The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure

Blood

Volumn 115, Issue 13, 2010, Pages 2704-2708

  Spellman, Stephen ^a   Bray, Robert ^b   Rosen Bronson, Sandra ^c   Haagenson, Michael ^d   Klein, John ^e   Flesch, Susan ^a   Vierra Green, Cynthia ^a   Anasetti, Claudio ^f  

^a NATIONAL MARROW DONOR PROGRAM   (United States)

^b EMORY UNIVERSITY   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH   (United States)

^e MEDICAL COLLEGE OF WISCONSIN   (United States)

^f H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; CALCINEURIN; HLA A ANTIGEN; HLA ANTIBODY; HLA B ANTIGEN; HLA DP ANTIGEN; METHOTREXATE; TACROLIMUS;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; BONE MARROW; CHILD; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MALE; MYELOABLATIVE CONDITIONING; MYELODYSPLASTIC SYNDROME; ORGAN DONOR; PRIORITY JOURNAL; SCHOOL CHILD;

EID: 77950965205     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-09-244525     Document Type: Article

References (15)

1. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. 2007;110(13):4576-4583. (Pubitemid 351377826)
2. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104(7):1923-1930. (Pubitemid 39297840)
3. Karanes C, Nelson GO, Chitphakdithai P, et al. Twenty years of unrelated donor hematopoietic cell transplantation for adult recipients facilitated by the National Marrow Donor Program. Biol Blood Marrow Transplant. 2008;14(9 suppl):8-15.
4. Taylor PA, Ehrhardt MJ, Roforth MM, et al. Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients. Blood. 2007;109(3):1307-1315.
5. Anasetti C, Amos D, Beatty PG, et al. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med. 1989;320(4):197-204. (Pubitemid 19034144)
6. Anasetti C, Velardi A. Hematopoietic cell transplantation from HLA partially matched related donors. In: Blume KG, Forman SJ, Applebaum JR, eds. Thomas' Hematopoietic Cell Transplantation, 3rd edition. Boston, MA: Blackwell Science; 2004:1116-1131.
7. Ottinger HD, Rebmann V, Pfeiffer KA, et al. Positive serum crossmatch as predictor for graft failure in HLA-mismatched allogeneic blood stem cell transplantation. Transplantation. 2002;73(8): 1280-1285. (Pubitemid 34454276)
8. Bray RA, Nickerson PW, Kerman RH, Gebel HM. Evolution of HLA antibody detection. Immunol Res. 2004;29(1-3):41-53.
9. Bray R, Nolan JD, Larsen C, et al. Transplanting the sensitized patient: the Emory Wlgorithm. Am J Transplant. 2006;6(10):2307-2315. (Pubitemid 44359415)
10. Zachary AA, Leffell MS. Detecting and monitoring human leukocyte antigen-specific antibodies. Hum Immunol. 2008;69(10):591-604.
11. Patel AM, Pancoska C, Mulgaonkar S, Weng FL. Renal transplantation in patients with pretransplant donor-specific antibodies and negative flow cytometry crossmatches. Am J Transplant. 2007; 7(10):2371-2377. (Pubitemid 47347867)
12. Takanashi M, Fujiwara K, Tanaka H, Satake M, Nakajima K. The impact of HLA antibodies on engraftment of unrelated cord blood transplants. Transfusion. 2008;48(4):791-793. (Pubitemid 351430361)
13. Spellman S, Setterholm M, Maiers M, et al. Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry. Biol Blood Marrow Transplant. 2008;14(9 suppl):37-44.
14. Petersdorf EW, Longton GM, Anasetti C, et al. Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors. Blood. 1997;89(5):1818-1823. (Pubitemid 27097479)
15. Shaw BE, Gooley TA, Malkki M, et al. The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Blood. 2007;110(13): 4560-4566. (Pubitemid 351377824)