Microvirin, a novel α(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile

Journal of Biological Chemistry

Volumn 285, Issue 32, 2010, Pages 24845-24854

  Huskens, Dana ^a   Férir, Geoffrey ^a   Vermeire, Kurt ^a   Kehr, Jan Christoph ^b   Balzarini, Jan ^a   Dittmann, Elke ^b   Schols, Dominique ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-HIV-1 ACTIVITY; ANTIVIRAL ACTIVITIES; CARBOHYDRATE BINDING; CELLULAR TOXICITIES; CLINICAL ISOLATES; CYANOBACTERIUM; CYTOTOXIC; GLYCANS; HIGHLY SENSITIVE; HUMAN IMMUNODEFICIENCY VIRUS; LONG TERM; MICROCYSTIS AERUGINOSA; PERIPHERAL BLOOD MONONUCLEAR CELLS; SHARP CONTRAST; T CELLS; T LYMPHOCYTES; VIRAL REPLICATION;

ABERRATIONS; BLOOD; CARBOHYDRATES; DC POWER TRANSMISSION; MONOCLONAL ANTIBODIES;

VIRUSES;

CD209 ANTIGEN; CD4 ANTIGEN; CD69 ANTIGEN; CYANOVIRIN N; GLYCOPROTEIN GP 120; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; LECTIN; MICROVIRIN; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BACTERIAL PROTEIN; CARRIER PROTEIN; LEUKOCYTE ANTIGEN; MANNOSE; MANNOSE BINDING LECTIN; MICROVIRIN PROTEIN, MICROCYSTIS AERUGINOSA; T LYMPHOCYTE ANTIGEN;

ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SAFETY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROCYSTIS AERUGINOSA; NONHUMAN; NOSTOC; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VIRUS MUTANT; VIRUS REPLICATION; BIOSYNTHESIS; CELL SEPARATION; CHEMISTRY; DRUG SCREENING; FLOW CYTOMETRY; MEDICINAL CHEMISTRY; METABOLISM; MICROCYSTIS; PROCEDURES; VIROLOGY;

ANTI-HIV AGENTS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BACTERIAL PROTEINS; CARRIER PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CHEMISTRY, PHARMACEUTICAL; DRUG EVALUATION, PRECLINICAL; FLOW CYTOMETRY; HIV-1; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LECTINS; LECTINS, C-TYPE; MANNOSE; MANNOSE-BINDING LECTIN; MICROCYSTIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROCYSTIS AERUGINOSA; NOSTOC ELLIPSOSPORUM;

EID: 77955288365     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.128546     Document Type: Article

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