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Volumn 8, Issue 3, 2011, Pages 635-641

The suppressive tumor microenvironment: A challenge in cancer immunotherapy

Author keywords

immunotherapy; myeloid derived suppressor cells (MDSC); T regulatory cells (Tregs); Therapeutic vaccine; tumor associated macrophages (TAMs)

Indexed keywords

DACLIZUMAB; TRANSCRIPTION FACTOR FOXP3;

EID: 79958293766     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp1004228     Document Type: Review
Times cited : (158)

References (72)
  • 1
    • 33746012881 scopus 로고    scopus 로고
    • Placebo-controlled phase III trial of immunologic therapy with Sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer
    • DOI 10.1200/JCO.2005.04.5252
    • Small, E. J.; Schellhammer, P. F.; Higano, C. S.; Redfern, C. H.; Nemunaitis, J. J.; Valone, F. H.; Verjee, S. S.; Jones, L. A.; Hershberg, R. M. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer J. Clin. Oncol. 2006, 24, 3089-3094 (Pubitemid 46638945)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.19 , pp. 3089-3094
    • Small, E.J.1    Schellhammer, P.F.2    Higano, C.S.3    Redfern, C.H.4    Nemunaitis, J.J.5    Valone, F.H.6    Verjee, S.S.7    Jones, L.A.8    Hershberg, R.M.9
  • 3
    • 78650239955 scopus 로고    scopus 로고
    • Regulation of the activity of an adeno-associated virus vector cancer vaccine administered with synthetic Toll-like receptor agonists
    • Triozzi, P. L.; Aldrich, W.; Ponnazhagan, S. Regulation of the activity of an adeno-associated virus vector cancer vaccine administered with synthetic Toll-like receptor agonists Vaccine 2010, 28, 7837-7843
    • (2010) Vaccine , vol.28 , pp. 7837-7843
    • Triozzi, P.L.1    Aldrich, W.2    Ponnazhagan, S.3
  • 4
    • 78149422805 scopus 로고    scopus 로고
    • Immunotherapy of MHC class I-deficient tumors
    • Reinis, M. Immunotherapy of MHC class I-deficient tumors Future Oncol. 2010, 6, 1577-1589
    • (2010) Future Oncol. , vol.6 , pp. 1577-1589
    • Reinis, M.1
  • 5
    • 79952575635 scopus 로고    scopus 로고
    • Decoy receptor 3: A pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer
    • Lin, W. W.; Hsieh, S. L. Decoy receptor 3: A pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer Biochem. Pharmacol. 2011, 81, 838-847
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 838-847
    • Lin, W.W.1    Hsieh, S.L.2
  • 6
    • 33847401888 scopus 로고    scopus 로고
    • Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: An update on implications for chronic infections and tumor evasion
    • DOI 10.1007/s00262-006-0272-1
    • Blank, C.; Mackensen, A. Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion Cancer Immunol. Immunother. 2007, 56, 739-745 (Pubitemid 46348742)
    • (2007) Cancer Immunology, Immunotherapy , vol.56 , Issue.5 , pp. 739-745
    • Blank, C.1    Mackensen, A.2
  • 7
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • DOI 10.1038/nature01322
    • Coussens, L. M.; Werb, Z. Inflammation and cancer Nature 2002, 420, 860-867 (Pubitemid 36019639)
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 9
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • DOI 10.1016/S0140-6736(00)04046-0
    • Balkwill, F.; Mantovani, A. Inflammation and cancer: back to Virchow? Lancet 2001, 357, 539-545 (Pubitemid 32173595)
    • (2001) Lancet , vol.357 , Issue.9255 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 10
    • 12244260787 scopus 로고    scopus 로고
    • A potential role of macrophage activation in the treatment of cancer
    • DOI 10.1016/S1040-8428(01)00203-7, PII S1040842801002037
    • Klimp, A. H.; de Vries, E. G.; Scherphof, G. L.; Daemen, T. A potential role of macrophage activation in the treatment of cancer Crit. Rev. Oncol. Hematol. 2002, 44, 143-161 (Pubitemid 36159043)
    • (2002) Critical Reviews in Oncology/Hematology , vol.44 , Issue.2 , pp. 143-161
    • Klimp, A.H.1    De Vries, E.G.E.2    Scherphof, G.L.3    Daemen, T.4
  • 11
    • 77951697822 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophage-dependent and -independent mechanisms
    • Hembruff, S. L.; Jokar, I.; Yang, L.; Cheng, N. Loss of transforming growth factor-beta signaling in mammary fibroblasts enhances CCL2 secretion to promote mammary tumor progression through macrophage-dependent and -independent mechanisms Neoplasia 2010, 12, 425-433
    • (2010) Neoplasia , vol.12 , pp. 425-433
    • Hembruff, S.L.1    Jokar, I.2    Yang, L.3    Cheng, N.4
  • 12
    • 33644674149 scopus 로고    scopus 로고
    • The absence of CCL2 expression in cervical carcinoma is associated with increased survival and loss of heterozygosity at 17q11.2
    • DOI 10.1002/path.1918
    • Zijlmans, H. J.; Fleuren, G. J.; Baelde, H. J.; Eilers, P. H.; Kenter, G. G.; Gorter, A. The absence of CCL2 expression in cervical carcinoma is associated with increased survival and loss of heterozygosity at 17q11.2 J. Pathol. 2006, 208, 507-517 (Pubitemid 43329337)
    • (2006) Journal of Pathology , vol.208 , Issue.4 , pp. 507-517
    • Zijlmaans, H.J.M.A.A.1    Fleuren, G.J.2    Baelde, H.J.3    Eilers, P.H.C.4    Kenter, G.G.5    Gorter, A.6
  • 13
    • 34250627302 scopus 로고    scopus 로고
    • CC ligand 2 levels are increased in LPS-stimulated peripheral monocytes of patients with non-small cell lung cancer
    • DOI 10.1016/j.rmed.2007.02.021, PII S0954611107000984
    • Miotto, D.; Boschetto, P.; Bononi, I.; Milani, G.; Legorini, C.; Cavallesco, G.; Lo Cascio, N.; Zeni, E.; Fabbri, L. M.; Mapp, C. E. CC ligand 2 levels are increased in LPS-stimulated peripheral monocytes of patients with non-small cell lung cancer Respir. Med. 2007, 101, 1738-1743 (Pubitemid 46930709)
    • (2007) Respiratory Medicine , vol.101 , Issue.8 , pp. 1738-1743
    • Miotto, D.1    Boschetto, P.2    Bononi, I.3    Milani, G.4    Legorini, C.5    Cavallesco, G.6    Lo Cascio, N.7    Zeni, E.8    Fabbri, L.M.9    Mapp, C.E.10
  • 14
    • 27744604016 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment
    • DOI 10.1158/1078-0432.CCR-05-0798
    • Kuroda, T.; Kitadai, Y.; Tanaka, S.; Yang, X.; Mukaida, N.; Yoshihara, M.; Chayama, K. Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment Clin. Cancer Res. 2005, 11, 7629-7636 (Pubitemid 41611603)
    • (2005) Clinical Cancer Research , vol.11 , Issue.21 , pp. 7629-7636
    • Kuroda, T.1    Kitadai, Y.2    Tanaka, S.3    Yang, X.4    Mukaida, N.5    Yoshihara, M.6    Chayama, K.7
  • 15
    • 34547184682 scopus 로고    scopus 로고
    • CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration
    • DOI 10.1593/neo.07307
    • Loberg, R. D.; Ying, C.; Craig, M.; Yan, L.; Snyder, L. A.; Pienta, K. J. CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration Neoplasia 2007, 9, 556-562 (Pubitemid 47121829)
    • (2007) Neoplasia , vol.9 , Issue.7 , pp. 556-562
    • Loberg, R.D.1    Ying, C.2    Craig, M.3    Yan, L.4    Snyder, L.A.5    Pienta, K.J.6
  • 16
    • 34247576326 scopus 로고    scopus 로고
    • Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer
    • DOI 10.1007/s10585-007-9060-3
    • Bailey, C.; Negus, R.; Morris, A.; Ziprin, P.; Goldin, R.; Allavena, P.; Peck, D.; Darzi, A. Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer Clin. Exp. Metastasis 2007, 24, 121-130 (Pubitemid 46669245)
    • (2007) Clinical and Experimental Metastasis , vol.24 , Issue.2 , pp. 121-130
    • Bailey, C.1    Negus, R.2    Morris, A.3    Ziprin, P.4    Goldin, R.5    Allavena, P.6    Peck, D.7    Darzi, A.8
  • 17
    • 34247374339 scopus 로고    scopus 로고
    • Tumour-associated macrophages secrete IL-6 and MCP-1 in head and neck squamous cell carcinoma tissue
    • DOI 10.1080/00016480600951384, PII 777399666
    • Kross, K. W.; Heimdal, J. H.; Olsnes, C.; Olofson, J.; Aarstad, H. J. Tumour-associated macrophages secrete IL-6 and MCP-1 in head and neck squamous cell carcinoma tissue Acta Otolaryngol. 2007, 127, 532-539 (Pubitemid 46633782)
    • (2007) Acta Oto-Laryngologica , vol.127 , Issue.5 , pp. 532-539
    • Kross, K.W.1    Heimdal, J.-H.2    Olsnes, C.3    Olofson, J.4    Aarstad, H.J.5
  • 18
    • 71749088821 scopus 로고    scopus 로고
    • CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization
    • Roca, H.; Varsos, Z. S.; Sud, S.; Craig, M. J.; Ying, C.; Pienta, K. J. CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization J. Biol. Chem. 2009, 284, 34342-34354
    • (2009) J. Biol. Chem. , vol.284 , pp. 34342-34354
    • Roca, H.1    Varsos, Z.S.2    Sud, S.3    Craig, M.J.4    Ying, C.5    Pienta, K.J.6
  • 19
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
    • DOI 10.1016/j.critrevonc.2007.07.004, PII S104084280700162X
    • Allavena, P.; Sica, A.; Solinas, G.; Porta, C.; Mantovani, A. The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages Crit. Rev. Oncol. Hematol. 2008, 66, 1-9 (Pubitemid 351324128)
    • (2008) Critical Reviews in Oncology/Hematology , vol.66 , Issue.1 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 20
    • 77957808350 scopus 로고    scopus 로고
    • Knockout of HIF-1alpha in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
    • Werno, C.; Menrad, H.; Weigert, A.; Dehne, N.; Goerdt, S.; Schledzewski, K.; Kzhyshkowska, J.; Brune, B. Knockout of HIF-1alpha in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses Carcinogenesis 2010, 31, 1863-1872
    • (2010) Carcinogenesis , vol.31 , pp. 1863-1872
    • Werno, C.1    Menrad, H.2    Weigert, A.3    Dehne, N.4    Goerdt, S.5    Schledzewski, K.6    Kzhyshkowska, J.7    Brune, B.8
  • 23
    • 33645027064 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer
    • Kagaya, T.; Nakamoto, Y.; Sakai, Y.; Tsuchiyama, T.; Yagita, H.; Mukaida, N.; Kaneko, S. Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer Cancer Gene Ther. 2006, 13, 357-366
    • (2006) Cancer Gene Ther. , vol.13 , pp. 357-366
    • Kagaya, T.1    Nakamoto, Y.2    Sakai, Y.3    Tsuchiyama, T.4    Yagita, H.5    Mukaida, N.6    Kaneko, S.7
  • 24
    • 17144398046 scopus 로고    scopus 로고
    • Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection
    • Guiducci, C.; Vicari, A. P.; Sangaletti, S.; Trinchieri, G.; Colombo, M. P. Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection Cancer Res. 2005, 65, 3437-3446 (Pubitemid 40524630)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3437-3446
    • Guiducci, C.1    Vicari, A.P.2    Sangaletti, S.3    Trinchieri, G.4    Colombo, M.P.5
  • 25
    • 77953069764 scopus 로고    scopus 로고
    • Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth
    • Bolpetti, A.; Silva, J. S.; Villa, L. L.; Lepique, A. P. Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth BMC Immunol. 2010, 11, 27
    • (2010) BMC Immunol. , vol.11 , pp. 27
    • Bolpetti, A.1    Silva, J.S.2    Villa, L.L.3    Lepique, A.P.4
  • 26
    • 35348836022 scopus 로고    scopus 로고
    • TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response
    • DOI 10.1002/eji.200737603
    • Ito, T.; Schaller, M.; Hogaboam, C. M.; Standiford, T. J.; Chensue, S. W.; Kunkel, S. L. TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response Eur. J. Immunol. 2007, 37, 2847-2855 (Pubitemid 47578304)
    • (2007) European Journal of Immunology , vol.37 , Issue.10 , pp. 2847-2855
    • Ito, T.1    Schaller, M.2    Hogaboam, C.M.3    Standiford, T.J.4    Chensue, S.W.5    Kunkel, S.L.6
  • 28
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich, D. I.; Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system Nat. Rev. Immunol. 2009, 9, 162-174
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 29
    • 77953487609 scopus 로고    scopus 로고
    • Myeloid cells in the tumor microenvironment: Modulation of tumor angiogenesis and tumor inflammation
    • Schmid, M. C.; Varner, J. A. Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation J. Oncol. 2010, 2010, 201026
    • (2010) J. Oncol. , vol.2010 , pp. 201026
    • Schmid, M.C.1    Varner, J.A.2
  • 30
    • 33846450675 scopus 로고    scopus 로고
    • The Terminology Issue for Myeloid-Derived Suppressor Cells
    • Yang, R.; Roden, R. B. S. The Terminology Issue for Myeloid-Derived Suppressor Cells Cancer Res. 2007, 67, 426
    • (2007) Cancer Res. , vol.67 , pp. 426
    • Yang, R.1    Roden, R.B.S.2
  • 31
    • 33746115391 scopus 로고    scopus 로고
    • + myeloid cells
    • DOI 10.1158/0008-5472.CAN-05-3755
    • Yang, R.; Cai, Z.; Zhang, Y.; Yutzy, W. H. t.; Roby, K. F.; Roden, R. B. CD80 in immune suppression by mouse ovarian carcinoma-associated Gr-1+CD11b+ myeloid cells Cancer Res. 2006, 66, 6807-6815 (Pubitemid 44085641)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6807-6815
    • Yang, R.1    Cai, Z.2    Zhang, Y.3    Yutzy IV, W.H.4    Roby, K.F.5    Roden, R.B.S.6
  • 33
    • 78649586268 scopus 로고    scopus 로고
    • The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity
    • Youn, J. I.; Gabrilovich, D. I. The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity Eur. J. Immunol. 2010, 40, 2969-2975
    • (2010) Eur. J. Immunol. , vol.40 , pp. 2969-2975
    • Youn, J.I.1    Gabrilovich, D.I.2
  • 34
    • 61449147270 scopus 로고    scopus 로고
    • Radiofrequency thermal ablation of breast tumors combined with intralesional administration of IL-7 and IL-15 augments anti-tumor immune responses and inhibits tumor development and metastasis
    • Habibi, M.; Kmieciak, M.; Graham, L.; Morales, J. K.; Bear, H. D.; Manjili, M. H. Radiofrequency thermal ablation of breast tumors combined with intralesional administration of IL-7 and IL-15 augments anti-tumor immune responses and inhibits tumor development and metastasis Breast Cancer Res. Treat. 2009, 114, 423-431
    • (2009) Breast Cancer Res. Treat. , vol.114 , pp. 423-431
    • Habibi, M.1    Kmieciak, M.2    Graham, L.3    Morales, J.K.4    Bear, H.D.5    Manjili, M.H.6
  • 35
    • 37349100945 scopus 로고    scopus 로고
    • Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis
    • DOI 10.1016/j.ccr.2007.12.004, PII S153561080700373X
    • Yang, L.; Huang, J.; Ren, X.; Gorska, A. E.; Chytil, A.; Aakre, M.; Carbone, D. P.; Matrisian, L. M.; Richmond, A.; Lin, P. C.; Moses, H. L. Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis Cancer Cell 2008, 13, 23-35 (Pubitemid 350309741)
    • (2008) Cancer Cell , vol.13 , Issue.1 , pp. 23-35
    • Yang, L.1    Huang, J.2    Ren, X.3    Gorska, A.E.4    Chytil, A.5    Aakre, M.6    Carbone, D.P.7    Matrisian, LynnM.8    Richmond, A.9    Lin, P.C.10    Moses, H.L.11
  • 36
    • 78349313304 scopus 로고    scopus 로고
    • Dendritic cell vaccine in addition to FOLFIRI regimen improve antitumor effects through the inhibition of immunosuppressive cells in murine colorectal cancer model
    • Kim, H. S.; Park, H. M.; Park, J. S.; Sohn, H. J.; Kim, S. G.; Kim, H. J.; Oh, S. T.; Kim, T. G. Dendritic cell vaccine in addition to FOLFIRI regimen improve antitumor effects through the inhibition of immunosuppressive cells in murine colorectal cancer model Vaccine 2010, 28, 7787-7796
    • (2010) Vaccine , vol.28 , pp. 7787-7796
    • Kim, H.S.1    Park, H.M.2    Park, J.S.3    Sohn, H.J.4    Kim, S.G.5    Kim, H.J.6    Oh, S.T.7    Kim, T.G.8
  • 37
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch, C.; Muthana, M.; Coffelt, S. B.; Lewis, C. E. The role of myeloid cells in the promotion of tumour angiogenesis Nat. Rev. Cancer 2008, 8, 618-631
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 38
    • 1642536454 scopus 로고    scopus 로고
    • + T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species
    • Kusmartsev, S.; Nefedova, Y.; Yoder, D.; Gabrilovich, D. I. Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species J. Immunol. 2004, 172, 989-999 (Pubitemid 38113758)
    • (2004) Journal of Immunology , vol.172 , Issue.2 , pp. 989-999
    • Kusmartsev, S.1    Nefedova, Y.2    Yoder, D.3    Gabrilovich, D.I.4
  • 39
    • 59849126377 scopus 로고    scopus 로고
    • Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1
    • Li, H.; Han, Y.; Guo, Q.; Zhang, M.; Cao, X. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1 J. Immunol. 2009, 182, 240-249
    • (2009) J. Immunol. , vol.182 , pp. 240-249
    • Li, H.1    Han, Y.2    Guo, Q.3    Zhang, M.4    Cao, X.5
  • 40
    • 29144504335 scopus 로고    scopus 로고
    • + immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1β-secreting cells
    • Song, X.; Krelin, Y.; Dvorkin, T.; Bjorkdahl, O.; Segal, S.; Dinarello, C. A.; Voronov, E.; Apte, R. N. CD11b+/Gr-1+ immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1beta-secreting cells J. Immunol. 2005, 175, 8200-8208 (Pubitemid 41798384)
    • (2005) Journal of Immunology , vol.175 , Issue.12 , pp. 8200-8208
    • Song, X.1    Krelin, Y.2    Dvorkin, T.3    Bjorkdahl, O.4    Segal, S.5    Dinarello, C.A.6    Voronov, E.7    Apte, R.N.8
  • 41
    • 0033757517 scopus 로고    scopus 로고
    • Chemoattraction of femoral CD34+ progenitor cells by tumor-derived vascular endothelial cell growth factor
    • Young, M. R.; Kolesiak, K.; Wright, M. A.; Gabrilovich, D. I. Chemoattraction of femoral CD34+ progenitor cells by tumor-derived vascular endothelial cell growth factor Clin. Exp. Metastasis 1999, 17, 881-888
    • (1999) Clin. Exp. Metastasis , vol.17 , pp. 881-888
    • Young, M.R.1    Kolesiak, K.2    Wright, M.A.3    Gabrilovich, D.I.4
  • 42
    • 4344590947 scopus 로고    scopus 로고
    • High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    • DOI 10.1158/0008-5472.CAN-04-0757
    • Serafini, P.; Carbley, R.; Noonan, K. A.; Tan, G.; Bronte, V.; Borrello, I. High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells Cancer Res. 2004, 64, 6337-6343 (Pubitemid 39129439)
    • (2004) Cancer Research , vol.64 , Issue.17 , pp. 6337-6343
    • Serafini, P.1    Carbley, R.2    Noonan, K.A.3    Tan, G.4    Bronte, V.5    Borrello, I.6
  • 43
    • 0034551670 scopus 로고    scopus 로고
    • Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells
    • Bronte, V.; Apolloni, E.; Cabrelle, A.; Ronca, R.; Serafini, P.; Zamboni, P.; Restifo, N. P.; Zanovello, P. Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells Blood 2000, 96, 3838-3846
    • (2000) Blood , vol.96 , pp. 3838-3846
    • Bronte, V.1    Apolloni, E.2    Cabrelle, A.3    Ronca, R.4    Serafini, P.5    Zamboni, P.6    Restifo, N.P.7    Zanovello, P.8
  • 44
    • 34548805636 scopus 로고    scopus 로고
    • Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response
    • Sinha, P.; Clements, V. K.; Bunt, S. K.; Albelda, S. M.; Ostrand-Rosenberg, S. Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response J. Immunol. 2007, 179, 977-983
    • (2007) J. Immunol. , vol.179 , pp. 977-983
    • Sinha, P.1    Clements, V.K.2    Bunt, S.K.3    Albelda, S.M.4    Ostrand-Rosenberg, S.5
  • 45
    • 78349285473 scopus 로고    scopus 로고
    • Adjuvant effects of formalin-inactivated HSV through activation of dendritic cells and inactivation of myeloid-derived suppressor cells in cancer immunotherapy
    • Ohkusu-Tsukada, K.; Ohta, S.; Kawakami, Y.; Toda, M. Adjuvant effects of formalin-inactivated HSV through activation of dendritic cells and inactivation of myeloid-derived suppressor cells in cancer immunotherapy Int. J. Cancer 2011, 128, 119-131
    • (2011) Int. J. Cancer , vol.128 , pp. 119-131
    • Ohkusu-Tsukada, K.1    Ohta, S.2    Kawakami, Y.3    Toda, M.4
  • 46
    • 33749461167 scopus 로고    scopus 로고
    • All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients
    • DOI 10.1158/0008-5472.CAN-06-1690
    • Mirza, N.; Fishman, M.; Fricke, I.; Dunn, M.; Neuger, A. M.; Frost, T. J.; Lush, R. M.; Antonia, S.; Gabrilovich, D. I. All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients Cancer Res. 2006, 66, 9299-9307 (Pubitemid 44521152)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9299-9307
    • Mirza, N.1    Fishman, M.2    Fricke, I.3    Dunn, M.4    Neuger, A.M.5    Frost, T.J.6    Lush, R.M.7    Antonia, S.8    Gabrilovich, D.I.9
  • 48
    • 25144466458 scopus 로고    scopus 로고
    • + myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • DOI 10.1158/1078-0432.CCR-05-0883
    • Suzuki, E.; Kapoor, V.; Jassar, A. S.; Kaiser, L. R.; Albelda, S. M. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity Clin. Cancer Res. 2005, 11, 6713-6721 (Pubitemid 41339014)
    • (2005) Clinical Cancer Research , vol.11 , Issue.18 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3    Kaiser, L.R.4    Albelda, S.M.5
  • 49
    • 70249097382 scopus 로고    scopus 로고
    • The Role of Treg Cells in the Cancer Immunological Response
    • Yang, Z.-Z.; Ansell, S. M. The Role of Treg Cells in the Cancer Immunological Response Am. J. Immunol. 2009, 5, 17-28
    • (2009) Am. J. Immunol. , vol.5 , pp. 17-28
    • Yang, Z.-Z.1    Ansell, S.M.2
  • 50
    • 58149399352 scopus 로고    scopus 로고
    • FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions
    • Ahmadzadeh, M.; Felipe-Silva, A.; Heemskerk, B.; Powell, D. J., Jr.; Wunderlich, J. R.; Merino, M. J.; Rosenberg, S. A. FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions Blood 2008, 112, 4953-4960
    • (2008) Blood , vol.112 , pp. 4953-4960
    • Ahmadzadeh, M.1    Felipe-Silva, A.2    Heemskerk, B.3    Powell Jr., D.J.4    Wunderlich, J.R.5    Merino, M.J.6    Rosenberg, S.A.7
  • 51
    • 38649109511 scopus 로고    scopus 로고
    • A simple but effective cancer vaccine consisting of an antigen and a cationic lipid
    • DOI 10.1007/s00262-007-0390-4
    • Chen, W.; Yan, W.; Huang, L. A simple but effective cancer vaccine consisting of an antigen and a cationic lipid Cancer Immunol. Immunother. 2008, 57, 517-530 (Pubitemid 351170535)
    • (2008) Cancer Immunology, Immunotherapy , vol.57 , Issue.4 , pp. 517-530
    • Chen, W.1    Yan, W.2    Huang, L.3
  • 52
    • 59449097574 scopus 로고    scopus 로고
    • Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma
    • Goforth, R.; Salem, A. K.; Zhu, X.; Miles, S.; Zhang, X. Q.; Lee, J. H.; Sandler, A. D. Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma Cancer Immunol. Immunother. 2009, 58, 517-530
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 517-530
    • Goforth, R.1    Salem, A.K.2    Zhu, X.3    Miles, S.4    Zhang, X.Q.5    Lee, J.H.6    Sandler, A.D.7
  • 53
    • 0035874949 scopus 로고    scopus 로고
    • + T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    • Woo, E. Y.; Chu, C. S.; Goletz, T. J.; Schlienger, K.; Yeh, H.; Coukos, G.; Rubin, S. C.; Kaiser, L. R.; June, C. H. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer Cancer Res. 2001, 61, 4766-4772 (Pubitemid 32691889)
    • (2001) Cancer Research , vol.61 , Issue.12 , pp. 4766-4772
    • Woo, E.Y.1    Chu, C.S.2    Goletz, T.J.3    Schlienger, K.4    Yeh, H.5    Coukos, G.6    Rubin, S.C.7    Kaiser, L.R.8    June, C.H.9
  • 55
    • 77951104539 scopus 로고    scopus 로고
    • Distribution of Foxp3-, CD4- and CD8-positive lymphocytic cells in benign and malignant prostate tissue
    • Valdman, A.; Jaraj, S. J.; Comperat, E.; Charlotte, F.; Roupret, M.; Pisa, P.; Egevad, L. Distribution of Foxp3-, CD4- and CD8-positive lymphocytic cells in benign and malignant prostate tissue APMIS 2010, 118, 360-365
    • (2010) APMIS , vol.118 , pp. 360-365
    • Valdman, A.1    Jaraj, S.J.2    Comperat, E.3    Charlotte, F.4    Roupret, M.5    Pisa, P.6    Egevad, L.7
  • 56
    • 33748492962 scopus 로고    scopus 로고
    • + regulatory T cells in mice with experimental brain tumors
    • El Andaloussi, A.; Han, Y.; Lesniak, M. S. Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors J. Neurosurg. 2006, 105, 430-437 (Pubitemid 44358755)
    • (2006) Journal of Neurosurgery , vol.105 , Issue.3 , pp. 430-437
    • Andaloussi, A.E.L.1    Han, Y.U.2    Lesniak, M.S.3
  • 58
    • 78650668115 scopus 로고    scopus 로고
    • Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6
    • Eikawa, S.; Ohue, Y.; Kitaoka, K.; Aji, T.; Uenaka, A.; Oka, M.; Nakayama, E. Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6 J. Immunol. 2010, 185, 6734-6740
    • (2010) J. Immunol. , vol.185 , pp. 6734-6740
    • Eikawa, S.1    Ohue, Y.2    Kitaoka, K.3    Aji, T.4    Uenaka, A.5    Oka, M.6    Nakayama, E.7
  • 61
    • 78049488702 scopus 로고    scopus 로고
    • NK depletion results in increased CCL22 secretion and Treg levels in Lewis lung carcinoma via the accumulation of CCL22-secreting CD11b+CD11c+ cells
    • Mailloux, A. W.; Clark, A. M.; Young, M. R. NK depletion results in increased CCL22 secretion and Treg levels in Lewis lung carcinoma via the accumulation of CCL22-secreting CD11b+CD11c+ cells Int. J. Cancer 2010, 127, 2598-2611
    • (2010) Int. J. Cancer , vol.127 , pp. 2598-2611
    • Mailloux, A.W.1    Clark, A.M.2    Young, M.R.3
  • 63
    • 0033928257 scopus 로고    scopus 로고
    • T-regulatory 1 cells: A novel subset of CD4 T cells with immunoregulatory properties
    • Levings, M. K.; Roncarolo, M. G. T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties J. Allergy Clin. Immunol. 2000, 106, S109-112
    • (2000) J. Allergy Clin. Immunol. , vol.106 , pp. 109-112
    • Levings, M.K.1    Roncarolo, M.G.2
  • 67
    • 70350496784 scopus 로고    scopus 로고
    • Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells
    • Rech, A. J.; Vonderheide, R. H. Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells Ann. N.Y. Acad. Sci. 2009, 1174, 99-106
    • (2009) Ann. N.Y. Acad. Sci. , vol.1174 , pp. 99-106
    • Rech, A.J.1    Vonderheide, R.H.2
  • 68
    • 50949115267 scopus 로고    scopus 로고
    • Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    • Morse, M. A.; Hobeika, A. C.; Osada, T.; Serra, D.; Niedzwiecki, D.; Lyerly, H. K.; Clay, T. M. Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines Blood 2008, 112, 610-618
    • (2008) Blood , vol.112 , pp. 610-618
    • Morse, M.A.1    Hobeika, A.C.2    Osada, T.3    Serra, D.4    Niedzwiecki, D.5    Lyerly, H.K.6    Clay, T.M.7
  • 70
    • 41149178490 scopus 로고    scopus 로고
    • Comparative methodologies of regulatory T cell depletion in a murine melanoma model
    • Matsushita, N.; Pilon-Thomas, S. A.; Martin, L. M.; Riker, A. I. Comparative methodologies of regulatory T cell depletion in a murine melanoma model J. Immunol. Methods 2008, 333, 167-179
    • (2008) J. Immunol. Methods , vol.333 , pp. 167-179
    • Matsushita, N.1    Pilon-Thomas, S.A.2    Martin, L.M.3    Riker, A.I.4
  • 71
    • 33745851479 scopus 로고    scopus 로고
    • CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
    • DOI 10.1172/JCI27745
    • Quezada, S. A.; Peggs, K. S.; Curran, M. A.; Allison, J. P. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells J. Clin. Invest. 2006, 116, 1935-1945 (Pubitemid 44033317)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1935-1945
    • Quezada, S.A.1    Peggs, K.S.2    Curran, M.A.3    Allison, J.P.4


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