Unique interaction pattern for a functionally biased ghrelin receptor agonist

Journal of Biological Chemistry

Volumn 286, Issue 23, 2011, Pages 20845-20860

  Sivertsen, Bjørn ^a   Lang, Manja ^b   Frimurer, Thomas M ^c   Holliday, Nicholas D ^d   Bach, Anders ^a   Els, Sylvia ^b   Engelstoft, Maja S ^a   Petersen, Pia S ^a   Madsen, Andreas N ^a   Schwartz, Thue W ^a   Beck Sickinger, Annette G ^b   Holst, Birgitte ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c University of Copenhagen   (Denmark)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGONIST BINDING SITE; ANCHOR POINT; AROMATIC CLUSTERS; EXTRACELLULAR; GHRELIN; GHRELIN RECEPTOR; INTERACTION PATTERN; RECOGNITION PATTERNS; SERUM RESPONSE ELEMENTS; SIGNALING PATHWAYS; SUBSTANCE-P;

MOLECULAR ORIENTATION; PEPTIDES; SIGNALING;

BIOMIMETICS;

DEXTRO TRYPTOPHANYLPHENYLALANINE DEXTRO TRYPTOPHAN 3 (3 AMINOBENZOIC ACID)AMIDE; DEXTRO TRYPTOPHANYLPHENYLALANINE DEXTRO TRYPTOPHAN 3 (4 AMINOBENZOIC ACID)AMIDE; DEXTRO TRYPTOPHANYLPHENYLALANINE DEXTRO TRYPTOPHAN 4 (2 AMINOETHYL)PIPERAZINE 1 YLACETIC ACID AMIDE; DEXTRO TRYPTOPHANYLPHENYLALANINE DEXTRO TRYPTOPHAN 4 AMINO 2 CYCLOPENTENE 1 CARBOXYLIC ACID AMIDE; DEXTRO TRYPTOPHANYLPHENYLALANINE DEXTRO TRYPTOPHAN AMINOHEXANOIC ACID AMIDE; DEXTRO TRYPTOPHANYLPHENYLALANINE DEXTRO TRYPTOPHAN GAMMA AMINOBUTYRIC ACID AMIDE; DEXTRO TRYPTOPHANYLPHENYLALANINE DEXTRO TRYPTOPHAN ISONIPECOTIC ACID AMIDE; GHRELIN; GHRELIN RECEPTOR; GHRELIN RECEPTOR STIMULATING AGENT; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HORMONE RECEPTOR STIMULATING AGENT; IBUTAMOREN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SERUM RESPONSIVE ELEMENT; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; PEPTIDOMIMETICS; RECEPTORS, GHRELIN; SUBSTANCE P;

EID: 79958001214     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.173237     Document Type: Article

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