Whey protein isolate protects against diet-induced obesity and fatty liver formation

International Dairy Journal

Volumn 21, Issue 8, 2011, Pages 513-522

  Shi, Jin ^a   Tauriainen, Eveliina ^a   Martonen, Essi ^a   Finckenberg, Piet ^a   Ahlroos Lehmus, Anu ^b   Tuomainen, Anita ^b   Pilvi, Taru K ^c   Korpela, Riitta ^a   Mervaala, Eero M ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c VALIO LTD   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AD LIBITUM; ADIPOSE TISSUE; BODY FATS; DIET-INDUCED OBESITY; ENERGY INTAKE; FATTY LIVER; GLUCOSE TOLERANCE; GROWTH FACTOR; LACTOFERRIN; LACTOPEROXIDASE; PROTEIN SOURCES; RIBOSOMAL PROTEINS; WEIGHT LOSS; WHEY PROTEIN ISOLATE;

CASEIN; GLUCOSE; MAMMALS; PHOSPHORYLATION; PROTEINS; TISSUE;

NUTRITION;

MUS;

EID: 79958251611     PISSN: 09586946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.idairyj.2011.03.006     Document Type: Article

References (38)

1. Akhavan T., Luhovyy B.L., Brown P.H., Cho C.E., Anderson G.H. Effects of premeal consumption of whey protein and its hydrolysate on food intake and postmeal glycemia and insulin responses in young adults. American Journal of Clinical Nutrition 2010, 91:966-975.
2. Anderson G.H., Tecimer S.N., Shah D., Zafar T.A. Protein source, quantity, and time of consumption determine the effect of proteins on short-term food intake in young men. Journal of Nutrition 2004, 134:3011-3015.
3. Belenky P., Racette F.G., Bogan K.L., McClure J.M., Smith J.S., Brenner C. Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 p.thways to NAD+. Cell 2007, 129:473-484.
4. Bieganowski P., Brenner C. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a preis-handler independent route to NAD+ in fungi and humans. Cell 2004, 117:495-502.
5. Bowen J., Noakes M., Clifton P.M. Effects of calcium and dairy foods in high protein, energy-restricted diets on weight loss and metabolic parameters in overweight adults. International Journal of Obesity 2005, 29:957-965.
6. Cani P.D., Amar J., Iglesias M.A., Poggi M., Knauf C., Bastelica D., et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007, 56:1761-1772.
7. Christensen R., Lorenzen J.K., Svith C.R., Bartels E.M., Melanson E.L., Saris W.H., et al. Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta-analysis of randomized controlled trials. Obesity Reviews: an Official Journal of the International Association for the Study of Obesity 2009, 10:475-486.
8. Finkel T., Deng C.X., Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009, 460:587-591.
9. Frestedt J.L., Zenk J.L., Kuskowski M.A., Ward L.S., Bastian E.D. A whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical study. Nutrition and Metabolism 2008, 5(8).
10. Haigis M.C., Sinclair D.A. Mammalian sirtuins: biological insights and disease relevance. Annual Review of Pathology 2010, 5:253-295.
11. Hall W.L., Millward D.J., Long S.J., Morgan L.M. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. British Journal of Nutrition 2003, 89:239-248.
12. Kleiner D.E., Brunt E.M., Van Natta M., Behling C., Contos M.J., Cummings O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321. (Baltimore, Md.).
13. Korsheninnikova E., van der Zon G.C., Voshol P.J., Janssen G.M., Havekes L.M., Grefhorst A., et al. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia 2006, 49:3049-3057.
14. Kotronen A., Yki-Järvinen H. Fatty liver: a novel component of the metabolic syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology 2008, 28:27-38.
15. Krissansen G.W. Emerging health properties of whey proteins and their clinical implications. Journal of the American College of Nutrition 2007, 26:713S-723S.
16. Laplante M., Sabatini D.M. An emerging role of mTOR in lipid biosynthesis. Current Biology 2009, 19:R1046-R1052.
17. Liu S., Choi H.K., Ford E., Manson J.E., Buring J.E., Ridker P.M. A prospective study of dairy intake and the risk of type 2 diabetes in women. Diabetes Care 2006, 29:1579-1584.
18. Liu S., Song Y., Ford E.S., Manson J.E., Buring J.E., Ridker P.M. Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care 2005, 28:2926-2932.
19. Machado M., Cortez-Pinto H. Non-alcoholic fatty liver disease and insulin resistance. European Journal of Gastroenterology and Hepatology 2005, 17:823-826.
20. Marques-Vidal P., Goncalves A., Dias C.M. Milk intake is inversely related to obesity in men and in young women: data from the Portuguese Health Interview Survey 1998-1999. International Journal of Obesity 2006, 30:88-93.
21. Mirmiran P., Esmaillzadeh A., Azizi F. Dairy consumption and body mass index: an inverse relationship. International Journal of Obesity 2005, 29:115-121.
22. Ono T., Murakoshi M., Suzuki N., Iida N., Ohdera M., Iigo M., et al. Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets. British Journal of Nutrition 2010, 104:1688-1695.
23. Pal S., Ellis V. The chronic effects of whey proteins on blood pressure, vascular function, and inflammatory markers in overweight individuals. Obesity 2009, 18:1354-1359. Silver Spring, Md.
24. Papakonstantinou E., Flatt W.P., Huth P.J., Harris T.B. High dietary calcium reduces body fat content, digestibility of fat, and serum vitamin D in rats. Obesity Research 2003, 11:387-394.
25. Parekh S., Anania F.A. Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology 2007, 132:2191-2207.
26. Pereira M.A., Jacobs D.R., Van Horn L., Slattery M.L., Kartashov A.I., Ludwig D.S. Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA study. Journal of American Medical Association 2002, 287:2081-2089.
27. Pilvi T.K., Harala S., Korpela R., Mervaala E.M. Effects of high-calcium diets with different whey proteins on weight loss and weight regain in high-fat-fed C57BL/6J mice. British Journal of Nutrition 2009, 102:337-341.
28. Pilvi T.K., Seppanen-Laakso T., Simolin H., Finckenberg P., Huotari A., Herzig K.H., et al. Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction. World Journal of Gastroenterology 2008, 14:4462-4472.
29. Rocha R., Cotrim H.P., Carvalho F.M., Siqueira A.C., Braga H., Freitas L.A. Body mass index and waist circumference in non-alcoholic fatty liver disease. Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association 2005, 18:365-370.
30. Royle P.J., Mclntosh G.H., Clifton P.M. Whey protein isolate and glycomacropeptide decrease weight gain and alter body composition in male Wistar rats. British Journal of Nutrition 2008, 100:88-93.
31. Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology 2006, 6:772-783.
32. Tiniakos D.G., Vos M.B., Brunt E.M. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annual Review of Pathology 2010, 5:145-171.
33. Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., et al. Absence of S6K1 p.otects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004, 431:200-205.
34. Varenna M., Binelli L., Casari S., Zucchi F., Sinigaglia L. Effects of dietary calcium intake on body weight and prevalence of osteoporosis in early postmenopausal women. American Journal of Clinical Nutrition 2007, 86:639-644.
35. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003, 112:1796-1808.
36. Xu H., Barnes G.T., Yang Q., Tan G., Yang D., Chou C.J., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 2003, 112:1821-1830.
37. Zemel M.B. The role of dairy foods in weight management. Journal of the American College of Nutrition 2005, 24(Suppl. 6):537S-546S.
38. Zemel M.B., Miller S.L. Dietary calcium and dairy modulation of adiposity and obesity risk. Nutrition Reviews 2004, 62:125-131.