[C4d]FlowPRA screening - A specific assay for selective detection of complement-activating anti-HLA alloantibodies

Human Immunology

Volumn 66, Issue 5, 2005, Pages 526-534

  Wahrmann, Markus ^a   Exner, Markus ^a   Haidbauer, Bettina ^a   Schillinger, Martin ^a   Regele, Heinz ^a   Körmöczi, Günther ^a   Böhmig, Georg A ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

C4d; Complement dependent cytotoxicity; FlowPRA; Sensitization; Transplantation

Indexed keywords

HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN G;

ALLOIMMUNITY; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXICITY; EVALUATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STANDARDIZATION; T LYMPHOCYTE;

B-LYMPHOCYTES; COMPLEMENT ACTIVATION; COMPLEMENT C4; CYTOTOXICITY TESTS, IMMUNOLOGIC; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA ANTIGENS; HUMANS; IMMUNOASSAY; ISOANTIBODIES; LEUKOCYTES, MONONUCLEAR; MICROSPHERES; REPRODUCIBILITY OF RESULTS; T-LYMPHOCYTES;

EID: 20444409174     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2004.12.007     Document Type: Article

References (23)

1. J.M. Cecka The UNOS scientific renal transplant registry Clin Transpl 1998 1
2. G. Opelz Collaborative transplant study - 10-year report Transplant Proc 24 1992 2342
3. R.J. Duquesnoy, M. Marrari Multilaboratory evaluation of serum analysis for HLA antibody and crossmatch reactivity by lymphocytotoxicity methods Arch Pathol Lab Med 127 2003 149
4. P.I. Terasaki, V.D. Mottironi, E.V. Barnett Cytotoxins in disease. Autocytotoxins in lupus N Engl J Med 283 1970 724
5. D. Mulligan, L. Gentry, L. Dombrausky, G. Klintmalm, A. Nikaein Monitoring of allograft recipients for the development of HLA-specific antibodies elimination of OKT3 as a complicating factor Clin Transplant 9 1995 438
6. C. Schönemann, J. Groth, S. Leverenz, G. May HLA class I and class II antibodies monitoring before and after kidney transplantation and their clinical relevance Transplantation 65 1998 1519
7. R. Pei, G. Wang, C. Tarsitani, S. Rojo, T. Chen, S. Takemura, A. Liu, J. Lee Simultaneous HLA class I and class II antibodies screening with flow cytometry Hum Immunol 59 1998 313
8. J.M. Rebibou, J. Chabod, M.C. Bittencourt, C. Thevenin, J.M. Chalopin, P. Herve, P. Tiberghien Flow-PRA evaluation for antibody screening in patients awaiting kidney transplantation Transpl Immunol 8 2000 125
9. J.E. Worthington, A.J. Robson, S. Sheldon, A. Langton, S. Martin A comparison of enzyme-linked immunoabsorbent assays and flow cytometry techniques for the detection of HLA specific antibodies Hum Immunol 62 2001 1178
10. M. Wahrmann, M. Exner, H. Regele, K. Derfler, G.F. Körmöczi, K. Lhotta, G.J. Zlabinger, G.A. Böhmig Flow cytometry based detection of HLA alloantibody mediated classical complement activation J Immunol Methods 275 2003 149
11. H.E. Feucht Complement C4d in graft capillaries - the missing link in the recognition of humoral alloreactivity Am J Transplant 3 2003 646
12. H. Regele, M. Exner, B. Watschinger, C. Wenter, M. Wahrmann, C. österreicher, M.D. Säemann, N. Mersich, W.H. Hörl, G.J. Zlabinger, G.A. Böhmig Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection Nephrol Dial Transplant 16 2001 2058
13. G.A. Böhmig, M. Exner, A. Habicht, M. Schillinger, U. Lang, J. Kletzmayr, M.D. Säemann, W.H. Hörl, B. Watschinger, H. Regele Capillary C4d deposition in kidney allografts a specific marker of alloantibody-dependent graft injury J Am Soc Nephrol 13 2002 1091
14. J. Janatova C3, C5 components and C3a, C4a, and C5a fragments of the complement system Methods Enzymol 162 1988 579
15. J.P. Gorski, J.B. Howard Effect of methylamine on the structure and function of the fourth component of human complement, C4 J Biol Chem 255 1980 10025
16. P.I. Terasaki, J.D. McClelland Microdroplet assay of human serum cytotoxins Nature 204 1964 998
17. N. Khan, A.J. Robson, J.E. Worthington, S. Martin The detection and definition of IgM alloantibodies in the presence of IgM autoantibodies using flowPRA beads Hum Immunol 64 2003 593
18. H.M. Gebel, R.A. Bray Sensitization and sensitivity defining the unsensitized patient Transplantation 69 2000 1370
19. S.S. Karuppan, S. Ohlman, E. Moller The occurrence of cytotoxic and non-complement-fixing antibodies in the crossmatch serum of patients with early acute rejection episodes Transplantation 54 1992 839
20. R.H. Kerman, B. Susskind, R. Buelow, J. Regan, P. Pouletty, J. Williams, K. Gerolami, D.H. Kerman, S.M. Katz, C.T. Van Buren, B.D. Kahan Correlation of ELISA-detected IgG and IgA anti-HLA antibodies in pretransplant sera with renal allograft rejection Transplantation 62 1996 201
21. S. Le Bas-Bernardet, M. Hourmant, N. Valentin, C. Paitier, M. Giral-Classe, S. Curry, G. Follea, J.P. Soulillou, J.D. Bignon Identification of the antibodies involved in B-cell crossmatch positivity in renal transplantation Transplantation 75 2003 477
22. M. Abe, T. Kawai, K. Futatsuyama, K. Tanabe, S. Fuchinoue, S. Teraoka, H. Toma, K. Ota Postoperative production of anti-donor antibody and chronic rejection in renal transplantation Transplantation 63 1997 1616
23. M. Müller-Steinhardt, L. Fricke, H. Kirchner, J. Hoyer, H. Klüter Monitoring of anti-HLA class I and II antibodies by flow cytometry in patients after first cadaveric kidney transplantation Clin Transplant 14 2000 85