Hepatolipidemic effects of naringenin in high cornstarch- versus high coconut oil-fed rats

Journal of Medicinal Food

Volumn 7, Issue 3, 2004, Pages 315-319

  Wood, Nelson ^a,b  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Coconut oil; Cornstarch; Flavonoids; Hepatic; Lipids; Naringenin

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; COCONUT OIL; DIACYLGLYCEROL; FATTY ACID; LIPID; LIVER PROTEIN; LYSOPHOSPHATIDYLCHOLINE; MONOACYLGLYCEROL; NARINGENIN; PHOSPHATIDIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; SPHINGOMYELIN; STARCH; TRIACYLGLYCEROL;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; DRUG EFFECT; LIPID DIET; LIPID LIVER LEVEL; LIVER LEVEL; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; FATTY ACIDS, NONESTERIFIED; FLAVANONES; LIPID METABOLISM; LIVER; MALE; ORGAN SIZE; PLANT OILS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STARCH; TRIGLYCERIDES;

ANIMALIA;

EID: 4644233222     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2004.7.315     Document Type: Article

References (22)

1. Wald NJ, Law MR: Serum cholesterol and ischaemic heart disease. Atherosclerosis 1995;118(Suppl):S1-S5.
2. Keys A: Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease, Harvard University Press, Cambridge, MA, 1980.
3. Kuhnau J: The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 1976;24:117-191.
4. Havsteen B: Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 1983;32:1141-1148.
5. Bors W, Heller W, Michel C, Saran N: Flavonoids as antioxidants: determination of radical-scavenging efficiencies. Methods Enzymol 1990;186:343-355.
6. Voskresenskii ON, Bobyrev VN: Effect of ascorbic acid and rutin on the development of experimental peroxide artherosclerosis. Farmakol Toksikol 1979;42:378-382.
7. Macon WL: Citrus bioflavonoids in the treatment of the common cold. Ind Med Surg 1956;25:525-527.
8. Bok S-H, Shin YW, Bae K-H, Jeong T-S, Kwon Y-K, Park YB, Choi M-S: Effects of naringin and lovastatin on plasma and hepatic lipids in high-fat and high-cholesterol-fed rats. Nutr Res 2000;20:1007-1015.
9. Choi M-S, Do K-M, Park YB, Jeon S-M, Jeong T-S, Lee Y-K, Bok S-H: Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E. Ann Nutr Metab 2001;45:193-201.
10. Lee SH, Park YB, Bae K-H, Kwon Y-K, Lee ES, Choi M-S: Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A:cholesterol acyltransferase in rats. Ann Nutr Metab 1999; 43:173-180.
11. Santos KFR, Oliveira TT, Nagem TJ, Pinto AS, Oliviera MGA: Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations. Pharmacol Res 1999;40:493-496.
12. Endo A: The discovery and development of HMG-CoA reductase inhibitors. J Lipid Res 1992;33:1569-1582.
13. Franceschini G, Cassinotti M, Vecchio G, Gianfranceschi G, Pazzucconi F, Murakami T, Sirtori M, D'Acquarica AL, Sirtori CR: Pravastatin effectively lowers LDL cholesterol in familial combined hyperlipidemia without changing LDL subclass pattern. Arterioscler Thromb 1994;14:1569-1575.
14. Helgerud P, Saarem K, Norum KR: Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzyme reaction. J Lipid Res 1981;22:271-277.
15. Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW: Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res 2001;42:725-734.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193: 265-275.
17. Folch J, Ascoli I, Lees M, Meath JA, Lebaron FN: Preparation of lipid extracts from brain tissue. J Biol Chem 1951;191:833-841.
18. Marsh JB, Weinstein DB: Simple charring method for determination of lipids. J Lipid Res 1966;7:574-576.
19. Mangold HK, Malins DC: Fractionation of fats, oils, and waxes on thin-layers of silicic acid. J Am Oil Chem Soc 1960;37: 383-385.
20. Blank ML, Schmit JA, Privett OS: Quantitative analysis of lipids by thin-layer chromatography. J Am Oil Soc 1964;41:371-376.
21. Parker F, Peterson NF: Quantitative analysis of phospholipids and phospholipid fatty acids from silica gel thin-layer chromatography. J Lipid Res 1965;6:455-460.
22. Awad AB, Chattopadhyay JP: Effect of dietary fats on the lipid composition and enzyme activities of rat cardiac sarcolemma. J Nutr 1983;113:1878-1884.