Synthesis and structural investigation of some pyrimido[5,4-c]quinolin- 4(3H)-one derivatives with a long-chain arylpiperazine moiety as potent 5-HT1A/2A and 5-HT7 receptor ligands

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3348-3361

  Lewgowd, Wieslawa ^a   Bojarski, Andrzej J ^b   Szczesio, Malgorzata ^c   Olczak, Andrzej ^c   Glowka, Marek L ^c   Mordalski, Stefan ^b   Stanczak, Andrzej ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

5 HT receptor ligands; Long chain arylpiperazines; Molecular modeling; Pyrimidoquinolones

Indexed keywords

1 ARYLPIPERAZINE; 3 [2 (4 PYRIMIDIN 2 YLPIPERAZIN 1 YL)ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (2 METHYLPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (3 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (3 TRIFLUOROMETHYL)PHENYL]PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [2 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [3 (4 PYRIMIDIN 2 YLPIPERAZIN 1 YL)ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [3 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL]PROPYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [3 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [3 [4 (3 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [3 [4 (4 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [3 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]PROPYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; 3 [3 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; [2 (4 PHENYLPIPERAZIN 1 YL)ETHYL]PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE; CYCLOBUTANE; DIMETHYL SULFOXIDE; PIPERAZINE DERIVATIVE; PYRIMIDO[5,4 C]QUINOLIN 4(3H) ONE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; GEOMETRY; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE; SIMULATION; X RAY ANALYSIS;

ANXIETY DISORDERS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERAZINES; PROTEIN BINDING; PYRIMIDINES; QUINOLONES; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 79958251406     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.060     Document Type: Article

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