Modulation of the serotonin system by endocannabinoid signaling

Neuropharmacology

Volumn 61, Issue 3, 2011, Pages 414-420

  Haj Dahmane, Samir ^a   Shen, Roh Yu ^a  

^a RESEARCH INSTITUTE ON ADDICTIONS   (United States)

Author keywords

Dorsal raphe; Endocannabinoid; Serotonin; Stress; Synaptic transmission

Indexed keywords

2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; ENDOCANNABINOID; FATTY ACID AMIDASE; GLUCOCORTICOID; OREXIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1,2 DIACETYLGLYCEROL; ALPHA BETA HYDROXYLASE DOMAIN 6; DIACYLGLYCEROL; G PROTEIN COUPLED RECEPTOR; INOSITOL (1,4,5) TRIPHOSPHATE; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR 1; N ARACHIDONYL DOPAMINE; OREXIN B; OREXIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHATIDYL INOSITOL BIPHOSPHATE 2; PHOSPHOLIPASE C; RETINOID X RECEPTOR; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1;

CATABOLISM; DORSAL RAPHE NUCLEUS; EXCITATORY POSTSYNAPTIC POTENTIAL; GABAERGIC TRANSMISSION; HYDROLYSIS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; LONG TERM DEPRESSION; MEMBRANE DEPOLARIZATION; MOLECULAR DYNAMICS; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NEUROMODULATION; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; RECEPTOR BLOCKING; REVIEW; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TRANQUILIZING ACTIVITY; ADIPOGENESIS; APOPTOSIS; BRAIN; BRAIN FUNCTION; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DEPOLARIZATION; DRUG ACCUMULATION; DRUG METABOLISM; DRUG PROTEIN BINDING; ELECTROPHYSIOLOGY; GENE DELETION; GENE TARGETING; GLUCOSE HOMEOSTASIS; INFLAMMATION; MAMMAL; MEDIAN RAPHE NUCLEUS; NEUROPHYSIOLOGY; OXIDATIVE STRESS; POSTSYNAPTIC MEMBRANE; RISK ASSESSMENT; STRESS;

ANIMALS; CENTRAL NERVOUS SYSTEM; ENDOCANNABINOIDS; HUMANS; NERVE TISSUE PROTEINS; NEURONS; RAPHE NUCLEI; RECEPTORS, CANNABINOID; RECEPTORS, SEROTONIN; SEROTONIN; STRESS, PHYSIOLOGICAL; STRESS, PSYCHOLOGICAL; SYNAPTIC TRANSMISSION;

EID: 79958148796     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.02.016     Document Type: Review

References (98)

1. C. Arevalo, R. De Miguel, and R. Hernandez-Tristan Cannabinoid effects on anxiety-related behaviors and hypothalamic neurotransmitters Pharmacol. Biochem. Behav. 70 2001 123 131 (Pubitemid 32786974)
2. 1 receptor activity impairs serotoninergic negative feedback J. Neurochem. 109 2009 935 944
3. N. Auclair, S. Otani, P. Soubrie, and F. Crepel Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex J. Neurophysiol. 83 2000 3287 3293 (Pubitemid 30408863)
4. S.C. Azad, M. Eder, G. Marsicano, B. Lutz, W. Zieglgansberger, and G. Rammes Activation of cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse Learn. Mem. 10 2003 116 128 (Pubitemid 36418722)
5. A. Bacci, J.R. Huguenard, and D.A. Prince Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids Nature 431 2004 312 316 (Pubitemid 39265666)
6. F.R. Bambico, T. Cassano, S. Dominguez-Lopez, N. Katz, C.D. Walker, D. Piomelli, and G. Gobbi Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotoninergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus Neuropsychopharmacology 35 2010 2083 2100
7. F.R. Bambico, N. Katz, G. Debonnel, and G. Gobbi Cannabinoids elicit antidepressant-like behavior and activate serotoninergic neurons through the medial prefrontal cortex J. Neurosci. 27 2007 11700 11711 (Pubitemid 350006914)
8. M.V. Baratta, C.M. Zarza, D.M. Gomez, S. Campeau, L.R. Watkins, and S.F. Maier Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress Eur. J. Neurosci. 30 2009 1111 1116
9. J. Bïque, C. de Montigny, P. Blier, and G. Debonnel Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat Neuropharmacology 39 2000 1800 1812 (Pubitemid 30398484)
10. M. Beltramo, N. Stella, A. Calignano, S.Y. Lin, A. Makriyannis, and D. Piomelli Functional role of high-affinity anandamide transport, as revealed by selective inhibition Science 277 1997 1094 1097 (Pubitemid 27371630)
11. A.R. Best, and W.G. Regehr Serotonin evokes endocannabinoid release and retrogradely suppresses excitatory synapses J. Neurosci. 28 2008 6508 6515
12. T. Bisogno, F. Howell, G. Williams, A. Minassi, M.G. Cascio, I. Matias, A. Schiano-Moriello, P. Paul, E.J. Williams, U. Gangadharan, C. Hobbs, V. Di Marzo, and P. Doherty Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain J. Cell. Biol. 163 2003 463 468 (Pubitemid 37429860)
13. 1 Biochem. J. 312 1995 637 641 (Pubitemid 26002235)
14. R.E. Brown, O.A. Sergeeva, K.S. Eriksson, and H.L. Haas Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline) J. Neurosci. 22 2002 8850 8859 (Pubitemid 35379054)
15. G.A. Carrasco, and L.D. Van de Kar Neuroendocrine pharmacology of stress Eur. J. Pharmacol. 463 2003 235 272 (Pubitemid 36205084)
16. M.J. Caterina, M.A. Schumacher, M. Tominaga, T.A. Rosen, J.D. Levine, and D. Julius The capsaicin receptor: a heat-activated ion channel in the pain pathway Nature 389 1997 816 824 (Pubitemid 27462969)
17. A.E. Chávez, C.Q. Chiu, and P.E. Castillo TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus Nat. Neurosci. 13 2010 1511 1518
18. V. Chevaleyre, and P.E. Castillo Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability Neuron 38 2003 461 472 (Pubitemid 36579147)
19. G. Chinetti, J.C. Fruchart, and B. Staels Peroxisome proliferators- activated receptors (PPARs): nuclear receptor at the crossroads between lipid metabolism and inflammation Inflamm. Res. 49 2000 497 505
20. B.F. Cravatt, D.K. Giang, S.P. Mayfield, D.L. Boger, R.A. Lerner, and N.B. Gilula Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides Nature 384 1996 83 87 (Pubitemid 26374593)
21. 1 receptor antagonist SR 141716A increase brain serotonin and dopamine levels and turnover Pharmacol. Biochem. Behav. 75 2003 777 787 (Pubitemid 37289462)
22. W.A. Devane, F.A. Dysarz 3rd, M.R. Johnson, L.S. Melvin, and A.C. Howlett Determination and characterization of cannabinoid receptor in rat brain Mol. Pharmacol. 34 1988 605 613 (Pubitemid 19007296)
23. W.A. Devane, L. Hanus, A. Breuer, R.G. Oertwee, L.A. Stevenson, G. Griffin, D. Gibson, A. Mandelbaum, A. Etinger, and R. Mechoulam Isolation and structure of a brain constituent that binds to the cannabinoid receptor Science 258 1992 1946 1949 (Pubitemid 23026736)
24. S. Di, R. Malcher-Lopes, K.C. Halmos, and J.G. Tasker Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism J. Neurosci. 23 2003 4850 4857 (Pubitemid 36793211)
25. V. Di Marzo Endocannabinoids: synthesis and degradation Rev. Physiol. Biochem. Pharmacol. 160 2008 1 24
26. V. Di Marzo, A. Fontana, H. Cadas, S. Schinelli, G. Cimino, J.C. Schwartz, and D. Piomelli Formation and inactivation of endogenous cannabinoid anandamide in central neurons Nature 372 1994 686 691
27. N. Egashira, K. Mishima, S. Katsurabayashi, T. Yoshitake, Y. Matsumoto, J. Ishida, M. Yamaguchi, K. Iwasaki, and M. Fujiwara Involvement of 5-hydroxytryptamine neuronal system in Delta(9)-tetrahydrocannabinol-induced impairment of spatial memory Eur. J. Pharmacol. 445 2002 221 229 (Pubitemid 34655679)
28. 1 cannabinoid receptor expression in the mouse brain: evidence of a widespread role of fatty acid amide hydrolase Neuroscience 119 2003 481 496 (Pubitemid 36588826)
29. 1 J. Comp. Neurol. 422 2000 159 171 (Pubitemid 30390161)
30. S. Galigue, S. Mary, J. Marchand, D. Dussossoy, D. Carrire, P. Carayon, M. Bouaboula, D. Shire, G. Le Fur, and P. Casellas Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations Eur. J. Biochem. 232 1995 54 61
31. P. Gerdeman, J. Ronesi, and D.M. Lovinger Postsynaptic endocannabinoid release is critical to long-term depression in the striatum Nat. Neurosci. 5 2002 446 451 (Pubitemid 34454250)
32. J.A. Gingrich, and R. Hen Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice Psychopharmacology 155 2001 1 10 (Pubitemid 32295763)
33. G. Gobbi, E.R. Bambico, R. Mangieri, M. Bortolato, P. Campolongo, M. Solinas, M. Cassano, M.G. Morgese, G. Debonnel, A. Duranti, A. Tontini, G. Tarzia, M. Mor, V. Trezza, S.R. Goldberg, V. Cuomo, and D. Piomelli Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis Proc. Natl. Acad. Sci. U.S.A. 102 2005 18620 18625 (Pubitemid 43011275)
34. S.K. Goparaju, N. Ueda, K. Taniguchi, and S. Yamamoto Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol an endogenous ligand of cannabinoid receptors Biochem. Pharmacol. 57 1999 417 423 (Pubitemid 29065290)
35. 1 receptor antagonist rimonabant in models of emotional reactivity in rodents Biol. Psychiatry 57 2005 261 267 (Pubitemid 40187370)
36. B.A. Grueter, G. Brasnjo, and R.C. Malenka Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens Nat. Neurosci. 13 2010 1519 1525
37. + channel and 5-hydroxytryptamine1A autoreceptor interaction in the rat dorsal raphe nucleus: an in vitro electrophysiological study Neuroscience 41 1991 495 505
38. S. Haj-Dahmane, and R.-Y. Shen The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling J. Neurosci. 25 2005 896 905 (Pubitemid 40171005)
39. 1 receptors J. Pharmacol. Exp. Ther. 331 2009 186 196
40. S. Haj-Dahmane, and R.-Y. Shen Regulation of plasticity of glutamate synapses by endocannabinoids and the cyclic-AMP/protein kinase A pathway in midbrain dopamine neurons J. Physiol. 588 2010 2589 2604
41. W. Hall, and N. Solowij Adverse effects of cannabis Lancet 352 1998 1611 1616 (Pubitemid 28515256)
42. 1 cannabinoid gene disruption on anxiety-like and social behavior in mice Eur. J. Neurosci. 16 2004 1906 1912 (Pubitemid 38482578)
43. 1-specific agents Behav. Pharmacol. 15 2004 299 304 (Pubitemid 39062560)
44. B.D. Heifets, and P.E. Castillo Endocannabinoid signaling and long-term synaptic plasticity Annu. Rev. Physiol. 71 2009 283 306
45. M. Herkenham, A.B. Lynn, M.R. Johnson, L.S. Melvin, B.R. de Costa, and K.C. Rice Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autographic study J. Neurosci. 11 1991 563 583
46. Hill, M.N., McLaughin, R.J., Viau, V., Gorzalka, B.B., Hillard, C.J., 2007. Stress-induced alterations in limbic endocannabinoid content in the rat: correlations to HPA axis activation. In: 17th Annual Symposium of the International Cannabinoid Research Society, vol. 23, 2007.
47. C.J. Hillard, W.S. Edgemond, A. Jarrahian, and W.B. Campbell Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion J. Neurochem. 69 1997 631 638 (Pubitemid 27327964)
48. M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe Endocannabinoid-mediated control of synaptic transmission Physiol. Rev. 89 2009 309 380
49. S. Kathuria, S. Gaetani, D. Fegley, F. Valino, A. Duranti, A. Tontini, M. Mor, G. Tarzia, G. La Rana, A. Calignano, A. Giustino, M. Tattoli, M. Palmery, V. Cuomo, and D. Piomelli Modulation of anxiety through blockade of anandamide hydrolysis Nat. Med. 9 2003 76 81 (Pubitemid 36098263)
50. L.G. Kirby, Y.Z. Pan, E. Freeman-Daniels, S. Rani, J.D. Nunan, A. Akanwa, and S.G. Beck Cellular effects of swim stress in the dorsal raphe nucleus Psychoneuroendocrinology 32 2007 712 723 (Pubitemid 47017590)
51. K.R. Kozak, S.W. Rowlinson, and L.J. Marnett Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2 J. Biol. Chem. 275 2000 33744 33749
52. A.C. Kreitzer, and W.G. Regehr Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto the purkinje cells Neuron 29 2001 717 727 (Pubitemid 32323944)
53. L. Lanfumey, R. Mongeau, C. Cohen-Salmon, and M. Hamon Cortcosteroid-serotonin interactions in the neurobiological mechanisms of stress-related disorders Neurosci. Biobehav. Rev. 32 2008 1174 1184
54. M. Lehrke, and M.A. Lazar The many faces of PPARgamma Cell 123 2005 993 999
55. R.J. Liu, A.N. van den Pol, and G.K. Aghajanian Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory direct actions J. Neurosci. 22 2002 9453 9464 (Pubitemid 35356188)
56. K. Mackie, and B. Hille Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells Proc. Natl. Acad. Sci. U.S.A. 89 1992 3825 3829
57. K. Mackie, Y. Lai, R. Westenbroek, and R. Mitchell Cannabinoids activate an inward rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor J. Neurosci. 15 1995 6552 6561
58. T. Maejima, K. Hashimoto, T. Yoshida, A. Aiba, and M. Kano Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoids receptors Neuron 31 2001 463 475 (Pubitemid 32778564)
59. D.T. Malone, and D.A. Taylor Involvement of somatodendritic 5-HT (1A) receptors in Delta (9)-tetrahydrocannabinol-induced hypothermia in the rat Pharmacol. Biochem. Behav. 69 2001 595 601 (Pubitemid 32758746)
60. E.M. Marco, L. Perez-Alverez, E. Borcel, M. Rubio, C. Guaza, E. Ambrosio, S.E. File, and M.P. Viveros Involvement of 5-HT1A receptors in behavioral effects of cannabinoid receptor agonist CP 55,940 in male rats Behav. Pharmacol. 15 2004 21 27 (Pubitemid 38241510)
61. W.R. Marrs, J.L. Blankman, E.A. Horne, A. Thomazeau, Y.H. Lin, J. Coy, A.L. Bodor, G.G. Muccioli, S.S.-J. Hu, G. Woodruff, S. Fung, M. Lafourcade, J.P. Alexander, J.Z. Long, C. Xu, T. Möller, K. Mackie, O.J. Manzoni, B.F. Cravatt, and N. Stella The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors Nat. Neurosci. 13 2010 951 957
62. G. Marsicano, C.T. Wotjak, S.C. Azad, T. Bisogno, G. Rammes, M.G. Cascio, H. Hermann, J. Tang, C. Hofmann, W. Zieglgänsberger, V. Di Marzo, and B. Lutz The endogenous cannabinoid system controls extinction of aversive memories Nature 418 2002 530 534 (Pubitemid 34851398)
63. 1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A /C receptors J. Neurochem. 103 2007 2111 2120 (Pubitemid 350126641)
64. L.A. Matsuda, T.L. Bonner, and S.J. Lolait Localization of cannabinoid receptor mRNA in rat brain J. Comp. Neurol. 327 1993 535 550 (Pubitemid 23033649)
65. L.A. Matsuda, S.J. Lolait, M.J. Brownstein, A.C. Young, and T.I. Bonner Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 1990 561 564
66. R. Mechoulam, S. Ben-Shabat, L. Hanus, M. Ligumsky, N.E. Kaminski, A.R. Schatz, A. Gopher, B.R. Almog, D.R. Compton, R.G. Pertwee, G. Griffin, M. Bayewitch, J. Barg, and Z. Vogel Identification of endogenous 2-monoglyceride, present in canine gut that binds to cannabinoid receptors Biochem. Pharmacol. 50 1995 83 90
67. 1 receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices Br. J. Pharmacol. 158 2009 1579 1587
68. L. Michalik, J. Auwerx, J.P. Berger, V.K. Chatterjee, C.K. Glass, F.J. Gonzalez, P.A. Grimaldi, T. Kadowaki, M.A. Lazar, S. O'Rahilly, C.N. Palmer, J. Plutzky, J.K. Reddy, B.M. Spielgelman, B. Staels, and W. Wahli International Union of Pharmacology. LXI. Peroxisome proliferators-activated receptors Pharmacol. Rev. 58 2006 726 741 (Pubitemid 44833742)
69. D. Moranta, S. Esteban, and J.A. Garcia-Sevilla Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain Naunyn-Schmiedeberg Arch. Pharmacol. 379 2009 61 72
70. 2 type cannabinoid receptors at CNS synapses Neuropharmacology 57 2009 356 368
71. S. Munro, K.L. Thomas, and M. Abu-Shaar Molecular characterization of a peripheral receptor for cannabinoids Nature 365 1993 61 65 (Pubitemid 23305569)
72. E. Murillo-Rodriguez, D. Millán-Aldaco, V. Di Marzo, and R. Drucker-Colin The anandamide membrane transporter inhibitor, VDM-11 modulates sleep and c-Fos expression in the rat brain Neuroscience 157 2008 1 11
73. M. Nakazi, U. Bauer, T. Nickel, M. Kathmann, and E. Schlicker Inhibition of serotonin release in the mouse brain via presynaptic CB receptors Naunyn-Schmiedeberg Arch. Pharmacol. 361 2000 19 24 (Pubitemid 30064649)
74. C.B. Nemeroff Anxiolytics: past, present, and future agents J. Clin. Psychiatry 64 3 2003 3 6 (Pubitemid 36389865)
75. T. Ohno-Shosaku, T. Maejima, and M. Kano Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals Neuron 29 2001 729 739
76. S. Patel, C.T. Roelke, D.J. Radmecher, W.E. Cullina, and C.J. Hillard Endocannabinoid signaling negatively regulate stress-induced activation of the hypothalamic-pituitary-adrenal axis Endocrinology 145 2004 5431 5438 (Pubitemid 39564580)
77. L. Qi, A. Jacob, P. Wang, and R. Wu Peroxisome proliferator activated receptor-γ and traumatic brain injury Int. J. Clin. Exp. Med. 3 2010 283 292
78. 1A receptors are involved in the cannabidiol-induced attenuation of behavioral and cardiovascular responses to acute restraint stress in rats Br. J. Pharmacol. 156 2009 181 188
79. M.A. Steiner, G. Marsicano, E.J. Nestler, F. Holsboer, B. Lutz, and C.T. Wotjak Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice Psychoneuroendocrinology 33 2008 54 62
80. N. Stella, P. Schweittzer, and D. Piomelli A second endogenous cannabinoid that modulates long-term potentiation Nature 388 1997 773 778 (Pubitemid 27375156)
81. T. Sugiura, S. Kondo, A. Sukagawa, T. Tonegawa, S. Nakane, A. Yamashita, and K. Waku Enzymatic synthesis of anandamide, an endogenous cannabinoid receptor ligand, through N-acylphosphatidylethanolamine pathway in testis: involvement of Ca(2+)-dependent transacyclase and phosphodiesterase activities Biochem. Biophys. Res. Commun. 218 1996 113 117
82. Y. Sun, S.P. Alexander, M.J. Garle, C.L. Gibson, K. Hewitt, S.P. Murphy, D.A. Kendall, and A.J. Bennett Cannabinoid activation of PPARα; a novel neuroprotective mechanism Br. J. Pharmacol. 152 2007 734 743 (Pubitemid 350034991)
83. B. Szabo, L. Dorner, C. Pfreundtner, W. Norenberg, and K. Starke Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum Neuroscience 85 1998 395 403 (Pubitemid 28218661)
84. A. Tanimura, A. Yamazaki, Y. Hashimotodani, M. Uchigashima, S. Kawata, M. Abe, Y. Kita, K. Hashimoto, T. Shimizu, M. Watanabe, K. Sakimura, and M. Kano The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase α mediates retrograde suppression of synaptic transmission Neuron 65 2010 320 327
85. P. Tontonoz, E. Hu, and B.M. Spiegelman Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipi-activated transcription factor Cell 79 1994 1147 1156
86. A. Tóth, P.M. Blumberg, and J. Boczán Anandamide and the vanilloid receptor (TRPV1) Vitam. Horm. 81 2009 389 419
87. M. Tournier, F. Sorbara, C. Gindre, J.D. Swendsen, and H. Verdoux Cannabis use and anxiety in daily life: a naturalistic investigation in a non-clinical population Psychiatry Res. 118 2003 1 8 (Pubitemid 36577554)
88. 1 receptors in the rat central nervous system Neuroscience 83 1998 393 411 (Pubitemid 28062631)
89. 1 receptor antagonist SR 141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions Br. J. Pharmacol. 138 2003 544 553 (Pubitemid 36315302)
90. 1 receptors Neuropharmacology 46 2004 966 973 (Pubitemid 38471950)
91. 2 receptors Science 31 2005 329 332 (Pubitemid 41457202)
92. K. Venkatachalam, and C. Montel TRP channels Annu. Rev. Biochem. 76 2007 387 417
93. M.P. Viveros, E.M. Marco, and S.E. File Endocannabinoid system and stress and anxiety responses Pharmacol. Biochem. Behav. 81 2005 331 342 (Pubitemid 40807131)
94. S.J. Ward, T.W. Lefever, C. Jackson, R.J. Tallarida, and E.A. Walker Effects of a cannabinoid 1 receptor antagonist and Serotonin2C receptor agonist alone and in combination on motivation for palatable food: a dose-addition analysis study in mice J. Pharmacol. Exp. Ther. 325 2008 567 576 (Pubitemid 351574781)
95. E.M. Williamson, and F.J. Evans Cannabinoids in clinical practice Drugs 60 2000 1303 1314 (Pubitemid 32039388)
96. R.I. Wilson, G. Kunos, and R.A. Nicoll Presynaptic specificity of endocannabinoid signaling in the hippocampus Neuron 31 2001 453 462 (Pubitemid 32778563)
97. K. Zavitsanou, H. Wang, V.S. Dalton, and V. Nguyen Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats Neuroscience 169 2010 315 324
98. P.M. Zygmunt, J. Petersson, D.A. Andersson, H. Chuang, M. Sergárd, V. Di Marzo, D. Julius, and E.D. Högestätt Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide Nature 400 1999 452 457 (Pubitemid 29361798)