epstein-Barr virus BERF4-encoded epitope occurring also in Asp-57 region of HLA-DQ8 beta chain. Clin. Exp. Immunol. 1994, 95:287.
131. Patel R., Terasaki P.I. Significance of the crossmatch test in kidney transplantation. N. Engl. J. Med. 1969, 280:735.
132. Payne R. The development and persistence of leukoagglutinins in parous women. Blood 1962, 19:411.
133. Pei R., Lee J.H., Shih N.J., Chen M., Terasaki P.I. Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation 2003, 75:43.
134. Pellegrino M., Belvedere M., Pellegrino A., Ferrore S. B peripheral lymphocytes express more HLA antigens than T peripheral lymphocytes. Transplantation 1978, 25:93.
135. Petersdorf E.W. Optimal HLA matching in hematopoietic cell transplantation. Curr. Opin. Immunol. 2008, 20:588.
136. Petersdorf E.W., Hansen J.A. A comprehehsive approach for typing the alleles of the HLA-B locus by automated sequencing. Tissue Antigens 1995, 46:73.
137. Ray J.G., Scott R.C., Hare B.M., Harris C.E., Kayhoe D.E. Manual of Tissue Typing Techniques. DHEW Publication No. (NIH)75-545, Washington DC 1974.
138. Reinsmoen N.L. A new era for T-cell immune function assays in transplantation. Tissue Antigens 2010, 75:658.
139. Reinsmoen N.l., Mickelson E. HLA-DW typing. American Society for Histocompatibility and Immunogenetics Procedure Manual 1994, II.C.3.1. American Society for Histocompatibility and Immunogenetics, Lenexa, Kans. third ed. A. Nikaein (Ed.).
140. Reinsmoen N.l., Zeevi A. Evaluation of cellular immune response in transplantation. Manual of Molecular and Clinical Laboratory Immunology 2006, 1128. ASM Press, Washington DC. 7th ed. B. Detrick, R.G. Hamilton, J.D. Folds (Eds.).
141. Reinsmoen N.L., Lai C.H., Vo A., Cao K., Ong G., Naim M., Wang Q., Jordan S.C. Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy. Transplantation 2008, 86:820.
142. Roberts J.P., Wolfe R.A., Bragg-Gresham J.L., Rush S.H., Wynn J.J., Distant D.A., Ashby V.B., Held P.J., Port F.K. Effect of changing the priority for HLA matching on the rates and outcomes of kidney transplantation in minority groups. N. Engl. J. Med. 2004, 350:545.
143. Rogers N.M., Eng H.S., Yu R., Kireta S., Tsiopelas E., Bennett G.D., Brook N.R., Gillis D., Russ G.R., Coates P.T. Desensitization for renal transplantation: depletion of donor-specific anti-HLA antibodies, preservation of memory antibodies, and clinical risks. Transpl. Int. 2011, 24:21.
144. Roggero A.L., Crowe D.O. Quality control program. American Society for Histocompatibility and Immunogenetics Laboratory Manual 2000, III.D.1.1. American Society for Histocompatibility and Immunogenetics, Lenexa, Kans. fourth ed. A. Hahn, G.A. Land, R.M. Strothman (Eds.).
145. Rose M.L., Smith J.D. Clinical relevance of complement-fixing antibodies in cardiac transplantation. Hum. Immunol. 2009, 70:605.
146. Rozemuller E.H., Tilanus M.G. Bioinformatics: analysis of HLA sequence data. Rev. Immunogenet. 2000, 2:492.
147. Saiz P.A., Blanck C.E. Lymphocyte crossmatch: extended incubation and antiglobulin augmented. American Society for Histocompatibility and Immunogenetics Laboratory Manual 2000, I.C.9.1. American Society for Histocompatibility and Immunogenetics, Lenexa, Kans. fourth ed. A. Hahn, G.A. Land, R.M. Strothman (Eds.).
148. Samaniego M., Mezrich J., Torrealba J., Lorentzen D., Schadde E., Djamali A., Zachariah M., Sollinger H., Pirsch J. C4d-positive acute antibody-mediated rejection due to anti-HLA-DP antibody: a tale of one patient and a review of the University of Wisconsin experience. Clin. Transpl. 2006 2006, 503. J.M. Cecka, P.I. Terrasaki (Eds.).
149. Sanger F., Nicklen S., Coulson A. DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. 1977, 74:5463.
150. Santamaria P., Boyce-Jacino M.T., Lindstrom A.L., Barbosa J.J., Faras A.J., Rich S.S. HLA class II "typing": direct sequencing of DRB, DQB, and DQA genes. Hum. Immunol. 1992, 33:69.
151. Sasportes M., Lebrun A., Rapaport F.T., Dausset J. Studies of skin allograft survival and mixed lymphocyte culture reaction in Hl-A-genotyped families. Transplant. Proc. 1972, 4:209.
152. Scornik J., LeFor W., Cicciarelli J., Brunson M., Bogaard T., Howard R., Ackermann J., Mendez R., Shires D., Pfaff W. Hyperacute and acute kidney graft rejection due to antibodies against B cells. Transplantation 1992, 54:61.
153. Shackelford D.A., Mann D.L., van Rood J.J., Ferrara G.B., Strominger J.L. Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen. Proc. Natl. Acad. Sci. U.S.A. 1981, 78:4566.
154. Sharples L.D., Tamm M., McNeil K., Higenbottam T.W., Stewart S., Wallwork J. Development of bronchiolitis obliterans syndrome in recipients of heart-lung transplantation-early risk factors. Transplantation 1996, 61:560.
155. Shaw B.E., Gooley T.A., Malkki M., Madrigal J.A., Begovich A.B., Horowitz M.M., Gratwohl A., Ringden O., Marsh S.G., Petersdorf E.W. The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Blood 2007, 110:4560.
156. Shaw B.E., Mayor N.P., Russell N.H., Apperley J.F., Clark R.E., Cornish J., Darbyshire P., Ethell M.E., Goldman J.M., Little A.M., Mackinnon S., Marks D.I., Pagliuca A., Thomson K., Marsh S.G., Madrigal J.A. Diverging effects of HLA-DPB1 matching status on outcome following unrelated donor transplantation depending on disease stage and the degree of matching for other HLA alleles. Leukemia 2010, 24:58.
157. Siemionow M.Z., Kulahci Y., Bozkurt M. Composite tissue allotransplantation. Plast. Reconstr. Surg. 2009, 124:e327.
158. Smith R.A., Belcher R. Disparity in HLA-DR typing and mixed lymphocyte culture reactivity. Ann. Clin. Lab. Sci. 1987, 17:318.
159. Smith J.D., Hamour I.M., Banner N.R., Rose M.L. C4d fixing, luminex binding antibodies-a new tool for prediction of graft failure after heart transplantation. Am. J. Transplant. 2007, 7:2809.
160. Smith J.D., Brunner V.M., Jigjidsuren S., Hamour I.M., McCormack A.M., Banner N.R., Role M.L. Lack of effect of MICA antibodies on graft survival following heart transplantation. Am. J. Transplant. 2009, 9:1912.
161. Snell G. The genetic and antigenic basis of tumour transplantation. J. Pathol. Bacteriol. 1937, 44:691.
162. Spellman S., Warden M.B., Haagenson M., Pietz B.C., Goulmy E., Warren E.H., Wang T., Ellis T.M. Effects of mismatching for minor histocompatibility antigens on clinical outcomes in HLA-matched, unrelated hematopoietic stem cell transplants. Biol. Blood Marrow Transplant. 2009, 15:856.
163. Spellman S., Bray R., Rosen-Bronson S., Haagenson M., Klein J., Flesch S., Vierra-Green C., Anasetti C. The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure. Blood 2010, 115:2704.
164. Spierings E., Hendriks M., Absi L., Canossi A., Chhaya S., Crowley J., Dolstra H., Eliaou J.F., Ellis T., Enczmann J., Fasano M.E., Gervais T., Gorodezky C., Kircher B., Laurin D., Leffell M.S., Loiseau P., Malkki M., Markiewicz M., Martinetti M., Maruya E., Mehra N., Oguz F., Oudshoorn M., Pereira N., Rani R., Sergeant R., Thomson J., Tran T.H., Turpeinen H., Yang K.L., Zunec R., Carrington M., de Knijff P., Goulmy E. Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations. PLoS Genet. 2007, 3:e103.
165. Suarez-Alvarez B., Lopez-Vazquez A., Gonzalez M.Z., Fdez-Morera J.L., Diaz-Molina B., Blanco-Gelaz M.A., Pascual D., Martinez-Borra J., Muro M., Alvarez-Lopez M.R., Lopez-Larrea C. The relationship of anti-MICA antibodies and MICA expression with heart allograft rejection. Am. J. Transplant. 2007, 7:1842.
166. Sumitran-Holgersson S. Beyond ABO and human histocompatibility antigen: other histocompatibility antigens with a role in transplantation. Curr. Opin. Organ Transplant. 2008, 13:425.
167. Sumitran-Karuppan S., Tyden G., Reinholt F., Berg U., Moller E. Hyperacute rejections of two consecutive renal allografts and early loss of the third transplant caused by non-HLA antibodies specific for endothelial cells. Transpl. Immunol. 1997, 5:321.
168. Susskind B.M., Kerman R.H., Browne B.J., Hartwell B.A., Davis B.G., Katz S.M., Van Buren C.T., Kahan B.D. The impact of elevated serum IgA and race on primary recipient renal allograft survival. Transplantation 1996, 61:205.
169. Symons H.J., Leffell M.S., Rossiter N.D., Zahurak M., Jones R.J., Fuchs E.J. Improved survival with inhibitory killer immunoglobulin receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation. Biol. Blood Marrow Transplant. 2010, 16:533.
170. Tait B.D., Hudson F., Brewin G., Cantwell L., Holdsworth R. Solid phase HLA antibody detection technology-challenges in interpretation. Tissue Antigens 2010, 76:87.
171. Terasaki P.I., Cai J. Human leukocyte antigen antibodies and chronic rejection: from association to causation. Transplantation 2008, 86:377.
172. Terasaki P.I., McClelland J.D. Microdroplet assay of human serum cytotoxins. Nature 1964, 204:998.
173. Terasaki P.I., Machioro T.H., Starzl T.E. Sero-typing of human lymphocyte antigens: preliminary trials on long-term kidney homograft survivals. Histocompatibility Testing: Report of a Conference and Workshop. Washington DC: National Academy of Sciences - National Research Council, 1965 1965, 83. National Research Council, Washington D.C. D.B. Amos (Ed.).
174. Teresi G.A., Fuller A. Absorption with lymphocytes. American Society for Histocompatibility and Immunogenetics Laboratory Manual 2000, I.B.2.1. American Society for Histocompatibility and Immunogenetics, Lenexa, Kans. fourth ed. A. Hahn, G.A. Land, R.M. Strothman (Eds.).
175. Termijtelen A., Boettcher B., Bradley B.A., D'Amaro J., van Leeuwen A., van Rood J.J. DR typing in Australian aborigines. An indication for a second locus in the HLA-D region defined by serology. Tissue Antigens 1980, 16:140.
176. Thomsen M., Cullen M., Carrington M., Foissac A., Abbal M., de Preval C., Crouau-Roy B., Cambon-Thomsen A. Localization of the recombination points in a family with twoDR/DP recombinations. Tissue Antigens 1996, 47:492.
177. Thorne N., Klingman L.L., Teresi G.A., Cook D.J. Effects of heat inactivation and DTT treatment of serum on immunoglobulin binding. Hum. Immunol. 1993, 37:123.
178. Thorsby E. Homologies between the H-2 and HL-A systems. Tissue Antigens 1971, 1:294.
179. Thorsby E. A short history of HLA. Tissue Antigens 2009, 74:101.
180. Thorsby E., Piazza A. Joint report from the sixth international histocompatibility workshop conference. II. Typing for HLA-D (LD-1 or MLC) determinants. Histocompatibility Testing 1975 1975, 414. Munksgaard, Copenhagen. F. Kissmeyer-Nielsen (Ed.).
181. Thorsby E., Sandberg L., Lindholm A., Kissmeyer-Nielsen F. The HL-A system: evidence of a third sub-locus. Scand. J. Haematol. 1970, 7:195.
182. Tiercy J. Molecular basis of HLA polymorphism: implications in clinical transplantation. Transpl. Immunol. 2002, 9:173.
183. Tinckam K. Histocompatibility methods. Transplant. Rev. (Orlando) 2009, 23:80.
184. Vaidya S. Clinical importance of anti-human leukocyte antigen-specific antibody concentration in performing calculated panel reactive antibody and virtual crossmatches. Transplantation 2008, 85:1046.
185. van den Berg J.W., Hepkema B.G., Geertsma A., Koeter G.H., Postma D.S., de Boer W.J., Lems S.P., van der Bij W. Long-term outcome of lung transplantation is predicted by the number of HLA-DR mismatches. Transplantation 2001, 71:368.
186. van den Berg-Loonen E.M., Billen E.V., Voorter C.E., van Heurn L.W., Claas F.H., van Hoof J.P., Christiaans M.H. Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant recipients. Transplantation 2008, 85:1086.
187. van Rood J., Van Leeuwen A. Leukocyte grouping: a method and its application. J. Clin. Invest. 1963, 42:1382.
188. Vega R.M., Iglehart B.A., Callender C.J., Hart J.M., Leffell M.S., Zachary A.A. Laboratory automation: coming of age. Hum. Immunol. 2008, 69(S1):S105.
189. Velardi A., Ruggeri L., Mancusi A., Aversa F., Christiansen F.T. Natural killer cell allorecognition of missing self in allogeneic hematopoietic transplantation: a tool for immunotherapy of leukemia. Curr. Opin. Immunol. 2009, 21:525.
190. Vlad G., Ho E.K., Vasilescu E.R., Colovai A.I., Stokes M.B., Markowitz G.S., D'Agat V.D., Cohen D.J., Ratner L.E., Suciu-Foca N. Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival. Hum. Immunol. 2009, 70:589.
191. Vo A.A., Lukovsky M., Toyoda M., Wang J., Reinsmoen N.L., Lai C.H., Peng A., Villicana R., Jordan S.C. Rituximab and intravenous immune globulin for desensitization during renal transplantation. N. Engl. J. Med. 2008, 359:242.
192. Voorter C.E., Mulkers E., Liebelt P., Sleyster E., van den Berg-Loonen E.M. Reanalysis of sequence-based HLA-A, -B and -Cw typings: how ambiguous is today's SBT typing tomorrow. Tissue Antigens 2007, 70:383.
193. Wahrmann M., Exner M., Haidbauer B., Schillinger M., Regele H., Kormoczi G., Bohmig G.A. C4d]FlowPRA screening-a specific assay for selective detection of complement-activating anti-HLA alloantibodies. Hum. Immunol. 2005, 66:526.
194. Wahrmann M., Exner M., Schillinger M., Haidbauer B., Regele H., Kormoczi G.F., Horl W.H., Bohmig G.A. Pivotal role of complement-fixing HLA alloantibodies in presensitized kidney allograft recipients. Am. J. Transplant. 2006, 6:1033.
195. Wake C.T., Long E.O., Mach B. Allelic polymorphism and complexity of the genes for HLA-DR beta-chains-direct analysis by DNA-DNA hybridization. Nature 1982, 300:372.
196. Walford R.L., Colombani J., Dausset J. Retrospective leukocyte typing of unrelated human donor-recipient pairs in relation to skin allograft survival times. A study of 17 well defined specificities. Transplantation 1969, 7:188.
197. Warner P.R., Youngs D., Nelson K.A. HLA density on microparticles versus antibody detecting sensitivity: implication for crossmatch prediction. Hum. Immunol. 2007, 68:S28.
198. Warren D.S., Montgomery R.A. Incompatible kidney transplantation: lessons from a decade of desensitization and paired kidney exchange. Immunol. Res. 2010, 47:257.
199. Welsh K., Bunce M. Molecular typing for the MHC with PCR-SSP. Rev. Immunogenet. 1999, 1:157.
200. Williams G.M., Hume D.M., Hudson R.P., Morris P.J., Kano K., Milgrom F. "Hyperacute" renal-homograft rejection in man. N. Engl. J. Med. 1968, 279:611.
201. Woolfrey A., Lee S.J., Gooley T.A., Malkki M., Martin P.J., Pagel J.M., Hansen J.A., Petersdorf E. Biol. Blood Marrow Transplant. 2010, 16:1382.
202. Zachary A.A., Leffell M.S. Detecting and monitoring human leukocyte antigen-specific antibodies. Hum. Immunol. 2008, 69:591.
203. Zachary A.A., Leffell M.S. Barriers to successful transplantation of the sensitized patient. Expert Rev. Clin. Immunol. 2010, 6:449.
204. Zachary A.A., Klingman L., Thorne N., Smerglia A.R., Teresi G.A. Variations of the lymphocytotoxicity test. An evaluation of sensitivity and specificity. Transplantation 1995, 60:498.
205. Zachary A.A., Hart J.M., Lucas D.P., Leffell M.S. The co$t of mi$matching. Clin. Transpl. 2007, 261.
206. Zachary A.A., Kopchaliiska D., Montgomery R.A., Leffell M.S. HLA-specific B cells: I. A method for their detection, quantification, and isolation using HLA tetramers. Transplantation 2007, 83:982.
207. Zachary A.A., Montgomery R.A., Jordan S.C., Reinsmoen N.L., Claas F.H., Reed E.F. 14th International HLA and Immunogenetics Workshop: report on understanding antibodies in transplantation. Tissue Antigens 2007, 69(Suppl. 1):160.
208. Zachary A.A., Montgomery R.A., Leffell M.S. Defining unacceptable HLA antigens. Curr. Opin. Organ Transplant. 2008, 13:405.
209. Zachary A.A., Lucas D.P., Detrick B., Leffell M.S. Naturally occurring interference in Luminex assays for HLA-specific antibodies: characteristics and resolution. Hum. Immunol. 2009, 70:496.
210. Zachary A.A., Sholander J.T., Houp J.A., Leffell M.S. Using real data for a virtual crossmatch. Hum. Immunol. 2009, 70:574.
211. Zangwill S.D., Ellis T.M., Zlotocha J., Jaquiss R.D., Tweddell J.S., Mussatto K.A., Berger S. The virtual crossmatch-a screening tool for sensitized pediatric heart transplant recipients. Pediatr. Transplant. 2006, 10:38.
212. Zeevi A., Annen K., Scheffel C., Duquesnoy R.J. Detection of non-HLA-DR determinants by alloreactive lymphocyte clones. Hum. Immunol. 1983, 6:97.
213. Zeevi A., Girnita A.L., Duquesnoy R.J. HLA antibody analysis: sensitivity, specificity and clinical significance in solid organ transplantation. Immunol. Res. 2006, 36:255.
214. Zhang X., Reed E.F. Effect of antibodies on endothelium. Am. J. Transplant. 2009, 11:2459.
215. Zou Y., Stastny P., Susal C., Dohler B., Opelz G. Antibodies against MICA antigens and kidney transplant rejection. N. Engl. J. Med. 2007, 357:1293.