Solution structure of the monovalent lectin microvirin in complex with Manα(1-2)Man provides a basis for anti-HIV activity with low toxicity

Journal of Biological Chemistry

Volumn 286, Issue 23, 2011, Pages 20788-20796

  Shahzad ul Hussan, Syed ^a   Gustchina, Elena ^a   Ghirlando, Rodolfo ^a   Clore, G Marius ^a   Bewley, Carole A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ULTRACENTRIFUGATION; ANTI-HIV ACTIVITY; ENVELOPE GLYCOPROTEINS; GLYCAN EPITOPES; GLYCANS; INFECTIVITY ASSAY; LOW TOXICITY; MULTIVALENCY; NON-SPECIFIC BINDING; SOLUTION STRUCTURES; STRONG INTERACTION; TIME WINDOWS;

CARBOHYDRATES; CENTRIFUGATION; TOXICITY;

VIRUSES;

CYANOVIRIN N; EPITOPE; GLYCAN; GLYCOPROTEIN GP 120; LECTIN; MICROVIRIN; MONOCLONAL ANTIBODY 2G12; MONOMER; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SPECIFICITY; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN STRUCTURE; VIRUS ENTRY;

ANTI-HIV AGENTS; BACTERIAL PROTEINS; BINDING SITES; DISACCHARIDASES; HEK293 CELLS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MANNOSE; MANNOSE-BINDING LECTIN; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;

CYANOBACTERIA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79958009424     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.232678     Document Type: Article

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