Seeking a Spotless Mind: Extinction, Deconsolidation, and Erasure of Fear Memory

Neuron

Volumn 70, Issue 5, 2011, Pages 830-845

  Maren, Stephen ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLOSERINE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; PRAZOSIN; YOHIMBINE;

ACROPHOBIA; BRAIN ELECTROPHYSIOLOGY; BRAIN FUNCTION; BRAIN LEVEL; CLAUSTROPHOBIA; CONDITIONING; DRUG MECHANISM; EMOTIONAL MEMORY; ERECTILE DYSFUNCTION; FEAR MEMORY; HUMAN; LEARNING; MEMORY; MEMORY CONSOLIDATION; MEMORY DECONSOLIDATION; NERVE CELL PLASTICITY; NEUROANATOMY; NEUROMODULATION; NIGHTMARE; NONHUMAN; PHOBIA; PRIORITY JOURNAL; RECALL; REINFORCEMENT; REVIEW; SLEEP DISORDER; SOCIAL PHOBIA; SPIDER PHOBIA; SURVIVAL; SYNAPTIC TRANSMISSION; THREAT;

ANIMALS; BRAIN; EXTINCTION, PSYCHOLOGICAL; FEAR; HUMANS; MEMORY; SYNAPTIC TRANSMISSION;

EID: 79958055504     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2011.04.023     Document Type: Review

References (244)

1. Agranoff B.W., Klinger P.D. Puromycin effect on memory fixation in goldfish. Science 1964, 146:952-953.
2. Agranoff B.W., Davis R.E., Brink J.J. Memory fixation in the goldfish. Proc. Natl. Acad. Sci. USA 1965, 54:788-793.
3. Amano T., Unal C.T., Paré D. Synaptic correlates of fear extinction in the amygdala. Nat. Neurosci. 2010, 13:489-494.
4. Anokhin K.V., Tiunova A.A., Rose S.P.R. Reminder effects - reconsolidation or retrieval deficit? Pharmacological dissection with protein synthesis inhibitors following reminder for a passive-avoidance task in young chicks. Eur. J. Neurosci. 2002, 15:1759-1765.
5. Apergis-Schoute A.M., Debiec J., Doyère V., LeDoux J.E., Schafe G.E. Auditory fear conditioning and long-term potentiation in the lateral amygdala require ERK/MAP kinase signaling in the auditory thalamus: a role for presynaptic plasticity in the fear system. J. Neurosci. 2005, 25:5730-5739.
6. Archbold G.E.B., Bouton M.E., Nader K. Evidence for the persistence of contextual fear memories following immediate extinction. Eur. J. Neurosci. 2010, 31:1303-1311.
7. Azad S.C., Monory K., Marsicano G., Cravatt B.F., Lutz B., Zieglgänsberger W., Rammes G. Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. J. Neurosci. 2004, 24:9953-9961.
8. Barot S.K., Chung A., Kim J.J., Bernstein I.L. Functional imaging of stimulus convergence in amygdalar neurons during Pavlovian fear conditioning. PLoS ONE 2009, 4:e6156.
9. Ben Mamou C., Gamache K., Nader K. NMDA receptors are critical for unleashing consolidated auditory fear memories. Nat. Neurosci. 2006, 9:1237-1239.
10. Bernardi R.E., Lattal K.M. A role for alpha-adrenergic receptors in extinction of conditioned fear and cocaine conditioned place preference. Behav. Neurosci. 2010, 124:204-210.
11. Berretta S., Pantazopoulos H., Caldera M., Pantazopoulos P., Paré D. Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdala. Neuroscience 2005, 132:943-953.
12. Bissiere S., Zelikowsky M., Ponnusamy R., Jacobs N.S., Blair H.T., Fanselow M.S. Electrical synapses control hippocampal contributions to fear learning and memory. Science 2011, 331:87-91.
13. Blair H.T., Schafe G.E., Bauer E.P., Rodrigues S.M., LeDoux J.E. Synaptic plasticity in the lateral amygdala: a cellular hypothesis of fear conditioning. Learn. Mem. 2001, 8:229-242.
14. Bolles R. Species-specific defense reactions and avoidance learning. Psychol. Rev. 1970, 77:32-48.
15. Bontempi B., Laurent-Demir C., Destrade C., Jaffard R. Time-dependent reorganization of brain circuitry underlying long-term memory storage. Nature 1999, 400:671-675.
16. Bourtchouladze R., Abel T., Berman N., Gordon R., Lapidus K., Kandel E.R. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learn. Mem. 1998, 5:365-374.
17. Bouton M.E. Context and ambiguity in the extinction of emotional learning: implications for exposure therapy. Behav. Res. Ther. 1988, 26:137-149.
18. Bouton M.E. Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychol. Bull. 1993, 114:80-99.
19. Bouton M.E., Bolles R.C. Contextual control of the extinction of conditioned fear. Learn. Motiv. 1979, 10:445-466.
20. Bouton M.E., Bolles R.C. Role of conditioned contextual stimuli in reinstatement of extinguished fear. J. Exp. Psychol. Anim. Behav. Process. 1979, 5:368-378.
21. Bouton M.E., Mineka S., Barlow D.H. A modern learning theory perspective on the etiology of panic disorder. Psychol. Rev. 2001, 108:4-32.
22. Bouton M.E., Westbrook R.F., Corcoran K.A., Maren S. Contextual and temporal modulation of extinction: behavioral and biological mechanisms. Biol. Psychiatry 2006, 60:352-360.
23. Bouton M.E., Westbrook R.F., Corcoran K.A., Maren S. Contextual and temporal modulation of extinction: behavioral and biological mechanisms. Biol. Psychiatry 2006, 60:352-360.
24. Bouton M.E., Vurbic D., Woods A.M. D-cycloserine facilitates context-specific fear extinction learning. Neurobiol. Learn. Mem. 2008, 90:504-510.
25. Brambilla R., Gnesutta N., Minichiello L., White G., Roylance A.J., Herron C.E., Ramsey M., Wolfer D.P., Cestari V., Rossi-Arnaud C., et al. A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 1997, 390:281-286.
26. Brunet A., Orr S.P., Tremblay J., Robertson K., Nader K., Pitman R.K. Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J. Psychiatr. Res. 2008, 42:503-506.
27. Burgos-Robles A., Vidal-Gonzalez I., Santini E., Quirk G.J. Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron 2007, 53:871-880.
28. Cain C.K., Blouin A.M., Barad M. Adrenergic transmission facilitates extinction of conditional fear in mice. Learn. Mem. 2004, 11:179-187.
29. Chan W.Y.M., Leung H.T., Westbrook R.F., McNally G.P. Effects of recent exposure to a conditioned stimulus on extinction of Pavlovian fear conditioning. Learn. Mem. 2010, 17:512-521.
30. Chang C.H., Maren S. Early extinction after fear conditioning yields a context-independent and short-term suppression of conditional freezing in rats. Learn. Mem. 2009, 16:62-68.
31. Chang C.H., Maren S. Strain difference in the effect of infralimbic cortex lesions on fear extinction in rats. Behav. Neurosci. 2010, 124:391-397.
32. Chang C.H., Maren S. Medial prefrontal cortex activation facilitates re-extinction of fear in rats. Learn. Mem. 2011, 18:221-225.
33. Chang C.H., Berke J.D., Maren S. Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats. PLoS ONE 2010, 5:e11971. 10.1371/journal.pone.0011971.
34. Chhatwal J.P., Davis M., Maguschak K.A., Ressler K.J. Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear. Neuropsychopharmacology 2005, 30:516-524.
35. Chhatwal J.P., Myers K.M., Ressler K.J., Davis M. Regulation of gephyrin and GABAA receptor binding within the amygdala after fear acquisition and extinction. J. Neurosci. 2005, 25:502-506.
36. Chhatwal J.P., Stanek-Rattiner L., Davis M., Ressler K.J. Amygdala BDNF signaling is required for consolidation but not encoding of extinction. Nat. Neurosci. 2006, 9:870-872.
37. Chhatwal J.P., Gutman A.R., Maguschak K.A., Bowser M.E., Yang Y., Davis M., Ressler K.J. Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning. Neuropsychopharmacology 2009, 34:509-521.
38. Ciocchi S., Herry C., Grenier F., Wolff S.B.E., Letzkus J.J., Vlachos I., Ehrlich I., Sprengel R., Deisseroth K., Stadler M.B., et al. Encoding of conditioned fear in central amygdala inhibitory circuits. Nature 2010, 468:277-282.
39. Clem R.L., Huganir R.L. Calcium-permeable AMPA receptor dynamics mediate fear memory erasure. Science 2010, 330:1108-1112.
40. Corcoran K.A., Maren S. Hippocampal inactivation disrupts contextual retrieval of fear memory after extinction. J. Neurosci. 2001, 21:1720-1726.
41. Corcoran K.A., Maren S. Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction. Learn. Mem. 2004, 11:598-603.
42. Corcoran K.A., Desmond T.J., Frey K.A., Maren S. Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction. J. Neurosci. 2005, 25:8978-8987.
43. Cousens G., Otto T. Both pre- and posttraining excitotoxic lesions of the basolateral amygdala abolish the expression of olfactory and contextual fear conditioning. Behav. Neurosci. 1998, 112:1092-1103.
44. Craske M.G., Kircanski K., Zelikowsky M., Mystkowski J., Chowdhury N., Baker A. Optimizing inhibitory learning during exposure therapy. Behav. Res. Ther. 2008, 46:5-27.
45. Davis M. Neural systems involved in fear and anxiety measured with fear-potentiated startle. Am. Psychol. 2006, 61:741-756.
46. Davis H.P., Squire L.R. Protein synthesis and memory: a review. Psychol. Bull. 1984, 96:518-559.
47. Davis M., Myers K.M., Chhatwal J., Ressler K.J. Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy. NeuroRx 2006, 3:82-96.
48. Deadwyler S.A., Dunwiddie T., Lynch G. A critical level of protein synthesis is required for long-term potentiation. Synapse 1987, 1:90-95.
49. Debiec J., Ledoux J.E. Disruption of reconsolidation but not consolidation of auditory fear conditioning by noradrenergic blockade in the amygdala. Neuroscience 2004, 129:267-272.
50. Debiec J., Doyère V., Nader K., Ledoux J.E. Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala. Proc. Natl. Acad. Sci. USA 2006, 103:3428-3433.
51. Do-Monte F.H.M., Allensworth M., Carobrez A.P. Impairment of contextual conditioned fear extinction after microinjection of alpha-1-adrenergic blocker prazosin into the medial prefrontal cortex. Behav. Brain Res. 2010, 211:89-95.
52. Doyère V., Debiec J., Monfils M.-H., Schafe G.E., LeDoux J.E. Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala. Nat. Neurosci. 2007, 10:414-416.
53. Falls W.A., Miserendino M.J., Davis M. Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala. J. Neurosci. 1992, 12:854-863.
54. Fanselow M.S., Lester L.S. A functional behavioristic approach to aversively motivated behavior: predatory imminence as a determinant of the topography of defensive behavior. Evolution and Learning 1988, 185-211. Erlbaum, Hillsdale, NJ. R.C. Bolles, M.D. Beecher (Eds.).
55. Fanselow M.S., Poulos A.M. The neuroscience of mammalian associative learning. Annu. Rev. Psychol. 2005, 56:207-234.
56. Farinelli M., Deschaux O., Hugues S., Thevenet A., Garcia R. Hippocampal train stimulation modulates recall of fear extinction independently of prefrontal cortex synaptic plasticity and lesions. Learn. Mem. 2006, 13:329-334.
57. Fendt M. Injections of the NMDA receptor antagonist aminophosphonopentanoic acid into the lateral nucleus of the amygdala block the expression of fear-potentiated startle and freezing. J. Neurosci. 2001, 21:4111-4115.
58. Fischer A., Sananbenesi F., Schrick C., Spiess J., Radulovic J. Distinct roles of hippocampal de novo protein synthesis and actin rearrangement in extinction of contextual fear. J. Neurosci. 2004, 24:1962-1966.
59. Fischer A., Radulovic M., Schrick C., Sananbenesi F., Godovac-Zimmermann J., Radulovic J. Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior. Neurobiol. Learn. Mem. 2007, 87:149-158.
60. Frankland P.W., Bontempi B. The organization of recent and remote memories. Nat. Rev. Neurosci. 2005, 6:119-130.
61. Frankland P.W., Bontempi B., Talton L.E., Kaczmarek L., Silva A.J. The involvement of the anterior cingulate cortex in remote contextual fear memory. Science 2004, 304:881-883.
62. Gale G.D., Anagnostaras S.G., Godsil B.P., Mitchell S., Nozawa T., Sage J.R., Wiltgen B., Fanselow M.S. Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of rats. J. Neurosci. 2004, 24:3810-3815.
63. Garcia R., Chang C.H., Maren S. Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear. Learn. Mem. 2006, 13:14-17.
64. Gewirtz J.C., Falls W.A., Davis M. Normal conditioned inhibition and extinction of freezing and fear-potentiated startle following electrolytic lesions of medical prefrontal cortex in rats. Behav. Neurosci. 1997, 111:712-726.
65. Gogolla N., Caroni P., Lüthi A., Herry C. Perineuronal nets protect fear memories from erasure. Science 2009, 325:1258-1261.
66. Goosens K.A., Maren S. Pretraining NMDA receptor blockade in the basolateral complex, but not the central nucleus, of the amygdala prevents savings of conditional fear. Behav. Neurosci. 2003, 117:738-750.
67. Goosens K.A., Maren S. NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala. Eur. J. Neurosci. 2004, 20:537-548.
68. Goosens K.A., Holt W., Maren S. A role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in rats. Behav. Brain Res. 2000, 114:145-152.
69. Goosens K.A., Hobin J.A., Maren S. Auditory-evoked spike firing in the lateral amygdala and Pavlovian fear conditioning: mnemonic code or fear bias?. Neuron 2003, 40:1013-1022.
70. Guastella A.J., Dadds M.R., Lovibond P.F., Mitchell P., Richardson R. A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear. J. Psychiatr. Res. 2007, 41:466-471.
71. Guastella A.J., Lovibond P.F., Dadds M.R., Mitchell P., Richardson R. A randomized controlled trial of the effect of D-cycloserine on extinction and fear conditioning in humans. Behav. Res. Ther. 2007, 45:663-672.
72. Guastella A.J., Richardson R., Lovibond P.F., Rapee R.M., Gaston J.E., Mitchell P., Dadds M.R. A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder. Biol. Psychiatry 2008, 63:544-549.
73. Han J.H., Kushner S.A., Yiu A.P., Cole C.J., Matynia A., Brown R.A., Neve R.L., Guzowski J.F., Silva A.J., Josselyn S.A. Neuronal competition and selection during memory formation. Science 2007, 316:457-460.
74. Han J.-H., Kushner S.A., Yiu A.P., Hsiang H.-L.L., Buch T., Waisman A., Bontempi B., Neve R.L., Frankland P.W., Josselyn S.A. Selective erasure of a fear memory. Science 2009, 323:1492-1496.
75. Harris J.A., Westbrook R.F. Evidence that GABA transmission mediates context-specific extinction of learned fear. Psychopharmacology (Berl.) 1998, 140:105-115.
76. Haubensak W., Kunwar P.S., Cai H.J., Ciocchi S., Wall N.R., Ponnusamy R., Biag J., Dong H.W., Deisseroth K., Callaway E.M., et al. Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature 2010, 468:270-276.
77. Hefner K., Whittle N., Juhasz J., Norcross M., Karlsson R.M., Saksida L.M., Bussey T.J., Singewald N., Holmes A. Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain. J. Neurosci. 2008, 28:8074-8085.
78. Helmstetter F.J., Bellgowan P.S. Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats. Behav. Neurosci. 1994, 108:1005-1009.
79. Hermans D., Craske M.G., Mineka S., Lovibond P.F. Extinction in human fear conditioning. Biol. Psychiatry 2006, 60:361-368.
80. Herry C., Mons N. Resistance to extinction is associated with impaired immediate early gene induction in medial prefrontal cortex and amygdala. Eur. J. Neurosci. 2004, 20:781-790.
81. Herry C., Trifilieff P., Micheau J., Lüthi A., Mons N. Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdala. Eur. J. Neurosci. 2006, 24:261-269.
82. Herry C., Ciocchi S., Senn V., Demmou L., Müller C., Lüthi A. Switching on and off fear by distinct neuronal circuits. Nature 2008, 454:600-606.
83. Herry C., Ferraguti F., Singewald N., Letzkus J.J., Ehrlich I., Lüthi A. Neuronal circuits of fear extinction. Eur. J. Neurosci. 2010, 31:599-612.
84. Hobin J.A., Goosens K.A., Maren S. Context-dependent neuronal activity in the lateral amygdala represents fear memories after extinction. J. Neurosci. 2003, 23:8410-8416.
85. Hobin J.A., Ji J., Maren S. Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats. Hippocampus 2006, 16:174-182.
86. Holmes A., Quirk G.J. Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders-the case of yohimbine. Trends Pharmacol. Sci. 2010, 31:2-7.
87. Huff N.C., Hernandez J.A., Blanding N.Q., LaBar K.S. Delayed extinction attenuates conditioned fear renewal and spontaneous recovery in humans. Behav. Neurosci. 2009, 123:834-843.
88. Hugues S., Chessel A., Lena I., Marsault R., Garcia R. Prefrontal infusion of PD098059 immediately after fear extinction training blocks extinction-associated prefrontal synaptic plasticity and decreases prefrontal ERK2 phosphorylation. Synapse 2006, 60:280-287.
89. Ji J.Z., Maren S. Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction. Learn. Mem. 2005, 12:270-276.
90. Ji J., Maren S. Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear. Learn. Mem. 2008, 15:244-251.
91. Ji J., Maren S. Lesions of the entorhinal cortex or fornix disrupt the context-dependence of fear extinction in rats. Behav. Brain Res. 2008, 194:201-206.
92. Jimenez S.A., Maren S. Nuclear disconnection within the amygdala reveals a direct pathway to fear. Learn. Mem. 2009, 16:766-768.
93. Johansen J.P., Tarpley J.W., Ledoux J.E., Blair H.T. Neural substrates for expectation-modulated fear learning in the amygdala and periaqueductal gray. Nat. Neurosci. 2010, 13:979-986.
94. Jovanovic T., Ressler K.J. How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD. Am. J. Psychiatry 2010, 167:648-662.
95. Kandel E.R. The biology of memory: a forty-year perspective. J. Neurosci. 2009, 29:12748-12756.
96. Kim J.H., Richardson R. A developmental dissociation of context and GABA effects on extinguished fear in rats. Behav. Neurosci. 2007, 121:131-139.
97. Kim J.H., Richardson R. The effect of temporary amygdala inactivation on extinction and reextinction of fear in the developing rat: unlearning as a potential mechanism for extinction early in development. J. Neurosci. 2008, 28:1282-1290.
98. Kim J.H., Richardson R. New findings on extinction of conditioned fear early in development: theoretical and clinical implications. Biol. Psychiatry 2010, 67:297-303.
99. Kim J., Lee S., Park K., Hong I., Song B., Son G., Park H., Kim W.R., Park E., Choe H.K., et al. Amygdala depotentiation and fear extinction. Proc. Natl. Acad. Sci. USA 2007, 104:20955-20960.
100. Kim J., Song B., Hong I., Kim J., Lee J., Park S., Eom J.Y., Lee C.J., Lee S., Choi S. Reactivation of fear memory renders consolidated amygdala synapses labile. J. Neurosci. 2010, 30:9631-9640.
101. Kim S.C., Jo Y.S., Kim I.H., Kim H., Choi J.-S. Lack of medial prefrontal cortex activation underlies the immediate extinction deficit. J. Neurosci. 2010, 30:832-837.
102. Kindt M., Soeter M., Vervliet B. Beyond extinction: erasing human fear responses and preventing the return of fear. Nat. Neurosci. 2009, 12:256-258.
103. Knapska E., Maren S. Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear. Learn. Mem. 2009, 16:486-493.
104. Krettek J.E., Price J.L. A description of the amygdaloid complex in the rat and cat with observations on intra-amygdaloid axonal connections. J. Comp. Neurol. 1978, 178:255-280.
105. Krug M., Lössner B., Ott T. Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats. Brain Res. Bull. 1984, 13:39-42.
106. Kwapis J.L., Jarome T.J., Lonergan M.E., Helmstetter F.J. Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus. Behav. Neurosci. 2009, 123:844-850.
107. Lamprecht R., Farb C.R., LeDoux J.E. Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex. Neuron 2002, 36:727-738.
108. Lamprecht R., Dracheva S., Assoun S., LeDoux J.E. Fear conditioning induces distinct patterns of gene expression in lateral amygdala. Genes Brain Behav. 2009, 8:735-743.
109. Lattal K.M., Abel T. Different requirements for protein synthesis in acquisition and extinction of spatial preferences and context-evoked fear. J. Neurosci. 2001, 21:5773-5780.
110. Lattal K.M., Abel T. Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. Proc. Natl. Acad. Sci. USA 2004, 101:4667-4672.
111. Laurent V., Westbrook R.F. Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear. Learn. Mem. 2008, 15:657-666.
112. Laurent V., Westbrook R.F. Inactivation of the infralimbic but not the prelimbic cortex impairs consolidation and retrieval of fear extinction. Learn. Mem. 2009, 16:520-529.
113. Laurent V., Marchand A.R., Westbrook R.F. The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear. Learn. Mem. 2008, 15:304-314.
114. Ledgerwood L., Richardson R., Cranney J. Effects of D-cycloserine on extinction of conditioned freezing. Behav. Neurosci. 2003, 117:341-349.
115. Ledgerwood L., Richardson R., Cranney J. D-cycloserine and the facilitation of extinction of conditioned fear: consequences for reinstatement. Behav. Neurosci. 2004, 118:505-513.
116. Ledgerwood L., Richardson R., Cranney J. D-cycloserine facilitates extinction of learned fear: effects on reacquisition and generalized extinction. Biol. Psychiatry 2005, 57:841-847.
117. LeDoux J.E. Emotion circuits in the brain. Annu. Rev. Neurosci. 2000, 23:155-184.
118. Lee H., Kim J.J. Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. J. Neurosci. 1998, 18:8444-8454.
119. Lee Y., Walker D., Davis M. Lack of a temporal gradient of retrograde amnesia following NMDA-induced lesions of the basolateral amygdala assessed with the fear-potentiated startle paradigm. Behav. Neurosci. 1996, 110:836-839.
120. Likhtik E., Popa D., Apergis-Schoute J., Fidacaro G.A., Paré D. Amygdala intercalated neurons are required for expression of fear extinction. Nature 2008, 454:642-645.
121. Lin C.H., Yeh S.H., Lin C.H., Lu K.T., Leu T.H., Chang W.C., Gean P.W. A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron 2001, 31:841-851.
122. Lin C.-H., Lee C.-C., Gean P.-W. Involvement of a calcineurin cascade in amygdala depotentiation and quenching of fear memory. Mol. Pharmacol. 2003, 63:44-52.
123. Lin C.H., Yeh S.H., Lu H.Y., Gean P.W. The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory. J. Neurosci. 2003, 23:8310-8317.
124. Lin H.C., Mao S.C., Chen P.S., Gean P.W. Chronic cannabinoid administration in vivo compromises extinction of fear memory. Learn. Mem. 2008, 15:876-884.
125. Ling D.S.F., Benardo L.S., Serrano P.A., Blace N., Kelly M.T., Crary J.F., Sacktor T.C. Protein kinase Mzeta is necessary and sufficient for LTP maintenance. Nat. Neurosci. 2002, 5:295-296.
126. López de Armentia M., Sah P. Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala. J. Physiol. 2007, 581:961-970.
127. Lu K.T., Walker D.L., Davis M. Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle. J. Neurosci. 2001, 21:RC162.
128. Lutz B. The endocannabinoid system and extinction learning. Mol. Neurobiol. 2007, 36:92-101.
129. Makkar S.R., Zhang S.Q., Cranney J. Behavioral and neural analysis of GABA in the acquisition, consolidation, reconsolidation, and extinction of fear memory. Neuropsychopharmacology 2010, 35:1625-1652.
130. Malkani S., Wallace K.J., Donley M.P., Rosen J.B. An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning. Learn. Mem. 2004, 11:617-624.
131. Mao S.-C., Hsiao Y.-H., Gean P.-W. Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace. J. Neurosci. 2006, 26:8892-8899.
132. Mao S.C., Lin H.C., Gean P.W. Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors. Neuropsychopharmacology 2008, 33:3085-3095.
133. Maren S. Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. Trends Neurosci. 1999, 22:561-567.
134. Maren S. Auditory fear conditioning increases CS-elicited spike firing in lateral amygdala neurons even after extensive overtraining. Eur. J. Neurosci. 2000, 12:4047-4054.
135. Maren S. Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci. 2001, 24:897-931.
136. Maren S. Building and burying fear memories in the brain. Neuroscientist 2005, 11:89-99.
137. Maren S. Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats. Eur. J. Neurosci. 2008, 28:1661-1666.
138. Maren S., Chang C.H. Recent fear is resistant to extinction. Proc. Natl. Acad. Sci. USA 2006, 103:18020-18025.
139. Maren S., Hobin J.A. Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala. Learn. Mem. 2007, 14:318-324.
140. Maren S., Holt W. The hippocampus and contextual memory retrieval in Pavlovian conditioning. Behav. Brain Res. 2000, 110:97-108.
141. Maren S., Quirk G.J. Neuronal signalling of fear memory. Nat. Rev. Neurosci. 2004, 5:844-852.
142. Maren S., Aharonov G., Fanselow M.S. Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient. Behav. Neurosci. 1996, 110:718-726.
143. Maren S., Aharonov G., Stote D.L., Fanselow M.S. N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats. Behav. Neurosci. 1996, 110:1365-1374.
144. Maren S., Yap S.A., Goosens K.A. The amygdala is essential for the development of neuronal plasticity in the medial geniculate nucleus during auditory fear conditioning in rats. J. Neurosci. 2001, 21:RC135.
145. Maren S., Ferrario C.R., Corcoran K.A., Desmond T.J., Frey K.A. Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats. Eur. J. Neurosci. 2003, 18:3080-3088.
146. Marsicano G., Wotjak C.T., Azad S.C., Bisogno T., Rammes G., Cascio M.G., Hermann H., Tang J.R., Hofmann C., Zieglgänsberger W., et al. The endogenous cannabinoid system controls extinction of aversive memories. Nature 2002, 418:530-534.
147. Martin S.J., Grimwood P.D., Morris R.G. Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 2000, 23:649-711.
148. McGaugh J.L. Memory-a century of consolidation. Science 2000, 287:248-251.
149. McKernan M.G., Shinnick-Gallagher P. Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature 1997, 390:607-611.
150. Meins M., Herry C., Müller C., Ciocchi S., Moreno E., Lüthi A., Monard D. Impaired fear extinction in mice lacking protease nexin-1. Eur. J. Neurosci. 2010, 31:2033-2042.
151. Merino S.M., Maren S. Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory. Eur. J. Neurosci. 2006, 23:196-204.
152. Migues P.V., Hardt O., Wu D.C., Gamache K., Sacktor T.C., Wang Y.T., Nader K. PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat. Neurosci. 2010, 13:630-634.
153. Milad M.R., Quirk G.J. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 2002, 420:70-74.
154. Milad M.R., Vidal-Gonzalez I., Quirk G.J. Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behav. Neurosci. 2004, 118:389-394.
155. Milekic M.H., Alberini C.M. Temporally graded requirement for protein synthesis following memory reactivation. Neuron 2002, 36:521-525.
156. Miller R.R., Matzel L.D. Memory involves far more than 'consolidation'. Nat. Rev. Neurosci. 2000, 1:214-216.
157. Misanin J.R., Miller R.R., Lewis D.J. Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace. Science 1968, 160:554-555.
158. Miserendino M.J., Sananes C.B., Melia K.R., Davis M. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 1990, 345:716-718.
159. Moita M.A.P., Lamprecht R., Nader K., LeDoux J.E. A-kinase anchoring proteins in amygdala are involved in auditory fear memory. Nat. Neurosci. 2002, 5:837-838.
160. Monfils M.-H., Cowansage K.K., Klann E., LeDoux J.E. Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories. Science 2009, 324:951-955.
161. Mueller D., Bravo-Rivera C., Quirk G.J. Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses. Biol. Psychiatry 2010, 68:1055-1060.
162. Muller J., Corodimas K.P., Fridel Z., LeDoux J.E. Functional inactivation of the lateral and basal nuclei of the amygdala by muscimol infusion prevents fear conditioning to an explicit conditioned stimulus and to contextual stimuli. Behav. Neurosci. 1997, 111:683-691.
163. Muravieva E.V., Alberini C.M. Limited efficacy of propranolol on the reconsolidation of fear memories. Learn. Mem. 2010, 17:306-313.
164. Myers K.M., Davis M. Behavioral and neural analysis of extinction. Neuron 2002, 36:567-584.
165. Myers K.M., Ressler K.J., Davis M. Different mechanisms of fear extinction dependent on length of time since fear acquisition. Learn. Mem. 2006, 13:216-223.
166. Nader K. Identifying the neural mechanisms by which boundary conditions inhibit reconsolidation from occurring. Mol. Pain 2006, 2:38.
167. Nader K., Hardt O. A single standard for memory: the case for reconsolidation. Nat. Rev. Neurosci. 2009, 10:224-234.
168. Nader K., Schafe G.E., Le Doux J.E. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 2000, 406:722-726.
169. Ohman A., Mineka S. Fears, phobias, and preparedness: toward an evolved module of fear and fear learning. Psychol. Rev. 2001, 108:483-522.
170. Osten P., Valsamis L., Harris A., Sacktor T.C. Protein synthesis-dependent formation of protein kinase Mzeta in long-term potentiation. J. Neurosci. 1996, 16:2444-2451.
171. Pape H.C., Pare D. Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear. Physiol. Rev. 2010, 90:419-463.
172. Paré D., Smith Y. The intercalated cell masses project to the central and medial nuclei of the amygdala in cats. Neuroscience 1993, 57:1077-1090.
173. Paré D., Smith Y. Intrinsic circuitry of the amygdaloid complex: common principles of organization in rats and cats. Trends Neurosci. 1998, 21:240-241.
174. Paré D., Smith Y., Paré J.F. Intra-amygdaloid projections of the basolateral and basomedial nuclei in the cat: Phaseolus vulgaris-leucoagglutinin anterograde tracing at the light and electron microscopic level. Neuroscience 1995, 69:567-583.
175. Paré D., Quirk G.J., Ledoux J.E. New vistas on amygdala networks in conditioned fear. J. Neurophysiol. 2004, 92:1-9.
176. Parsons R.G., Gafford G.M., Baruch D.E., Riedner B.A., Helmstetter F.J. Long-term stability of fear memory depends on the synthesis of protein but not mRNA in the amygdala. Eur. J. Neurosci. 2006, 23:1853-1859.
177. Pascoe J.P., Kapp B.S. Electrophysiological characteristics of amygdaloid central nucleus neurons during Pavlovian fear conditioning in the rabbit. Behav. Brain Res. 1985, 16:117-133.
178. Pastalkova E., Serrano P., Pinkhasova D., Wallace E., Fenton A.A., Sacktor T.C. Storage of spatial information by the maintenance mechanism of LTP. Science 2006, 313:1141-1144.
179. Pavlov I.P. Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex 1927, Oxford University Press, London.
180. Peters J., Dieppa-Perea L.M., Melendez L.M., Quirk G.J. Induction of fear extinction with hippocampal-infralimbic BDNF. Science 2010, 328:1288-1290.
181. Pitkänen A., Savander V., LeDoux J.E. Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala. Trends Neurosci. 1997, 20:517-523.
182. Pitman R.K., Brunet A., Orr S.P., Tremblay J., Nader K. A novel treatment for post-traumatic stress disorder by reconsolidation blockade with propranolol. Neuropsychopharmacol. 2006, 31:S8-S9.
183. Plendl W., Wotjak C.T. Dissociation of within- and between-session extinction of conditioned fear. J. Neurosci. 2010, 30:4990-4998.
184. Ploski J.E., Pierre V.J., Smucny J., Park K., Monsey M.S., Overeem K.A., Schafe G.E. The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is required for memory consolidation of pavlovian fear conditioning in the lateral amygdala. J. Neurosci. 2008, 28:12383-12395.
185. Ploski J.E., Park K.W., Ping J.L., Monsey M.S., Schafe G.E. Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala. J. Neurochem. 2010, 112:636-650.
186. Power A.E., Berlau D.J., McGaugh J.L., Steward O. Anisomycin infused into the hippocampus fails to block " reconsolidation" but impairs extinction: the role of re-exposure duration. Learn. Mem. 2006, 13:27-34.
187. Powers M.B., Smits J.A.J., Otto M.W., Sanders C., Emmelkamp P.M.G. Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial of yohimbine augmentation. J. Anxiety Disord. 2009, 23:350-356.
188. Powers M.B., Halpern J.M., Ferenschak M.P., Gillihan S.J., Foa E.B. A meta-analytic review of prolonged exposure for posttraumatic stress disorder. Clin. Psychol. Rev. 2010, 30:635-641.
189. Quirk G.J., Mueller D. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology 2008, 33:56-72.
190. Quirk G.J., Armony J.L., LeDoux J.E. Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala. Neuron 1997, 19:613-624.
191. Quirk G.J., Russo G.K., Barron J.L., Lebron K. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J. Neurosci. 2000, 20:6225-6231.
192. Quirk G.J., Garcia R., González-Lima F. Prefrontal mechanisms in extinction of conditioned fear. Biol. Psychiatry 2006, 60:337-343.
193. Raskind M.A., Peskind E.R., Hoff D.J., Hart K.L., Holmes H.A., Warren D., Shofer J., O'Connell J., Taylor F., Gross C., et al. A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol. Psychiatry 2007, 61:928-934.
194. Rasmusson A.M., Charney D.S. Animal models of relevance to PTSD. Ann. N Y Acad. Sci. 1997, 821:332-351.
195. Reijmers L.G., Perkins B.L., Matsuo N., Mayford M. Localization of a stable neural correlate of associative memory. Science 2007, 317:1230-1233.
196. Repa J.C., Muller J., Apergis J., Desrochers T.M., Zhou Y., LeDoux J.E. Two different lateral amygdala cell populations contribute to the initiation and storage of memory. Nat. Neurosci. 2001, 4:724-731.
197. Rescorla R.A. Spontaneous recovery. Learn. Mem. 2004, 11:501-509.
198. Rescorla R.A., Heth C.D. Reinstatement of fear to an extinguished conditioned stimulus. J. Exp. Psychol. Anim. Behav. Process. 1975, 1:88-96.
199. Ressler K.J., Rothbaum B.O., Tannenbaum L., Anderson P., Graap K., Zimand E., Hodges L., Davis M. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch. Gen. Psychiatry 2004, 61:1136-1144.
200. Rogan M.T., LeDoux J.E. LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit. Neuron 1995, 15:127-136.
201. Romanski L.M., Clugnet M.C., Bordi F., LeDoux J.E. Somatosensory and auditory convergence in the lateral nucleus of the amygdala. Behav. Neurosci. 1993, 107:444-450.
202. Rothbaum B.O., Davis M. Applying learning principles to the treatment of post-trauma reactions. Ann. N Y Acad. Sci. 2003, 1008:112-121.
203. Royer S., Paré D. Conservation of total synaptic weight through balanced synaptic depression and potentiation. Nature 2003, 422:518-522.
204. Rudy J.W., Morledge P. Ontogeny of contextual fear conditioning in rats: implications for consolidation, infantile amnesia, and hippocampal system function. Behav. Neurosci. 1994, 108:227-234.
205. Rudy J.W., Biedenkapp J.C., Moineau J., Bolding K. Anisomycin and the reconsolidation hypothesis. Learn. Mem. 2006, 13:1-3.
206. Rumpel S., LeDoux J., Zador A., Malinow R. Postsynaptic receptor trafficking underlying a form of associative learning. Science 2005, 308:83-88.
207. Sacktor T.C. How does PKMζ maintain long-term memory?. Nat. Rev. Neurosci. 2011, 12:9-15.
208. Samson R.D., Paré D. Activity-dependent synaptic plasticity in the central nucleus of the amygdala. J. Neurosci. 2005, 25:1847-1855.
209. Sananbenesi F., Fischer A., Wang X.Y., Schrick C., Neve R., Radulovic J., Tsai L.H. A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nat. Neurosci. 2007, 10:1012-1019.
210. Sara S.J. Retrieval and reconsolidation: toward a neurobiology of remembering. Learn. Mem. 2000, 7:73-84.
211. Schafe G.E., LeDoux J.E. Memory consolidation of auditory pavlovian fear conditioning requires protein synthesis and protein kinase A in the amygdala. J. Neurosci. 2000, 20:RC96.
212. Schafe G.E., Nadel N.V., Sullivan G.M., Harris A., LeDoux J.E. Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase. Learn. Mem. 1999, 6:97-110.
213. Schafe G.E., Atkins C.M., Swank M.W., Bauer E.P., Sweatt J.D., LeDoux J.E. Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning. J. Neurosci. 2000, 20:8177-8187.
214. Schiller D., Monfils M.-H., Raio C.M., Johnson D.C., Ledoux J.E., Phelps E.A. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 2010, 463:49-53.
215. Serrano P., Friedman E.L., Kenney J., Taubenfeld S.M., Zimmerman J.M., Hanna J., Alberini C., Kelley A.E., Maren S., Rudy J.W., et al. PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories. PLoS Biol. 2008, 6:2698-2706. 10.1371/journal.pbio.0060318.
216. Shumyatsky G.P., Tsvetkov E., Malleret G., Vronskaya S., Hatton M., Hampton L., Battey J.F., Dulac C., Kandel E.R., Bolshakov V.Y. Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 2002, 111:905-918.
217. Shumyatsky G.P., Malleret G., Shin R.M., Takizawa S., Tully K., Tsvetkov E., Zakharenko S.S., Joseph J., Vronskaya S., Yin D.Q., et al. stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell 2005, 123:697-709.
218. Sierra-Mercado D., Padilla-Coreano N., Quirk G.J. Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 2011, 36:529-538.
219. Soliman F., Glatt C.E., Bath K.G., Levita L., Jones R.M., Pattwell S.S., Jing D.Q., Tottenham N., Amso D., Somerville L.H., et al. A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 2010, 327:863-866.
220. Sotres-Bayon F., Quirk G. Prefrontal control of fear: more than just extinction. Curr. Opin. Neurobiol. 2010, 20:231-235.
221. Sotres-Bayon F., Cain C.K., LeDoux J.E. Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex. Biol. Psychiatry 2006, 60:329-336.
222. Squire L.R., Alvarez P. Retrograde amnesia and memory consolidation: a neurobiological perspective. Curr. Opin. Neurobiol. 1995, 5:169-177.
223. Stanton P.K., Sarvey J.M. Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis. J. Neurosci. 1984, 4:3080-3088.
224. Swanson L.W., Petrovich G.D. What is the amygdala?. Trends Neurosci. 1998, 21:323-331.
225. Szapiro G., Vianna M.R.M., McGaugh J.L., Medina J.H., Izquierdo I. The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear. Hippocampus 2003, 13:53-58.
226. Tang J.R., Wotjak C.T., Wagner S., Williams G., Schachner M., Dityatev A. Potentiated amygdaloid auditory-evoked potentials and freezing behavior after fear conditioning in mice. Brain Res. 2001, 919:232-241.
227. Thompson B.M., Baratta M.V., Biedenkapp J.C., Rudy J.W., Watkins L.R., Maier S.F. Activation of the infralimbic cortex in a fear context enhances extinction learning. Learn. Mem. 2010, 17:591-599.
228. Tronson N.C., Taylor J.R. Molecular mechanisms of memory reconsolidation. Nat. Rev. Neurosci. 2007, 8:262-275.
229. Tronson N.C., Schrick C., Guzman Y.F., Huh K.H., Srivastava D.P., Penzes P., Guedea A.L., Gao C., Radulovic J. Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear. J. Neurosci. 2009, 29:3387-3394.
230. Tsvetkov E., Carlezon W.A., Benes F.M., Kandel E.R., Bolshakov V.Y. Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala. Neuron 2002, 34:289-300.
231. Tye K.M., Prakash R., Kim S.Y., Fenno L.E., Grosenick L., Zarabi H., Thompson K.R., Gradinaru V., Ramakrishnan C., Deisseroth K. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature 2011, 471:358-362.
232. Van Liempt S., Vermetten E., Geuze E., Westenberg H. Pharmacotherapeutic treatment of nightmares and insomnia in posttraumatic stress disorder - An overview of the literature. Psychobiology of Posttraumatic Stress Disorder: A Decade of Progress 2006, 1071:502-507.
233. Vianna M.R.M., Szapiro G., McGaugh J.L., Medina J.H., Izquierdo I. Retrieval of memory for fear-motivated training initiates extinction requiring protein synthesis in the rat hippocampus. Proc. Natl. Acad. Sci. USA 2001, 98:12251-12254.
234. Vidal-Gonzalez I., Vidal-Gonzalez B., Rauch S.L., Quirk G.J. Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. Learn. Mem. 2006, 13:728-733.
235. Walker D.L., Ressler K.J., Lu K.T., Davis M. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J. Neurosci. 2002, 22:2343-2351.
236. Wang S.H., de Oliveira Alvares L., Nader K. Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation. Nat. Neurosci. 2009, 12:905-912.
237. Wilensky A.E., Schafe G.E., Kristensen M.P., LeDoux J.E. Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning. J. Neurosci. 2006, 26:12387-12396.
238. Wolpe J., Rowan V.C. Panic disorder: a product of classical conditioning. Behav. Res. Ther. 1988, 26:441-450.
239. Woods A.M., Bouton M.E. D-cycloserine facilitates extinction but does not eliminate renewal of the conditioned emotional response. Behav. Neurosci. 2006, 120:1159-1162.
240. Woods A.M., Bouton M.E. Immediate extinction causes a less durable loss of performance than delayed extinction following either fear or appetitive conditioning. Learn. Mem. 2008, 15:909-920.
241. Yang Y.L., Lu K.T. Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala. Neuroscience 2005, 134:247-260.
242. Yehuda R., LeDoux J. Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 2007, 56:19-32.
243. Zimmerman J.M., Maren S. NMDA receptor antagonism in the basolateral but not central amygdala blocks the extinction of Pavlovian fear conditioning in rats. Eur. J. Neurosci. 2010, 31:1664-1670.
244. Zimmerman J.M., Rabinak C.A., McLachlan I.G., Maren S. The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining. Learn. Mem. 2007, 14:634-644.