메뉴 건너뛰기




Volumn 14, Issue 3, 2011, Pages 177-190

Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: A systematic review

Author keywords

Cisplatin; Erlotinib; Gefitinib; NSCLC; Ovarian cancer; Platinum

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CELECOXIB; CETUXIMAB; CISPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; NAVELBINE; OXALIPLATIN; PACLITAXEL; PEMETREXED; ROFECOXIB; TAMOXIFEN;

EID: 79958227079     PISSN: 13687646     EISSN: 15322084     Source Type: Journal    
DOI: 10.1016/j.drup.2011.02.004     Document Type: Article
Times cited : (60)

References (121)
  • 1
    • 0021905666 scopus 로고
    • Isolation and genetic characterization of human KB cell lines resistant to multiple drugs
    • DOI 10.1007/BF01534700
    • S. Akiyama, A. Fojo, J.A. Hanover, I. Pastan, and M.M. Gottesman Isolation and genetic characterization of human KB cell lines resistant to multiple drugs Somat. Cell Mol. Genet. 11 1985 117 126 (Pubitemid 15149285)
    • (1985) Somatic Cell and Molecular Genetics , vol.11 , Issue.2 , pp. 117-126
    • Akiyama, S.1    Fojo, A.2    Hanover, J.A.3
  • 2
    • 74549205168 scopus 로고    scopus 로고
    • Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2
    • C.M. Annunziata, A.J. Walker, L. Minasian, M. Yu, H. Kotz, and B.J. Wood Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2 Clin. Cancer Res. 16 2010 664 672
    • (2010) Clin. Cancer Res. , vol.16 , pp. 664-672
    • Annunziata, C.M.1    Walker, A.J.2    Minasian, L.3    Yu, M.4    Kotz, H.5    Wood, B.J.6
  • 4
    • 66849091226 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV non-small-cell lung cancer
    • H. Bai, L. Mao, H.S. Wang, J. Zhao, L. Yang, and T.T. An Epidermal growth factor receptor mutations in plasma DNA samples predict tumor response in Chinese patients with stages IIIB to IV non-small-cell lung cancer J. Clin. Oncol. 7 2009 2653 2659
    • (2009) J. Clin. Oncol. , vol.7 , pp. 2653-2659
    • Bai, H.1    Mao, L.2    Wang, H.S.3    Zhao, J.4    Yang, L.5    An, T.T.6
  • 9
    • 79251585977 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: An NCIC Clinical Trials Group Study
    • J.J. Biagi, A.M. Oza, H.I. Chalchal, R. Grimshaw, S.L. Ellard, and U. Lee A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group Study Ann. Oncol. 2010 10.1093/annonc/mdq357
    • (2010) Ann. Oncol.
    • Biagi, J.J.1    Oza, A.M.2    Chalchal, H.I.3    Grimshaw, R.4    Ellard, S.L.5    Lee, U.6
  • 10
    • 0037616593 scopus 로고    scopus 로고
    • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
    • DOI 10.1038/sj.onc.1206388
    • R. Bianco, I. Shin, C.A. Ritter, F.M. Yakes, A. Basso, and N. Rosen Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors Oncogene 22 2003 2812 2822 (Pubitemid 36609595)
    • (2003) Oncogene , vol.22 , Issue.18 , pp. 2812-2822
    • Bianco, R.1    Shin, I.2    Ritter, C.A.3    Yakes, F.M.4    Basso, A.5    Rosen, N.6    Tsurutani, J.7    Dennis, P.A.8    Mills, G.B.9    Arteaga, C.L.10
  • 11
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • G.R. Blumenschein Jr., U. Gatzemeier, F. Fossella, D.J. Stewart, L. Cupit, and F. Cihon Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer J. Clin. Oncol. 27 2009 4274 4280
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4274-4280
    • Blumenschein Jr., G.R.1    Gatzemeier, U.2    Fossella, F.3    Stewart, D.J.4    Cupit, L.5    Cihon, F.6
  • 12
    • 45749108933 scopus 로고    scopus 로고
    • How do real tumors become resistant to cisplatin?
    • P. Borst, S. Rottenberg, and J. Jonkers How do real tumors become resistant to cisplatin? Cell Cycle 7 2008 1353 1359 (Pubitemid 351872573)
    • (2008) Cell Cycle , vol.7 , Issue.10 , pp. 1353-1359
    • Borst, P.1    Rottenberg, S.2    Jonkers, J.3
  • 13
    • 24644443129 scopus 로고    scopus 로고
    • Modifications of DNA by platinum complexes: Relation to resistance of tumors to platinum antitumor drugs
    • DOI 10.1016/j.drup.2005.04.006, PII S1368764605000324
    • V. Brabec, and J. Kasparkova Modifications of DNA by platinum complexes: relation to resistance of tumors to platinum antitumor drugs Drug Resist. Updat. 8 2005 131 146 (Pubitemid 41267064)
    • (2005) Drug Resistance Updates , vol.8 , Issue.3 , pp. 131-146
    • Brabec, V.1    Kasparkova, J.2
  • 14
    • 78049477139 scopus 로고    scopus 로고
    • Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer
    • S.K. Chambers, M.C. Clouser, A.F. Baker, D.J. Roe, H. Cui, and M.A. Brewer Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer Clin. Cancer Res. 16 2010 5320 5328
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5320-5328
    • Chambers, S.K.1    Clouser, M.C.2    Baker, A.F.3    Roe, D.J.4    Cui, H.5    Brewer, M.A.6
  • 15
    • 34247599684 scopus 로고    scopus 로고
    • Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy
    • DOI 10.1002/cncr.22616
    • Y.M. Chen, J.M. Liu, T.Y. Chou, R.P. Perng, C.M. Tsai, and J. Whang-Peng Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy Cancer 109 2007 1821 1828 (Pubitemid 46668546)
    • (2007) Cancer , vol.109 , Issue.9 , pp. 1821-1828
    • Chen, Y.-M.1    Liu, J.M.2    Chou, T.-Y.3    Perng, R.-.4    Tsai, C.-M.5    Whang-Peng, J.6
  • 16
    • 58149218582 scopus 로고    scopus 로고
    • Reduced erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: A cell culture model of second-line erlotinib treatment
    • T.M. Chin, M.P. Quinlan, A. Singh, L.V. Sequist, T.J. Lynch, and D.A. Haber Reduced erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: a cell culture model of second-line erlotinib treatment Clin. Cancer Res. 14 2008 6867 6876
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6867-6876
    • Chin, T.M.1    Quinlan, M.P.2    Singh, A.3    Sequist, L.V.4    Lynch, T.J.5    Haber, D.A.6
  • 18
    • 0027027092 scopus 로고
    • Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A
    • M. Clynes, A. Redmond, E. Moran, and U. Gilvarry Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A Cytotechnology 10 1992 75 89
    • (1992) Cytotechnology , vol.10 , pp. 75-89
    • Clynes, M.1    Redmond, A.2    Moran, E.3    Gilvarry, U.4
  • 19
    • 14644435131 scopus 로고    scopus 로고
    • Enhanced sensitivity to the HER1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines
    • DOI 10.1158/1078-0432.CCR-04-0993
    • Q. Dai, Y.H. Ling, M. Lia, Y.Y. Zou, G. Kroog, and K.K. Iwata Enhanced sensitivity to the HER1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib hydrochloride in chemotherapy-resistant tumor cell lines Clin. Cancer Res. 11 2005 1572 1578 (Pubitemid 40315242)
    • (2005) Clinical Cancer Research , vol.11 , Issue.4 , pp. 1572-1578
    • Dai, Q.1    Ling, Y.-H.2    Lia, M.3    Zou, Y.-Y.4    Kroog, G.5    Iwata, K.K.6    Perez-Soler, R.7
  • 22
    • 52449101985 scopus 로고    scopus 로고
    • A phase II pharmacodynamic study of erlotinib in patients with advanced non-small cell lung cancer previously treated with platinum-based chemotherapy
    • E. Felip, F. Rojo, M. Reck, A. Heller, B. Klughammer, and G. Sala A phase II pharmacodynamic study of erlotinib in patients with advanced non-small cell lung cancer previously treated with platinum-based chemotherapy Clin. Cancer Res. 14 2008 3867 3874
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3867-3874
    • Felip, E.1    Rojo, F.2    Reck, M.3    Heller, A.4    Klughammer, B.5    Sala, G.6
  • 24
    • 78650382003 scopus 로고    scopus 로고
    • Biologically targeted cancer therapy and marginal benefits: Are we making too much of too little or are we achieving too little by giving too much?
    • T. Fojo, and D.R. Parkinson Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much? Clin. Cancer Res. 16 2010 5972 5980
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5972-5980
    • Fojo, T.1    Parkinson, D.R.2
  • 27
    • 77952782303 scopus 로고    scopus 로고
    • Triplet chemotherapy with cisplatin, docetaxel, and irinotecan for patients with recurrent or refractory non-small cell lung cancer
    • N. Fujimoto, K. Kiura, N. Takigawa, Y. Fujiwara, S. Toyooka, and S. Umemura Triplet chemotherapy with cisplatin, docetaxel, and irinotecan for patients with recurrent or refractory non-small cell lung cancer Acta Med. Okayama 64 2010 33 37
    • (2010) Acta Med. Okayama , vol.64 , pp. 33-37
    • Fujimoto, N.1    Kiura, K.2    Takigawa, N.3    Fujiwara, Y.4    Toyooka, S.5    Umemura, S.6
  • 28
    • 34247882824 scopus 로고    scopus 로고
    • Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC)
    • DOI 10.1097/01.JTO.0000263712.61697.69, PII 0124389420070400000009
    • S.M. Gadgeel, J.C. Ruckdeschel, E.I. Heath, L.K. Heilbrun, R. Venkatramanamoorthy, and A. Wozniak Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC) J. Thorac. Oncol. 2 2007 299 305 (Pubitemid 47181712)
    • (2007) Journal of Thoracic Oncology , vol.2 , Issue.4 , pp. 299-305
    • Gadgeel, S.M.1    Ruckdeschel, J.C.2    Heath, E.I.3    Heilbrun, L.K.4    Venkatramanamoorthy, R.5    Wozniak, A.6
  • 31
    • 4644274700 scopus 로고    scopus 로고
    • Mutations and addiction to EGFR: The Achilles 'heal' of lung cancers?
    • DOI 10.1016/j.molmed.2004.08.008, PII S1471491404002163
    • A.F. Gazdar, H. Shigematsu, J. Herz, and J.D. Minna Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers? Trends Mol. Med. 10 2004 481 486 (Pubitemid 39303620)
    • (2004) Trends in Molecular Medicine , vol.10 , Issue.10 , pp. 481-486
    • Gazdar, A.F.1    Shigematsu, H.2    Herz, J.3    Minna, J.D.4
  • 32
    • 78650026375 scopus 로고    scopus 로고
    • ALK inhibition for non-small cell lung cancer: From discovery to therapy in record time
    • D.E. Gerber, and J.D. Minna ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time Cancer Cell 18 2010 548 551
    • (2010) Cancer Cell , vol.18 , pp. 548-551
    • Gerber, D.E.1    Minna, J.D.2
  • 34
    • 77649104920 scopus 로고    scopus 로고
    • First-line systemic chemotherapy in the treatment of advanced non-small cell lung cancer: A systematic review
    • J. Goffin, C. Lacchetti, P.M. Ellis, Y.C. Ung, and W.K. Evans First-line systemic chemotherapy in the treatment of advanced non-small cell lung cancer: a systematic review J. Thorac. Oncol. 5 2010 260 274
    • (2010) J. Thorac. Oncol. , vol.5 , pp. 260-274
    • Goffin, J.1    Lacchetti, C.2    Ellis, P.M.3    Ung, Y.C.4    Evans, W.K.5
  • 35
    • 28944439741 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: Results from a phase II multicenter study
    • DOI 10.1111/j.1525-1438.2005.00137.x
    • A.N. Gordon, N. Finkler, R.P. Edwards, A.A. Garcia, M. Crozier, and D.H. Irwin Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II multicenter study Int. J. Gynecol. Cancer 15 2005 785 792 (Pubitemid 41783082)
    • (2005) International Journal of Gynecological Cancer , vol.15 , Issue.5 , pp. 785-792
    • Gordon, A.N.1    Finkler, N.2    Edwards, R.P.3    Garcia, A.A.4    Crozier, M.5    Irwin, D.H.6    Barrett, E.7
  • 36
    • 36048982143 scopus 로고    scopus 로고
    • Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer
    • DOI 10.1200/JCO.2007.12.3026
    • R.S. Herbst, V.J. O'Neill, L. Fehrenbacher, C.P. Belani, P.D. Bonomi, and L. Hart Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer J. Clin. Oncol. 25 2007 4743 4750 (Pubitemid 350086476)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.30 , pp. 4743-4750
    • Herbst, R.S.1    O'Neill, V.J.2    Fehrenbacher, L.3    Belani, C.P.4    Bonomi, P.D.5    Hart, L.6    Melnyk, O.7    Ramies, D.8    Lin, M.9    Sandler, A.10
  • 37
    • 49349089206 scopus 로고    scopus 로고
    • EGFR inhibitor enhances cisplatin sensitivity of oral squamous cell carcinoma cell lines
    • Y. Hiraishi, T. Wada, K. Nakatani, I. Tojyo, T. Matsumoto, and N. Kiga EGFR inhibitor enhances cisplatin sensitivity of oral squamous cell carcinoma cell lines Pathol. Oncol. Res. 14 2008 39 43
    • (2008) Pathol. Oncol. Res. , vol.14 , pp. 39-43
    • Hiraishi, Y.1    Wada, T.2    Nakatani, K.3    Tojyo, I.4    Matsumoto, T.5    Kiga, N.6
  • 38
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • DOI 10.1200/JCO.2003.11.069
    • F.R. Hirsch, M. Varella-Garcia, P.A. Bunn Jr., M.V. Di Maria, R. Veve, R.M. Bremmes, A.E. Barón, C. Zeng, and W.A. Franklin Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis J. Clin. Oncol. 21 2003 3798 3807 (Pubitemid 46606235)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.20 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3    Di Maria, M.V.4    Veve, R.5    Bremnes, R.M.6    Baron, A.E.7    Zeng, C.8    Franklin, W.A.9
  • 39
    • 77955552371 scopus 로고    scopus 로고
    • A phase II study of erlotinib (OSI-774) given in combination with carboplatin in patients with recurrent epithelial ovarian cancer (NCIC CTG IND.149)
    • H. Hirte, A. Oza, K. Swenerton, S.L. Ellard, R. Grimshaw, and B. Fisher A phase II study of erlotinib (OSI-774) given in combination with carboplatin in patients with recurrent epithelial ovarian cancer (NCIC CTG IND.149) Gynecol. Oncol. 118 2010 308 312
    • (2010) Gynecol. Oncol. , vol.118 , pp. 308-312
    • Hirte, H.1    Oza, A.2    Swenerton, K.3    Ellard, S.L.4    Grimshaw, R.5    Fisher, B.6
  • 40
    • 58149219264 scopus 로고    scopus 로고
    • A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: Final results of a PMH, Chicago and California consortia trial
    • H.W. Hirte, L. Vidal, G.F. Fleming, A.K. Sugimoto, R.J. Morgan, and J.J. Biagi A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: final results of a PMH, Chicago and California consortia trial ASCO Meet. Abstr. 26 2008 5521
    • (2008) ASCO Meet. Abstr. , vol.26 , pp. 5521
    • Hirte, H.W.1    Vidal, L.2    Fleming, G.F.3    Sugimoto, A.K.4    Morgan, R.J.5    Biagi, J.J.6
  • 41
    • 0034017475 scopus 로고    scopus 로고
    • ERbB-2 expression is rate-limiting for epidermal growth factor-mediated stimulation of ovarian cancer cell proliferation
    • DOI 10.100 2/(SIC I)1097-02 15(2000 0601)86:5<6 44::AID-IJ C7>3.0.CO;2-T
    • S.S. Hsieh, C. Malerczyk, A. Aigner, and F. Czubayko ERbB-2 expression is rate-limiting for epidermal growth factor-mediated stimulation of ovarian cancer cell proliferation Int. J. Cancer 86 2000 644 651 (Pubitemid 30249874)
    • (2000) International Journal of Cancer , vol.86 , Issue.5 , pp. 644-651
    • Hsieh, S.S.1    Malerczyk, C.2    Aigner, A.3    Czubayko, F.4
  • 42
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • DOI 10.1038/nrc1609
    • N.E. Hynes, and H.A. Lane ERBB receptors and cancer: the complexity of targeted inhibitors Nat. Rev. Cancer 5 2005 341 354 (Pubitemid 40637826)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 43
    • 75149122087 scopus 로고    scopus 로고
    • Proteogenomic studies in epithelial ovarian cancer: Established knowledge and future needs
    • F. Jacob, D.R. Goldstein, D. Fink, and V. Heinzelmann-Schwarz Proteogenomic studies in epithelial ovarian cancer: established knowledge and future needs Biomark. Med. 3 2009 743 756
    • (2009) Biomark. Med. , vol.3 , pp. 743-756
    • Jacob, F.1    Goldstein, D.R.2    Fink, D.3    Heinzelmann-Schwarz, V.4
  • 44
    • 0037499945 scopus 로고    scopus 로고
    • Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: Limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways
    • M.L. Janmaat, F.A. Kruyt, J.A. Rodriguez, and G. Giaccone Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways Clin. Cancer Res. 9 2003 2316 2326 (Pubitemid 36687658)
    • (2003) Clinical Cancer Research , vol.9 , Issue.6 , pp. 2316-2326
    • Janmaat, M.L.1    Kruyt, F.A.E.2    Rodriguez, J.A.3    Giaccone, G.4
  • 45
    • 33646716077 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors
    • H. Ji, X. Zhao, Y. Yuza, T. Shimamura, D. Li, and A. Protopopov Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors Proc. Natl. Acad. Sci. U.S.A. 103 2006 7817 7822
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 7817-7822
    • Ji, H.1    Zhao, X.2    Yuza, Y.3    Shimamura, T.4    Li, D.5    Protopopov, A.6
  • 47
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): A randomised phase III trial
    • E.S. Kim, V. Hirsh, T. Mok, M.A. Socinski, R. Gervais, and Y.L. Wu Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial Lancet 372 2008 1809 1818
    • (2008) Lancet , vol.372 , pp. 1809-1818
    • Kim, E.S.1    Hirsh, V.2    Mok, T.3    Socinski, M.A.4    Gervais, R.5    Wu, Y.L.6
  • 48
    • 77955942384 scopus 로고    scopus 로고
    • Functional proteomics to dissect tyrosine kinase signalling pathways in cancer
    • W. Kolch, and A. Pitt Functional proteomics to dissect tyrosine kinase signalling pathways in cancer Nat. Rev. Cancer 10 2010 618 629
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 618-629
    • Kolch, W.1    Pitt, A.2
  • 49
    • 33750302365 scopus 로고    scopus 로고
    • Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    • DOI 10.1158/1078-0432.CCR-06-0714
    • T. Kosaka, Y. Yatabe, H. Endoh, K. Yoshida, T. Hida, and M. Tsuboi Analysis of epidermal growth factor receptor gene mutation in patients with non-small-cell lung cancer and acquired resistance to gefitinib Clin. Cancer Res. 12 2006 5764 5769 (Pubitemid 44629607)
    • (2006) Clinical Cancer Research , vol.12 , Issue.19 , pp. 5764-5769
    • Kosaka, T.1    Yatabe, Y.2    Endoh, H.3    Yoshida, K.4    Hida, T.5    Tsuboi, M.6    Tada, H.7    Kuwano, H.8    Mitsudomi, T.9
  • 51
    • 61449374843 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: A phase II study
    • K. Kubota, Y. Nishiwaki, T. Tamura, K. Nakagawa, K. Matsui, and K. Watanabe Efficacy and safety of erlotinib monotherapy for Japanese patients with advanced non-small cell lung cancer: a phase II study J. Thorac. Oncol. 3 2008 1439 1445
    • (2008) J. Thorac. Oncol. , vol.3 , pp. 1439-1445
    • Kubota, K.1    Nishiwaki, Y.2    Tamura, T.3    Nakagawa, K.4    Matsui, K.5    Watanabe, K.6
  • 52
    • 0025905727 scopus 로고
    • Different drug sensitivity in two neuroblastoma cell lines established from the same patient before and after chemotherapy
    • H. Kuroda, T. Sugimoto, K. Ueda, S. Tsuchida, Y. Horii, and J. Inazawa Different drug sensitivity in two neuroblastoma cell lines established from the same patient before and after chemotherapy Int. J. Cancer 47 1991 732 737
    • (1991) Int. J. Cancer , vol.47 , pp. 732-737
    • Kuroda, H.1    Sugimoto, T.2    Ueda, K.3    Tsuchida, S.4    Horii, Y.5    Inazawa, J.6
  • 53
    • 31544463584 scopus 로고    scopus 로고
    • Response of ovarian carcinomas to gefitinib-carboplatin-paclitaxel combination is not associated with EGFR kinase domain somatic mutations [5]
    • DOI 10.1002/ijc.21460
    • L. Lacroix, P. Pautier, P. Duvillard, N. Motte, P. Saulnier, and J.M. Bidart Response of ovarian carcinomas to gefitinib-carboplatin-paclitaxel combination is not associated with EGFR kinase domain somatic mutations Int. J. Cancer 118 2006 1068 1069 (Pubitemid 43157690)
    • (2006) International Journal of Cancer , vol.118 , Issue.4 , pp. 1068-1069
    • Lacroix, L.1    Pautier, P.2    Duvillard, P.3    Motte, N.4    Saulnier, P.5    Bidart, J.-M.6    Soria, J.-C.7
  • 54
    • 41949100690 scopus 로고    scopus 로고
    • Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer
    • J.M. Lafky, J.A. Wilken, A.T. Baron, and N.J. Maihle Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer Biochim. Biophys. Acta (Rev. Cancer) 1785 2008 232 265
    • (2008) Biochim. Biophys. Acta (Rev. Cancer) , vol.1785 , pp. 232-265
    • Lafky, J.M.1    Wilken, J.A.2    Baron, A.T.3    Maihle, N.J.4
  • 55
    • 33746742412 scopus 로고    scopus 로고
    • Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma
    • DOI 10.1007/s00109-006-0054-4
    • H. Lassus, H. Sihto, A. Leminen, H. Joensuu, J. Isola, and N.N. Nupponen Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma J. Mol. Med. 84 2006 671 681 (Pubitemid 44164262)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.8 , pp. 671-681
    • Lassus, H.1    Sihto, H.2    Leminen, A.3    Joensuu, H.4    Isola, J.5    Nupponen, N.N.6    Butzow, R.7
  • 56
    • 76749154617 scopus 로고    scopus 로고
    • Randomized phase III trial of gefitinib versus docetaxel in non-small cell lung cancer patients who have previously received platinum-based chemotherapy
    • D.H. Lee, K. Park, J.H. Kim, J.S. Lee, S.W. Shin, and J.H. Kang Randomized phase III trial of gefitinib versus docetaxel in non-small cell lung cancer patients who have previously received platinum-based chemotherapy Clin. Cancer Res. 16 2010 1307 1314
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1307-1314
    • Lee, D.H.1    Park, K.2    Kim, J.H.3    Lee, J.S.4    Shin, S.W.5    Kang, J.H.6
  • 58
    • 15544369937 scopus 로고    scopus 로고
    • Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line
    • DOI 10.1016/j.ygyno.2004.11.051
    • S. Lee, E.J. Choi, C. Jin, and D.H. Kim Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line Gynecol. Oncol. 97 2005 26 34 (Pubitemid 40403670)
    • (2005) Gynecologic Oncology , vol.97 , Issue.1 , pp. 26-34
    • Lee, S.1    Choi, E.-J.2    Jin, C.3    Kim, D.-H.4
  • 59
    • 39749087795 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib or standard chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2
    • DOI 10.1200/JCO.2007.13.2720
    • R. Lilenbaum, R. Axelrod, S. Thomas, A. Dowlati, L. Seigel, and D. Albert Randomized phase II trial of erlotinib or standard chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2 J. Clin. Oncol. 26 2008 863 869 (Pubitemid 351398077)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.6 , pp. 863-869
    • Lilenbaum, R.1    Axelrod, R.2    Thomas, S.3    Dowlati, A.4    Seigel, L.5    Albert, D.6    Witt, K.7    Botkin, D.8
  • 60
    • 0032864463 scopus 로고    scopus 로고
    • Altered drug sensitivity in response to idarubicin treatment in K562 human leukaemia cells
    • DOI 10.1046/j.1365-2141.1999.01494.x
    • V.L. Locke, R.A. Davey, and M.W. Davey Altered drug sensitivity in response to idarubicin treatment in K562 human leukaemia cells Br. J. Haematol. 106 1999 86 91 (Pubitemid 29343531)
    • (1999) British Journal of Haematology , vol.106 , Issue.1 , pp. 86-91
    • Locke, V.L.1    Davey, R.A.2    Davey, M.W.3
  • 62
    • 77955096407 scopus 로고    scopus 로고
    • KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: A meta-analysis of 22 studies
    • C. Mao, L.-X. Qiu, R.-Y. Liao, F.-B. Du, H. Ding, and W.-C. Yang KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: a meta-analysis of 22 studies Lung Cancer 69 2010 272 278
    • (2010) Lung Cancer , vol.69 , pp. 272-278
    • Mao, C.1    Qiu, L.-X.2    Liao, R.-Y.3    Du, F.-B.4    Ding, H.5    Yang, W.-C.6
  • 63
    • 0026517086 scopus 로고
    • Responses to salvage chemotherapy in ovarian cancer: A critical need for precise definitions of the treated population
    • M. Markman, and W. Hoskins Responses to salvage chemotherapy in ovarian cancer: a critical need for precise definitions of the treated population J. Clin. Oncol. 10 1992 513 514
    • (1992) J. Clin. Oncol. , vol.10 , pp. 513-514
    • Markman, M.1    Hoskins, W.2
  • 64
    • 52049125250 scopus 로고    scopus 로고
    • Phase III study V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer
    • R. Maruyama, Y. Nishiwaki, T. Tamura, N. Yamamoto, M. Tsuboi, and K. Nakagawa Phase III study V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer J. Clin. Oncol. 26 2008 4244 4252
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4244-4252
    • Maruyama, R.1    Nishiwaki, Y.2    Tamura, T.3    Yamamoto, N.4    Tsuboi, M.5    Nakagawa, K.6
  • 65
    • 73949123481 scopus 로고    scopus 로고
    • Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer
    • U.A. Matulonis, S. Berlin, P. Ivy, K. Tyburski, C. Krasner, and C. Zarwan Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer J. Clin. Oncol. 27 2009 5601 5606
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5601-5606
    • Matulonis, U.A.1    Berlin, S.2    Ivy, P.3    Tyburski, K.4    Krasner, C.5    Zarwan, C.6
  • 66
    • 77649190700 scopus 로고    scopus 로고
    • Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha
    • E.C. Merkhofer, P. Cogswell, and A.S. Baldwin Her2 activates NF-kappaB and induces invasion through the canonical pathway involving IKKalpha Oncogene 29 2010 1238 1248
    • (2010) Oncogene , vol.29 , pp. 1238-1248
    • Merkhofer, E.C.1    Cogswell, P.2    Baldwin, A.S.3
  • 67
    • 58149187465 scopus 로고    scopus 로고
    • Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins
    • M. Michaelis, J. Bliss, S.C. Arnold, N. Hinsch, F. Rothweiler, and H.E. Deubzer Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins Clin. Cancer Res. 14 2008 6531 6537
    • (2008) Clin. Cancer Res. , vol.14 , pp. 6531-6537
    • Michaelis, M.1    Bliss, J.2    Arnold, S.C.3    Hinsch, N.4    Rothweiler, F.5    Deubzer, H.E.6
  • 69
    • 66249118670 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
    • A. Morabito, M.C. Piccirillo, F. Falasconi, G. De Feo, A. Del Giudice, and J. Bryce Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions Oncologist 14 2009 378 390
    • (2009) Oncologist , vol.14 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3    De Feo, G.4    Del Giudice, A.5    Bryce, J.6
  • 70
    • 79851516240 scopus 로고    scopus 로고
    • Antitumor activity of bortezomib in human cancer cells with acquired resistance to anti-epidermal growth factor receptor tyrosine kinase inhibitors
    • F. Morgillo, E. D'Aiuto, T. Troiani, E. Martinelli, T. Cascone, and R. De Palma Antitumor activity of bortezomib in human cancer cells with acquired resistance to anti-epidermal growth factor receptor tyrosine kinase inhibitors Lung Cancer 2010 10.1016/j.lungcan.2010.06.005
    • (2010) Lung Cancer
    • Morgillo, F.1    D'Aiuto, E.2    Troiani, T.3    Martinelli, E.4    Cascone, T.5    De Palma, R.6
  • 72
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a two-part, double-blind, randomized phase ii study
    • R.B. Natale, D. Bodkin, R. Govindan, B.G. Sleckman, N.A. Rizvi, and A. Capo Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase ii study J. Clin. Oncol. 27 2009 2523 2529
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3    Sleckman, B.G.4    Rizvi, N.A.5    Capo, A.6
  • 73
    • 70349476412 scopus 로고    scopus 로고
    • Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST)
    • R.B. Natale, S. Thongprasert, F.A. Greco, M. Thomas, C.M. Tsai, and P. Sunpaweravong Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: a randomized, double-blind phase III trial (ZEST) J. Clin. Oncol. 27 15 Suppl. 2009 8009 (Meeting Abstracts)
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 SUPPL. , pp. 8009
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3    Thomas, M.4    Tsai, C.M.5    Sunpaweravong, P.6
  • 74
    • 70350655546 scopus 로고    scopus 로고
    • Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer
    • S. Novello, G.V. Scagliotti, R. Rosell, M.A. Socinski, J. Brahmer, and J. Atkins Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer Br. J. Cancer 101 2009 1543 1548
    • (2009) Br. J. Cancer , vol.101 , pp. 1543-1548
    • Novello, S.1    Scagliotti, G.V.2    Rosell, R.3    Socinski, M.A.4    Brahmer, J.5    Atkins, J.6
  • 75
    • 34548212389 scopus 로고    scopus 로고
    • Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non-small-cell lung cancer
    • DOI 10.1200/JCO.2006.09.2791
    • K.J. O'Byrne, S. Danson, D. Dunlop, N. Botwood, F. Taguchi, and D. Carbone Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non small-cell lung cancer J. Clin. Oncol. 25 2007 3266 3273 (Pubitemid 47325611)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.22 , pp. 3266-3273
    • O'Byrne, K.J.1    Danson, S.2    Dunlop, D.3    Botwood, N.4    Taguchi, F.5    Carbone, D.6    Ranson, M.7
  • 76
    • 2642570481 scopus 로고    scopus 로고
    • Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation
    • M. Ono, A. Hirata, T. Kometani, M. Miyagawa, S.i. Ueda, and H. Kinoshita Sensitivity to gefitinib (Iressa ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation Mol. Cancer Ther. 3 2004 465 472 (Pubitemid 39193724)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.4 , pp. 465-472
    • Ono, M.1    Hirata, A.2    Kometani, T.3    Miyagawa, M.4    Ueda, S.-I.5    Kinoshita, H.6    Fujii, T.7    Kuwano, M.8
  • 77
    • 74249089783 scopus 로고    scopus 로고
    • Phase II study of gefitinib in combination with paclitaxel (P) and carboplatin (C) as second-line therapy for ovarian, tubal or peritoneal adenocarcinoma (1839IL/0074)
    • P. Pautier, F. Joly, P. Kerbrat, P. Bougnoux, P. Fumoleau, and T. Petit Phase II study of gefitinib in combination with paclitaxel (P) and carboplatin (C) as second-line therapy for ovarian, tubal or peritoneal adenocarcinoma (1839IL/0074) Gynecol. Oncol. 116 2010 157 162
    • (2010) Gynecol. Oncol. , vol.116 , pp. 157-162
    • Pautier, P.1    Joly, F.2    Kerbrat, P.3    Bougnoux, P.4    Fumoleau, P.5    Petit, T.6
  • 80
    • 79960295130 scopus 로고    scopus 로고
    • Sunitinib in pretreated advanced non-small-cell lung carcinoma: A primary result from Asian population
    • G. Ping, W. Hui-Min, W. Wei-Min, and H. Bao-Hui Sunitinib in pretreated advanced non-small-cell lung carcinoma: a primary result from Asian population Med. Oncol. 2010 10.1007/s12032-010-9500-9
    • (2010) Med. Oncol.
    • Ping, G.1    Hui-Min, W.2    Wei-Min, W.3    Bao-Hui, H.4
  • 83
    • 37549030869 scopus 로고    scopus 로고
    • Efficacy and side effects of cisplatin- and carboplatin-based doublet chemotherapeutic regimens versus non-platinum-based doublet chemotherapeutic regimens as first line treatment of metastatic non-small cell lung carcinoma: A systematic review of randomized controlled trials
    • A. Rajeswaran, A. Trojan, B. Burnand, and M. Giannelli Efficacy and side effects of cisplatin- and carboplatin-based doublet chemotherapeutic regimens versus non-platinum-based doublet chemotherapeutic regimens as first line treatment of metastatic non-small cell lung carcinoma: a systematic review of randomized controlled trials Lung Cancer 59 2008 1 11
    • (2008) Lung Cancer , vol.59 , pp. 1-11
    • Rajeswaran, A.1    Trojan, A.2    Burnand, B.3    Giannelli, M.4
  • 84
    • 43249110958 scopus 로고    scopus 로고
    • Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): A phase I study
    • DOI 10.1097/JTO.0b013e3181653d1b, PII 0124389420080300000010
    • S. Ramalingam, J. Forster, C. Naret, T. Evans, M. Sulecki, and H. Lu Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I study J. Thorac. Oncol. 3 2008 258 264 (Pubitemid 351654325)
    • (2008) Journal of Thoracic Oncology , vol.3 , Issue.3 , pp. 258-264
    • Ramalingam, S.1    Forster, J.2    Naret, C.3    Evans, T.4    Sulecki, M.5    Lu, H.6    Teegarden, P.7    Weber, M.R.8    Belani, C.P.9
  • 85
    • 77958455487 scopus 로고    scopus 로고
    • Erlotinib in combination with pemetrexed for patients with advanced non-small-cell lung cancer (NSCLC): A phase i dose-finding study
    • M. Ranson, M. Reck, A. Anthoney, A.R. Hanauske, E. Dean, and I. Melezinek Erlotinib in combination with pemetrexed for patients with advanced non-small-cell lung cancer (NSCLC): a phase I dose-finding study Ann. Oncol. 21 2010 2233 2239
    • (2010) Ann. Oncol. , vol.21 , pp. 2233-2239
    • Ranson, M.1    Reck, M.2    Anthoney, A.3    Hanauske, A.R.4    Dean, E.5    Melezinek, I.6
  • 87
    • 78149249388 scopus 로고    scopus 로고
    • Personalized medicine in non-small-cell lung cancer: Is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy?
    • P.J. Roberts, T.E. Stinchcombe, C.J. Der, and M.A. Socinski Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy? J. Clin. Oncol. 28 2010 4769 4777
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4769-4777
    • Roberts, P.J.1    Stinchcombe, T.E.2    Der, C.J.3    Socinski, M.A.4
  • 88
    • 38649109498 scopus 로고    scopus 로고
    • Molecular-targeted therapies: Lessons from years of clinical development
    • DOI 10.1016/j.ctrv.2007.07.019, PII S0305737207000977
    • D.D. Rosa, G. Ismael, L.D. Lago, and A. Awada Molecular-targeted therapies: lessons from years of clinical development Cancer Treat. Rev. 34 2008 61 80 (Pubitemid 351168606)
    • (2008) Cancer Treatment Reviews , vol.34 , Issue.1 , pp. 61-80
    • Rosa, D.D.1    Ismael, G.2    Lago, L.D.3    Awada, A.4
  • 89
    • 74749106342 scopus 로고    scopus 로고
    • Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care
    • D.H. Roukos Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care Expert Rev. Mol. Diagn. 10 2010 33 48
    • (2010) Expert Rev. Mol. Diagn. , vol.10 , pp. 33-48
    • Roukos, D.H.1
  • 90
    • 0027159063 scopus 로고
    • Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung
    • V. Rusch, J. Baselga, C. Cordon-Cardo, J. Orazem, M. Zaman, and S. Hoda Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung Cancer Res. 53 1993 2379 2385 (Pubitemid 23156828)
    • (1993) Cancer Research , vol.53 , Issue.10 , pp. 2379-2385
    • Rusch, V.1    Baselga, J.2    Cordon-Cardo, C.3    Orazem, J.4    Zaman, M.5    Hoda, S.6    McIntosh, J.7    Kurie, J.8    Dmitrovsky, E.9
  • 92
    • 23044511620 scopus 로고    scopus 로고
    • Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: A Gynecologic Oncology Group Study
    • DOI 10.1158/1078-0432.CCR-05-0462
    • R.J. Schilder, M.W. Sill, X. Chen, K.M. Darcy, S.L. Decesare, and G. Lewandowski Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study Clin. Cancer Res. 11 2005 5539 5548 (Pubitemid 41060831)
    • (2005) Clinical Cancer Research , vol.11 , Issue.15 , pp. 5539-5548
    • Schilder, R.J.1    Sill, M.W.2    Chen, X.3    Darcy, K.M.4    Decesare, S.L.5    Lewandowski, G.6    Lee, R.B.7    Arciero, C.A.8    Wu, H.9    Godwin, A.K.10
  • 93
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • DOI 10.1038/nrc2109, PII NRC2109
    • S. Schubbert, K. Shannon, and G. Bollag Hyperactive Ras in developmental disorders and cancer Nat. Rev. Cancer 7 2007 295 308 (Pubitemid 46480970)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.4 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 94
    • 57349172709 scopus 로고    scopus 로고
    • Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib
    • T. Servidei, A. Riccardi, S. Mozzetti, C. Ferlini, and R. Riccardi Chemoresistant tumor cell lines display altered epidermal growth factor receptor and HER3 signaling and enhanced sensitivity to gefitinib Int. J. Cancer 123 2008 2939 2949
    • (2008) Int. J. Cancer , vol.123 , pp. 2939-2949
    • Servidei, T.1    Riccardi, A.2    Mozzetti, S.3    Ferlini, C.4    Riccardi, R.5
  • 95
    • 33744931651 scopus 로고    scopus 로고
    • Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation
    • DOI 10.1002/jcp.20659
    • T. Servidei, A. Riccardi, M. Sanguinetti, C. Dominici, and R. Riccardi Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation J. Cell. Physiol. 208 2006 220 228 (Pubitemid 43849008)
    • (2006) Journal of Cellular Physiology , vol.208 , Issue.1 , pp. 220-228
    • Servidei, T.1    Riccardi, A.2    Sanguinetti, M.3    Dominici, C.4    Riccardi, R.5
  • 99
    • 0141960451 scopus 로고    scopus 로고
    • Resistance to gefitinib in PTEN-Null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling
    • Q.B. She, D. Solit, A. Basso, and M.M. Moasser Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling Clin. Cancer Res. 9 2003 4340 4346 (Pubitemid 37248389)
    • (2003) Clinical Cancer Research , vol.9 , Issue.12 , pp. 4340-4346
    • She, Q.-B.1    Solit, D.2    Basso, A.3    Moasser, M.M.4
  • 102
    • 33645322927 scopus 로고    scopus 로고
    • Epithelial growth factor receptor status in primary and recurrent ovarian cancer
    • S. Stadlmann, U. Gueth, U. Reiser, P.A. Diener, A.G. Zeimet, and E. Wight Epithelial growth factor receptor status in primary and recurrent ovarian cancer Mod. Pathol. 19 2006 607 610
    • (2006) Mod. Pathol. , vol.19 , pp. 607-610
    • Stadlmann, S.1    Gueth, U.2    Reiser, U.3    Diener, P.A.4    Zeimet, A.G.5    Wight, E.6
  • 104
    • 33646481633 scopus 로고    scopus 로고
    • Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells
    • B.K. Stordal, M.W. Davey, and R.A. Davey Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells Cancer Chemother. Pharmacol. 58 2006 256 265
    • (2006) Cancer Chemother. Pharmacol. , vol.58 , pp. 256-265
    • Stordal, B.K.1    Davey, M.W.2    Davey, R.A.3
  • 105
    • 35649024810 scopus 로고    scopus 로고
    • Understanding cisplatin resistance using cellular models
    • DOI 10.1080/15216540701636287, PII 782123898
    • B. Stordal, and M. Davey Understanding cisplatin resistance using cellular models IUBMB Life 59 2007 696 699 (Pubitemid 350035586)
    • (2007) IUBMB Life , vol.59 , Issue.11 , pp. 696-699
    • Stordal, B.1    Davey, M.2
  • 106
    • 36049015023 scopus 로고    scopus 로고
    • A systematic review of platinum and taxane resistance from bench to clinic: An inverse relationship
    • DOI 10.1016/j.ctrv.2007.07.013, PII S0305737207000989
    • B. Stordal, N. Pavlakis, and R. Davey A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship Cancer Treat. Rev. 33 2007 688 703 (Pubitemid 350089290)
    • (2007) Cancer Treatment Reviews , vol.33 , Issue.8 , pp. 688-703
    • Stordal, B.1    Pavlakis, N.2    Davey, R.3
  • 107
    • 34248570744 scopus 로고    scopus 로고
    • Oxaliplatin for the treatment of cisplatin-resistant cancer: A systematic review
    • DOI 10.1016/j.ctrv.2007.01.009, PII S0305737207000321
    • B. Stordal, N. Pavlakis, and R. Davey Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review Cancer Treat. Rev. 33 2007 347 357 (Pubitemid 46760527)
    • (2007) Cancer Treatment Reviews , vol.33 , Issue.4 , pp. 347-357
    • Stordal, B.1    Pavlakis, N.2    Davey, R.3
  • 108
    • 0141570766 scopus 로고    scopus 로고
    • The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status
    • DOI 10.1016/S0169-5002(03)00278-2
    • T. Suzuki, T. Nakagawa, H. Endo, T. Mitsudomi, A. Masuda, and Y. Yatabe The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status Lung Cancer 42 2003 35 41 (Pubitemid 37153133)
    • (2003) Lung Cancer , vol.42 , Issue.1 , pp. 35-41
    • Suzuki, T.1    Nakagawa, T.2    Endo, H.3    Mitsudomi, T.4    Masuda, A.5    Yatabe, Y.6    Sugiura, T.7    Takahashi, T.8    Hida, T.9
  • 109
    • 78751505463 scopus 로고    scopus 로고
    • Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer
    • Y. Tanaka, Y. Terai, A. Tanabe, H. Sasaki, T. Sekijima, and S. Fujiwara Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer Cancer Biol. Ther. 11 2011 50 57
    • (2011) Cancer Biol. Ther. , vol.11 , pp. 50-57
    • Tanaka, Y.1    Terai, Y.2    Tanabe, A.3    Sasaki, H.4    Sekijima, T.5    Fujiwara, S.6
  • 110
    • 75749145931 scopus 로고    scopus 로고
    • Management of patients with advanced non-small cell lung cancer: Current and emerging options
    • L.R. Triano, H. Deshpande, and S.N. Gettinger Management of patients with advanced non-small cell lung cancer: current and emerging options Drugs 70 2010 167 179
    • (2010) Drugs , vol.70 , pp. 167-179
    • Triano, L.R.1    Deshpande, H.2    Gettinger, S.N.3
  • 111
    • 21044450999 scopus 로고    scopus 로고
    • ESMO minimum clinical recommendations for diagnosis, treatment and follow-up of epithelial ovarian carcinoma
    • P.A. Vasey, J. Herrstedt, and S. Jelic ESMO minimum clinical recommendations for diagnosis, treatment and follow-up of epithelial ovarian carcinoma Ann. Oncol. 16 Suppl. 1 2005 i13 i15
    • (2005) Ann. Oncol. , vol.16 , Issue.SUPPL. 1
    • Vasey, P.A.1    Herrstedt, J.2    Jelic, S.3
  • 112
    • 40749101689 scopus 로고    scopus 로고
    • Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers
    • J. Vermeij, E. Teugels, C. Bourgain, J. Xiangming, P. in't Veld, and V. Ghislain Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers BMC Cancer 8 2008 3
    • (2008) BMC Cancer , vol.8 , pp. 3
    • Vermeij, J.1    Teugels, E.2    Bourgain, C.3    Xiangming, J.4    In'T Veld, P.5    Ghislain, V.6
  • 113
    • 33947318253 scopus 로고    scopus 로고
    • Gefitinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy-A phase II trial of the AGO Ovarian Cancer Study Group (AGO-OVAR 2.6)
    • DOI 10.1016/j.ygyno.2006.10.053, PII S0090825806008985
    • U. Wagner, A. du Bois, J. Pfisterer, J. Huober, S. Loibl, and H.-J. Lück Gefitinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy - a phase II trial of the AGO Ovarian Cancer Study Group (AGO-OVAR 2.6) Gynecol. Oncol. 105 2007 132 137 (Pubitemid 46441449)
    • (2007) Gynecologic Oncology , vol.105 , Issue.1 , pp. 132-137
    • Wagner, U.1    Du Bois, A.2    Pfisterer, J.3    Huober, J.4    Loibl, S.5    Luck, H.-J.6    Sehouli, J.7    Gropp, M.8    Stahle, A.9    Schmalfeldt, B.10    Meier, W.11    Jackisch, C.12
  • 114
    • 43949125179 scopus 로고    scopus 로고
    • EGFR/KRAS mutations and gefitinib therapy in Chinese NSCLC patients
    • DOI 10.1159/000116736
    • Z. Wang, Y.L. Wu, G.C. Zhang, Q. Zhou, C.R. Xu, and A.L. Guo EGFR/KRAS mutations and gefitinib therapy in Chinese NSCLC patients Onkologie 31 2008 174 178 (Pubitemid 351700540)
    • (2008) Onkologie , vol.31 , Issue.4 , pp. 174-178
    • Wang, Z.1    Wu, Y.L.2    Zhang, G.C.3    Zhou, Q.4    Xu, C.R.5    Guo, A.L.6
  • 115
    • 70349732865 scopus 로고    scopus 로고
    • Adhesion-mediated apoptosis resistance in cancer
    • M.A. Westhoff, and S. Fulda Adhesion-mediated apoptosis resistance in cancer Drug Resist. Updat. 12 2009 127 136
    • (2009) Drug Resist. Updat. , vol.12 , pp. 127-136
    • Westhoff, M.A.1    Fulda, S.2
  • 116
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • I.B. Weinstein, and A. Joe Oncogene addiction Cancer Res. 68 2008 3077 3088
    • (2008) Cancer Res. , vol.68 , pp. 3077-3088
    • Weinstein, I.B.1    Joe, A.2
  • 117
    • 78449283888 scopus 로고    scopus 로고
    • Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations
    • C. Yamamoto, Y. Basaki, A. Kawahara, K. Nakashima, M. Kage, and H. Izumi Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations Cancer Res. 70 2010 8715 8725
    • (2010) Cancer Res. , vol.70 , pp. 8715-8725
    • Yamamoto, C.1    Basaki, Y.2    Kawahara, A.3    Nakashima, K.4    Kage, M.5    Izumi, H.6
  • 119
    • 33645516362 scopus 로고    scopus 로고
    • Akt-mediated cisplatin resistance in ovarian cancer: Modulation of p53 action on caspase-dependent mitochondrial death pathway
    • X. Yang, M. Fraser, U.M. Moll, A. Basak, and B.K. Tsang Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway Cancer Res. 66 2006 3126 3136
    • (2006) Cancer Res. , vol.66 , pp. 3126-3136
    • Yang, X.1    Fraser, M.2    Moll, U.M.3    Basak, A.4    Tsang, B.K.5
  • 121
    • 23844517762 scopus 로고    scopus 로고
    • The EGFR mutation and its correlation with response of gefitinib in previously treated Chinese patients with advanced non-small-cell lung cancer
    • DOI 10.1093/annonc/mdi340
    • X.T. Zhang, L.Y. Li, X.L. Mu, Q.C. Cui, X.Y. Chang, and W. Song The EGFR mutation and its correlation with response of gefitinib in previously treated Chinese patients with advanced non-small-cell lung cancer Ann. Oncol. 16 2005 1334 1342 (Pubitemid 41158479)
    • (2005) Annals of Oncology , vol.16 , Issue.8 , pp. 1334-1342
    • Zhang, X.-T.1    Li, L.-Y.2    Mu, X.-L.3    Cui, Q.-C.4    Chang, X.-Y.5    Song, W.6    Wang, S.-L.7    Wang, M.-Z.8    Zhong, W.9    Zhang, L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.