ERbB-2 expression is rate-limiting for epidermal growth factor-mediated stimulation of ovarian cancer cell proliferation

International Journal of Cancer

Volumn 86, Issue 5, 2000, Pages 644-651

  Hsieh, Susie S ^a   Malerczyk, Claudius ^c   Aigner, Achim ^c   Czubayko, Frank ^b  

^a ELI LILLY AND COMPANY   (United States)

^b Medizinische Forschungseinrichtungen   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; ONCOPROTEIN; RIBOZYME;

ADENOCARCINOMA; ANCHORAGE INDEPENDENT GROWTH; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE;

APOPTOSIS; CELL DIVISION; EPIDERMAL GROWTH FACTOR; FEMALE; GLYCOPROTEINS; HUMANS; NEUREGULIN-1; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RNA, CATALYTIC; TUMOR CELLS, CULTURED;

EID: 0034017475     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000601)86:5<644::AID-IJC7>3.0.CO;2-T     Document Type: Article

References (21)

1. ALIMANDI, M., WANG, L.M., BOTTARO, D., FRANKEL, M., FEDI, P., TANG, C., LIPPMAN, M. and PIERCE, J.H., Epidermal growth factor and betacellulin mediate signal transduction through co-expressed ErbB2 and ErbB3 receptors. EMBO J., 16, 5608-5617 (1997).
2. ALROY, I. and YARDEN, Y., The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett., 410, 83-86 (1997).
3. CARRAWAY, K.L., III and CANTLEY, L.C., A Neu acquaintance for ErbB3 and ErbB4: a role for receptor heterodimerization in growth signaling. Cell, 78, 5-8 (1994).
4. CZUBAYKO, F., DOWNING, S.G., HSIEH, S.S., GOLDSTEIN, D.J., LU, P.Y., TRAPNELL, B.C. and WELLSTEIN, A., Adenovirus-mediated transduction of ribozymes abrogates HER-2/neu and pleiotrophin expression and inhibits tumor cell proliferation. Gene Ther., 4, 943-949 (1997).
5. DALY, J.M., JANNOT, C.B., BEERLI, R.R., GRAUS-PORTA, D., MAURER, F.G. and HYNES, N.E., Neu differentiation factor induces down-regulation and apoptosis of ErbB2-overexpressing breast tumor cells. Cancer Res., 57, 3804-3811 (1997).
6. FANG, W.J., HARTMANN, N., CHOW, D., RIEGEL, A.T. and WELLSTEIN, A., Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer. J. biol. Chem., 267, 25889-25897 (1992).
7. GRAUS-PORTA, D., BEERLI, R.R., DALY, J.M. and HYNES, N.E., ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J., 16, 1647-1655 (1997).
8. GRAUS-PORTA, D., BEERLI, R.R. and HYNES, N.E., Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling. Mol cell. Biol., 15, 1182-1191 (1995).
9. HURWITZ, E., STANCOVSKI, I., SELA, M. and YARDEN, Y., Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake. Proc. nat. Acad. Sci. (Wash.), 92, 3353-3357 (1995).
10. JUHL, H., DOWNING, S.G., WELLSTEIN, A. and CZUBAYKO, F., HER-2/neu is rate-limiting for ovarian cancer growth: conditional depletion of HER-2/neu by ribozyme targeting. J. biol. Chem., 272, 29482-29486 (1997).
11. KARUNAGARAN, D., TZAHAR, E., BEERLI, R.R., CHEN, X., GRAUS-PORTA, D., RATZKIN, B.J., SEGER, R., HYNES, N.E. and YARDEN, Y., ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J., 15, 254-264 (1996).
12. LEWIS, G.D., LOFGREN, J.A., MCMURTREY, A.E., NUIJENS, A., FENDLY, B.M., BAUER, K.D. and SLIWKOWSKI, M.X., Growth regulation of human breast and ovarian tumor cells by heregulin: evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness. Cancer Res., 56, 1457-1465 (1996).
13. PIERCE, J.H., RUGGIERO, M., FLEMING, T.P., DI FIORE, P.P., GREENBERGER, J.S., VARTICOVSKI, L., SCHLESSINGER, J., ROVERA, G. and AARONSON, S.A., Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells. Science, 239, 628-631 (1988)
14. PINKAS-KRAMARSKI, R., SOUSSAN, L., WATERMAN, H., LEVKOWITZ, G., ALROY, I., KLAPPER, L., LAVI, S., SEGER, R., RATZKIN, B.J., SELA, M. and YARDEN, Y., Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J., 15, 2452-2467 (1996).
15. SALOMON, D.S., BRANDT, R., CIARDIELLO, F. and NORMANNO, N., Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol., 19, 183-232 (1995).
16. SHAK, S., Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2 overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group. Semin. Oncol., 26 (Suppl. 12) 71-77 (1999).
17. SLAMON, D.J., GODOLPHIN, W., JONES, L.A., HOLT, J.A., WONG, S.G., KEITH, D.E., LEVIN, W.J., STUART, S.G., UDOVE, J. and ULLRICH, A., Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science, 244, 707-712 (1989).
18. SOUTTOU, B., AHMAD, S., RIEGEL, A.T. and WELLSTEIN, A., Signal transduction pathways involved in the mitogenic activity of pleiotrophin. Implication of mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. J. biol. Chem., 272, 19588-19593 (1997).
19. TZAHAR, E., LEVKOVITZ, G., KARUNAGARAN, D., YI, L., PELES, E., LAVI, S., CHANG, D., LIU, N. and YAYON, A., ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms. J. biol. Chem., 269, 25226-25233 (1994).
20. TZAHAR, E., PINKAS-KRAMARSKI, R., MOYER, J.D., KLAPPER, L.N., ALROY, I., LEVKOWITZ, G., SHELLY, M., HENIS, S., EISENSTEIN, M., RATZKIN, B.J., SELA, M., ANDREWS, G.C. and YARDEN, Y., Bivalence of EGF-like ligands drives the ErbB signaling network. EMBO J., 16, 4938-4950 (1997).
21. VAUGHN, J.P., IGLEHART, J.D., DEMIRDJI, S., DAVIS, P., BABISS, L.E., CARUTHERS, M.H. and MARKS, J.R., Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay. Proc. nat. Acad. Sci. (Wash.), 92, 8338-8342 (1995).