Regulation of V(β) germline transcription in RAG-deficient mice by the CD3ε-mediated signals: Implication of V(β) transcriptional regulation in TCR β allelic exclusion

International Immunology

Volumn 10, Issue 5, 1998, Pages 553-560

  Senoo, Makoto ^a   Shinkai, Yoichi ^a  

^a NIPPON ROCHE RESEARCH CENTER   (Japan)

Author keywords

DNA accessibility; Methylation status; Pre TCR CD3 complex; Signal transduction; Thymocyte development; Transcriptional enhancer; V( )14; V(D)J recombinase

Indexed keywords

ANTIBODY; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; RECOMBINASE; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; DNA BINDING PROTEIN; DNA POLYMERASE; LYMPHOCYTE ANTIGEN RECEPTOR; PRIMER DNA; RAG2 PROTEIN, MOUSE; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINEAGE; CONTROLLED STUDY; DEVELOPMENT; GENE REARRANGEMENT; GERM LINE; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE; THYMUS; TRANSCRIPTION REGULATION; ALLELE; ANIMAL; C57BL MOUSE; DNA METHYLATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION;

ALLELES; ANIMALS; ANTIGENS, CD3; BASE SEQUENCE; DNA METHYLATION; DNA NUCLEOTIDYLTRANSFERASES; DNA PRIMERS; DNA-BINDING PROTEINS; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TRANSCRIPTION, GENETIC; VDJ RECOMBINASES;

EID: 0032060447     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.5.553     Document Type: Article

References (39)

1. Fowlkes, B. J. and Pardoll, D. M. 1989. Molecular and cellular events of T cell development. Adv. Immunol. 44:207.
2. von Boehmer, H. 1992. Thymic selection: a matter of life and death. Immunol. Today 13:454.
3. von Boehmer, H. 1990. Developmental biology of T cells in T cell receptor transgenic mice. Annu. Rev. Immunol. 8:531.
4. Loh, D. Y. 1991. Molecular requirements for cell fate determination during T lymphocyte development. New Biol. 3:924.
5. Philpott, K. L., Viney, J. L., Kay, G., Rastan. S., Gardiner, E. M., Chae. S., Mayday, A. S. and Owen, M. J. 1992. Lymphoid development in mice congentally lacking T cell receptor αβ-expressing cells. Science 256:1448.
6. Mombaerts, P., Clark, A. R., Rudnicki, M. A., Iacomini, J., Itohara, S., Lafaille, J. J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M. L. and Tonegawa. S. 1992. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360:225.
7. Kishi, H., Borgulya, P., Scott, B., Karjalainen, K., Traunecker, A., Kaufman, J. and von Boehmer, H. 1991. Surface expression of the β T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. EMBO J. 10:93.
8. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. and Papaioannou, V. E. 1992. Rag-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
9. Shinkai, Y., Rathbun, G., Lam, K. P., Oltz, U. M., Stewart, V., Mendelsohn, M., Charon, J., Datta, M., Young, F., Stall, A. M. and Alt, F. W. 1992. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
10. Jacobs, H., Iacomini, J., van de Ven, M., Tonegawa, S. and Berns, A. 1996. Domains of the TCR β-chain required for early thymocyte development. J. Exp. Med. 184:1833.
11. Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M. J., Mayday, A. C. and von Boehmer, H. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33Kd glycoprotein. Cell 75:283.
12. Saint-Ruf, C., Ungewiss, K. and Groettrup M. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science 266:1208.
13. Fehling, H. J., Krotkova, A., Saint-Ruf, C. and von Boehmer, H. 1995. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature 375:795.
14. Uematsu, Y., Ryser, S., Dembic, Z., Borgulya, P., Krimpenfort, P., Berns, A., von Boehmer, H. and Steinmetz, M. 1988. In transgenic mice the introduced functional t cell receptor β gene prevents expression of endogenous β genes. Cell 52:831.
15. Krimpenfort, P., Ossendorp, F., Borst, J., Melief, C. and Berns, A. 1989. T cell depletion in transgenic mice carrying a mutant gene for TCR-beta. Nature 341:742.
16. + lymphocytes in embryonic thymus organ culture. Immunology 63:639.
17. Levelt, C. N., Ehrfeld, A. and Eichmann, K. 1993. Regulation of thymocyte development through CD3. Timepoint of ligation of CDSε determines clonal deletion or induction of developmental program. J. Exp. Med. 177:707.
18. lck. EMBO J 11:4877.
19. lck controls allelic exclusion of T-cell receptor β-chain genes. Nature 365:552.
20. Yancopoulos, G D., Blackwell, T. K., Suh, H., Hood, L. and Alt, F. W. 1986. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell 44:251.
21. Sleckman, B. P., Gorman, J. R. and Alt, F. W. 1996. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu. Rev. Immunol. 14:459.
22. Okada, A. and Alt, F. W. 1994. Mechanisms that control antigen receptor variable region gene assembly. Immunology 6:185.
23. + thymocytes in RAG2-/- mice in the absence of TCR β chain expression. Int. Immunol. 6:995.
24. Jacobs, H., Vandeputte, D., Tolkamp, L., de Vries, E., Borst, J. and Berns, A. 1994. CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur. J. Immunol. 24:934.
25. Levelt, N. C., Wang, B., Ehrfeld, A., Terhorst, C. and Eichmann, K. 1995. Regulation of T cell receptor (TCR)-β locus allelic exclusion and initiation of TCR-α locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur. J. Immunol. 25:1257.
26. Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. and Bluestone, J. A. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl Acad Sci. USA 84:1374.
27. Parks, D. R., Lanier, L. L. and Herzenberg, L. A. 1986. Flow cytometry and fluorescence activated cell sorting (FACS). In Weir, D. M., Blackwell, C. C. and Herzenberg, L. A., eds, Handbook of Experimental Immunology, p. 29.1. Blackwell Scientific, London.
28. Ledbetter, J., Rouse, R., Micklem, S. A. and Herzenberg, L. A. 1980. T cell subsets defined by expression of Lyt-1, 2, 3 and Thy-1 antigens. J. Exp. Med. 152:280.
29. Ortega, G., Robb, R., Shevack, E. and Malek, T. 1984. The murine IL-2 receptor. J. Immunol. 133:1970.
30. Yagita, H., Nakamura, T., Karasuyama, H. and Okumura, K. 1989. Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc. Natl Acad. Sci. USA 86:645.
31. Vieira, J. and Messing, J. 1991. New pUC-derived cloning vectors with different selectable markers and DNA replication origins Gene 100:189.
32. β gene segments. Nature 316:517.
33. Sambrook, J., Fritsch, F. E. and Maniatis, T. 1989. Molecular Cloning, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY..
34. Koyasu, S., Clayton, L. K., Lerner, A., Heiken, H., Parkes, A. and Reinherz, E. L. 1997. Pre-TCR signaling components trigger transcriptional activation of a rearranged TCR alpha gene locus and silencing of the pre- TCR alpha locus: implications for intrathymic differentiation. Int. Immunol. 9:1475.
35. Schlissel, M. S. and Morrow, T. 1994. Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination. J. Immunol. 153:1645.
36. Bories, J. C., Demengeot, J., Davidson, L. and Alt, F. W. 1996. Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc. Natl Acad. Sci. USA 93:7871.
37. Bouvier, G., Watrin, F., Naspetti, M., Verthuy, C., Naquet, P. and Ferrier, P. 1996. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development. Proc. Natl Acad. Sci. USA 93:7877.
38. Li, Z. I., Dordai, D., Lee, J. and Desiderio, S. 1996. A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. Immunity 5:575.
39. Stanhope-Baker, P., Hudson, K. M., Shaffer, A. L., Constantinescu, A. and Schlissel, M. S. 1996. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85:887.