NMR-based metabolomics of mammalian cell and tissue cultures

Journal of Biomolecular NMR

Volumn 49, Issue 3-4, 2011, Pages 195-206

  Aranibar, Nelly ^b   Borys, Michael ^a   Mackin, Nancy A ^a   Ly, Van ^b   Abu Absi, Nicholas ^a   Abu Absi, Susan ^a   Niemitz, Matthias ^c   Schilling, Bernhard ^a   Li, Zheng Jian ^a   Brock, Barry ^b   Russell II, Reb J ^b   Tymiak, Adrienne ^b   Reily, Michael D ^b  

^a BRISTOL MYERS SQUIBB COMPANY   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c Perch Solutions Ltd   (Finland)

Author keywords

Bioprocess; Bioreactor; CHO cell; Liver slice; Metabolomics; NMR

Indexed keywords

AMINO ACID ANALYSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOREACTOR; CARBOHYDRATE ANALYSIS; CELL CULTURE; CITRIC ACID CYCLE; LIVER SLICE; MALE; MAMMAL CELL; METABOLOMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; QUANTUM MECHANICS; RAT; TISSUE CULTURE;

ANIMALS; CHO CELLS; CHOLINE; CITRIC ACID CYCLE; CRICETINAE; CRICETULUS; HISTIDINE; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; QUANTUM THEORY; RECOMBINANT PROTEINS;

CRICETULUS GRISEUS; MAMMALIA;

EID: 79958773294     PISSN: 09252738     EISSN: 15735001     Source Type: Journal    
DOI: 10.1007/s10858-011-9490-8     Document Type: Article

References (31)

1. Adams MA, Chen Z, Landman P, Colmer TD (1999) Simultaneous determination by capillary gas chromatography of organic acids, sugars, and sugar alcohols in plant tissue extracts as their trimethylsilyl derivatives. Anal Biochem 266:77-84 (Pubitemid 29024610)
2. Altamirano C, Illanes A, Becerra S, Cairo JJ, Godia F (2006) Considerations on the lactate consumption by CHO cells in the presence of galactose. J Biotechnol 125:547-556 (Pubitemid 44333124)
3. Bradley SA, Ouyang A, Purdie J, Smitka TA, Wang T, Kaerner A (2010) Fermentanomics: monitoring mammalian cell cultures with NMR spectroscopy. J Am Chem Soc 132:9531-9533
4. Chong WPK, Goh LT, Reddy SG, Yusufi FNK, Lee DY, Wong NSC, Heng CK, Yap MGS, Ho YS (2009) Metabolomics profiling of extracellular metabolites in recombinant Chinese Hamster ovary fed-batch culture. Rapid Commun Mass Spectrom 23:3763-3771
5. Chong WPK, Reddy SG, Yusufi FNK, Lee DY, Wong NSC, Heng CK, Yap MGS, Ho YS (2010) Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II. J Biotechnol 147:116-121
6. Chrysanthopoulos PK, Goudar CT, Klapa MI (2010) Metabolomics for high-resolution monitoring of the cellular physiological state in cell culture engineering. Metab Eng 12:212-222
7. Cuperlovic-Culf M, Barnett DA, Culf AS, Chute I (2010) Cell culture metabolomics: applications and future directions. Drug Discov Tod 15:610-621
8. Dee KU, Shuler ML, Wood HA (1997) Inducing single-cell suspension of BTI-TN5B1-4 insect cells: I. The use of sulfated polyanions to prevent cell aggregation and enhance recombinant protein production. Biotechnol Bioeng 54:191-205
9. Dunn WB, Brown M, Worton SA, Crocker IP, Broadhurst D, Horgan R, Kenny LC, Baker PN, Kell DB, Heazell AEP (2009) Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia. Placenta 30:974-980
10. Frey PA (1996) The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. FASEB J 10:461-470
11. Goldin RD, Ratnayaka ID, Breach CS, Brown IN, Wickramasinghe SN (1996) Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity. J Pathol 179:432-435 (Pubitemid 26276115)
12. Gomez-Lechon MJ, Lahoz A, Gombau L, Castell JV, Donato MT (2010) In Vitro evaluation of potential hepatotoxicity induced by drugs. Curr Pharm Des 16:1963-1977
13. Hu W-S, Aunins JG (1997) Large-scale mammalian cell culture. Curr Opin Biotechnol 8:148-153 (Pubitemid 27154070)
14. Issaq HJ, Van QN, Waybright TJ, Muschik GM, Veenstra TD (2009) Analytical and statistical approaches to metabolomics research. J Sep Sci 32:2183-2199
15. Jellum E, Kvittingen EA, Stokke O (1988) Mass spectrometry in diagnosis of metabolic disorders. Biomed Environ Mass Spectrom 16:57-62 (Pubitemid 18265774)
16. Laatikainen R, Niemitz M, Weber U, Sundelin J, Hassinen T, Vepsäläinen J (1996) General Strategies for total-lineshape-type spectral analysis of NMR spectra using integral-transform iterator. J Magn Reson Ser A 120:1-10 (Pubitemid 126751733)
17. Laskin DL, Pilaro AM (1986) Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver. Toxicol Appl Pharmacol 86:204-215
18. Laskin DL, Pilaro AM, Ji S (1986) Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation. Toxicol Appl Pharmacol 86:216-226
19. Lerche-Langrand C, Toutain HJ (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:221-253
20. Lim Y, Wong NSC, Lee YY, Ku SCY, Wong DCF, Yap MGS (2010) Engineering mammalian cells in bioprocessing - current achievements and future perspectives. Biotechnol Appl Biochem 55:175-189
21. Lindon JC, Nicholson JK, Everett JR (1999) NMR spectroscopy of biofluids. Ann Rep NMR Spect 38:1-88
22. Moore A, Mercer J, Dutina G, Donahue CJ, Bauer KD, Mather JP, Etcheverry T, Ryll T (1997) Effects of temperature shift on cell cycle, apoptosis and nucleotide pools in CHO cell batch cultures. Cytotechnology 23:47-54 (Pubitemid 27141109)
23. Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Review 28 refs. Xenobiotica 29:1181-1189
24. Olinga P, Merema MT, De Jager MH, Derks F, Melgert BN, Moshage H, Slooff MJH, Meijer DKF, Poelstra K, Groothuis GMM (2001) Rat liver slices as a tool to study LPS-induced inflammatory response in the liver. J Hepatol 35:187-194 (Pubitemid 32803473)
25. Pauling L, Robinson AB, Teranishi R, Cary P (1971) Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc Natl Acad Sci USA 68:2374-2376
26. Reily MD, Robosky LC, Manning ML, Butler A, Baker JD, Winters RT (2006) DFTMP, an NMR reagent for assessing the nearneutral pH of biological samples. J Am Chem Soc 128:12360-12361
27. Robertson DG, Reily MD, Baker JD (2007) Metabonomics in pharmaceutical discovery and development. J Proteome Res 6:526-539
28. Sauter H, Lauer M, Fritsch H (1991) Metabolic profiling of plants - a new diagnostic technique. ACS Symp Ser 443:288-299
29. Seagle C, Christie MA, Winnike JH, McClelland RE, Ludlow JW, O'Connell TM, Gamcsik MP, Macdonald JM (2008) Highthroughput nuclear magnetic resonance metabolomic footprinting for tissue engineering. Tissue Eng Part C Methods 14:107-118 (Pubitemid 351838711)
30. Trethewey RN, Krotzky AJ, Willmitzer L (1999) Commentary. Metabolic profiling: a Rosetta stone for genomics? Curr Opin Plant Biol 2:83-85
31. Zanghi JA, Renner WA, Bailey JE, Fussenegger M (2000) The growth factor inhibitor suramin reduces apoptosis and cell aggregation in protein-free CHO cell batch cultures. Biotechnol Prog 16:319-325 (Pubitemid 30368999)