-
1
-
-
0035966870
-
Molecular models of N-Benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-δ
-
DOI 10.1021/jm000289v
-
Roaten JB, Kazanietz MG, Sweatman TW et al (2001) Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-delta. J Med Chem 44:1028-1034 (Pubitemid 32852129)
-
(2001)
Journal of Medicinal Chemistry
, vol.44
, Issue.7
, pp. 1028-1034
-
-
Roaten, J.B.1
Kazanietz, M.G.2
Sweatman, T.W.3
Lothstein, L.4
Israel, M.5
Parrill, A.L.6
-
2
-
-
1842532926
-
Circumvention of Nuclear Factor κB-Induced Chemoresistance by Cytoplasmic-Targeted Anthracyclines
-
DOI 10.1124/mol.65.4.1038
-
Bilyeu JD, Panta GR, Cavin LG et al (2004) Circumvention of nuclear factor kappaB-induced chemoresistance by cytoplasmic-targeted anthracyclines. Mol Pharmacol 65:1038-1047 (Pubitemid 38420510)
-
(2004)
Molecular Pharmacology
, vol.65
, Issue.4
, pp. 1038-1047
-
-
Bilyeu, J.D.1
Panta, G.R.2
Cavin, L.G.3
Barrett, C.M.4
Turner, E.J.5
Sweatman, T.W.6
Israel, M.7
Lothstein, L.8
Arsura, M.9
-
3
-
-
0036561858
-
Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: Structural requirements, isoform specificity, and correlation with drug cytotoxicity
-
Roaten JB, Kazanietz MG, Caloca MJ et al (2002) Interaction of the novel anthracycline antitumor agent N-benzyladriamycin-14-valerate with the C1-regulatory domain of protein kinase C: structural requirements, isoform specificity, and correlation with drug cytotoxicity. Mol Cancer Ther 1:483-492
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 483-492
-
-
Roaten, J.B.1
Kazanietz, M.G.2
Caloca, M.J.3
-
4
-
-
0031936753
-
Cytotoxicity and intracellular biotransformation of N-benzyladriamycin- 14-valerate (AD 198) are modulated by changes in 14-O-acyl chain length
-
DOI 10.1097/00001813-199801000-00007
-
Lothstein L, Rodrigues PJ, Sweatman TW et al (1998) Cytotoxicity and intracellular biotransformation of N-benzyladriamycin-14-valerate (AD 198) are modulated by changes in 14-O-acyl chain length. Anticancer Drugs 9:58-66 (Pubitemid 28088180)
-
(1998)
Anti-Cancer Drugs
, vol.9
, Issue.1
, pp. 58-66
-
-
Lothstein, L.1
Rodrigues, P.J.2
Sweatman, T.W.3
Israel, M.4
-
5
-
-
0028082161
-
Protein kinase C - A question of specificity
-
DOI 10.1016/0968-0004(94)90038-8
-
Dekker LV, Parker PJ (1994) Protein kinase C - a question of specificity. Trends Biochem Sci 19:73-77 (Pubitemid 24055564)
-
(1994)
Trends in Biochemical Sciences
, vol.19
, Issue.2
, pp. 73-77
-
-
Dekker, L.V.1
Parker, P.J.2
-
6
-
-
33947607017
-
Protein kinase C δ enhances proliferation and survival of murine mammary cells
-
DOI 10.1002/mc.20287
-
Grossoni VC, Falbo KB, Kazanietz MG et al (2007) Protein kinase C delta enhances proliferation and survival of murine mammary cells. Mol Carcinog 46:381-390 (Pubitemid 46744458)
-
(2007)
Molecular Carcinogenesis
, vol.46
, Issue.5
, pp. 381-390
-
-
Grossoni, V.C.1
Falbo, K.B.2
Kazanietz, M.G.3
Bal De Kier Joffe, E.D.4
Urtreger, A.J.5
-
7
-
-
0032104245
-
The extended protein kinase C superfamily
-
Mellor H, Parker PJ (1998) The extended protein kinase C superfamily. Biochem J 332(Pt 2):281-292 (Pubitemid 28271856)
-
(1998)
Biochemical Journal
, vol.332
, Issue.2
, pp. 281-292
-
-
Mellor, H.1
Parker, P.J.2
-
8
-
-
0030987070
-
Regulation of protein kinase C
-
DOI 10.1016/S0955-0674(97)80058-0
-
Newton AC (1997) Regulation of protein kinase C. Curr Opin Cell Biol 9:161-167 (Pubitemid 27135982)
-
(1997)
Current Opinion in Cell Biology
, vol.9
, Issue.2
, pp. 161-167
-
-
Newton, A.C.1
-
9
-
-
0028811653
-
Protein kinase C: Structure, function, and regulation
-
Newton AC (1995) Protein kinase C: structure, function, and regulation. J Biol Chem 270:28495-28498
-
(1995)
J Biol Chem
, vol.270
, pp. 28495-28498
-
-
Newton, A.C.1
-
10
-
-
0037246123
-
Regulation of cell apoptosis by protein kinase c δ
-
DOI 10.1023/A:1021640817208
-
Brodie C, Blumberg PM (2003) Regulation of cell apoptosis by protein kinase c delta. Apoptosis 8:19-27 (Pubitemid 36133134)
-
(2003)
Apoptosis
, vol.8
, Issue.1
, pp. 19-27
-
-
Brodie, C.1
Blumberg, P.M.2
-
11
-
-
0034452416
-
Overexpression of protein kinase C δ represses expression of proliferin in NIH3T3 cells that regulates cell proliferation
-
DOI 10.1006/mcbr.2001.0276
-
Kang Y, Park JS, Kim SH et al (2000) Overexpression of protein kinase C delta represses expression of proliferin in NIH3T3 cells that regulates cell proliferation. Mol Cell Biol Res Commun 4:181-187 (Pubitemid 32298901)
-
(2000)
Molecular Cell Biology Research Communications
, vol.4
, Issue.3
, pp. 181-187
-
-
Kang, Y.1
Park, J.S.2
Kim, S.H.3
Shin, Y.J.4
Kim, W.5
Joo, H.-J.6
Chun, J.-S.7
Kim, H.J.8
Ha, M.J.9
-
12
-
-
0027418816
-
Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
-
Mischak H, Goodnight JA, Kolch W et al (1993) Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 268:6090-6096 (Pubitemid 23099293)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.9
, pp. 6090-6096
-
-
Mischak, H.1
Goodnight, J.2
Kolch, W.3
Martiny-Baron, G.4
Schaechtle, C.5
Kazanietz, M.G.6
Blumberg, P.M.7
Pierce, J.H.8
Mushinski, J.F.9
-
13
-
-
0007543134
-
Differential role of specific PKC isoforms in the proliferation of glial cells and the expression of the astrocytic markers GFAP and glutamine synthetase
-
DOI 10.1016/S0169-328X(98)00035-7, PII S0169328X98000357
-
Brodie C, Kuperstein I, Acs P et al (1998) Differential role of specific PKC isoforms in the proliferation of glial cells and the expression of the astrocytic markers GFAP and glutamine syn-thetase. Brain Res Mol Brain Res 56:108-117 (Pubitemid 28271667)
-
(1998)
Molecular Brain Research
, vol.56
, Issue.1-2
, pp. 108-117
-
-
Brodie, C.1
Kuperstein, I.2
Acs, P.3
Blumberg, P.M.4
-
14
-
-
0031001002
-
Enhancement of migration by protein kinase Cα and inhibition of proliferation and cell cycle progression by protein kinase Cδ in capillary endothelial cells
-
DOI 10.1074/jbc.272.11.7390
-
Harrington EO, Loffler J, Nelson PR et al (1997) Enhancement of migration by protein kinase Calpha and inhibition of proliferation and cell cycle progression by protein kinase Cdelta in capillary endothelial cells. J Biol Chem 272:7390-7397 (Pubitemid 27166450)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.11
, pp. 7390-7397
-
-
Harrington, E.O.1
Loffler, J.2
Nelson, P.R.3
Kent, K.C.4
Simons, M.5
Ware, J.A.6
-
15
-
-
18844380261
-
Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation
-
DOI 10.1007/s10549-004-6456-5
-
Vucenik I, Ramakrishna G, Tantivejkul K et al (2005) Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Res Treat 91:35-45 (Pubitemid 40684937)
-
(2005)
Breast Cancer Research and Treatment
, vol.91
, Issue.1
, pp. 35-45
-
-
Vucenik, I.1
Ramakrishna, G.2
Tantivejkul, K.3
Anderson, L.M.4
Ramljak, D.5
-
16
-
-
0035004512
-
PKC-δ inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells
-
Cerda SR, Bissonnette M, Scaglione-Sewell B et al (2001) PKC-delta inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells. Gastroenterology 120:1700-1712 (Pubitemid 32523488)
-
(2001)
Gastroenterology
, vol.120
, Issue.7
, pp. 1700-1712
-
-
Cerda, S.R.1
Bissonnette, M.2
Scaglione-Sewell, B.3
Lyons, M.R.4
Khare, S.5
Mustafi, R.6
Brasitus, T.A.7
-
17
-
-
0141594871
-
Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway
-
DOI 10.1074/jbc.M303313200
-
Tanaka Y, Gavrielides MV, Mitsuuchi Y et al (2003) Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J Biol Chem 278:33753-33762 (Pubitemid 37553209)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.36
, pp. 33753-33762
-
-
Tanaka, Y.1
Gavrielides, M.V.2
Mitsuuchi, Y.3
Fujii, T.4
Kazanietz, M.G.5
-
18
-
-
0033581954
-
Increased protein kinase C delta in mammary tumor cells: Relationship to transformation and metastatic progression
-
Kiley SC, Clark KJ, Duddy SK et al (1999) Increased protein kinase C delta in mammary tumor cells: relationship to transformation and metastatic progression. Oncogene 18:6748-6757
-
(1999)
Oncogene
, vol.18
, pp. 6748-6757
-
-
Kiley, S.C.1
Clark, K.J.2
Duddy, S.K.3
-
19
-
-
0348231006
-
Protein kinase C delta is a prosurvival factor in human breast tumor cell lines
-
McCracken MA, Miraglia LJ, McKay RA et al (2003) Protein kinase C delta is a prosurvival factor in human breast tumor cell lines. Mol Cancer Ther 2:273-281
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 273-281
-
-
McCracken, M.A.1
Miraglia, L.J.2
McKay, R.A.3
-
20
-
-
0037443030
-
Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCδ promotes cellular survival and chemotherapeutic resistance
-
Clark AS, West KA, Blumberg PM et al (2003) Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. Cancer Res 63:780-786 (Pubitemid 36231976)
-
(2003)
Cancer Research
, vol.63
, Issue.4
, pp. 780-786
-
-
Clark, A.S.1
West, K.A.2
Blumberg, P.M.3
Dennis, P.A.4
-
22
-
-
10344242925
-
Kinase signaling cascades in the mitochondrion: A matter of life or death
-
DOI 10.1016/j.freeradbiomed.2004.09.030, PII S0891584904007567
-
Horbinski C, Chu CT (2005) Kinase signaling cascades in the mitochondrion: a matter of life or death. Free Radic Biol Med 38:2-11 (Pubitemid 39626903)
-
(2005)
Free Radical Biology and Medicine
, vol.38
, Issue.1
, pp. 2-11
-
-
Horbinski, C.1
Chu, C.T.2
-
23
-
-
33845696273
-
BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes
-
Hsieh HL, Wang HH, Wu CY et al (2007) BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes. Cell Signal 19:330-340
-
(2007)
Cell Signal
, vol.19
, pp. 330-340
-
-
Hsieh, H.L.1
Wang, H.H.2
Wu, C.Y.3
-
24
-
-
4444260453
-
PKC-δ and -ε regulate NF-κB activation induced by cholecystokinin and TNF-α in pancreatic acinar cells
-
DOI 10.1152/ajpgi.00087.2004
-
Satoh A, Gukovskaya AS, Nieto JM et al (2004) PKC-delta and-epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 287:G582-G591 (Pubitemid 39096624)
-
(2004)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.287
, Issue.3
-
-
Satoh, A.1
Gukovskaya, A.S.2
Nieto, J.M.3
Cheng, J.H.4
Gukovsky, I.5
Reeve Jr., J.R.6
Shimosegawa, T.7
Pandol, S.J.8
-
25
-
-
67651049300
-
Protein kinase cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha
-
Lu ZG, Liu H, Yamaguchi T et al (2009) Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha. Cancer Res 69:5927-5935
-
(2009)
Cancer Res
, vol.69
, pp. 5927-5935
-
-
Lu, Z.G.1
Liu, H.2
Yamaguchi, T.3
-
26
-
-
63249119308
-
Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
-
Minhajuddin M, Bijli KM, Fazal F et al (2009) Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. J Biol Chem 284:4052-4061
-
(2009)
J Biol Chem
, vol.284
, pp. 4052-4061
-
-
Minhajuddin, M.1
Bijli, K.M.2
Fazal, F.3
-
27
-
-
43749098070
-
NF-kappaB and cancer-identifying targets and mechanisms
-
Naugler WE, Karin M (2008) NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev 18:19-26
-
(2008)
Curr Opin Genet Dev
, vol.18
, pp. 19-26
-
-
Naugler, W.E.1
Karin, M.2
-
28
-
-
0030036566
-
Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a fibroblastic (f) morphotype in culture
-
Van den Broecke C, Vleminckx K, De Bruyne G et al (1996) Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a fibroblastic (f) morphotype in culture. Clin Exp Metastasis 14:282-296 (Pubitemid 26246574)
-
(1996)
Clinical and Experimental Metastasis
, vol.14
, Issue.3
, pp. 282-296
-
-
Van Den Broecke, C.1
Vleminckx, K.2
De Bruyne, G.3
Van Hoorde, L.4
Vakaet, L.5
Van Roy, F.6
Mareel, M.7
-
29
-
-
0041426722
-
Immortalized mammary epithelial cells overexpressing protein kinase C γ acquire a malignant phenotype and become tumorigenic in vivo
-
Mazzoni E, Adam A, Bal de Kier Joffe E et al (2003) Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo. Mol Cancer Res 1:776-787 (Pubitemid 37025596)
-
(2003)
Molecular Cancer Research
, vol.1
, Issue.10
, pp. 776-787
-
-
Mazzoni, E.1
Adam, A.2
De Kier Joffe, E.B.3
Aguirre-Ghiso, J.A.4
-
30
-
-
11144273927
-
Atypical protein kinase C-ζ modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells
-
DOI 10.1002/mc.20066
-
Urtreger AJ, Grossoni VC, Falbo KB et al (2005) Atypical protein kinase C-zeta modulates clonogenicity, motility, and secretion of proteolytic enzymes in murine mammary cells. Mol Carcinog 42:29-39 (Pubitemid 40041483)
-
(2005)
Molecular Carcinogenesis
, vol.42
, Issue.1
, pp. 29-39
-
-
Urtreger, A.J.1
Grossoni, V.C.2
Falbo, K.B.3
Kazanietz, M.G.4
Bal De Kier Joffe, E.D.5
-
31
-
-
0016364219
-
Glandular epithelial cells from mice: A method for selective cultivation
-
Owens RB (1974) Glandular epithelial cells from mice: a method for selective cultivation. J Natl Cancer Inst 52:1375-1378
-
(1974)
J Natl Cancer Inst
, vol.52
, pp. 1375-1378
-
-
Owens, R.B.1
-
32
-
-
1642263353
-
Involvement of protein kinase C-δ in DNA damage-induced apoptosis
-
Basu A (2003) Involvement of protein kinase C-delta in DNA damage-induced apoptosis. J Cell Mol Med 7:341-350 (Pubitemid 44151685)
-
(2003)
Journal of Cellular and Molecular Medicine
, vol.7
, Issue.4
, pp. 341-350
-
-
Basu, A.1
-
33
-
-
33748191247
-
2+ influx
-
PII 0000181320060600000002
-
Lothstein L, Savranskaya L, Barrett CM et al (2006) N-benzy-ladriamycin- 14-valerate (AD 198) activates protein kinase C-delta holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx. Anticancer Drugs 17:495-502 (Pubitemid 44309965)
-
(2006)
Anti-Cancer Drugs
, vol.17
, Issue.5
, pp. 495-502
-
-
Lothstein, L.1
Savranskaya, L.2
Barrett, C.M.3
Israel, M.4
Sweatman, T.W.5
-
34
-
-
33947603008
-
Protein kinase C and other diacylglycerol effectors in cancer
-
DOI 10.1038/nrc2110, PII NRC2110
-
Griner EM, Kazanietz MG (2007) Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer 7:281-294 (Pubitemid 46480971)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.4
, pp. 281-294
-
-
Griner, E.M.1
Kazanietz, M.G.2
-
35
-
-
74049146296
-
PKC delta (PKCd) promotes tumoral progression of human ductal pancreatic cancer
-
Mauro LV, Grossoni VC, Urtreger AJ et al (2010) PKC delta (PKCd) promotes tumoral progression of human ductal pancreatic cancer. Pancreas 39:31-41
-
(2010)
Pancreas
, vol.39
, pp. 31-41
-
-
Mauro, L.V.1
Grossoni, V.C.2
Urtreger, A.J.3
-
36
-
-
0040909283
-
Regulation of caspase activation and cis-diamminedichloroplatinum(II)- induced cell death by protein kinase C
-
DOI 10.1021/bi982854q
-
Basu A, Akkaraju GR (1999) Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C. Biochemistry 38:4245-4251 (Pubitemid 29172183)
-
(1999)
Biochemistry
, vol.38
, Issue.14
, pp. 4245-4251
-
-
Basu, A.1
Akkaraju, G.R.2
-
37
-
-
0142187112
-
1 cells
-
DOI 10.1016/S0009-2797(03)00102-9
-
Gopee NV, He Q, Sharma RP (2003) Fumonisin B1-induced apoptosis is associated with delayed inhibition of protein kinase C, nuclear factor-kappaB and tumor necrosis factor alpha in LLC-PK1 cells. Chem Biol Interact 146:131-145 (Pubitemid 37323877)
-
(2003)
Chemico-Biological Interactions
, vol.146
, Issue.2
, pp. 131-145
-
-
Gopee, N.V.1
He, Q.2
Sharma, R.P.3
-
38
-
-
34948824884
-
Protein kinase C δ inhibits the production of proteolytic enzymes in murine mammary cells
-
DOI 10.1007/s10585-007-9088-4
-
Grossoni VC, Falbo KB, Mauro LV et al (2007) Protein kinase C delta inhibits the production of proteolytic enzymes in murine mammary cells. Clin Exp Metastasis 24:513-520 (Pubitemid 47524809)
-
(2007)
Clinical and Experimental Metastasis
, vol.24
, Issue.7
, pp. 513-520
-
-
Grossoni, V.C.1
Falbo, K.B.2
Mauro, L.V.3
Krasnapolski, M.A.4
Kazanietz, M.G.5
Bal De Kier Joffe, E.D.6
Urtreger, A.J.7
-
39
-
-
0036561332
-
Novel extranu-clear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis
-
Barrett CM, Lewis FL, Roaten JB et al (2002) Novel extranu-clear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis. Mol Cancer Ther 1:469-481
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 469-481
-
-
Barrett, C.M.1
Lewis, F.L.2
Roaten, J.B.3
-
40
-
-
0035190606
-
Anthracycline drug targeting: Cytoplasmic versus nuclear - A fork in the road
-
DOI 10.1054/drup.2001.0201
-
Lothstein L, Israel M Sweatman TW (2001) Anthracycline drug targeting: cytoplasmic versus nuclear - a fork in the road. Drug Resist Updat 4:169-177 (Pubitemid 33089454)
-
(2001)
Drug Resistance Updates
, vol.4
, Issue.3
, pp. 169-177
-
-
Lothstein, L.1
Israel, M.2
Sweatman, T.W.3
|