UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation

Clinical Cancer Research

Volumn 7, Issue 3, 2001, Pages 669-674

  Hsueh, Chung Tsen ^a   Wu, Yu Chung ^b   Schwartz, Gary K ^c  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; CALPASTATIN; CYCLIN B1; LACTACYSTIN; PROTEASOME; PROTEIN P21; PROTEIN P27; TRANSCRIPTION FACTOR E2F; UBIQUITIN;

ARTICLE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG MECHANISM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER;

ACETYLCYSTEINE; ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; DOWN-REGULATION; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; ENZYME INHIBITORS; GLYCOPROTEINS; HUMANS; PROTEIN BIOSYNTHESIS; STAUROSPORINE; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034905291     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
2. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
3. Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
4. The retinoblastoma gene product is a negative modulator of the apoptotic pathway
5. 1/S-regulatory genes
6. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines
7. Role of E2F-1 in chemosensitivity
8. Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma
9. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: An analysis of response and survival
10. Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase
11. Autoregulatory control of E2FI expression in response to positive and negative regulators of cell cycle progression
12. Differential regulation of E2F transactivation by cyclin/cdk2 complexes
13. Degradation of E2F by the ubiquitin-proteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins
14. Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRb tumor suppressor protein
15. 1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells
16. The Chkl protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
17. UCN-01 suppresses thymidylate synthase gene expression and enhances 5-fluorouracil-induced apoptosis in a sequence-dependent manner
18. Characterization of cell lines established from human gastric-esophageal adenocarcinomas
19. The mutational status of p53 protein in gastric and esophageal adenocarcinoma cell lines predicts sensitivity to chemotherapeutic agents
20. A new rapid and simple nonradioactive assay to monitor and determine the proliferation of lymphocytes: An alternative to [3H]thymidine incorporation assay
21. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway
22. Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes
23. Posttranslational regulation of cyclin D1 by retinoic acid: A chemoprevention mechanism
24. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
25. Proteasomes: Structurebiology
26. Cell cycle regulation by the ubiquitin pathway
27. The ubiquitin system
28. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
29. Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase
30. Retinoic acid inhibition of cell cycle progression in MCF-7 human breast cancer cells
31. Modulation of E2F activity is linked to interferon-induced growth suppression of hematopoietic cells