Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Aβ pathology in Alzheimer's disease

Acta Neuropathologica

Volumn 120, Issue 2, 2010, Pages 195-207

  Morawski, Markus ^a   Hartlage Rübsamen, Maike ^a   Jäger, Carsten ^a   Waniek, Alexander ^a   Schilling, Stephan ^b   Schwab, Claudia ^c   McGeer, Patrick L ^c   Arendt, Thomas ^a   Demuth, Hans Ulrich ^b,d   Roßner, Steffen ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b PROBIODRUG AG   (Germany)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d Ingenium Pharmaceuticals AG   (Germany)

Author keywords

Alzheimer's disease; Edinger westphal nucleus; Glutaminyl cyclase; Locus coeruleus; Nucleus basalis meynert; Pyroglutamate abeta

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN ENZYME; GLUTAMIC ACID; GLUTAMINYL CYCLASE; UNCLASSIFIED DRUG; UROCORTIN I; AMINOACYLTRANSFERASE; CHOLINE ACETYLTRANSFERASE; GLUTAMINYL PEPTIDE CYCLOTRANSFERASE; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; PYROGLUTAMIC ACID; TYROSINE 3 MONOOXYGENASE; UCN1 PROTEIN, MOUSE; UROCORTIN;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN NUCLEUS; BRAIN REGION; CELL POPULATION; CHOLINERGIC NERVE; CHOLINERGIC NERVE CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LOCUS CERULEUS; MAGNOCELLULAR NUCLEUS; MALE; MEYNERT BASAL NUCLEUS; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; NORADRENERGIC NERVE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CONFOCAL MICROSCOPY; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM; MIDDLE AGED; MOUSE MUTANT; PATHOLOGY; PERIAQUEDUCTAL GRAY MATTER; PHYSIOLOGY;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMINOACYLTRANSFERASES; AMYLOID BETA-PROTEIN; ANIMALS; BASAL NUCLEUS OF MEYNERT; CHOLINE O-ACETYLTRANSFERASE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LOCUS COERULEUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MIDDLE AGED; PERIAQUEDUCTAL GRAY; PYRROLIDONECARBOXYLIC ACID; TYROSINE 3-MONOOXYGENASE; UROCORTINS;

EID: 77957273422     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0685-y     Document Type: Article

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