Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6-and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6

Journal of Immunology

Volumn 185, Issue 11, 2010, Pages 6734-6740

  Eikawa, Shingo ^a,b   Ohue, Yoshihiro ^a,b   Kitaoka, Kenta ^a   Aji, Toshiki ^a   Uenaka, Akiko ^a   Oka, Mikio ^b   Nakayama, Eiichi ^a,c  

^a OKAYAMA UNIVERSITY   (Japan)

^b KAWASAKI MEDICAL SCHOOL   (Japan)

^c KAWASAKI UNIVERSITY OF MEDICAL WELFARE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR1; INTERLEUKIN 6; INTERLEUKIN 8; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CANCER; LYMPHOCYTE MIGRATION; MALIGNANT MESOTHELIOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TUMOR CELL;

CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL MOVEMENT; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LUNG NEOPLASMS; MELANOMA; MESOTHELIOMA; RECEPTORS, INTERLEUKIN-8A; T-LYMPHOCYTES, REGULATORY; TUMOR CELLS, CULTURED; TUMOR ESCAPE;

EID: 78650668115     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000225     Document Type: Article

References (37)

1. Drake, C. G., E. Jaffee, and D. M. Pardoll. 2006. Mechanisms of immune evasion by tumors. Adv. Immunol. 90:51-81.
2. Koebel, C. M., W. Vermi, J. B. Swann, N. Zerafa, S. J. Rodig, L. J. Old, M. J. Smyth, and R. D. Schreiber. 2007. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450:903-907.
3. Marincola, F. M., E. M. Jaffee, D. J. Hicklin, and S. Ferrone. 2000. Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv. Immunol. 74:181-273.
4. Onizuka, S., I. Tawara, J. Shimizu, S. Sakaguchi, T. Fujita, and E. Nakayama. 1999. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. Cancer Res. 59:3128-3133.
5. Curiel, T. J., G. Coukos, L. Zou, X. Alvarez, P. Cheng, P. Mottram, M. Evdemon-Hogan, J. R. Conejo-Garcia, L. Zhang, M. Burow, et al. 2004. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 10:942-949.
6. Wolf, D., A. M. Wolf, H. Rumpold, H. Fiegl, A. G. Zeimet, E. Muller-Holzner, M. Deibl, G. Gastl, E. Gunsilius, and C. Marth. 2005. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin. Cancer Res. 11:8326-8331.
7. Sato, E., S. H. Olson, J. Ahn, B. Bundy, H. Nishikawa, F. Qian, A. A. Jungbluth, D. Frosina, S. Gnjatic, C. Ambrosone, et al. 2005. Intraepithelial CD8+ tumorinfiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc. Natl. Acad. Sci. USA 102:18538-18543.
8. Beyer, M., and J. L. Schultze. 2006. Regulatory T cells in cancer. Blood 108:804-811.
9. Nicholaou, T., L. M. Ebert, I. D. Davis, G. A. McArthur, H. Jackson, N. Dimopoulos, B. Tan, E. Maraskovsky, L. Miloradovic, W. Hopkins, et al. 2009. Regulatory T-cell-mediated attenuation of T-cell responses to the NY-ESO-1 ISCOMATRIX vaccine in patients with advanced malignant melanoma. Clin. Cancer Res. 15:2166-2173.
10. Nishikawa, H., and S. Sakaguchi. 2010. Regulatory T cells in tumor immunity. Int. J. Cancer 127:759-767.
11. Ishida, T., and R. Ueda. 2006. CCR4 as a novel molecular target for immunotherapy of cancer. Cancer Sci. 97:1139-1146.
12. Nguyen-Jackson, H., A. D. Panopoulos, H. Zhang, H. S. Li, and S. S. Watowich. 2010. STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction. Blood 115:3354-3363.
13. Gandour-Edwards, R., S. B. Kapadia, P. H. Gumerlock, and L. Barnes. 1995. Immunolocalization of interleukin-6 in salivary gland tumors. Hum. Pathol. 26:501-503.
14. Basolo, F., L. Fiore, G. Fontanini, P. G. Conaldi, S. Calvo, V. Falcone, and A. Toniolo. 1996. Expression of and response to interleukin 6 (IL6) in human mammary tumors. Cancer Res. 56:3118-3122.
15. Basolo, F., L. Fiore, L. Pollina, G. Fontanini, P. G. Conaldi, and A. Toniolo. 1998. Reduced expression of interleukin 6 in undifferentiated thyroid carcinoma: in vitro and in vivo studies. Clin. Cancer Res. 4:381-387.
16. Schadendorf, D., A. Möller, B. Algermissen, M. Worm, M. Sticherling, and B. M. Czarnetzki. 1993. IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor. J. Immunol. 151:2667-2675.
17. Shain, K. H., D. N. Yarde, M. B. Meads, M. Huang, R. Jove, L. A. Hazlehurst, and W. S. Dalton. 2009. Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation. Cancer Res. 69:1009-1015.
18. Walter, M., S. Liang, S. Ghosh, P. J. Hornsby, and R. Li. 2009. Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene 28:2745-2755.
19. Betz, U. A., and W. Müller. 1998. Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation. Int. Immunol. 10:1175-1184.
20. Singh, S., K. C. Nannuru, A. Sadanandam, M. L. Varney, and R. K. Singh. 2009. CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion. Br. J. Cancer 100:1638-1646.
21. Singh, S., A. Sadanandam, K. C. Nannuru, M. L. Varney, R. Mayer-Ezell, R. Bond, and R. K. Singh. 2009. Small-molecule antagonists for CXCR2 and CXCR1 inhibit human melanoma growth by decreasing tumor cell proliferation, survival, and angiogenesis. Clin. Cancer Res. 15:2380-2386.
22. Waugh, D. J., and C. Wilson. 2008. The interleukin-8 pathway in cancer. Clin. Cancer Res. 14:6735-6741.
23. Tsuji, K., T. Hamada, A. Uenaka, H. Wada, E. Sato, M. Isobe, K. Asagoe, O. Yamasaki, H. Shiku, G. Ritter, et al. 2008. Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient. Cancer Immunol. Immunother. 57:1429-1437.
24. Delens, N., E. Torreele, H. Savelkool, P. de Baetselier, and L. Bouwens. 1994. Tumor-derived transforming growth factor-beta 1 and interleukin-6 are chemotactic for lymphokine-activated killer cells. Int. J. Cancer 57:696-700.
25. Weissenbach, M., T. Clahsen, C. Weber, D. Spitzer, D. Wirth, D. Vestweber, P. C. Heinrich, and F. Schaper. 2004. Interleukin-6 is a direct mediator of T cell migration. Eur. J. Immunol. 34:2895-2906.
26. Hong, T. M., L. J. Teng, C. T. Shun, M. C. Peng, and J. C. Tsai. 2009. Induced interleukin-8 expression in gliomas by tumor-associated macrophages. J. Neurooncol. 93:289-301.
27. Dienz, O., S. M. Eaton, J. P. Bond, W. Neveu, D. Moquin, R. Noubade, E. M. Briso, C. Charland, W. J. Leonard, G. Ciliberto, et al. 2009. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J. Exp. Med. 206:69-78.
28. Dienz, O., and M. Rincon. 2009. The effects of IL-6 on CD4 T cell responses. Clin. Immunol. 130:27-33.
29. Mihara, M., Y. Ohsugi, and T. Kishimoto. 2009. Evidence for the role of Th17 cell inhibition in the prevention of autoimmune diseases by anti-interluekin-6 receptor antibody. Biofactors 35:47-51.
30. Fujimoto, M., S. Serada, M. Mihara, Y. Uchiyama, H. Yoshida, N. Koike, Y. Ohsugi, T. Nishikawa, B. Ripley, A. Kimura, et al. 2008. Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum. 58:3710-3719.
31. Littman, D. R., and A. Y. Rudensky. 2010. Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140:845-858.
32. + Regulatory T Cells. Int. J. Clin. Exp. Med. 1:192-202.
33. + regulatory T cells. J. Immunol. 182:2795-2807.
34. Koenen, H. J., R. L. Smeets, P. M. Vink, E. van Rijssen, A. M. Boots, and I. Joosten. 2008. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 112:2340-2352.
35. Korn, T., E. Bettelli, M. Oukka, and V. K. Kuchroo. 2009. IL-17 and Th17 Cells. Annu. Rev. Immunol. 27:485-517.
36. Rincón, M., J. Anguita, T. Nakamura, E. Fikrig, and R. A. Flavell. 1997. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med. 185:461-469.
37. Nurieva, R. I., Y. Chung, D. Hwang, X. O. Yang, H. S. Kang, L. Ma, Y. H. Wang, S. S. Watowich, A. M. Jetten, Q. Tian, and C. Dong. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29:138-149.