The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Hathcock, Karen S ^a   Farrington, Lila ^a   Ivanova, Irina ^b   Livak, Ferenc ^c   Selimyan, Roza ^b   Sen, Ranjan ^b   Williams, Joy ^a   Tai, Xuguang ^a   Hodes, Richard J ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; PRE T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; CD86 ANTIGEN; DNA BINDING PROTEIN; HISTONE; LYMPHOCYTE ANTIGEN RECEPTOR; LYSINE; MEMBRANE PROTEIN; PRE T CELL RECEPTOR ALPHA; PRE-T CELL RECEPTOR ALPHA; RAG2 PROTEIN, MOUSE;

ALLELIC EXCLUSION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; GENE REARRANGEMENT; GENETIC RECOMBINATION; LYMPHOCYTOPOIESIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMUS; TISSUE DIFFERENTIATION; ANIMAL; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; METHYLATION; TRANSGENIC MOUSE;

MURINAE;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD86; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENE REARRANGEMENT, ALPHA-CHAIN T-CELL ANTIGEN RECEPTOR; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; HISTONES; LYSINE; MEMBRANE GLYCOPROTEINS; METHYLATION; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION, GENETIC;

EID: 79958072369     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020639     Document Type: Article

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