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Volumn 65, Issue , 2011, Pages 195-206

The importance of pharmacogenetic tests in evaluation of the effectiveness of methotrexate treatment in rheumatoid arthritis (part 1);Znaczenie badán farmakogenetycznych w efektywności leczenia metotreksatem chorych na reumatoidalne zapalenie stawów (Czȩść 1)

Author keywords

Methotrexate; Polymorphism; Rheumatoid arthritis

Indexed keywords

ANTIRHEUMATIC AGENT; BIOLOGICAL MARKER; METHOTREXATE;

EID: 79958774140     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: 10.5604/17322693.936689     Document Type: Review
Times cited : (3)

References (70)
  • 2
    • 55349093579 scopus 로고    scopus 로고
    • Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: A study of polymorphisms affecting methotrexate transport and folate metabolism
    • Bohanec Grabar P., Logar D., Lestan B., Dolzan V.: Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism. Eur. J. Clin. Pharmacol., 2008; 64: 1057-1068.
    • (2008) Eur. J. Clin. Pharmacol. , vol.64 , pp. 1057-1068
    • Bohanec, G.P.1    Logar, D.2    Lestan, B.3    Dolzan, V.4
  • 3
    • 0034570111 scopus 로고    scopus 로고
    • Cellular aspects of folate and antifolate membrane transport
    • Brzezińska A., Wińska P., Balińska M.: Cellular aspects of folate and antifolate membrane transport. Acta Biochim. Pol., 2000; 47: 735-749.
    • (2000) Acta Biochim. Pol. , vol.47 , pp. 735-749
    • Brzezińska, A.1    Wińska, P.2    Balińska, M.3
  • 4
    • 34447574771 scopus 로고    scopus 로고
    • Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis. Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis
    • Campalani E., Arenas M., Marinaki A.M., Lewis C.M., Barker J.N., Smith C.H.: Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis. Polymorphisms in folate, pyrimidine, and purine metabolism are associated with efficacy and toxicity of methotrexate in psoriasis. J. Invest. Dermatol., 2007; 127: 1860-1867.
    • (2007) J. Invest. Dermatol. , vol.127 , pp. 1860-1867
    • Campalani, E.1    Arenas, M.2    Marinaki, A.M.3    Lewis, C.M.4    Barker, J.N.5    Smith, C.H.6
  • 5
    • 0036952564 scopus 로고    scopus 로고
    • DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency
    • Cao H., Hegele R.A.: DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency. J. Hum. Genet., 2002; 47: 620-622. (Pubitemid 36083264)
    • (2002) Journal of Human Genetics , vol.47 , Issue.11 , pp. 620-622
    • Cao, H.1    Hegele, R.A.2
  • 7
    • 0242321228 scopus 로고    scopus 로고
    • Identification of single nucleotide polymorphisms in the human γ-glutamyl hydrolase gene and characterization of promoter polymorphisms
    • DOI 10.1016/S0378-1119(03)00807-2
    • Chave K.J., Ryan T.J., Chmura S.E., Galivan J.: Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms. Gene, 2003; 13: 167-175. (Pubitemid 37346211)
    • (2003) Gene , vol.319 , Issue.1-2 , pp. 167-175
    • Chave, K.J.1    Ryan, T.J.2    Chmura, S.E.3    Galivan, J.4
  • 9
    • 0036606023 scopus 로고    scopus 로고
    • Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system
    • Chen Z.S., Lee K., Walther S.: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res., 2002; 62: 3144-3150. (Pubitemid 34602407)
    • (2002) Cancer Research , vol.62 , Issue.11 , pp. 3144-3150
    • Chen, Z.-S.1    Lee, K.2    Walther, S.3    Raftogianis, R.B.4    Kuwano, M.5    Zeng, H.6    Kruh, G.D.7
  • 11
    • 4143124340 scopus 로고    scopus 로고
    • A substrate specific functional polymorphism of human γ-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells
    • DOI 10.1097/01.fpc.0000114761.78957.7e
    • Cheng Q., Wu B., Kager L., Panetta J.C., Zheng J., Pui C.H., Relling M.V., Evans W.E.: A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells. Pharmacogenetics, 2004; 14: 557-567. (Pubitemid 39100007)
    • (2004) Pharmacogenetics , vol.14 , Issue.8 , pp. 557-567
    • Cheng, Q.1    Wu, B.2    Kager, L.3    Panetta, J.C.4    Zheng, J.5    Pui, C.-H.6    Relling, M.V.7    Evans, W.E.8
  • 13
    • 0035360869 scopus 로고    scopus 로고
    • Effects of overexpression of γ-glutamyl hydrolase on methotrexate metabolism and resistance
    • Cole P.D., Kamen B.A., Gorlick R., Banerjee D., Smith A.K., Magill E., Bertino J.R.: Effects of overexpression of gamma-glutamyl hydrolase on methotrexate metabolism and resistance. Cancer Res., 2001; 61: 4599-4604. (Pubitemid 32685795)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4599-4604
    • Cole, P.D.1    Kamen, B.A.2    Gorlick, R.3    Banerjee, D.4    Smith, A.K.5    Magill, E.6    Bertino, J.R.7
  • 14
    • 22944470530 scopus 로고    scopus 로고
    • Low-dose methotrexate: A mainstay in the treatment of rheumatoid arthritis
    • DOI 10.1124/pr.57.2.3
    • Cronstein B.N.: Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol. Rev., 2005; 57: 163-172. (Pubitemid 41043882)
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 163-172
    • Cronstein, B.N.1
  • 15
    • 23444443994 scopus 로고    scopus 로고
    • Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: Results of a multicentred cross sectional observational study
    • DOI 10.1136/ard.2004.033399
    • Dervieux T., Furst D., Lein D.O.: Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study. Ann. Rheum. Dis., 2005; 64: 1180-1185. (Pubitemid 41113353)
    • (2005) Annals of the Rheumatic Diseases , vol.64 , Issue.8 , pp. 1180-1185
    • Dervieux, T.1    Furst, D.2    Lein, D.O.3    Capps, R.4    Smith, K.5    Caldwell, J.6    Kremer, J.7
  • 16
    • 4444376725 scopus 로고    scopus 로고
    • Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
    • DOI 10.1002/art.20460
    • Dervieux T., Furst D., Lein D.O., Capps R., Smith K., Walsh M., Kremer J.: Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum., 2004; 50: 2766-2774. (Pubitemid 39209513)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.9 , pp. 2766-2774
    • Dervieux, T.1    Furst, D.2    Lein, D.O.3    Capps, R.4    Smith, K.5    Walsh, M.6    Kremer, J.7
  • 17
    • 33750352061 scopus 로고    scopus 로고
    • Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis
    • DOI 10.1002/art.22129
    • Dervieux T., Greenstein N., Kremer J.: Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis. Arthritis Rheum., 2006; 54: 3095-3103. (Pubitemid 44622078)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.10 , pp. 3095-3103
    • Dervieux, T.1    Greenstein, N.2    Kremer, J.3
  • 18
    • 9244264949 scopus 로고    scopus 로고
    • Contribution of common polymorphisms in reduced folate carrier and γ-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis
    • DOI 10.1097/00008571-200411000-00004
    • Dervieux T., Kremer J., Lein D.O., Capps R., Barham R., Meyer G., Smith K., Caldwell J., Furst D.E.: Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis. Pharmacogenetics, 2004; 14: 733-739. (Pubitemid 39552788)
    • (2004) Pharmacogenetics , vol.14 , Issue.11 , pp. 733-739
    • Dervieux, T.1    Kremer, J.2    Lein, D.O.3    Capps, R.4    Barham, R.5    Meyer, G.6    Smith, K.7    Caldwell, J.8    Furst, D.E.9
  • 19
    • 36649028325 scopus 로고    scopus 로고
    • Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis
    • DOI 10.1038/sj.tpj.6500438, PII 6500438
    • Drozdzik M., Rudas T., Pawlik A., Gornik W., Kurzawski M., Herczynska M.: Reduced folate carrier-1 80G>A polymorphism affects methotrexate treatment outcome in rheumatoid arthritis. Pharmacogenomics J., 2007; 7: 404-407. (Pubitemid 350192886)
    • (2007) Pharmacogenomics Journal , vol.7 , Issue.6 , pp. 404-407
    • Drozdzik, M.1    Rudas, T.2    Pawlik, A.3    Gornik, W.4    Kurzawski, M.5    Herczynska, M.6
  • 20
    • 0030756226 scopus 로고    scopus 로고
    • Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: Mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity
    • Galpin A.J., Schuetz J.D., Masson E., Yanishevski Y., Synold T.W., Barredo J.C., Pui C.H., Relling M.V., Evans W.E.: Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity. Mol. Pharmacol., 1997; 52: 155-163. (Pubitemid 27318631)
    • (1997) Molecular Pharmacology , vol.52 , Issue.1 , pp. 155-163
    • Galpin, A.J.1    Schuetz, J.D.2    Masson, E.3    Yanishevski, Y.4    Synold, T.W.5    Barredo, J.C.6    Pui, C.-H.7    Relling, M.V.8    Evans, W.E.9
  • 21
    • 43249121301 scopus 로고    scopus 로고
    • Are thymidylate synthase and methylene tetrahydrofolate reductase genes linked with methotrexate response (efficacy, toxicity) in Indian (Asian) rheumatoid arthritis patients?
    • Ghodke Y., Chopra A., Joshi K., Patwardhan B.: Are thymidylate synthase and methylene tetrahydrofolate reductase genes linked with methotrexate response (efficacy, toxicity) in Indian (Asian) rheumatoid arthritis patients? Clin. Rheumatol., 2008; 27: 787-789.
    • (2008) Clin. Rheumatol. , vol.27 , pp. 787-789
    • Ghodke, Y.1    Chopra, A.2    Joshi, K.3    Patwardhan, B.4
  • 22
    • 0034771885 scopus 로고    scopus 로고
    • A novel single-nucleotide polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene with enhanced expression
    • Goto Y., Yue L., Yokoi A., Uehara T., Koizumi S., Saikawa Y.: A novel single-nucleotide polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene with enhanced expression. Clin. Cancer Res., 2001; 7: 1952-1956. (Pubitemid 32994830)
    • (2001) Clinical Cancer Research , vol.7 , Issue.7 , pp. 1952-1956
    • Goto, Y.1    Yue, L.2    Yokoi, A.3    Nishimura, R.4    Uehara, T.5    Koizumi, S.6    Saikawa, Y.7
  • 23
    • 34548706595 scopus 로고    scopus 로고
    • G>C SNP of thymidylate synthase with respect to colorectal cancer
    • DOI 10.2217/14622416.8.8.985
    • Gusella M., Padrini R.: G>C SNP of thymidylate synthase with respect to colorectal cancer. Pharmacogenomics, 2007; 8: 985-996. (Pubitemid 47423688)
    • (2007) Pharmacogenomics , vol.8 , Issue.8 , pp. 985-996
    • Gusella, M.1    Padrini, R.2
  • 24
    • 34147122766 scopus 로고    scopus 로고
    • Genetic polymorphism of C452T (T127I) in human γ-glutamyl hydrolase in a Japanese population
    • DOI 10.1248/bpb.30.839
    • Hayashi H., Fujimaki C., Inoue K., Suzuki T., Itoh K.: Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population. Biol. Pharm. Bull., 2007; 30: 839-841. (Pubitemid 46571013)
    • (2007) Biological and Pharmaceutical Bulletin , vol.30 , Issue.4 , pp. 839-841
    • Hayashi, H.1    Fujimaki, C.2    Inoue, K.3    Suzuki, T.4    Itoh, K.5
  • 27
    • 34848881538 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms within adenosine receptor A2a are associated with gastrointestinal (GI) adverse events on MTX therapy
    • Hider S.L., Mack L.F., Armstrong D.J., Shadforth M.F., Bruce I.N., Thomson W.: Single nucleotide polymorphisms within adenosine receptor A2a are associated with gastrointestinal (GI) adverse events on MTX therapy. Rheumatology, 2006, 45: i104.
    • (2006) Rheumatology , vol.45
    • Hider, S.L.1    Mack, L.F.2    Armstrong, D.J.3    Shadforth, M.F.4    Bruce, I.N.5    Thomson, W.6
  • 29
    • 0031969348 scopus 로고    scopus 로고
    • Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate- cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defect
    • Hol F.A., van der Put N.M., Geurds M.P., Heil S.G., Trijbels F.J., Harnel B.C., Mariman E.C., Blom H.J.: Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects. Clin. Genet., 1998; 53: 119-125. (Pubitemid 28188213)
    • (1998) Clinical Genetics , vol.53 , Issue.2 , pp. 119-125
    • Hol, F.A.1    Van Der Put, N.M.J.2    Geurds, M.P.A.3    Heil, S.G.4    Trijbels, F.J.M.5    Hamel, B.C.J.6    Mariman, E.C.M.7    Blom, H.J.8
  • 30
    • 33846557901 scopus 로고    scopus 로고
    • Pharmacogentic study of methyleneterahyrofolate reductase and thymidylate synthase in Japanese and assessment of ethnic and gender differences
    • DOI 10.2217/14622416.8.1.41
    • Inoue S., Hashiguchi M., Chiyoda T., Sunami Y., Tanaka T., Mochizuki M.: Pharmacogenetic study of methylenetetrahydrofolate reductase and thymidylate synthase in Japanese and assessment of ethnic and gender differences. Pharmacogenomics, 2007; 8: 41-47. (Pubitemid 46157756)
    • (2007) Pharmacogenomics , vol.8 , Issue.1 , pp. 41-47
    • Inoue, S.1    Hashiguchi, M.2    Chiyoda, T.3    Sunami, Y.4    Tanaka, T.5    Mochizuki, M.6
  • 31
    • 41849093365 scopus 로고    scopus 로고
    • Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis
    • James H.M., Gillis D., Hissaria P., Lester S., Somogyi A.A., Cleland L.G., Proudman S.M.: Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis. J. Rheumatol., 2008; 35: 562-571. (Pubitemid 351500050)
    • (2008) Journal of Rheumatology , vol.35 , Issue.4 , pp. 562-571
    • James, H.M.1    Gillis, D.2    Hissaria, P.3    Lester, S.4    Somogyi, A.A.5    Cleland, L.G.6    Proudman, S.M.7
  • 32
    • 0141507954 scopus 로고    scopus 로고
    • Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene
    • Kawakami K., Watanabe G.: Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res., 2003; 15: 6004-6007. (Pubitemid 37187503)
    • (2003) Cancer Research , vol.63 , Issue.18 , pp. 6004-6007
    • Kawakami, K.1    Watanabe, G.2
  • 33
    • 49949114320 scopus 로고    scopus 로고
    • MTHFD1 gene: Role in disease susceptibility and pharmacogenetics
    • Krajinovic M.: MTHFD1 gene: role in disease susceptibility and pharmacogenetics. Pharmacogenomics, 2008; 9: 829-832.
    • (2008) Pharmacogenomics , vol.9 , pp. 829-832
    • Krajinovic, M.1
  • 34
    • 1342268390 scopus 로고    scopus 로고
    • Role of polymorphism in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia
    • DOI 10.1038/sj.tpj.6500224
    • Krajinovic M., Lemieux-Blanchard E., Chiasson S., Primeau M., Costea I., Moghrabi A.: Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia. Pharmacogenomics J., 2004; 4: 66-72. (Pubitemid 38256607)
    • (2004) Pharmacogenomics Journal , vol.4 , Issue.1 , pp. 66-72
    • Krajinovic, M.1    Lemieux-Blanchard, E.2    Chiasson, S.3    Primeau, M.4    Costea, I.5    Moghrabi, A.6
  • 35
    • 0642286407 scopus 로고    scopus 로고
    • Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis
    • Kumagai K., Hiyama K., Oyama T., Maeda H., Kohno N.: Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis. Int. J. Mol. Med., 2003; 11: 593-600.
    • (2003) Int. J. Mol. Med. , vol.11 , pp. 593-600
    • Kumagai, K.1    Hiyama, K.2    Oyama, T.3    Maeda, H.4    Kohno, N.5
  • 36
    • 0037110469 scopus 로고    scopus 로고
    • 80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia
    • DOI 10.1182/blood.V100.10.3832
    • Laverdiere C., Chiasson S., Costea I., Moghrabi A., Krajinovic M.: Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia. Blood, 2002; 100: 3832-3834. (Pubitemid 35303961)
    • (2002) Blood , vol.100 , Issue.10 , pp. 3832-3834
    • Laverdiere, C.1    Chiasson, S.2    Costea, I.3    Moghrabi, A.4    Krajinovic, M.5
  • 37
    • 0027378870 scopus 로고
    • Increased activity of γ-glutamyl hydrolase in human sarcoma cell lines: A novel mechanism of intrinsic resistance to methotrexate (MTX)
    • Li W.W., Waltham M., Tong W., Schweitzer B.I., Bertino J.R.: Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX). Adv. Exp. Med. Biol., 1993; 338: 635-638. (Pubitemid 23340667)
    • (1993) Advances in Experimental Medicine and Biology , vol.338 , pp. 635-638
    • Wei Wei Li1    Waltham, M.2    Tong, W.3    Schweitzer, B.I.4    Bertino, J.R.5
  • 38
    • 0030831351 scopus 로고    scopus 로고
    • Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells
    • Longo G.S., Gorlick R., Tong W.P., Ercikan E., Bertino J.R.: Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells. Blood, 1997; 90: 1241-1245. (Pubitemid 27314162)
    • (1997) Blood , vol.90 , Issue.3 , pp. 1241-1245
    • Longo, G.S.A.1    Gorlick, R.2    Tong, W.P.3    Ercikan, E.4    Bertino, J.R.5
  • 39
    • 0036102129 scopus 로고    scopus 로고
    • Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles
    • DOI 10.1023/A:1014589105977
    • Luo H.R., Lü X.M., Yao Y.G., Horie N., Takeishi K., Jorde L.B., Zhang Y.P.: Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles. Biochem. Genet., 2002; 40: 41-51. (Pubitemid 34407095)
    • (2002) Biochemical Genetics , vol.40 , Issue.1-2 , pp. 41-51
    • Luo, H.-R.1    Lu, X.-M.2    Yao, Y.-G.3    Horie, N.4    Takeishi, K.5    Jorde, L.B.6    Zhang, Y.-P.7
  • 40
    • 31544462629 scopus 로고    scopus 로고
    • Thymidylate synthase pharmacogenetics
    • DOI 10.1007/s10637-005-4021-7, Recent Advances in Pharmacogenetic Approaches to Cancer Chemotherapy
    • Marsh S.: Thymidylate synthase pharmacogenetics. Invest. New Drugs, 2005; 23: 533-537. (Pubitemid 43162472)
    • (2005) Investigational New Drugs , vol.23 , Issue.6 , pp. 533-537
    • Marsh, S.1
  • 41
    • 0035430487 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
    • Marsh S., McKay J.A., Cassidy J., McLeod H.L.: Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int. J. Oncol., 2001; 19: 383-386.
    • (2001) Int. J. Oncol. , vol.19 , pp. 383-386
    • Marsh, S.1    McKay, J.A.2    Cassidy, J.3    McLeod, H.L.4
  • 42
    • 6344278272 scopus 로고    scopus 로고
    • Associations between polymorphisms in the thymidylate synthase gene, the expression of thymidylate synthase mRNA and the microsatellite instability phenotype of colorectal cancer
    • Merkelbach-Bruse S., Hans V., Mathiak M., Sanguedolce R., Alessandro R., Rüschoff J., Büttner R., Houshdaran F., Gullotti L.: Associations between polymorphisms in the thymidylate synthase gene, the expression of thymidylate synthase mRNA and the microsatellite instability phenotype of colorectal cancer. Oncol. Rep., 2004; 11: 839-843.
    • (2004) Oncol. Rep. , vol.11 , pp. 839-843
    • Merkelbach-Bruse, S.1    Hans, V.2    Mathiak, M.3    Sanguedolce, R.4    Alessandro, R.5    Rüschoff, J.6    Büttner, R.7    Houshdaran, F.8    Gullotti, L.9
  • 43
    • 34248524004 scopus 로고    scopus 로고
    • The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: Findings in a study of ecto-5'-nucleotidase gene-deficient mice
    • DOI 10.1002/art.22643
    • Montesinos M.C., Takedachi M., Thompson L.F., Wilder T.F., Fernández P., Cronstein B.N.: The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5'-nucleotidase: findings in a study of ec-to-5'-nucleotidase gene-deficient mice. Arthritis Rheum., 2007; 56: 1440-1445. (Pubitemid 46764071)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.5 , pp. 1440-1445
    • Montesinos, M.C.1    Takedachi, M.2    Thompson, L.F.3    Wilder, T.F.4    Fernandez, P.5    Cronstein, B.N.6
  • 44
    • 0033509413 scopus 로고    scopus 로고
    • Selective expression of folate receptor β and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis
    • DOI 10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L
    • Nakashima-Matsushita N., Homma T., Yu S., Matsuda T., Sunahara N., Nakamura T., Tsukano M., Ratnam M., Matsuyama T.: Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum., 1999; 42: 1609-1616. (Pubitemid 30263627)
    • (1999) Arthritis and Rheumatism , vol.42 , Issue.8 , pp. 1609-1616
    • Nakashima-Matsushita, N.1    Homma, T.2    Yu, S.3    Matsuda, T.4    Sunahara, N.5    Nakamura, T.6    Tsukano, M.7    Ratnam, M.8    Matsuyama, T.9
  • 45
    • 0035992440 scopus 로고    scopus 로고
    • Methotrexate intracellular disposition in acute lymphoblastic leukemia: A mathematical model of γ-glutamyl hydrolase activity
    • Panetta J.C., Wall A., Pui C.H., Relling M.V., Evans W.E.: Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of gamma-glutamyl hydrolase activity. Clin. Cancer Res., 2002; 8: 2423-2429. (Pubitemid 34753618)
    • (2002) Clinical Cancer Research , vol.8 , Issue.7 , pp. 2423-2429
    • Panetta, J.C.1    Wall, A.2    Pui, C.-H.3    Relling, M.V.4    Evans, W.E.5
  • 46
    • 28844432455 scopus 로고    scopus 로고
    • Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone
    • DOI 10.1016/j.ejphar.2005.10.068, PII S0014299905010794
    • Pawlik A., Baskiewicz-Masiuk M., Machalinski B., Kurzawski M., Gawronska-Szklarz B.: Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and de-xamethasone. Eur. J. Pharmacol., 2005, 28: 27-36. (Pubitemid 41773648)
    • (2005) European Journal of Pharmacology , vol.528 , Issue.1-3 , pp. 27-36
    • Pawlik, A.1    Baskiewicz-Masiuk, M.2    Machalinski, B.3    Kurzawski, M.4    Gawronska-Szklarz, B.5
  • 48
    • 0027222801 scopus 로고
    • Acquisition of resistance to antifolates caused by enhanced γ-glutamyl hydrolase activity
    • Rhee M.S., Wang Y., Nair M.G., Galivan J.: Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity. Cancer Res., 1993; 15: 2227-2230. (Pubitemid 23156804)
    • (1993) Cancer Research , vol.53 , Issue.10 , pp. 2227-2230
    • Rhee, M.S.1    Wang, Y.2    Nair, M.G.3    Galivan, J.4
  • 49
    • 0036844903 scopus 로고    scopus 로고
    • Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines
    • DOI 10.1042/BJ20020801
    • Rothem L., Ifergan I., Kaufman Y., Priest D.G., Jansen G., Assaraf Y.G.: Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines. Biochem. J., 2002; 367: 741-750. (Pubitemid 35305713)
    • (2002) Biochemical Journal , vol.367 , Issue.3 , pp. 741-750
    • Rothem, L.1    Ifergan, I.2    Kaufman, Y.3    Priest, D.G.4    Jansen, G.5    Assaraf, Y.G.6
  • 50
    • 0033104709 scopus 로고    scopus 로고
    • Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia
    • Rots M.G., Pieters R., Peters G.J., Noordhuis P., van Zantwijk C.H., Kaspers G.J., Hählen K., Creutzig U., Veerman A.J., Jansen G.: Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia. Blood, 1999; 93: 1677-1683. (Pubitemid 29102496)
    • (1999) Blood , vol.93 , Issue.5 , pp. 1677-1683
    • Rots, M.G.1    Pieters, R.2    Peters, G.J.3    Noordhuis, P.4    Van Zantwijk, C.H.5    Kaspers, G.J.L.6    Hahlen, K.7    Creutzig, U.8    Veerman, A.J.P.9    Jansen, G.10
  • 52
    • 33750082401 scopus 로고    scopus 로고
    • Gamma-glutamyl hydrolase and drug resistance
    • DOI 10.1016/j.cca.2006.05.044, PII S0009898106003755
    • Schneider E., Ryan T.J.: Gamma-glutamyl hydrolase and drug resistance. Clin. Chim. Acta, 2006; 374: 25-32. (Pubitemid 44574494)
    • (2006) Clinica Chimica Acta , vol.374 , Issue.1-2 , pp. 25-32
    • Schneider, E.1    Ryan, T.J.2
  • 54
    • 33751401805 scopus 로고    scopus 로고
    • The use of low dose methotrexate in rheumatoid arthritis-are we entering a new era of therapeutic drug monitoring and pharmacogenomics?
    • DOI 10.1016/j.biopha.2006.09.007, PII S0753332206002927
    • Stamp L., Roberts R., Kennedy M., Barclay M., O'Donnell J., Chapman P.: The use of low dose methotrexate in rheumatoid arthritis - are we entering a new era of therapeutic drug monitoring and pharmacogenomics? Biomed. Pharmacother., 2006; 60: 678-687. (Pubitemid 44821708)
    • (2006) Biomedicine and Pharmacotherapy , vol.60 , Issue.10 , pp. 678-687
    • Stamp, L.1    Roberts, R.2    Kennedy, M.3    Barclay, M.4    O'Donnell, J.5    Chapman, P.6
  • 55
    • 0346035928 scopus 로고    scopus 로고
    • Expression of folylpolyglutamyl synthetase predicts poor response to methotrexate therapy in patients with rheumatoid arthritis
    • Stranzl T., Wolf J., Leeb B.F., Smolen J.S., Pirker R., Filipits M.: Expression of folylpolyglutamyl synthetase predicts poor response to methotrexate therapy in patients with rheumatoid arthritis. Clin. Exp. Rheumatol., 2003; 2: 27-32. (Pubitemid 36267528)
    • (2003) Clinical and Experimental Rheumatology , vol.21 , Issue.1 , pp. 27-32
    • Stranzl, T.1    Wolf, J.2    Leeb, B.F.3    Smolen, J.S.4    Pirker, R.5    Filipits, M.6
  • 56
    • 79958848333 scopus 로고    scopus 로고
    • Is toxicity of methotrexate in rheumatoid arthritis associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes?
    • Świerkot J., Ślezak R., Karpinski P., Pawlowska J., Noga L.: Is toxicity of methotrexate in rheumatoid arthritis associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes? Ann. Rheum. Dis., 2009; 68(Suppl. 3): 588.
    • (2009) Ann. Rheum. Dis. , vol.68 , Issue.SUPPL. 3 , pp. 588
    • Świerkot, J.1    Ślezak, R.2    Karpinski, P.3    Pawlowska, J.4    Noga, L.5
  • 58
    • 0036765747 scopus 로고    scopus 로고
    • Thymidylate synthase: A novel genetic determinant of plasma homocysteine and folate levels
    • DOI 10.1007/s00439-002-0779-2
    • Trinh B.N., Ong C.N., Coetzee G.A., Yu M.C., Laird P.W.: Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels. Hum. Genet., 2002; 111: 299-302. (Pubitemid 36075054)
    • (2002) Human Genetics , vol.111 , Issue.3 , pp. 299-302
    • Trinh, B.N.1    Ong, C.-N.2    Coetzee, G.A.3    Yu, M.C.4    Laird, P.W.5
  • 59
    • 0034518362 scopus 로고    scopus 로고
    • Searching expressed sequence tag databases: Discovery and confirmation of a common polymorphism in the thymidylate synthase gene
    • Ulrich C.M., Bigler J., Velicer C.M., Greene E.A., Farin F.M., Potter J.D.: Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol. Biomarkers Prev., 2000; 9: 1381-1385. (Pubitemid 32044809)
    • (2000) Cancer Epidemiology Biomarkers and Prevention , vol.9 , Issue.12 , pp. 1381-1385
    • Ulrich, C.M.1    Bigler, J.2    Velicer, C.M.3    Greene, E.A.4    Farin, F.M.5    Potter, J.D.6
  • 60
    • 33847075831 scopus 로고    scopus 로고
    • Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients
    • van der Straaten R., Wessels J.A., de Vries-Bouwstra J.K.: Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients. Pharmacogenomics, 2007; 8: 141-150.
    • (2007) Pharmacogenomics , vol.8 , pp. 141-150
    • Van Der Straaten, R.1    Wessels, J.A.2    De Vries-Bouwstra, J.K.3
  • 63
    • 0036732010 scopus 로고    scopus 로고
    • Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance
    • Volk E.L., Farley K.M., Wu Y., Li F., Robey R.W., Schneider E.: Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance. Cancer Res., 2002; 62: 5035-5040. (Pubitemid 34984431)
    • (2002) Cancer Research , vol.62 , Issue.17 , pp. 5035-5040
    • Volk, E.L.1    Farley, K.M.2    Wu, Y.3    Li, F.4    Robey, R.W.5    Schneider, E.6
  • 65
    • 32444436350 scopus 로고    scopus 로고
    • Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis
    • DOI 10.1002/art.21573
    • Weisman M.H., Furst D.E., Park G.S., Kremer J.M., Smith K.M., Wallace D.J., Caldwell J.R., Dervieux T.: Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis. Arthritis Rheum., 2006; 54: 607-612. (Pubitemid 43228638)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.2 , pp. 607-612
    • Weisman, M.H.1    Furst, D.E.2    Park, G.S.3    Kremer, J.M.4    Smith, K.M.5    Wallace, D.J.6    Caldwell, J.R.7    Dervieux, T.8
  • 68
    • 0346037346 scopus 로고    scopus 로고
    • The human reduced folate carrier gene is regulated by the AP2 and Sp1 transcription factor families and a functional 61-base pair polymorphism
    • DOI 10.1074/jbc.M208296200
    • Whetstine J.R., Witt T.L., Matherly L.H.: The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism. J. Biol. Chem., 2002; 277: 43873-43880. (Pubitemid 36157810)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.46 , pp. 43873-43880
    • Whetstine, J.R.1    Witt, T.L.2    Matherly, L.H.3
  • 70
    • 47949088019 scopus 로고    scopus 로고
    • Pharmacogenetic study of 5, 10-methylenetetrahydrofolate reductase C677T and thymidylate synthase 3R/2R gene polymorphisms and methotrexate-related toxicity in Chinese Han patients with inflammatory arthritis
    • Zeng Q.Y., Wang Y.K., Xiao Z.Y., Chen S.B.: Pharmacogenetic study of 5, 10-methylenetetrahydrofolate reductase C677T and thymidylate synthase 3R/2R gene polymorphisms and methotrexate-related toxicity in Chinese Han patients with inflammatory arthritis. Ann. Rheum. Dis., 2008; 67: 1193-1194.
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1193-1194
    • Zeng, Q.Y.1    Wang, Y.K.2    Xiao, Z.Y.3    Chen, S.B.4


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