Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 8, 2003, Pages 2518-2525

  O'Keefe, Barry R ^a   Smee, Donald F ^d   Turpin, Jim A ^c,g   Saucedo, Carrie J ^b   Gustafson, Kirk R ^a   Mori, Toshiyuki ^a   Blakeslee, Dennis ^e   Buckheit, Robert ^c,h   Boyd, Michael R ^f  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

^d UTAH STATE UNIVERSITY   (United States)

^e Omniviral Therapeutics   (United States)

^f UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^g HowPin International Consulting   (United States)

^h TherImmune Research Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOVIRIN N; VIRUS HEMAGGLUTININ;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; DRUG POTENCY; ENTERIC VIRUS; FLAVIVIRUS; HEPATITIS VIRUS; HERPES VIRUS; IC 50; INFLUENZA VIRUS; INFLUENZA VIRUS A; INFLUENZA VIRUS B; NONHUMAN; PARAINFLUENZA VIRUS; PRIORITY JOURNAL; PROTEIN BINDING; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RHINOVIRUS; VIRUS ISOLATION; VIRUS PARTICLE;

ANTIVIRAL AGENTS; BACTERIAL PROTEINS; BIOLOGICAL ASSAY; BLOTTING, WESTERN; CARRIER PROTEINS; CELLS, CULTURED; CYTOPATHOGENIC EFFECT, VIRAL; DRUG RESISTANCE, VIRAL; HEMAGGLUTININS; HUMANS; ORTHOMYXOVIRIDAE; VIRUS REPLICATION;

EID: 0043270574     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.8.2518-2525.2003     Document Type: Article

References (31)

1. Anders, E. M., C. A. Hartley, and D. C. Jackson. 1990. Bovine and mouse serum β inhibitors of influenza A viruses are mannose-binding lectins. Proc. Natl. Acad. Sci. USA 87:4485-4489.
2. Arora, D. J. S., P. Tremblay, R. Bourgault, and S. Boileau. 1985. Concentration and purification of influenza virus from allantoic fluid. Anal. Biochem. 144:189-192.
3. Banks, J., E. S. Speidel, E. Moore, L. Plowright, A. Piccirillo, I. Capua, P. Cordioli, A. Fioretti, and D. J. Alexander. 2001. Changes in the haemagglutinin and the neuraminidase genes prior to the emergence of highly pathogenic H7N1 avian influenza viruses in Italy. Arch. Virol. 146:963-973.
4. 1,2 and inhibits infectivity of the Ebola virus. Antivir. Res. 58:47-56.
5. Bewley, C. A. 2001. Solution structure of a cyanovirin-N:Man alpha 1-2Man complex: structural basis for high-affinity carbohydrate-mediated binding of gpl20. Structure 9:931-940.
6. Bolmstedt, A. J., B. R. O'Keefe, S. R. Shenoy, J. B. McMahon, and M. R. Boyd. 2001. Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner. Mol. Pharmacol. 59:949-954.
7. Botos, I., B. R. O'Keefe, S. R. Shenoy, L. K. Cartner, D. M. Ratner, P. H. Seeberger, M. R. Boyd, and A. Wlodawer. 2002. Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high-mannose oligosaccharides. J. Biol. Chem. 277:34336-34342.
8. Boyd, M. R., K. R. Gustafson, J. B. McMahon, R. H. Shoemaker, B. R. O'Keefe, T. Mori, R. J. Gulakowski, L. Wu, M. I. Rivera, C. M. Laurencot, M. J. Currens, J. H. Cardellina II, R. W. Buckheit, Jr., P. L. Nara, L. K. Pannell, R. C. Sowder II, and L. E. Henderson. 1997. Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120; potential applications to microbicide development. Antimicrob. Agents Chemother. 41:1521-1530.
9. Buckheit, R. W., Jr., T. L. Kinjersky, V. Fliakas-Boltz, J. D. Russell, T. L. Stup, L. A. Panllansch, W. G. Brouwer, D. C. Dao, W. A. Harrison, R. J. Schultz, J. P. Bader, and S. S. Yang. 1995. Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type 1-specific compounds related to oxathiin carboxanilide. Antimicrob. Agents Chemother. 39:2718-2727.
10. Caton, A. J., G. G. Brownlee, J. W. Yewdell, and W. Gerhard. 1982. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell 31:417-427.
11. Dey, B., D. L. Lerner, P. Lusso, M. R. Boyd, J. H. Elder, and E. A. Berger. 2000. Multiple antiviral activities of cyanovirin-N: blocking of gp120 interaction with CD4 and coreceptor, and inhibition of diverse enveloped viruses. J. Virol. 74:4562-4569.
12. Edson, C. M., and D. A. Thorley-Lawson. 1983. Synthesis and processing of the three major envelope glycoproteins of Epstein-Barr virus. J. Virol. 46:547-556.
13. Finter, N. B. 1969. Dye uptake methods for assessing viral cytopathogenicity and their application to interferon assays. J. Gen. Virol. 5:419-427.
14. Gubareva, L. V., L. Kaiser, and F. G. Hayden. 2000. Influenza virus neuraminidase inhibitors. Lancet 355:827-835.
15. Hartley, C. A., P. C. Reading, A. C. Ward, and E. M. Anders. 1997. Changes in the hemagglutinin molecule of influenza type A (H3N2) virus associated with increased virulence for mice. Arch. Virol. 142:75-88.
16. Hartshorn, K. L., M. R. White, D. R. Voelker, J. Coburn, K. Zaner, and E. C. Crouch. 2000. Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity. Biochem. J. 351:449-458.
17. Inudoh, M., H. Nyunoya, T. Tanaka, M. Hijikata, N. Kato, and K. Shimotohno. 1996. Antigenicity of hepatitis C virus envelope proteins expressed in Chinese hamster ovary cells. Vaccine 17-18:1590-1596.
18. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
19. McKimm-Breschkin, J. L. 2000. Resistance of influenza viruses to neuraminidase inhibitors - a review. Antivir. Res. 47:1-17.
20. Mori, T., L. G. Barrientos, Z. Han, A. M. Gronenborn, J. A. Turpin, and M. R. Boyd. 2002. Functional homologs of cyanovirin-N amenable to mass production in prokaryotic and eukaryotic hosts. Protein Expr. Purif. 26:42-49.
21. Mori, T., K. R. Gustafson, R. C. Sowder II, L. K. Pannell, J. B. McMahon, R. H. Shoemaker, L. Wu, and M. R. Boyd. 1998. Recombinant production of cyanovirin-N, a potent human immunodeficiency virus-inactivating protein derived from a cultured cyanobacterium. Protein Expr. Purif. 12:151-158.
22. O'Keefe, B. R., S. R. Shenoy, D. Xie, W. Zhang, J. M. Muschik, M. J. Currens, I. Chaiken, and M. R. Boyd. 2000. Analysis of the interaction between the HIV-inactivating protein cyanovirin-N and soluble forms of the envelope glycoproteins gp120 and gp41. Mol. Pharmacol. 58:982-992.
23. Okuno, T., H. Shao, H. Asada, K. Shiraki, M. Takahashi, and K. Yamanishi. 1992. Analysis of human herpesvirus 6 glycoproteins recognized by monoclonal antibody OHV1. J. Gen. Virol. 73:443-447.
24. Reed, L. J., and M. Muench. 1938. A simple method of estimating fifty-percent end points. Am. J. Hyg. 27:493-498.
25. Seidel, W., F. Kunkel, B. Geisler, W. Garten, B. Hermann, L. Dohner, and H. D. Klenk. 1991. Interepidemic variants of influenza virus H3 hemagglutinin differing in the number of carbohydrate side chains. Arch. Virol. 120:289-296.
26. Serafini-Cessi, F., F. Dall'Olio, L. Pereira, and G. Campadelli-Fiume. 1984. Processing of N-linked oligosaccharides from precursor- to mature-form herpes simplex virus type 1 glycoprotein gC. J. Virol. 51:838-844.
27. Shenoy, S. R., L. G. Barrientos, D. M. Ratner, B. R. O'Keefe, P. H. Seeberger, A. M. Gronenborn, and M. R. Boyd. 2002. Multi-site and multivalent binding between cyanovirin-N and branched oligomannosides: NMR and calorimetric characterization. Chem, Biol. 9:1109-1118.
28. Shenoy, S. R., B. R. O'Keefe, A. J. Bolmstedt, L. K. Cartner, and M. R. Boyd. 2001. Selective interactions of the human immunodeficiency virus-inactivating protein cyanovirin-N with high-mannose oligosaccharides on gp120 and other glycoproteins. J. Pharmacol. Exp. Ther. 297:704-710.
29. Smee, D. F., R. W. Sidwell, A. C. Morrison, K. W. Bailey, E. Z. Baum, L. Ly, and P. C. Wagaman. 2001. Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201. Antivir. Res. 52:251-259.
30. Tsuchiya, E., K. Sugawara, S. Hongo, Y. Matsuzaki, Y. Muraki, Z.-N. Li, and K. Nakamura. 2001. Antigenic structure of the haemagglutinin of human influenza A/H2N2 virus. J. Gen. Virol. 82:2475-2484.
31. Yoshima, H., M. Nakanishi, Y. Okada, and A. Kobata. 1981. Carbohydrate structures of HVJ (Sendai virus) glycoproteins. J. Biol. Chem. 256:5355-5361.