1-palmitoyl-2-(9′-oxononanoyl)- sn -glycero-3-phosphocholine, an oxidized phospholipid, accelerates finnish type familial gelsolin amyloidosis in vitro

Biochemistry

Volumn 50, Issue 22, 2011, Pages 4877-4889

  Mahalka, Ajay K ^a   Maury, C Peter J ^b   Kinnunen, Paavo K J ^a  

^a AALTO UNIVERSITY   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CHAIN; ALDEHYDE MOIETY; AMYLOID DISEASE; AMYLOID FIBERS; AMYLOID FIBRIL; AMYLOID FORMATION; AMYLOIDOGENESIS; COMPREHENSIVE ANALYSIS; DETAILED KINETICS; FIBRIL ELONGATION; FIBRIL FORMATION; FINNISH; GELSOLIN; IN-VITRO; KINETICS AND MECHANISM; PHOSPHOCHOLINE; PHOSPHOLIPID MEMBRANE; SCHIFF-BASE; STRUCTURAL TRANSITIONS; THIOFLAVIN T; TRP-FLUORESCENCE;

ALDEHYDES; CHEMICAL MODIFICATION; CRITICAL MICELLE CONCENTRATION; FLUORESCENCE; FUNCTIONAL GROUPS; GLYCOPROTEINS; HYDROCARBONS; MICELLES; NEURODEGENERATIVE DISEASES; NUCLEATION; PROTEINS; TISSUE;

PHOSPHOLIPIDS;

1 PALMITOYL 2 (9' OXONONANOYL) SN GLYCERO 3 PHOSPHOCHOLINE; AMYLOID; GELSOLIN; PHOSPHORYLCHOLINE; REACTIVE OXYGEN METABOLITE; THIOFLAVINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CRITICAL MICELLE CONCENTRATION; DEGENERATIVE DISEASE; ELECTRON MICROSCOPY; ENZYME KINETICS; FINNISH TYPE FAMILIAL AMYLOIDOSIS; FLUORESCENCE MICROSCOPY; IN VITRO STUDY; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID; AMYLOIDOSIS, FAMILIAL; GELSOLIN; HUMANS; KINETICS; MICELLES; MUTATION; OXIDATION-REDUCTION; PHOSPHATIDYLCHOLINES; SPECTROMETRY, FLUORESCENCE;

EID: 79958031499     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200195s     Document Type: Article

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