Morphotypic plasticity in vitro and in nude mice of epithelial mouse mammary cells (NMuMG) displaying an epithelioid (e) or a fibroblastic (f) morphotype in culture

Clinical and Experimental Metastasis

Volumn 14, Issue 3, 1996, Pages 282-296

  Van Den Broecke, Caroline ^a   Vleminckx, Kris ^b   De Bruyne, Georges ^a   Van Hoorde, Leen ^a   Vakaet, Luc ^a   Van Roy, Frans ^b   Mareel, Marc ^a,c  

^a University Hospital   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

E cadherin; Invasion; Mammary cancer cells; Metastasis; ras

Indexed keywords

UVOMORULIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BREAST BIOPSY; BREAST CARCINOMA; CANCER INVASION; CELL DIFFERENTIATION; EPITHELIOID CELL; FIBROBLAST; IMMUNOHISTOCHEMISTRY; METASTASIS POTENTIAL; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE RAS; PLASTICITY;

EID: 0030036566     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00053902     Document Type: Article

References (43)

1. Jouanneau J, Tucker GC, Boyer B, Vallés AM and Thiery JP, 1991, Epithelial cell plasticity in neoplasia. Cancer Cells, 3, 525-9.
2. Van Roy F and Mareel M, 1992, Tumour invasion: effects of cell adhesion and motility. Trends Cell Biol, 2, 163-9.
3. Mareel M, Bracke M, Van Roy F and Vakaet L, 1993, Expression of E-cadherin in embryogenetic ingression and cancer invasion. Int J Dev Biol, 37, 227-35.
4. Stoler AB, Stenback F and Balmain A, 1993, The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. J Cell Biol, 122, 1103-17.
5. Borén T, Falk P, Roth KA, Larson G and Normark S, 1993, Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science, 262, 1892-5.
6. Berg JW and Hutter RVP, 1995, Breast cancer. Cancer, 75 (Suppl), 257-69.
7. Sanford KK, Dunn TB, Westfall BB, Covalesky AB, Dupree LT and Earle WR, 1961, Sarcomatous change and maintenance of differentiation in long-term cultures of mouse mammary carcinoma. J Natl Cancer Inst, 26, 1139-83.
8. Dulbecco R, Henahan M, Bowman M, et al, 1981, Generation of fibroblast-like cells from cloned epithelial mammary cells in vitro: a possible new cell type. Proc Natl Acad Sci USA, 78, 2345-9.
9. Warburton MJ, Ferns SA, Hughes CM and Rudland PS, 1985, Characterization of rat mammary cell types in primary culture: lectins and antisera to basement membrane and intermediate filament proteins as indicators of cellular heterogeneity. J Cell Sci, 79, 287-304.
10. Sonnenberg A, Daams H, Calafat J and Hilgers J, 1986, In vitro differentiation and progression of mouse mammary tumor cells. Cancer Res, 46, 5913-22.
11. Vleminckx K, Vakaet L Jr, Mareel M, Fiers W and Van Roy F, 1991, Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 66, 107-19.
12. Nakanishi H, Taylor RM, Chrest FJ, et al. 1995, Progression of hormone-dependent adenocarcinoma cells to hormone-independent spindle carcinoma cells in vitro in a clonal spontaneous rat mammary tumor cell line. Cancer Res, 55, 399-407.
13. Reichmann E, Schwarz H, Deiner EM, et al. 1992, Activation of an inducible c-fosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell, 71, 1103-16.
14. Marcel MM, De Bruyne GK, Sonnenberg A and Hilgers J, 1986, Experimental results on invasiveness of mouse mammary cells: clinical implications? In: Hollmann KH and Verley JM, eds. New Frontiers in Mammary Pathology. Martinus Nijhoff Publishers, Boston, pp. 351-62.
15. Owens RB, Smith HS and Hackett AJ, 1974, Epithelial cell cultures from normal glandular tissue of mice. J Natl Cancer Inst, 53, 261-9.
16. Schaeffer WI, 1983, Usage of vertebrate, invertebrate and plant cell, tissue and organ culture terminology. TCA Report. 17, 19-23.
17. Vandenbossche GMR, De Bruyne GK, Bruyneel EA, et al 1994, Microencapsulation of MDCK-ras-e cells prevents loss of the E-cadherin invasion suppressor function in vivo. Int J Cancer, 57, 73-80.
18. Mareel MM, Van Roy FM, Messiaen LM, Boghaert ER and Bruyneel EA, 1987, Qualitative and quantitative analysis of tumour invasion in vivo and in vitro. J Cell Sci Suppl, 8, 141-63.
19. Mareel MM, Van Roy FM and Bracke ME, 1993, How and when do tumor cells metastasize? Crit Rev Oncogenesis, 4, 559-94.
20. Mareel MM, Behrens J, Birchmeier W, et al. 1991, Downregulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside nude mice tumors. Int J Cancer, 47, 922-8.
21. Van Roy FM, Messiaen L, Liebaut G, et al. 1986, Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes. Cancer Res, 46, 4787-95.
22. Van Muyen GNP, Ruiter DJ, Franke WW, et al. 1986, Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13. Exp Cell Res, 162, 97-113.
23. Mareel M, Kint J and Meyvisch C, 1979, Methods of study of the invasion of malignant C3H mouse fibroblasts into embryonic chick heart in vitro. Virchows Arch B Cell Pathol, 30, 95-111.
24. Mareel MM, De Bruyne GK, Vandesande F and Dragonetti C, 1981, Immunohistochemical study of embryonic chick heart invaded by malignant cells in three-dimensional culture. Inv Metastasis, 1, 195-204.
25. Bracke ME, Van Cauwenberge RM-L and Mareel MM, 1984, (+)-Catechin inhibits the invasion of malignant fibrosarcoma cells into chick heart in vitro. Clin Exp Metastasis, 2, 161-70.
26. Mareel M, Coopman P, Dragonetti C, et al. 1988, Spontaneous and oncogene-mediated acquisition of the invasive phenotype by cells in culture. In: Nicolson G and Fidler I, eds. UCLA Symposium on Molecular and Cellular Biology, Tumor Progression and Metastasis. 78, 179-88.
27. Frith CH and Ward JM, 1988, Color Atlas of Neoplastic and Non-neoplastic Lesions in Aging Mice. Elsevier Science Publishers BV, Amsterdam.
28. Mareel M, Bracke M, Bruyneel E, Van Larebeke N, Bourgois L and De Mets M, 1990, Assays in vitro and in vivo for invasion and metastasis: application to drug testing. In: Etiévant C, Cros J, Rustum YM, eds. New Concepts in Cancer Metastasis, Oncogenes and Growth Factors. P Fabre Monograph Series, Vol 3. McMillan Press Ltd, pp. 148-65.
29. David G and Bernfield M, 1982, Defective basal lamina formation by transformed mammary epithelial cells: a reduced effect of collagen on basal lamina (heparan sulfate-rich) proteoglycan degradation. J Cell Physiol, 110, 56-62.
30. David G and Van den Berghe H, 1985, Heparan sulfate-chondroitin sulfate hybrid proteoglycan of the cell surface and basement membrane of mouse mammary epithelial cells. J Biol Chem. 260, 11067-74.
31. Dulbecco R, Armstrong B and Allen R, 1988, Reversion toward an earlier stage of differentiation and loss of polarity during progression of N-methyl-N-nitrosourea-induced rat mammary tumors. Proc Natl Acad Sci USA, 85, 9292-6.
32. Gabbert HE, Meier S, Gerharz CD and Hommel G, 1992, Tumor-cell dissociation at the invasion front: a new prognostic parameter in gastric cancer patients, Int J Cancer, 50, 202-7.
33. Mareel M, Van Roy F and De Baetselier P, 1990, The invasive phenotypes. Cancer Metastasis Rev, 9, 45-62.
34. Mareel MM, De Baetselier P and Van Roy FM, 1991, Mechanisms of Invasion and Metastasis. CRC Press, Boca Raton, Ann Arbor, Boston. ISBN 0-8493-6254-7.
35. David G, Van der Schueren B and Bernfield M, 1981, Basal lamina formation by normal and transformed mouse mammary epithelial cells duplicated in vitro. J Natl Cancer Inst. 61, 719-28.
36. Mareel M, Bracke M and Van Roy F, 1994, Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin. Mol Biol Rep, 19, 45-67.
37. Behrens J, Frixen U, Schipper J, Weidner M and Birchmeier W, 1992, Cell adhesion in invasion and metastasis. Semin Cell Biol, 3, 169-78.
38. Takeichi M, 1991, Cadherin cell adhesion receptors as a morphogenetic regulator. Science, 251, 1451-5.
39. Vleminckx KL, Deman JJ, Bruyneel EA, et al. 1994, Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells. Cancer Res, 54, 873-7.
40. Oka H, Shiozaki H, Kobayashi K, et al. 1993, Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res, 53, 1696-701.
41. Becker KF, Atkinson MJ, Reich U, et al. 1993, Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. Hum Mol Genet, 2, 803-4.
42. Geiger B, Volberg T, Ginsberg D, Bitzur S and Sabanay I, 1990, Broad spectrum pan-cadherin antibodies, reactive with the c-terminal 24 amino acid residues of N-cadherin. J Cell Sci, 97, 607-14.
43. Hynes NE, Jaggi R, Kozma SC, et al. 1985, New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line. Mol Cell Biol, 5, 268-72.