N-benzyladriamycin-14-valerate (AD 198) activates protein kinase C-δ holoenzyme to trigger mitochondrial depolarization and cytochrome c release independently of permeability transition pore opening and Ca2+ influx

Anti-Cancer Drugs

Volumn 17, Issue 5, 2006, Pages 495-502

  Lothstein, Leonard ^a   Savranskaya, Luydmila ^a   Barrett, Christina M ^a,b   Israel, Mervyn ^a   Sweatman, Trevor W ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b GTx Inc   (United States)

Author keywords

AD 198; Apoptosis; Bcl 2; Mitochondria; Protein kinase C

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALCIUM CHELATING AGENT; CALCIUM ION; CYCLOSPORIN A; CYTOCHROME C; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; N BENZYLDOXORUBICIN 14 VALERATE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; ROTTLERIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; GENETIC TRANSFECTION; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MITOCHONDRION MEMBRANE DEPOLARIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 33748191247     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200606000-00002     Document Type: Article

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